scholarly journals Relevance of a Mobile Internet Platform for Capturing Inter- and Intrasubject Variabilities in Circadian Coordination During Daily Routine: Pilot Study (Preprint)

2018 ◽  
Author(s):  
Sandra Komarzynski ◽  
Qi Huang ◽  
Pasquale F Innominato ◽  
Monique Maurice ◽  
Alexandre Arbaud ◽  
...  
Keyword(s):  
Body Temperature ◽  
Cancer Patients ◽  
Healthy Subjects ◽  
Mobile Internet ◽  
The Body ◽  
Circadian Clocks ◽  
Daily Routine ◽  
Temperature Rhythm ◽  
Temperature Rhythms ◽  
Rest Activity

BACKGROUND Experimental and epidemiologic studies have shown that circadian clocks’ disruption can play an important role in the development of cancer and metabolic diseases. The cellular clocks outside the brain are effectively coordinated by the body temperature rhythm. We hypothesized that concurrent measurements of body temperature and rest-activity rhythms would assess circadian clocks coordination in individual patients, thus enabling the integration of biological rhythms into precision medicine. OBJECTIVE The objective was to evaluate the circadian clocks’ coordination in healthy subjects and patients through simultaneous measurements of rest-activity and body temperature rhythms. METHODS Noninvasive real-time measurements of rest-activity and chest temperature rhythms were recorded during the subject’s daily life, using a dedicated new mobile electronic health platform (PiCADo). It involved a chest sensor that jointly measured accelerations, 3D orientation, and skin surface temperature every 1-5 min and relayed them out to a mobile gateway via Bluetooth Low Energy. The gateway tele-transmitted all stored data to a server via General Packet Radio Service every 24 hours. The technical capabilities of PiCADo were validated in 55 healthy subjects and 12 cancer patients, whose rhythms were e-monitored during their daily routine for 3-30 days. Spectral analyses enabled to compute rhythm parameters values, with their 90% confidence limits, and their dynamics in each subject. RESULTS All the individuals displayed a dominant circadian rhythm in activity with maxima occurring from 12:09 to 20:25. This was not the case for the dominant temperature period, which clustered around 24 hours for 51 out of 67 subjects (76%), and around 12 hours for 13 others (19%). Statistically significant sex- and age-related differences in circadian coordination were identified in the noncancerous subjects, based upon the range of variations in temperature rhythm amplitudes, maxima (acrophases), and phase relations with rest-activity. The circadian acrophase of chest temperature was located at night for the majority of people, but it occurred at daytime for 26% (14/55) of the noncancerous people and 33% (4/12) of the cancer patients, thus supporting important intersubject differences in circadian coordination. Sex, age, and cancer significantly impacted the circadian coordination of both rhythms, based on their phase relationships. CONCLUSIONS Complementing rest-activity with chest temperature circadian e-monitoring revealed striking intersubject differences regarding human circadian clocks’ coordination and timing during daily routine. To further delineate the clinical importance of such finding, the PiCADo platform is currently applied for both the assessment of health effects resulting from atypical work schedules and the identification of the key determinants of circadian disruption in cancer patients.

Forced internal desynchronization between circadian temperature and activity rhythms in squirrel monkeys

1985 ◽  
Vol 248 (5) ◽  
pp. R567-R572
Author(s):  
P. H. Gander ◽  
R. Lydic ◽  
H. E. Albers ◽  
M. C. Moore-Ede
Keyword(s):  
Body Temperature ◽  
Squirrel Monkey ◽  
Activity Rhythm ◽  
The Body ◽  
Saimiri Sciureus ◽  
Dark Cycle ◽  
Temperature Rhythm ◽  
Internal Desynchronization ◽  
Body Temperature Rhythm ◽  
Rest Activity

In an attempt to force internal desynchronization between the rest-activity rhythm and the body temperature rhythm of the squirrel monkey (Saimiri sciureus), five animals were studied in a 14:14 light-dark cycle. In four animals a 28-h spectral component was found to predominate in the rest-activity rhythm, whereas an unentrained circadian component (tau = 25.9 +/- 0.4 h) predominated in the body temperature rhythm. Plots of the cycle-by-cycle acrophases of the two rhythms confirm that they desynchronize, due to the failure of the temperature rhythm to entrain to the light-dark cycle. These data from intact animals provide further support for the hypothesis that the squirrel monkey circadian timing system has at least two pacemakers. A rhythm for which the supra-chiasmatic nuclei (SCN) have previously been shown to be essential (rest-activity) simultaneously exhibited a different period from a rhythm (body temperature) that has been shown to persist after destruction of the SCN.

scholarly journals Circadian Disruption of Body Core Temperature and Rest–Activity Rhythms after General (Propofol) Anesthesia in Rats

2009 ◽  
Vol 110 (6) ◽  
pp. 1305-1315 ◽  
Author(s):  
Garance Dispersyn ◽  
Laure Pain ◽  
Yvan Touitou
Keyword(s):  
Body Temperature ◽  
Activity Rhythm ◽  
Temporal Structure ◽  
Intraperitoneal Administration ◽  
Body Core Temperature ◽  
Phase Advance ◽  
Temperature Rhythm ◽  
Temperature Rhythms ◽  
Normal Light ◽  
Rest Activity

Background General anesthesia is commonly associated with sleep disorders, fatigue, drowsiness, and mood alterations in patients. The authors examined whether general (propofol) anesthesia can impact the circadian temporal structure by disturbing circadian rest-activity and body temperature rhythms under normal light-dark conditions (light-dark 12:12 h) in rats. Methods A group of rats was anesthetized with propofol, and another was injected with 10% Intralipid, which was used as a control lipidic solution. The authors examined six groups of rats according to the Zeitgeber time of intraperitoneal administration (ZT6, ZT10, ZT16) and the substance injected (propofol or Intralipid). Results On the day after anesthesia, propofol induced a significant 60- to 80-min phase advance of both rest-activity and body temperature rhythms. A significant 45- to 60-min phase advance of body temperature and a significant 20-min phase advance of rest-activity were still observed on the second day after anesthesia. The amplitudes of both rest-activity and body temperature rhythms were decreased on the first and second days after anesthesia. The 24-h mean rest-activity rhythm was decreased on the day after anesthesia, whereas the 24-h mean body temperature rhythm was not modified. Conclusion The results demonstrate the disturbing effects of propofol anesthesia on the circadian time structure in rats under normal light conditions.

The glycemic index of a mid morning snack modifies the body temperature rhythm

2013 ◽  
Vol 14 ◽  
pp. e242-e243
Author(s):  
J. Belzunce ◽  
C. Noguera ◽  
L. Gené ◽  
R. Rial
Keyword(s):  
Body Temperature ◽  
Glycemic Index ◽  
The Body ◽  
Temperature Rhythm ◽  
Body Temperature Rhythm

scholarly journals XII.—The Effect of changing the Daily Routine on the Diurnal Rhythm in Body Temperature

1912 ◽  
Vol 48 (2) ◽  
pp. 231-261
Author(s):  
Sutherland Simpson
Keyword(s):  
Body Temperature ◽  
Diurnal Variation ◽  
Diurnal Rhythm ◽  
Temperature Curve ◽  
The Body ◽  
Daily Routine ◽  
Combined Effects ◽  
Diurnal Temperature ◽  
The Subject ◽  
The Individual

To determine whether the diurnal variation in body temperature is due to the combined effects of the various influences which are known to act upon it, such as muscular exercise, the ingestion of food, sleep, etc., or is present independently of these, the daily routine of the individual who is the subject of the experiment may be reversed artificially by causing him to work during the night and rest and sleep during the day, or it may be modified in another way, viz. by rapidly changing his longitude in a journey from west to east, or vice versa. If the temperature of the body is dependent on the influences mentioned, then a total reversal of the daily routine, or any modification of it, should produce a corresponding change in the diurnal temperature curve.

scholarly journals Telemonitored Human Circadian Temperature Dynamics During Daily Routine

2021 ◽  
Vol 12 ◽  
Author(s):  
Qi Huang ◽  
Sandra Komarzynski ◽  
Matei Bolborea ◽  
Barbel Finkenstädt ◽  
Francis Albert Lévi
Keyword(s):  
Spectral Analysis ◽  
Body Temperature ◽  
Core Body Temperature ◽  
Principal Component ◽  
Therapeutic Index ◽  
Molecular Clocks ◽  
Daily Routine ◽  
Treatment Timing ◽  
Temperature Rhythms ◽  
Age And Sex

BackgroundCircadian rhythms in body temperature coordinate peripheral molecular clocks, hence they could potentially predict optimal treatment timing (chronotherapy) in individual patients. Circadian parameters in chest surface body temperature (Chesttemp) were recorded remotely and in real time through the use of wearable sensors.MethodsThe dynamics of circadian oscillations in Chesttemp and core body temperature (Coretemp) and their moderation by sex and age were analysed in 38 men and 50 women, aged 21–78 years. In two studies (ST1 and ST2), Chesttemp was measured every minute and teletransmitted using a BLE-connected sensor for 3.6–28.3 days. Additionally, in ST2, Coretemp was recorded per minute in 33 age- and sex-stratified subjects using electronic ingestible pills with radio-frequency transmissions. Circadian parameters were computed using spectral analysis and cosinor modelling. The temporal relations between Chesttemp and Coretemp cosinor parameters were summarised with principal component (PC) analysis. The effect of sex and age was analysed through multivariate regression.ResultsUsing spectral analysis, a dominant period of 24- or 12-h was identified in 93.2% of the Chesttemp and in 100% of the Coretemp time series. The circadian parameters varied largely between-subjects both for Chesttemp (ranges: mesors, 33.2–36.6°C; amplitudes, 0.2–2.5°C; acrophases, 14:05–7:40), and Coretemp (mesors, 36.6–37.5°C; amplitudes, 0.2–0.7°C; bathyphases, 23:50–6:50). Higher PC loadings mainly corresponded to (i) large Chesttemp amplitudes, and phase advance of both temperature rhythms for the first PC (PC1, 27.2% of variance var.), (ii) high mesors in both temperature rhythms for PC2 (22.4% var.), and (iii) large Coretemp amplitudes for PC3 (12.9% var.). Chesttemp and Coretemp mesors and PC2 loadings decreased in females, while remaining quite stable in males as a function of age. In contrast, Coretemp amplitude and PC3 loadings increased with age in females, but decreased in males. Finally, older subjects, both female and male, displayed a reduction in ultradian variabilities, and an increase in both Chesttemp circadian amplitude and PC1 loadings.InterpretationThe dynamics relations between Chesttemp and Coretemp rhythms were largely moderated by age and sex, with results suggesting that treatment timing could be most critical for therapeutic index in women and in order people.

scholarly journals Heterothermy is associated with reduced fitness in wild rabbits

2017 ◽  
Vol 13 (12) ◽  
pp. 20170521 ◽  
Author(s):  
Shane K. Maloney ◽  
Maija K. Marsh ◽  
Steven R. McLeod ◽  
Andrea Fuller
Keyword(s):  
Body Temperature ◽  
Oryctolagus Cuniculus ◽  
Reproductive Output ◽  
Core Body Temperature ◽  
The Body ◽  
The Core ◽  
Temperature Rhythm ◽  
Body Temperature Rhythm ◽  
Core Body ◽  
Growth And Reproduction

An increase in variation in the 24 h pattern of body temperature (heterothermy) in mammals can be induced by energy and water deficits. Since performance traits such as growth and reproduction also are impacted by energy and water balance, we investigated whether the characteristics of the body temperature rhythm provide an indication of the reproductive success of an individual. We show that the amplitude of the daily rhythm of body temperature in wild rabbits ( Oryctolagus cuniculus ) prior to breeding is inversely related to the number of pregnancies in the subsequent seven months, while the minimum daily body temperature is positively correlated to the number of pregnancies. Because reproductive output could be predicted from characteristics of the core body temperature rhythm prior to the breeding season, we propose that the pattern of the 24 h body temperature rhythm could provide an index of animal fitness in a given environment.

scholarly journals Drosophila Temperature Preference Rhythms: An Innovative Model to Understand Body Temperature Rhythms

2019 ◽  
Vol 20 (8) ◽  
pp. 1988 ◽  
Author(s):  
Tadahiro Goda ◽  
Fumika N. Hamada
Keyword(s):  
Locomotor Activity ◽  
Body Temperature ◽  
The Body ◽  
Metabolic Energy ◽  
Temperature Preference ◽  
Preferred Temperature ◽  
Activity Rhythms ◽  
Temperature Rhythm ◽  
Body Temperature Rhythm ◽  
Human Body Temperature

Human body temperature increases during wakefulness and decreases during sleep. The body temperature rhythm (BTR) is a robust output of the circadian clock and is fundamental for maintaining homeostasis, such as generating metabolic energy and sleep, as well as entraining peripheral clocks in mammals. However, the mechanisms that regulate BTR are largely unknown. Drosophila are ectotherms, and their body temperatures are close to ambient temperature; therefore, flies select a preferred environmental temperature to set their body temperature. We identified a novel circadian output, the temperature preference rhythm (TPR), in which the preferred temperature in flies increases during the day and decreases at night. TPR, thereby, produces a daily BTR. We found that fly TPR shares many features with mammalian BTR. We demonstrated that diuretic hormone 31 receptor (DH31R) mediates Drosophila TPR and that the closest mouse homolog of DH31R, calcitonin receptor (Calcr), is essential for mice BTR. Importantly, both TPR and BTR are regulated in a distinct manner from locomotor activity rhythms, and neither DH31R nor Calcr regulates locomotor activity rhythms. Our findings suggest that DH31R/Calcr is an ancient and specific mediator of BTR. Thus, understanding fly TPR will provide fundamental insights into the molecular and neural mechanisms that control BTR in mammals.

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