Effect of Extrinsic Warming of Low-Osmolality CT Contrast Media (Iohexol 350) on Extravasations and Patient Reaction Rates: A Retrospective Study

Peripherally inserted central catheters (PICCs) may be used to administer contrast injection during CT (computed tomography) scans to improve diagnostic accuracy. This is usually done with the use of a power injector. Research has shown that misplacement of catheters following contrast injection can occur. The aim of this review was to analyse appropriately positioned pre-scan PICCs that malposition following injection of contrast media during a CT scan, evaluate whether tip location or right or left insertion plays a part in the displacement of PICCs after CT, and to ensure those involved are aware of the risks and the safety checks required following such procedures. A quantitative method was used, gathering information from the team's insertion database to review 2045 records of contrast-injectable PICCs between 1 January 2015 and 30 April 2020. Analysis of the data indicated that 1% of appropriately sited PICCs malposition following contrast CT injection and that the catheter is able to self-correct back to its original position at an average interval of 24–72 hours without any other intervention. Further research is needed to explore other factors that could influence the rate of self-correction and complications of prolonged catheter malposition.

Download Full-text

Skin tests for the exploration of hypersensitivity reactions associated with iodinated contrast media

Current Drug Safety ◽

10.2174/1574886316666210923143012 ◽

2021 ◽

Vol 16 ◽

Author(s):

Ahmed Zaiem ◽

Syrine Ben Hammamia ◽

Fares Ben Salem ◽

Ons Charfi ◽

Imen Aouinti ◽

...

Keyword(s):

Retrospective Study ◽

Hypersensitivity Reaction ◽

Contrast Media ◽

Skin Testing ◽

Skin Tests ◽

Hypersensitivity Reactions ◽

Iodinated Contrast Media ◽

Iodinated Contrast ◽

Intradermal Tests ◽

The One

Background: Iodinated contrast media (ICM) are responsible for multiple side effects, especially hypersensitivity reactions. These reactions can either be authentic allergies, or non-allergic hypersensitivity reactions. Skin tests (prick and intradermal tests) are simple to perform and can be of great help, especially if the ICM need to be re-used. The aim of the study was to assess the characteristics of the patients in whom skin tests were performed, and the results of these tests. Methods: This is a retrospective study from June 2014 to June 2019. All included patients had at least one episode of hypersensitivity reaction to ICM and underwent skin tests. Results : We included 35 patients aged 18 to 85 years. The iopromide was the most implicated ICM. The reactions were mainly cutaneous (n=30) and immediate (n=27). The skin tests were negative, except for two patients. The reuse of ICM occured in 11 patients: 9 with an ICM other than the one suspected and two patients with the same ICM. Among these patients, 5 did not have any premedication. Two of them had a second hypersensitivity reaction, the first with another ICM and the second with the same ICM. Conclusion: One of the main pillars of allergic exploration is ICM skin testing, not only to prevent recurrence, but also to allow patients to benefit from ICM reuse, which are sometimes essential.

Download Full-text

Adverse Drug Reactions to CT Contrast Media in South Korea: Incidence and Risk Factors

Journal of the Korean Society of Radiology ◽

10.3348/jksr.2016.75.1.41 ◽

2016 ◽

Vol 75 (1) ◽

pp. 41 ◽

Cited By ~ 6

Author(s):

Kyungsoo Bae ◽

Sang Min Lee ◽

Ji Young Ha ◽

Kyung Nyeo Jeon ◽

Jin Il Moon ◽

...

Keyword(s):

Risk Factors ◽

South Korea ◽

Contrast Media ◽

Adverse Drug Reactions ◽

Drug Reactions ◽

Ct Contrast

Download Full-text

Macrophage ablation significantly reduces uptake of imaging probe into organs of the reticuloendothelial system

Acta Radiologica ◽

10.1177/0284185120943048 ◽

2020 ◽

pp. 028418512094304

Author(s):

Bastian O Sabel ◽

Karsten Brand ◽

Johannes Rueckel ◽

Boj Hoppe ◽

Nicola Fink ◽

...

Keyword(s):

Computed Tomography ◽

Animal Model ◽

Contrast Media ◽

Reticuloendothelial System ◽

Ct Scans ◽

The Third ◽

Imaging Probes ◽

Kinetics Of ◽

Over Time ◽

Ct Contrast

Background Macrophages engulf particulate contrast media, which is pivotal for biomedical imaging. Purpose To introduce a macrophage ablation animal model by showing its power to manipulate the kinetics of imaging probes. Material and Methods The kinetics of a particulate computed tomography (CT) contrast media was compared in macrophage ablative mice and normal mice. Liposomes (size 220 µg), loaded with clodronate, were injected into the peritoneum of three C57BL/6 mice. On the third day, 200 µL of the particulate agent ExiTron nano 6000 were injected into three macrophage-ablative mice and three control mice. CT scans were acquired before and 3 min, 1 h, 6 h, and 24 h after the ExiTron application. The animals were sacrificed, and their spleens and livers removed. Relative CT values (CTV) were measured and analyzed. Results Liver and spleen enhancement of treated mice and controls were increasing over time. The median peak values were different with 225 CTV for treated mice and 582 CTV for controls in the liver ( P = 0.032) and 431 CTV for treated and 974 CTV in controls in the spleen ( P = 0.016). Conclusion Macrophage ablation leads to a decrease of enhancement in organs containing high numbers of macrophages, but only marginal changes in macrophage-poor organs. Macrophage ablation can influence the phagocytic activity and thus opens new potentials to investigate and manipulate the uptake of imaging probes.

Download Full-text