scholarly journals Benzene poisoning

2021 ◽  
Vol 17 (7) ◽  
pp. 5-9
Author(s):  
V.S. Tkachyshyn
Keyword(s):  
Bone Marrow ◽  
Nervous System ◽  
Cell Formation ◽  
Symptomatic Treatment ◽  
Brain Disorders ◽  
Chronic Intoxication ◽  
Atypical Form ◽  
Bone Marrow Damage ◽  
The Central Nervous System ◽  
Acute And Chronic Exposure

Benzene is a member of the aromatic hydrocarbon group and belongs to the group of blood poisons that cause inhibition of bone marrow hematopoiesis with the development of hypoplastic or aplastic anemia. The benzene can result in acute and chronic intoxication. Under industrial conditions, the penetration of benzene and its homologues into the human body is possible through the lungs and intact skin. The symptoms of changes in the nervous system and bone marrow hematopoiesis in acute and chronic exposure to benzene are different. Acute intoxication manifests itself with symptoms of damage to the central nervous system with the phenomena of general brain disorders, similar to poisoning with substances with narcotic properties. Chronic intoxication develops slowly, unnoticed by the patient, and is characterized by bone marrow damage with impaired blood cell formation. An atypical form of chronic benzene intoxication is the development of benzene leukemia. Therefore, benzene belongs to the group of industrial carcinogens. Typical forms of acute and chronic benzene intoxication are easy to recognize. To establish the diagnosis of benzene intoxication, it is necessary at first to have data confirming the patient’s contact with benzene. Repeated studies of peripheral blood, bone marrow puncture are important. There are no specific antidotes for benzene intoxication. Symptomatic treatment is performed only. Therefore, it is important to prevent the development of benzene intoxication in the workplace before the stage of deep irreversible disorders.

Mammalian Bone Marrow Acetylcholinesterase

1982 ◽  
Vol 40 ◽  
pp. 44-45
Author(s):  
Ezzatollah Keyhani
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Common Property ◽  
Extracellular Medium ◽  
The Central Nervous System ◽  
The Common ◽  
Mammalian Bone

Acetylcholinesterase (EC 3.1.1.7) (ACHE) has been localized at cholinergic junctions both in the central nervous system and at the periphery and it functions in neurotransmission. ACHE was also found in other tissues without involvement in neurotransmission, but exhibiting the common property of transporting water and ions. This communication describes intracellular ACHE in mammalian bone marrow and its secretion into the extracellular medium.

scholarly journals After Injection into the Striatum, in Vitro-Differentiated Microglia- and Bone Marrow-Derived Dendritic Cells Can Leave the Central Nervous System via the Blood Stream

2008 ◽  
Vol 173 (6) ◽  
pp. 1669-1681 ◽  
Author(s):  
Sonja Hochmeister ◽  
Manuel Zeitelhofer ◽  
Jan Bauer ◽  
Eva-Maria Nicolussi ◽  
Marie-Therese Fischer ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Dendritic Cells ◽  
Blood Stream ◽  
The Central Nervous System

scholarly journals Mantle Cell Lymphoma recurrence and involvement of the central nervous system after bone marrow transplantation: case report.

2021 ◽  
Author(s):  
Rafael Bragança Rodrigues Matias ◽  
Bruna Cardoso de Mattos Boccalini ◽  
Renata de Oliveira Costa ◽  
Maria Fernanda Mélega Mingossi
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Case Report ◽  
Bone Marrow Transplantation ◽  
Mantle Cell Lymphoma ◽  
Marrow Transplantation ◽  
Cell Lymphoma ◽  
Mantle Cell ◽  
The Central Nervous System

Introduction: Mantle cell lymphoma (MCL) is a subtype of uncommon nonHodgkin lymphoma. The involvement of the central nervous system (CNS) is uncommon in the course of the disease. Objective: To report a case of recurrence of MCL in the CNS as the first manifestation, after chemotherapy and bone marrow transplantation. Case report: Male patient, 49 years old, with no previous comorbidities diagnosed with stage IV MCL (bone marrow), submitted to chemotherapy and autologous transplantation. After two years, he sought out the neurology clinic with a complaint of blurred vision. Neurological examination: without motor deficit; bilateral partial ptosis, bilateral divergent strabismus, tongue shift to the right. CSF with 230 leukocytes/mm³, 70% of lymphocytes, glucose of 71 mg /dl and protein of 85 mg /dl; Skull MRI demonstrated bilateral and symmetrical enhancement of segments of the cisterns of the optic and oculomotor nerves; Trigeminal, facial, vestibulocochlear and glossopharyngeal, vagus and accessory nerves more exuberant on the left. CSF immunophenotyping showed CD19, CD5 and Kappa positive monoclonal, compatible with MCL recurrence. Intrathecal and systemic chemotherapy with methotrexate were initiated. Discussion: Risk of recurrence of MCL and infiltration of the CNS is uncommon (3.9 - 5%). The patient did not show any signs of systemic involvement, only the neurological findings, which is atypical since the neurological presentation is more associated with recurrence of MCL with a course of systemic findings. Conclusion:The authors point out that in patients with treated MCL who have neurological manifestations without systemic findings, tumor recurrence should be considered.

scholarly journals Expression of (pro)renin receptor and angiotensin II type 1 receptor on bone marrow‐related neurons in the central nervous system

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Christie Diane Kimball ◽  
Wencheng Li ◽  
Andrea Zsombok ◽  
Andrei Derbenev ◽  
Joseph Francis ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Angiotensin Ii ◽  
The Central Nervous System

TRIMETHADIONE (TRIDIONE®) NEPHROSIS

PEDIATRICS ◽  
1958 ◽  
Vol 22 (4) ◽  
pp. 614-615
Author(s):  
WALTER HEYMANN
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Nephrotic Syndrome ◽  
Microscopic Hematuria ◽  
Angioneurotic Edema ◽  
Renal Complications ◽  
The Central Nervous System ◽  
Erythema Exudativum Multiforme ◽  
Marrow Activity

TRIMETHADIONE (3,5,5-trimethyl-2,4-oxazolidinedione, Tridione® is a useful drug in the management of petit mal seizures. It may, however, like many pharmacologically effective agents, have untoward reactions. These can involve: 1) the central nervous system (diplopia, vertigo, headaches and hiccups); 2) the hematopoetic system (depression of bone marrow activity); 3) the skin (various forms of rashes, erythema exudativum multiforme and angioneurotic edema; and 4) the kidneys. Renal complications of trimethadione administration are noted in two different forms. Microscopic hematuria and cellular casts have been reported, and 10 years ago, the nephrotic syndrome due to prolonged trimethadione treatment was first described by Barnett.

Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system

2004 ◽  
Vol 7 (2) ◽  
pp. 167-180 ◽  
Author(s):  
Olivier F. Join-Lambert ◽  
Sophie Ezine ◽  
Alban Le Monnier ◽  
Francis Jaubert ◽  
Masaru Okabe ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Listeria Monocytogenes ◽  
Myeloid Cells ◽  
Bacterial Invasion ◽  
The Central Nervous System
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