scholarly journals A REVIEW ON THE NEURAL CIRCUITS IN ANXIETY DISORDERS

2016 ◽  
Vol 9 (9) ◽  
pp. 26
Author(s):  
Ashwani Arya ◽  
Gulshan Sindhwani
Keyword(s):  
Anxiety Disorders ◽  
Behavioral Problems ◽  
Social Withdrawal ◽  
Treatment Options ◽  
Brain Regions ◽  
Emotional And Behavioral Problems ◽  
Diverse Range ◽  
Evidence Based Treatment ◽  
Reciprocal Connections

ABSTRACTAnxiety disorders are among the most common mental, emotional, and behavioral problems. These affect one-eighth of the total population worldwide.Anxiety disorders are a group of mental disorders characterized by irritability, fear, insomnia, nervousness, tachycardia, inability to concentrate,poor coping skills, palpitation, sweating, agoraphobia, and social withdrawal. Brain regions and networks involved in anxiety symptomatology isan effort to better understand the mechanism involved and to develop more effective treatments for the anxiety disorders. Thus, neuroanatomicaland neuroimaging research in anxiety disorders has centered on the role of the amygdala, reciprocal connections between the amygdala and theprefrontal cortex, and, most recently, alterations in interoceptive processing by the anterior insula. Anxiety disorders are characterized by alterationsin a diverse range of neurochemical systems, suggesting ample novel targets for drug therapies. The neurotransmitter like corticotropin-releasingfactor, neuropeptides (substance P, neuropeptide Y, oxytocin, orexin, and galanin) are implicated in anxiety pathways. Each of these active areas ofresearch holds promise for expanding and improving evidence-based treatment options for individuals suffering with clinical anxiety. Therefore,this article gives the information on the neurocognitive mechanisms, causes, neurotransmitter involved in anxiety disorders and emphasize on thetherapeutic targets for anxiety disorders.Keywords: Anxiety, Stress, Amygdala, Corticotropin releasing factor, Insula, Thalamus.

scholarly journals Struggling with recurrent Clostridium difficile infections: is donor faeces the solution?

2009 ◽  
Vol 14 (34) ◽  
Author(s):  
E van Nood ◽  
P Speelman ◽  
E J Kuijper ◽  
J J Keller
Keyword(s):  
Clostridium Difficile ◽  
Case Reports ◽  
Treatment Options ◽  
Intestinal Flora ◽  
Treatment Strategies ◽  
Case Series ◽  
Oral Vancomycin ◽  
Vancomycin Therapy ◽  
Evidence Based Treatment

Patients with recurrent Clostridium difficile infections (CDI) in hospitals and the community constitute an increasing treatment problem. While most patients with a first infection respond to either metronidazole or oral vancomycin, therapy in recurrent C. difficile infections tends to fail repeatedly. Lack of alternative treatment options can be a tremendous burden, both to patients and their treating physicians. Most guidelines recommend prolonged oral vancomycin pulse and or tapering schedules, but evidence-based treatment strategies are lacking. The role of immunoglobulins, whey prepared from vaccinated cows, probiotics or other antibiotics is unclear. Since 1958 several case series and case reports describe a treatment strategy where faecal infusions are successfully given for the treatment of recurrent CDI. Restoring intestinal flora has been historically thought of as the mechanism responsible for cure in these patients. In the literature, more than 150 patients have received faeces from a healthy donor, either infused through an enema, or through a nasoduodenal or nasogastric tube. We summarise the literature regarding treatment with donor faeces for recurrent CDI, and introduce the FECAL trial, currently open for inclusion.

Psychologic Adjustment of Siblings of Children With Chronic Illness

PEDIATRICS ◽  
1979 ◽  
Vol 63 (4) ◽  
pp. 616-627 ◽  
Author(s):  
John V. Lavigne ◽  
Michael Ryan
Keyword(s):  
Plastic Surgery ◽  
Behavioral Problems ◽  
Social Withdrawal ◽  
Emotional And Behavioral Problems ◽  
Group Differences ◽  
Blood Disorders ◽  
Significant Group ◽  
Pediatric Hematology ◽  
Comparison Groups ◽  
Patient Groups

Although numerous references are made to the stressful, deleterious effects of chronic or terminal illnesses and handicaps on the siblings of pediatric patients, very few studies have been conducted using comparison groups. The present study compares the adjustment of 3-to 13-year-old siblings of pediatric hematology (N = 62), cardiology (N = 57), and plastic surgery patients (N = 37) with healthy siblings (N = 46). The adjusttuent measure was an objective, paper-and-pencil measure of children's emotional and behavioral problems, the Louisville Behavior Checklist. On analyses of covariance, the patient groups were more likely to show symptoms of irritability and social withdrawal, and the differences between illness groups approached significance on measures of fear and inhibition. Among the younger children, ages 3 to 6, there were significant group differences, with the siblings of patients undergoing plastic surgery showing the highest level of general psychopathology. Among children ages 7 to 13, male siblings of patients with blood disorders were more likely to show signs of emotional disturbance than female siblings. No group differences were noted on measures of aggression or learning problems. Significant interactions between sex and age relationship to the child were noted on scales of social withdrawal, inhibition, immaturity, and irritability.

scholarly journals Role of family composition and functioning on emotional and behavioral problems among adolescents

2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
Z Dankulincova Veselska ◽  
K Paclikova ◽  
D Filakovska Bobakova ◽  
A Madarasova Geckova
Keyword(s):  
Behavioral Problems ◽  
Emotional And Behavioral Problems ◽  
Family Composition

The Role of the Glutamatergic System in Posttraumatic Stress Disorder

CNS Spectrums ◽  
2008 ◽  
Vol 13 (7) ◽  
pp. 585-591 ◽  
Author(s):  
Jyotsna Nair ◽  
Sarbjot Singh Ajit
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Anxiety Disorders ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Brain Regions ◽  
Corticotropin Releasing Factor ◽  
Glutamatergic System ◽  
Symptom Complex ◽  
Crf System

ABSTRACTAntiglutamatergic agents, such as lamotrigine, have been used successfully for the treatment of posttraumatic stress disorder (PTSD). They could be potentially acting through the stabilization of the corticotropin-releasing factor (CRF) systems. Glutamate mediates CRF release in various brain regions involved in the pathophysiology of PTSD, antiglutamatergic agents could stabilize the CRF system and, thereby, improve the symptom complex of PTSD (reexperiencing, hyperarousal, and avoidance). The role of glutamate and CRF in PTSD and other anxiety disorders are still being elucidated. However, it is clear that the glutamatergic systems play a role in the pathophysiology of PTSD.

scholarly journals Child Maltreatment and Resilience: The Promotive and Protective Role of Future Orientation

2019 ◽  
Author(s):  
Zehua Cui ◽  
Assaf Oshri ◽  
Sihong Liu ◽  
Emilie Smith ◽  
Steven M. Kogan
Keyword(s):  
Child Maltreatment ◽  
Behavioral Problems ◽  
Future Orientation ◽  
Protective Role ◽  
Emotional And Behavioral Problems ◽  
Positive Development ◽  
Delinquent Behaviors ◽  
Youth Delinquency ◽  
Wide Range

Maltreatment is associated with risk for a wide range of socio-emotional and behavioral problems in adolescence. Despite this risk, many maltreated youth adjust well through the process of resilience. Extant research demonstrates that future orientation is linked to reduced risks for maladjustment in adolescence. Few studies, however, have tested the protective and promotive role of future orientation using positive and negative developmental outcomes among maltreated youth. The present study aimed to investigate the promotive and moderating role of future orientation among a longitudinal sample of maltreated and demographically comparable non-maltreated youth (N = 1,354, 51.5% female, 53.2% African American). Data collected from Time 1 (Mage = 4.56, SDage = .70) to Time 8 (Mage = 18.514, SDage = .615) were used. Compared to the non-maltreated youth, maltreated youth showed increased delinquent behaviors and reduced self-esteem. In addition, future orientation significantly predicted higher levels of social competence and attenuated the adverse effects of maltreatment on youth delinquency and substance use. The findings highlight the role of future orientation in the development of resilience among maltreated youth, bearing significant contributions to prevention and intervention programs designed to protect youth against risks linked to child maltreatment and promote their positive development.

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