scholarly journals THE DEGREE OF SECRETORY IMMUNOGLOBULIN A IN BURN PATIENTS WITH PROBIOTIC THERAPY

2019 ◽  
pp. 174-176
Author(s):  
LYNDA HARIANI ◽  
IRAWAN WAHYUDI ◽  
ISWINARNO DOSOSAPUTRO ◽  
SJAIFUDDIN NOER M
Keyword(s):  
Immune System ◽  
Immunoglobulin A ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Secretory Immunoglobulin A ◽  
Burn Patients ◽  
Double Blind ◽  
And Control ◽  
Secretory Immunoglobulin ◽  
Regular Intake

Background: One of the problems with burn patients is the impairment of host immunity, which makes difficult to treat. In burns, immunoglobulinA has demonstrated to decrease. Immunoglobulin A is the main product of mucous immune system, which increases viral clearance and decreasesbacterial adhesion in the intestine. Probiotics consist of living microflora, which control the balance of lactobacilli and bifidobacteria in the intestine.Instead of producing organic component, increasing the acidity of intestine, mucin and bacteriocin, they also activate the intestinal immune systemand secretory immunoglobulin A (sIgA). The goal of this study was to propose that regular intake of probiotic might help to improve the mucousimmune system, especially sIgA in intestines in burn patients.Methods: An experimental, double-blind, controlled clinical trial was carried out in 33 burn patients. Those patients were divided into two groups.The first group was given daily probiotic and the second group was given only placebo for 10 days. The treatment began on the 4th day admission, andthen, the degree of sIgA was evaluated before treatment and day 14 from fecal specimen.Results: Significant differences between probiotic and control group were observed (p<0.0001). The degree of sIgA in the probiotic group increased61.25%, and in the control group, it decreased to 36.80%.Conclusion: The mucous immune system, especially sIgA, increases by probiotic intake.

scholarly journals Probiotics maintain intestinal secretory immunoglobulin A levels in healthy formula-fed infants: a randomised, double-blind, placebo-controlled study

2019 ◽  
Vol 10 (7) ◽  
pp. 729-739 ◽  
Author(s):  
L. Xiao ◽  
C. Gong ◽  
Y. Ding ◽  
G. Ding ◽  
X. Xu ◽  
...  
Keyword(s):  
Placebo Group ◽  
Immune System ◽  
Immunoglobulin A ◽  
Lactobacillus Helveticus ◽  
Controlled Study ◽  
Secretory Immunoglobulin A ◽  
Anthropometric Parameters ◽  
Double Blind ◽  
Immune System Development ◽  
Secretory Immunoglobulin

Formula-fed infants are more susceptible to infectious diseases because they lack the maternal immune factors transferred from breast milk, while their own immune system is still immature. As timely probiotic administration was suggested to promote immune system development in formula-fed infants, this study aimed at assessing the safety and the effects of a probiotic supplement (Bifidobacterium infantis R0033, Bifidobacterium bifidum R0071, and Lactobacillus helveticus R0052) on mucosal immune competence and digestive function in formula-fed infants. Healthy infants (3.5-6 months old) were randomised to receive either probiotic- (n=66) or placebo-supplemented (n=66) formula once a day for four weeks. In the probiotics group, faecal secretory immunoglobulin A (SIgA) levels remained similar between visit 2 (baseline; V2) and visit 3 (end-of-treatment; V3), but decreased in the placebo group. Changes in SIgA levels following treatment (log10ΔV3-V2 [95%CI]) between the probiotic and placebo groups were statistically significant (23 ng/dl [-57;102] and -137 ng/dl [-212;-62], respectively (P=0.0044; ANCOVA)). While log10ΔV3-V2 [95%CI] for salivary SIgA levels increased in both groups, this trend was more pronounced in the probiotics than in the placebo group with an increase of 123 ng/dl [9;236] and 37 ng/dL [-72;147], respectively (P=0.2829; ANCOVA). The weekly average number of stools/day was significantly higher in the probiotics group compared to placebo during the last week of treatment for the per protocol population. There was no difference in microbiota composition or anthropometric parameters between groups. No serious adverse event was reported, and all adverse events were mild and unrelated to the product or study. Our results show that formula-fed infants receiving probiotics maintained higher faecal SIgA levels at the end of the four-week treatment period, suggesting a positive effect of probiotics on SIgA production. This study demonstrates the safety of this probiotic formulation in infants. Formula-fed infants may benefit from probiotics supplementation to sustain the development of mucosal immunity.

Progressive Muscle Relaxation and Secretory Immunoglobulin A

2001 ◽  
Vol 88 (3) ◽  
pp. 912-914 ◽  
Author(s):  
Geoff Lowe ◽  
Rachel Bland ◽  
John Greenman ◽  
Nadine Kirkpatrick ◽  
Gillian Lowe
Keyword(s):  
Muscle Relaxation ◽  
Immunoglobulin A ◽  
Progressive Muscle Relaxation ◽  
Control Group ◽  
Secretory Immunoglobulin A ◽  
Before And After ◽  
Secretory Immunoglobulin

30 healthy students produced saliva samples for Immunoglobulin A assay before and after sessions involving either progressive muscle relaxation ( n = 15) or a control condition ( n = 15). Levels of immunoglobulin A increased significantly in the relaxation group but not in the control group.

scholarly journals Choral Singing, Performance Perception, and Immune System Changes in Salivary Immunoglobulin A and Cortisol

2000 ◽  
Vol 18 (1) ◽  
pp. 87-106 ◽  
Author(s):  
R. J. Beck ◽  
T. C. Cesario ◽  
A. Yousefi ◽  
H. Enamoto
Keyword(s):  
Immune System ◽  
Rating Scales ◽  
Immunoglobulin A ◽  
Multiple Regression Model ◽  
System Response ◽  
Secretory Immunoglobulin A ◽  
Public Performance ◽  
Choral Singing ◽  
Salivary Immunoglobulin A ◽  
Secretory Immunoglobulin

In a naturalistic pre-post design, samples of saliva were collected from the members of a professional chorale during an early rehearsal (n = 31), a late rehearsal (n = 34) and a public performance (n = 32) of Beethoven's Missa Solemnis. As measures of immune system response, mean levels of secretory immunoglobulin A increased significantly, as a proportion of whole protein, 150% during rehearsals and 240% during the performance. Cortisol concentrations decreased significantly an average of 30% during rehearsals and increased 37% during performance. As measured through performance perception rating scales, a group of emotions and other experiential states that singers associated with professional singing were highly predictive of changes in level of secretory immunoglobulin A during the performance condition, but the results for the rehearsal conditions were not significant. The best multiple regression model for performance level of immunoglobulin A (p &lt; .0015) included seven emotional, cognitive, and evaluative variables generally associated with choral singing, including levels of mood before and during singing, stress, relaxation, feeling "high," detachment/engagement, and specific satisfaction with the immediate performance.

Downregulation of the immune system in low-quality child care: The case of Secretory Immunoglobulin A (SIgA) in toddlers

2012 ◽  
Vol 105 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Harriet J. Vermeer ◽  
Marinus H. van IJzendoorn ◽  
Marleen G. Groeneveld ◽  
Douglas A. Granger
Keyword(s):  
Child Care ◽  
Immune System ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
Quality Child Care ◽  
Quality Child ◽  
Secretory Immunoglobulin

scholarly journals A Preliminary Study on the Safety, Efficacy and Acceptability of the Community Preparation of Siling Labuyo (Capsicum frutescens) Liniment in the Management of Knee Osteoarthritis in a Six-Week, Active-Controlled Community-Based Clinical Trial

2019 ◽  
Vol 53 (4) ◽  
Author(s):  
Elizabeth R. Paterno ◽  
Clarisse A. Pangilinan ◽  
Erna C. Arollado ◽  
Rachael Marie B. Rosario
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Control Agent ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Control Groups ◽  
Double Blind ◽  
The Difference ◽  
And Control ◽  
Experimental Group

Objective. The study determined the safety, efficacy and acceptability of a Philippine community preparation of Siling Labuyo liniment in the management of knee osteoarthritis. Methods. A 6-week randomized, double-blind, active-controlled clinical trial was conducted in three municipalities of Cavite from 2017-2018. The municipalities were randomly assigned to either the control or experimental group, using a commercially available Diclofenac 1% gel as the control agent. Knee Injury and Osteoarthritis Outcome Score (KOOS) and Pain Visual Analogue Scale (VAS) were used to measure the outcomes. Results. Forty-seven participants completed the study. Statistically significant improvement (p<0.05) in pain relief, reduction of symptoms and increase in knee functionality was reported by participants in both the experimental and control groups. Across the dimensions measured, at least 30% improvement in scores was reported by the experimental group, and at least 40% by the control group. The difference was statistically not significant (p>0.05). Itching (13%), burning sensation (11%) and reddening of the skin (15%) were experienced in both the experimental and the active control groups. Conclusion. Use of the liniment led to a modest therapeutic effect and was well-tolerated by the participants.

scholarly journals Analgesic and antisympathetic effects of clonidine in burn patients, a randomized, double-blind, placebo-controlled clinical trial

2007 ◽  
Vol 40 (01) ◽  
pp. 29-33
Author(s):  
Ostadalipour Abbas ◽  
Jamshidi Mojgan ◽  
Zamani Alieh ◽  
Jamshidi Maryam ◽  
Ashrafi Tavasoli Ahmad
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Systolic Blood Pressure ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Case Group ◽  
Burn Patients ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Oral Clonidine

ABSTRACT Objectives:Unlike most other Analgesic drugs, α2 adrenoceptor agonists are capable of producing analgesia. The aim of this study was to evaluate the Analgesic and antisympathetic effects of clonidine, an α2 adrenoceptor agonist in burn patients.Materials and Methods:This randomized, double-blind, placebo-controlled clinical trial performed on one hundred burn patients in Zarea Hospital, Mazandaran, Iran from august 2004 to July 2005. All patients divided in two groups. Case group (n=50) received oral clonidine, 3.3μg/kg TDS and controls (n=50) received placebo. Heart rate and systolic blood pressure and pain severity Visual analogue score (VAS), were recorded after clonidine administration. Statistical analysis was done by means of Mann Witney U test. Results:50 patients (mean age 28.96±10 years) in case group, and 50 patients (mean age 27.60±11.4 years) in control group were studied. VAS pain scores and heart rate in the clonidine group were significantly lower than the control group (P< 0.0001, P< 0.02).there were no significant difference in systolic blood pressure between the two groups on the first and second day but on third day the systolic blood pressure in clonidine group, was lower than controls significantly (P=0.002). Conclusion: This study demonstrates that the use of oral clonidine affects the hemodynamic response to pain in burn patients. Our study demonstrated that clonidine can produce good analgesia and decreased in sympathetic over activity in burn patients, and also reduce opioid dose requirements.

FEATURES OF DEVELOPMENT OF GENERALIZED PERIODONTITIS IN PERSONS WITH SECRETORY IMMUNOGLOBULIN A DEFICIENCY AND ITS TREATMENT (LITERATURE REVIEW)

2021 ◽  
Vol 74 (6) ◽  
pp. 1510-1514
Author(s):  
Hanna M. Sylenko ◽  
Petro M. Skrypnykov ◽  
Yurii I. Sylenko ◽  
Olena A. Pisarenko
Keyword(s):  
Immune System ◽  
Medical Literature ◽  
Immunoglobulin A ◽  
Iga Deficiency ◽  
Secretory Immunoglobulin A ◽  
Secondary Immunodeficiency ◽  
Selective Iga Deficiency ◽  
Nonspecific Factors ◽  
Methods Analytical ◽  
Secretory Immunoglobulin

The aim: To present data on the possibility of occurrence and active progression of generalized periodontitis in persons with secretory immunoglobulin A deficiency and possible methods of its correction. Мaterials and methods: Analytical elaboration of scientific and medical literature based on the immunological aspect of generalized periodontitis. Conclusions: The deficiency of secretory immunoglobulin A may occur in cases of primary or secondary insufficiency of the immune system. Selective IgA deficiency is an example of primary insufficiency of the immune system. Secondary immunodeficiency disorders is a clinical and immunological syndrome that develops against the background of a previously normally functioning immune system, characterized by a steady decrease in quantitative or functional indicators of specific or(and) nonspecific factors of immunoresistance. Insufficient awareness of dentists about certain aspects of the etiology and pathogenesis of generalized periodontitis leads to deterioration of treatment results.

Influence of different inclusion levels and chain length of inulin on microbial ecology and the state of mucosal protective barrier in the large intestine of young pigs

2018 ◽  
Vol 58 (6) ◽  
pp. 1109 ◽  
Author(s):  
M. Barszcz ◽  
M. Taciak ◽  
J. Skomiał
Keyword(s):  
Microbial Activity ◽  
Large Intestine ◽  
Control Diet ◽  
Immunoglobulin A ◽  
Intraepithelial Lymphocytes ◽  
Control Group ◽  
Secretory Immunoglobulin A ◽  
Fatty Acid Production ◽  
Dietary Level ◽  
Secretory Immunoglobulin

The objective of the study was to examine the effect of inulin level, in regard to its degree of polymerisation (DP), on microbial activity and mucosal immune system of the large intestine of pigs. A total of 56 castrated male piglets (PIC × Penarlan P76) were allocated to seven groups and fed from the 10th day of life cereal-based diets without the addition of inulin or with 1%, 2% or 3% of inulin with an average DP of 10 (IN10) or 23 (IN23). Pigs were sacrificed at the age of 50 days. Feeding IN10 diets increased fructan concentration in the large intestine compared with IN23 diets, but did not affect microbial activity, except for digesta pH and mucinase activity in the middle colon, which were greater at the 1% level compared with the control group and other IN10 diets, respectively. The concentration of secretory immunoglobulin A in the caecum and middle colon was reduced by the 1% IN10 diet compared with the control group. Pigs fed the 2% IN23 diet had a higher butyric acid concentration in the caecum and proximal colon and greater isoacid concentrations in the middle and distal colon in comparison to the control. Dietary level of IN23 did not affect secretory immunoglobulin A concentration but the count of caecal intraepithelial lymphocytes was higher in pigs on the 1% IN23 diet than on the control diet. Neither IN10 nor IN23 diets affected populations of Bifidobacterium or Lactobacillus spp. In conclusion, the effects of inulin in the large intestine of pigs depended on dietary level and DP. IN23 increased short-chain fatty acid production at the 2% level and slightly activated mucosal immune status at the 1% level.

Sign in / Sign up

Export Citation Format

Share Document