scholarly journals Probiotics maintain intestinal secretory immunoglobulin A levels in healthy formula-fed infants: a randomised, double-blind, placebo-controlled study

2019 ◽  
Vol 10 (7) ◽  
pp. 729-739 ◽  
Author(s):  
L. Xiao ◽  
C. Gong ◽  
Y. Ding ◽  
G. Ding ◽  
X. Xu ◽  
...  
Keyword(s):  
Placebo Group ◽  
Immune System ◽  
Immunoglobulin A ◽  
Lactobacillus Helveticus ◽  
Controlled Study ◽  
Secretory Immunoglobulin A ◽  
Anthropometric Parameters ◽  
Double Blind ◽  
Immune System Development ◽  
Secretory Immunoglobulin

Formula-fed infants are more susceptible to infectious diseases because they lack the maternal immune factors transferred from breast milk, while their own immune system is still immature. As timely probiotic administration was suggested to promote immune system development in formula-fed infants, this study aimed at assessing the safety and the effects of a probiotic supplement (Bifidobacterium infantis R0033, Bifidobacterium bifidum R0071, and Lactobacillus helveticus R0052) on mucosal immune competence and digestive function in formula-fed infants. Healthy infants (3.5-6 months old) were randomised to receive either probiotic- (n=66) or placebo-supplemented (n=66) formula once a day for four weeks. In the probiotics group, faecal secretory immunoglobulin A (SIgA) levels remained similar between visit 2 (baseline; V2) and visit 3 (end-of-treatment; V3), but decreased in the placebo group. Changes in SIgA levels following treatment (log10ΔV3-V2 [95%CI]) between the probiotic and placebo groups were statistically significant (23 ng/dl [-57;102] and -137 ng/dl [-212;-62], respectively (P=0.0044; ANCOVA)). While log10ΔV3-V2 [95%CI] for salivary SIgA levels increased in both groups, this trend was more pronounced in the probiotics than in the placebo group with an increase of 123 ng/dl [9;236] and 37 ng/dL [-72;147], respectively (P=0.2829; ANCOVA). The weekly average number of stools/day was significantly higher in the probiotics group compared to placebo during the last week of treatment for the per protocol population. There was no difference in microbiota composition or anthropometric parameters between groups. No serious adverse event was reported, and all adverse events were mild and unrelated to the product or study. Our results show that formula-fed infants receiving probiotics maintained higher faecal SIgA levels at the end of the four-week treatment period, suggesting a positive effect of probiotics on SIgA production. This study demonstrates the safety of this probiotic formulation in infants. Formula-fed infants may benefit from probiotics supplementation to sustain the development of mucosal immunity.

scholarly journals THE DEGREE OF SECRETORY IMMUNOGLOBULIN A IN BURN PATIENTS WITH PROBIOTIC THERAPY

2019 ◽  
pp. 174-176
Author(s):  
LYNDA HARIANI ◽  
IRAWAN WAHYUDI ◽  
ISWINARNO DOSOSAPUTRO ◽  
SJAIFUDDIN NOER M
Keyword(s):  
Immune System ◽  
Immunoglobulin A ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Secretory Immunoglobulin A ◽  
Burn Patients ◽  
Double Blind ◽  
And Control ◽  
Secretory Immunoglobulin ◽  
Regular Intake

Background: One of the problems with burn patients is the impairment of host immunity, which makes difficult to treat. In burns, immunoglobulinA has demonstrated to decrease. Immunoglobulin A is the main product of mucous immune system, which increases viral clearance and decreasesbacterial adhesion in the intestine. Probiotics consist of living microflora, which control the balance of lactobacilli and bifidobacteria in the intestine.Instead of producing organic component, increasing the acidity of intestine, mucin and bacteriocin, they also activate the intestinal immune systemand secretory immunoglobulin A (sIgA). The goal of this study was to propose that regular intake of probiotic might help to improve the mucousimmune system, especially sIgA in intestines in burn patients.Methods: An experimental, double-blind, controlled clinical trial was carried out in 33 burn patients. Those patients were divided into two groups.The first group was given daily probiotic and the second group was given only placebo for 10 days. The treatment began on the 4th day admission, andthen, the degree of sIgA was evaluated before treatment and day 14 from fecal specimen.Results: Significant differences between probiotic and control group were observed (p<0.0001). The degree of sIgA in the probiotic group increased61.25%, and in the control group, it decreased to 36.80%.Conclusion: The mucous immune system, especially sIgA, increases by probiotic intake.

scholarly journals Choral Singing, Performance Perception, and Immune System Changes in Salivary Immunoglobulin A and Cortisol

2000 ◽  
Vol 18 (1) ◽  
pp. 87-106 ◽  
Author(s):  
R. J. Beck ◽  
T. C. Cesario ◽  
A. Yousefi ◽  
H. Enamoto
Keyword(s):  
Immune System ◽  
Rating Scales ◽  
Immunoglobulin A ◽  
Multiple Regression Model ◽  
System Response ◽  
Secretory Immunoglobulin A ◽  
Public Performance ◽  
Choral Singing ◽  
Salivary Immunoglobulin A ◽  
Secretory Immunoglobulin

In a naturalistic pre-post design, samples of saliva were collected from the members of a professional chorale during an early rehearsal (n = 31), a late rehearsal (n = 34) and a public performance (n = 32) of Beethoven's Missa Solemnis. As measures of immune system response, mean levels of secretory immunoglobulin A increased significantly, as a proportion of whole protein, 150% during rehearsals and 240% during the performance. Cortisol concentrations decreased significantly an average of 30% during rehearsals and increased 37% during performance. As measured through performance perception rating scales, a group of emotions and other experiential states that singers associated with professional singing were highly predictive of changes in level of secretory immunoglobulin A during the performance condition, but the results for the rehearsal conditions were not significant. The best multiple regression model for performance level of immunoglobulin A (p &lt; .0015) included seven emotional, cognitive, and evaluative variables generally associated with choral singing, including levels of mood before and during singing, stress, relaxation, feeling "high," detachment/engagement, and specific satisfaction with the immediate performance.

Downregulation of the immune system in low-quality child care: The case of Secretory Immunoglobulin A (SIgA) in toddlers

2012 ◽  
Vol 105 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Harriet J. Vermeer ◽  
Marinus H. van IJzendoorn ◽  
Marleen G. Groeneveld ◽  
Douglas A. Granger
Keyword(s):  
Child Care ◽  
Immune System ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
Quality Child Care ◽  
Quality Child ◽  
Secretory Immunoglobulin

scholarly journals Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study

2011 ◽  
Vol 108 (2) ◽  
pp. 327-333 ◽  
Author(s):  
Concetta Finocchiaro ◽  
Olivia Segre ◽  
Maurizio Fadda ◽  
Taira Monge ◽  
Mara Scigliano ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Placebo Group ◽  
Nutritional Status ◽  
Oxidative Status ◽  
Advanced Lung Cancer ◽  
Controlled Study ◽  
Anthropometric Parameters ◽  
Double Blind ◽  
Reactive Protein ◽  
Anti Inflammatory

PUFA from fish oil appear to have anti-inflammatory and anti-oxidative effects and improve nutritional status in cancer patients. With this as background, the aim of the present study was to investigate the effect of EPA plus DHA on inflammatory condition, and oxidative and nutritional status in patients with lung cancer. In our multicentre, randomised, double-blind trial, thirty-three patients with a diagnosis of advanced inoperable non-small-cell lung cancer and undergoing chemotherapy were divided into two groups, receiving four capsules/d containing 510 mg of EPA and 340 mg of DHA, or 850 mg of placebo, for 66 d. At the start of chemotherapy (T0), after 8 d (T1), 22 d (T2) and 66 d (T3), biochemical (inflammatory and oxidative status parameters) and anthropometric parameters were measured in both groups. A significant increase of body weight in the n-3 group at T3v. T0 was observed. Concerning inflammation, C-reactive protein and IL-6 levels differed significantly between the n-3 and placebo groups at T3, and progressively decreased during chemotherapy in the n-3 group, evidencing n-3 PUFA anti-inflammatory action. Concerning oxidative status, plasma reactive oxygen species levels increased in the placebo group v. the n-3 group at the later treatment times. Hydroxynonenal levels increased in the placebo group during the study, while they stabilised in the n-3 group. Our data confirm that the continual assumption of EPA plus DHA determined an anti-inflammatory and anti-oxidative action which could be considered a preliminary goal in anti-cachectic therapy.

FEATURES OF DEVELOPMENT OF GENERALIZED PERIODONTITIS IN PERSONS WITH SECRETORY IMMUNOGLOBULIN A DEFICIENCY AND ITS TREATMENT (LITERATURE REVIEW)

2021 ◽  
Vol 74 (6) ◽  
pp. 1510-1514
Author(s):  
Hanna M. Sylenko ◽  
Petro M. Skrypnykov ◽  
Yurii I. Sylenko ◽  
Olena A. Pisarenko
Keyword(s):  
Immune System ◽  
Medical Literature ◽  
Immunoglobulin A ◽  
Iga Deficiency ◽  
Secretory Immunoglobulin A ◽  
Secondary Immunodeficiency ◽  
Selective Iga Deficiency ◽  
Nonspecific Factors ◽  
Methods Analytical ◽  
Secretory Immunoglobulin

The aim: To present data on the possibility of occurrence and active progression of generalized periodontitis in persons with secretory immunoglobulin A deficiency and possible methods of its correction. Мaterials and methods: Analytical elaboration of scientific and medical literature based on the immunological aspect of generalized periodontitis. Conclusions: The deficiency of secretory immunoglobulin A may occur in cases of primary or secondary insufficiency of the immune system. Selective IgA deficiency is an example of primary insufficiency of the immune system. Secondary immunodeficiency disorders is a clinical and immunological syndrome that develops against the background of a previously normally functioning immune system, characterized by a steady decrease in quantitative or functional indicators of specific or(and) nonspecific factors of immunoresistance. Insufficient awareness of dentists about certain aspects of the etiology and pathogenesis of generalized periodontitis leads to deterioration of treatment results.

scholarly journals Lactobacillus helveticus SBT2171 Alleviates Perennial Allergic Rhinitis in Japanese Adults by Suppressing Eosinophils: A Randomized, Double-Blind, Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3620
Author(s):  
Maya Yamashita ◽  
Masaya Miyoshi ◽  
Masayuki Iwai ◽  
Ryuji Takeda ◽  
Takahiro Ono ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Placebo Group ◽  
Fermented Milk ◽  
Lactobacillus Helveticus ◽  
Controlled Study ◽  
Life Questionnaire ◽  
Perennial Allergic Rhinitis ◽  
Double Blind ◽  
Ocular Symptoms ◽  
Standard Quality

This article examines the effects of fermented milk (FM) containing Lactobacillus helveticus SBT2171 (LH2171) on the subjective symptoms of individuals with mild and moderate perennial allergy. Two hundred subjects were divided into two groups and consumed FM containing LH2171 or placebo FM once per day for 16 weeks. The primary endpoints were defined as per the degree of nasal and ocular symptoms and difficulty in daily life as determined by the Japanese guidelines for allergy rhinitis and the Japanese allergic rhinitis standard quality of life questionnaire, respectively. The secondary endpoints included parameters related to allergic symptoms in the blood and nasal fluids, as well as the mental status. The severity of allergic rhinitis significantly improved in the LH2171 group compared to that in the placebo group. Additionally, the LH2171 group showed a significantly lower degree of “stuffy nose” (as per the diary survey) than the placebo group. Eosinophil counts in the nasal fluids and in the blood were significantly lower in the LH2171 group compared to the placebo group. Thus, the oral administration of FM containing LH2171 cells alleviated perennial allergic rhinitis in individuals with mild and moderate symptoms, possibly via suppression of eosinophils in both the blood and nasal fluids.

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