A Preliminary Study on the Safety, Efficacy and Acceptability of the Community Preparation of Siling Labuyo (Capsicum frutescens) Liniment in the Management of Knee Osteoarthritis in a Six-Week, Active-Controlled Community-Based Clinical Trial

Objective. The study determined the safety, efficacy and acceptability of a Philippine community preparation of Siling Labuyo liniment in the management of knee osteoarthritis. Methods. A 6-week randomized, double-blind, active-controlled clinical trial was conducted in three municipalities of Cavite from 2017-2018. The municipalities were randomly assigned to either the control or experimental group, using a commercially available Diclofenac 1% gel as the control agent. Knee Injury and Osteoarthritis Outcome Score (KOOS) and Pain Visual Analogue Scale (VAS) were used to measure the outcomes. Results. Forty-seven participants completed the study. Statistically significant improvement (p<0.05) in pain relief, reduction of symptoms and increase in knee functionality was reported by participants in both the experimental and control groups. Across the dimensions measured, at least 30% improvement in scores was reported by the experimental group, and at least 40% by the control group. The difference was statistically not significant (p>0.05). Itching (13%), burning sensation (11%) and reddening of the skin (15%) were experienced in both the experimental and the active control groups. Conclusion. Use of the liniment led to a modest therapeutic effect and was well-tolerated by the participants.

Download Full-text

Effects of Mindfulness-Based Psychoeducation on the Internalized Stigmatization Level of Patients With Schizophrenia

Clinical Nursing Research ◽

10.1177/1054773818797871 ◽

2018 ◽

Vol 29 (7) ◽

pp. 496-503 ◽

Cited By ~ 2

Author(s):

Emine Yılmaz ◽

Funda Kavak

Keyword(s):

Health Centers ◽

Control Group ◽

Community Mental Health Centers ◽

Control Groups ◽

Face To Face ◽

Significant Difference ◽

The Difference ◽

Mental Health Centers ◽

And Control ◽

Experimental Group

The aim of this study was to determine the effects of mindfulness-based psychoeducation on internalized stigma in patients with schizophrenia. The patients were recruited from the community mental health centers. This quasiexperimental study was conducted using pretests and posttests with a control group. The participants were 69 patients with schizophrenia; 34 were part of the experimental group and 35 were part of the control group. The patients in the experimental group participated 2 days a week for 6 weeks in a total of 12 sessions which were given in the form of face-to-face group training. The difference between the scale mean posttest scores of the patients in the experimental and control groups was found to be statistically significant ( p < .05). In the intragroup comparisons, a significant difference was found between the stigma mean scores in the experimental group ( p < .05). It was concluded that mindfulness-based psychoeducation was effective in reducing stigma in patients with schizophrenia.

Download Full-text

The Effect of Vitamin B6 on Reducing the Number and the Size of Breast Cysts and the Amount of Recurrence after Aspiration in Women

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2019/v31i630348 ◽

2019 ◽

pp. 1-7

Author(s):

Setareh Soltany ◽

Hamid Reza Hemmati ◽

Jafar Alavy Toussy ◽

Parisa Alavi Toosi

Keyword(s):

Vitamin B6 ◽

Intervention Group ◽

Control Group ◽

Control Groups ◽

Double Blind ◽

Breast Cyst ◽

The Difference ◽

Palpable Breast ◽

Breast Lumps ◽

And Control

Introduction: Palpable breast lumps are one of the most prevalent breast problems in women who visit a doctor. Most of these lumps are benign, and many of these benign lumps, have cystic nature. One of the suggested treatments for breast cyst is vitamin B6 intake. So, this study aimed to determine the effect of vitamin B6 on reducing the number and the size of breast cysts and reducing the amount of recurrence after aspiration. Materials and Methods: This study is a double-blind randomized clinical trial. Patients simply divided into two groups randomly, intervention group (receiving 150 mg vitamin B6 twice a day for two months) and control group (placebo). After data collection, the database produced, and information came in by SPSS-22 software. Descriptive results extracted in the form of tables and graphs. In all cases was used α=0.05. Results: At the end of the study, 65 patients (34 people in the intervention group, and 31 people in the control group) studied. At the end of the survey in the non-palpable cysts, was observed a significant decrease in the number and the size of breast cysts in each group receiving vitamin B6 or placebo. Still, the difference was not significant in comparing the two groups. 19 patients (2.29%) had palpable cysts that aspiration performed in all cases. After the study period, no recurrence of cysts observed in any of the intervention and control groups. Conclusion: The study showed that vitamin B6 had no effect on reducing the size and the number of non-palpable breast cysts and prevent recurrence of palpable cysts after aspiration.

Download Full-text

Efficacy of Herbal Mouthwash with Extracts of Coriandrum Sativum, Mint and Clove in the Treatment of Chronic Gingivitis- A Randomized Controlled Clinical Trial

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i39b32180 ◽

2021 ◽

pp. 59-63

Author(s):

Sneha Puri ◽

Mahvash Fatema ◽

Akhilesh Shewale ◽

Rashmi Bele

Keyword(s):

Test Group ◽

Coriandrum Sativum ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

The Mean ◽

Mechanical Therapy ◽

And Control ◽

Antibiotic Agents ◽

Experimental Group

Introduction: Herbal antiseptic or antibiotic agents are introduced very widely that are effective against plaque microorganisms for the healing of gingival and periodontal tissue. However, none of literature has shown antibacterial effect of coriandrum sativum, clove and mint on the levels of dental plaque when used as a mouthwash. Aim: To assess the efficacy of a newly formulated mouthwash containing Coriandrum sativum, mint and clove to reduce plaque and inflammation to maintain the oral hygiene. Methodology: Twenty systemically healthy patients were randomly allocated to either the test group [G1(coriandrm sativum, mint,clove = 10 patients)] or the control group [G2 (Placebo gel = 10 patients]. Full mouth Gingival Index (GI); Full mouth Plaque Index (PI) was evaluated at baseline and on 14 and 21st day. Result: The mean reduction in PI from 2.28 to 0.85 and 2.13 to 1.21 was noted in the experimental and control groups, respectively. The experimental group (2.21–0.76) comparatively showed better reduction in mean PBI than the control group (2.17–1.29). The results obtained were statistically significant at baseline and 14th and 21st day in all the groups. Remarkable improvement was noted from baseline to 14th and 21st day in all the groups. Conclusion: The encouraging results of our study suggest that the newly formulated mouthwash containing coriandrum Sativum, mint and clove demonstrates anti-inflammatory properties, which may be useful as an adjunctive to mechanical therapy in the prevention and treatment of gingivitis.

Download Full-text

The effect of delivery ball and warm shower on the childbirth experience of nulliparous women: A randomized controlled clinical trial

10.21203/rs.3.rs-903099/v1 ◽

2021 ◽

Author(s):

parvaneh sharifipour ◽

Masoomeh Kheirkhah ◽

Mojgan Rajati ◽

hamid haghani

Keyword(s):

Clinical Trial ◽

Pregnant Women ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

Childbirth Experience ◽

Nulliparous Women ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background Childbirth is a unique experience that affects women’s life. Therefore, this study was performed to determine the effect of delivery ball and warm shower on the childbirth experience of primiparous women. Methods This study is a clinical trial that was carried out on primiparous pregnant women referred to Motazedi Hospital in Kermanshah, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of delivery ball-warm shower (n = 33), delivery ball (n = 33) and control (n = 33). Exercise with ball at the dilation of 4 cm was similar in the two groups of delivery ball-warm shower and delivery ball, but the first group also used warm shower at the dilatation of 7 cm. The control group only received the routine delivery care. Demographic information form consisting of pregnancy history and information about the mother and infant were completed and the childbirth experience questionnaire (CEQ) were completed by the women two hours after the childbirth. Results There was a statistically significant difference in the mean score of childbirth experience after the intervention between the two groups of delivery ball-warm shower and control (P = 0.001), and also between the delivery ball and control groups (P = 0.001). There was a statistically significant difference in the mean scores of professional support between the two groups of delivery ball-warm shower and control (P = 0.02) and also between the delivery ball and control groups (p = 0.02). There was a statistically significant difference in the mean scores of participation between the two groups of delivery ball-warm shower and control (P = 0.003) and also between the delivery ball and control groups (P = 0.01). There was also a statistically significant difference in the mean scores of sense of security between the two groups of delivery ball-warm shower and control (P = 0.01). Conclusion Delivery ball and warm shower were effective interventions to create a positive childbirth experience. This method was more effective than using delivery ball alone in childbirth experience. To achieve a positive experience of childbirth in mothers, the use of both intervention (delivery ball and warm shower) is recommended.

Download Full-text

Pengaruh Pemberian Pelatihan Pengembangan Diri terhadap Loyalitas Anggota di Formasi Ar-Ruuh UMA

JURNAL DIVERSITA ◽

10.31289/diversita.v4i2.1939 ◽

2018 ◽

Vol 4 (2) ◽

pp. 84

Author(s):

Ihsan Habib Siregar ◽

Hairul Anwar Dalimunthe

Keyword(s):

Wilcoxon Test ◽

Control Group ◽

Research Subjects ◽

Control Groups ◽

Average Value ◽

Significant Difference ◽

Self Development ◽

The Difference ◽

And Control ◽

Experimental Group

<p><em>This study aims to see the influence of self-development training to member loyalty. Research subjects are 40 members of Formasi Ar-Ruuh UMA. The samples were divided into experimental groups (Trained) and control groups (No training). Using 50 instruments of loyalty as a measuring instrument. Data analysis techniques using Wilcoxon Test, with the following results: 1. There’s influence of training on experimental group, significance coefficient 0.005. p 0.005 <0.05, hypothesis is accepted. 2. There’s no significant increase in the control group. p = 0,513. p 0,513> 0,05, hypothesis is rejected. 3. There’s no significant difference between the two groups, p = 0.225. p 0.225> 0.05, hypothesis is rejected. The experimental group further increased its loyalty score by a pretest average of 125.85, the posttest rising to 130.25. The control group obtained a pretest average of 124.75, the posttest rising to 125.00. Self-development training affects loyalty improvement with pretest empirical mean experimental group 125,85, pretest control group 124,75, posttest experimental group 130,25, posttest control group 125,00. The empirical average value is greater than the hypothetical value (100) and the difference over the SD number is 11.440, 16.227, 5.447, 16.387.</em></p>

Download Full-text

The Effects of Topical Olive Oil on the Pain Intensity among Patients with Knee Osteoarthritis

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i19b31335 ◽

2021 ◽

pp. 33-38

Author(s):

Abas Ghaysouri ◽

Golbahar Iri ◽

Amirhosein Meisami ◽

Milad Borji ◽

Behrouz Soltany

Keyword(s):

Knee Osteoarthritis ◽

Pain Intensity ◽

Olive Oil ◽

Control Group ◽

Control Groups ◽

Group A ◽

The Mean ◽

And Control ◽

Experimental Group ◽

Scale Data

Given the importance of relieving pain and disability experienced by the patients, the present study aimed to study the Effects of topical olive oil on the pain intensity among patients with knee osteoarthritis. The patients were randomly assigned into the experimental (28 patients) and control groups (27 patients). Firstly, in tropical olive oil (TOO) group, a high-quality olive oil, branded as Famila was used and in the control group, Diclofenac gel was applied. In experimental groups, 5 drops of herbal oils were applied to the knee thrice a day at morning, noon and evening and the knees were covered with a nylon sheet for more absorption. The patients were followed up for 4 weeks and their capability and pain intensities were evaluated prior the study, during the first week, the second week and the fourth week with Visual Analogue Scale. Data were analyzed using descriptive and analytical tests by SPSS V. 16 software. According to the findings, also the Mean (SD) pre-intervention Pain score in experimental group A was 8.10(0.91), which decreased to 1.78(0.78) after the intervention and in the control group from 8.55(0.69) to 3.85(0.98). Due to the greater effect of olive oil compared to Diclofenac gel on reducing pain of patients with KOA, it is recommended that patients use olive oil. Further studies are also recommended.

Download Full-text

The Efficacy and Safety of a Herbal Toothpaste in Reducing Gingivitis: A Double-Blind, Randomized, Placebo-Controlled, Parallel Allocation Clinical Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/3764936 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Jinfeng He ◽

Yalan Deng ◽

Fangzhi Zhu ◽

Ting Zhong ◽

Nanyu Luo ◽

...

Keyword(s):

Clinical Trial ◽

Test Group ◽

Control Group ◽

Efficacy And Safety ◽

Control Groups ◽

Double Blind ◽

Rhizoma Chuanxiong ◽

Baseline Status ◽

Main Components ◽

And Control

Aim. To examine the efficacy and safety of the toothpaste containing Rhizoma Chuanxiong and Rhizoma Imperatae extracts in reducing gingivitis. Method. A double-blind clinical trial was conducted, in which 120 volunteers were randomly assigned to the test group (N = 60) or the control group (N = 60). Tetramethylpyrazine, senkyunolide A, ferulic acid, and ligustilide are the main effective components of Rhizoma Chuanxiong and Rhizoma Imperatae contains the main components of cylindrin, carotene, 5-hydroxytryptamine, potassium, and calcium. The control group used placebo toothpaste containing neither Rhizoma Chuanxiong extract nor Rhizoma Imperatae extract. Plaque, gingivitis, and bleeding were assessed at the baseline, prior to the supragingival scaling, and at 4, 8, and 12 weeks. Results. During the trial, both test and control groups showed a decreasing trend compared to the baseline. At the end of 12 weeks, with respect to Gingival Index (GI), Bleeding Index (BI), and Bleeding on Probing percentage (BOP%) scores, there were significant differences between test and control groups (GI, P<0.001, BI, P<0.001, and BOP%, P<0.001, resp.). After 4 weeks of usage, there were no statistically significant differences in all of GI, BI, and BOP% scores between the two groups. However, the decrease became statistically significant at next two intervals (GI, P<0.001, BI, P<0.001, and BOP%, P<0.001, resp.) in the efficiency of GI, BI, and BOP% which was 8.04%, 11.02%, and 37.16%, respectively. There were no treatment-related adverse events reported. Conclusion. The toothpaste containing Rhizoma Chuanxiong and Rhizoma Imperatae extracts was well tolerated and significantly reduced gingivitis and bleeding after usage for 12 weeks. There was better improvement at molars, and the more serious the baseline status was, the better the efficacy was.

Download Full-text

Effect of selegiline augmentation with antipsychotic drugs on treatment of the negative symptoms in patients with schizophrenic disorder

European Psychiatry ◽

10.1016/s0924-9338(11)73190-x ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1486-1486

Author(s):

F. Ranjbar ◽

M. Sabagh Razavi ◽

M.A. Ghorayshizadeh ◽

J. Shokri ◽

M. Asadlo

Keyword(s):

Negative Symptoms ◽

Antipsychotic Drugs ◽

Intervention Group ◽

Control Group ◽

Control Groups ◽

Double Blind ◽

Significant Difference ◽

Schizophrenic Patients ◽

The Difference ◽

And Control

IntroductionConsidering the shortcomings of antipsychotics in treatment of negative symptoms of schizophrenic patients, the use of augmentation treatment for decreasing the negative symptoms is highly important.AimsThe aim of this research was to study the effect of selegiline augmentation with antipsychotic drugs in decreasing the negative symptoms of schizophrenic patients.MethodsIn this double blind randomized control trial study 70 schizophrenic in- patients who were under treatment with antipsychotics were randomly divided into two intervention and control groups. The patients of both groups were given placebo for two weeks along with antipsychotics. For 12 weeks the intervention group was given selegiline 10 mg/day and control group was given placebo. The patients were evaluated with PANSS scale and Hamilton depression test at the end of first and second weeks and then at the end of every other week for twelve weeks. Then the results were analyzed statistically.ResultsThere was no significant difference between intervention and control groups considering PANSS score on first and second weeks, but the difference on 4-14 weeks was statistically significant. There was also no statistically significant difference in Hamilton depression Test between the two groups in first to 10 Th weeks. But the difference was statistically significant in 12–14 weeks.ConclusionsAugmentation treatment with selegiline can improve the negative symptoms of schizophrenic patients.

Download Full-text

Study on efficacy and safety of Tong-luo Qu-tong plaster treatment for knee osteoarthritis: study protocol for a randomised, double-blind, parallel positive control, multi-center clinical trial

10.21203/rs.2.267/v2 ◽

2019 ◽

Author(s):

Bao-ping Xu ◽

Min Yao ◽

Zi-rui Tian ◽

Long-yun Zhou ◽

Long Yang ◽

...

Keyword(s):

Clinical Trial ◽

Knee Osteoarthritis ◽

Clinical Symptoms ◽

Positive Control ◽

Control Group ◽

Efficacy And Safety ◽

Adhesive Plaster ◽

Double Blind ◽

Experimental Group

Abstract Background: Knee osteoarthritis (KOA) is a common chronic musculoskeletal disorder that seriously affect quality of life. Patients with KOA frequently develop one or more of the typically following symptoms: joint pain, stiffness, joint friction noise, impaired functionality. Traditional Chinese medicines (TCM) have showed a superior effect and peculiar advantage on the treatment of KOA, among TCMs, the Tong-luo Qu-tong plaster is the convenient and most commonly used method in China to improve symptoms including pain, stiffness and limited mobility in patients with KOA, as it causes few adverse effects. But there is a lack of high quality of clinical evidences to support the therapeutic effect that Chinese adhesive plaster can relieve pain and stiffness. The purpose of this study will be to evaluate the efficacy and safety of Tong-luo Qu-tong plaster in patients with KOA. Methods/Design: This study will be a randomised, double-blind, parallel positive control, multi-center clinical trial, a non-inferiority trial design was adopted. A total of 2000 participants older than 40 years with KOA, will be randomly allocated into a experimental group (n=1500) and a control group (n=500). All participants will receive a conventional conservative treatment lasted for 14 days as two courses, daily 1 time. Tong-luo Qu-tong plaster will be administered externally to participants in the experimental group, while the control group will receive a Qi-zheng Xiao-tong plaster. The outcome of the total Western Ontario and McMaster Universities Arthritis Index scores, TCM syndrome quantitative score, visual analog scale scores will be measured during the assessment visits (baseline and 1-, 2-week follow-up). In addition, adverse events concerning clinical symptoms and signs as well as laboratory tests will be documented during clinical trials. Discussion: This study will be a randomized, double-blind, parallel positive control trial to further evaluate the effectiveness and safety of Tong-luo Qu-tong plaster for patients with KOA in nine medical centers compared with control group, it is expected that the patients with KOA will benefit from this study.

Download Full-text

Effect of cryotherapy in preventing mucositis associated with the use of 5-fluorouracil

Revista Latino-Americana de Enfermagem ◽

10.1590/1518-8345.3953.3363 ◽

2020 ◽

Vol 28 ◽

Author(s):

Andrea Bezerra Rodrigues ◽

Maria Isis Freire De Aguiar ◽

Patrícia Peres De Oliveira ◽

Naiana Pacifico Alves ◽

Renan Alves Silva ◽

...

Keyword(s):

Statistical Significance ◽

Antineoplastic Agent ◽

Control Group ◽

Control Groups ◽

Double Blind ◽

Physiological Serum ◽

Significant Difference ◽

Oral Cryotherapy ◽

And Control ◽

Experimental Group

Objective: to evaluate the effect of oral cryotherapy compared to physiological serum on the development of oral mucositis in outpatient cancer patients using the 5-fluorouracil antineoplastic agent. Method: this is a controlled, randomized, double-blind, and multi-center clinical trial, conducted with 60 patients undergoing chemotherapy. The experimental group (n=30) used oral cryotherapy during the infusion of the 5-FU antineoplastic agent, while the control group (n=30) performed mouthwash with physiological serum at their homes. The oral cavity of the participants was assessed at three times: before randomization, and on the 7th and 14th days after using 5-FU. For data analysis, descriptive analyses and the ANOVA, paired t, and McNemar tests were used. Results: there was no statistically significant difference between the experimental and control groups in the assessments regarding the grade of mucositis. However, cryotherapy presented the chance to reduce the presence of intragroup mucositis, between the first and second assessments (p=0.000126). Conclusion: cryotherapy did not obtain statistical significance in relation to oral hygiene with serum, but it proved to be effective intragroup. Record number: RBR-4k7zh3

Download Full-text