Focally amplified long non-coding RNA in epithelial cancer as a potential biomarker and therapeutic target

2021 ◽  
Author(s):  
Yahya H Hobani
Keyword(s):  
Therapeutic Target ◽  
Multiple Cancer ◽  
Phosphatase And Tensin Homolog ◽  
Tensin Homolog ◽  
Non Coding Rna ◽  
Potential Biomarker ◽  
Noninvasive Biomarker ◽  
Cancer Types ◽  
Molecular Therapeutic ◽  
Long Non Coding Rna

Deregulation of long non-coding RNAs (lncRNAs) has been implicated in tumorigenesis. FALEC is a lncRNA upregulated in multiple cancer types. FALEC functions as an oncogene through various mechanisms, such as competitively binding miRNAs and regulation of PI3K/AKT, Tp53 and phosphatase and tensin homolog signaling pathways. Pertinent to clinical practice, the use of FALEC as a putative biomarker has been identified. These findings suggested that FALEC might play a pivotal role in human cancers. Further studies are warranted to examine the diagnostic and prognostic performance of FALEC as a noninvasive biomarker in liquid biopsy samples and promote its development to be a clinically utilizable prognostic cancer biomarker and molecular therapeutic target.

scholarly journals Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Xiaolei Yuan ◽  
Ying Huang ◽  
Man Guo ◽  
Xiaowei Hu ◽  
Peiling Li
Keyword(s):  
Ovarian Cancer ◽  
Normal Control ◽  
Immune Cell ◽  
Multiple Cancer ◽  
Non Coding Rna ◽  
Incidence And Mortality ◽  
Cancer Types ◽  
Oncogenic Driver ◽  
Therapy Target ◽  
Long Non Coding Rna

Abstract Objective Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) is demonstrated play an important roles in a many cancers, the detailed function and mechanism has not been reported in OC. Results We integrated multiple kinds of bioinformatics approaches and experiments validated method to evaluate functions of FAM83H-AS1 in OC. Some differential expressed lncRNAs were identified between OC and normal control tissues. FAM83H-AS1 was one of most differentially expressed lncRNAs and up-regulated in multiple cancer types. Specially, expression of FAM83H-AS1 was higher in OC and showed difference in diverse stages. High FAM83H-AS1 expression is associated with worse pan-cancer and OC outcomes. FAM83H-AS1-centric network including lncRNA-miRNA, lncRNA-protein and lncRNA-mRNA ceRNA network were constructed to infer the function and mechanism of FAM83H-AS1. There were two methylation sites including cg01399317 and cg20519035 located at FAM83H-AS1. The methylation level of cg01399317 was correlated with gene expression of FAM83H-AS1. The expression level of FAM83H-AS1 was correlated with infiltration level of immune cell including macrophage, neutrphil and dendritic cell in OC patients. Lastly, qRT-PCR showed that the expression of FAM83H-AS1 was higher in OC tissues than normal control tissues. Conclusion Collectively, these results indicated that FAM83H-AS1 may act as an oncogenic driver and it may be a potential therapy target in OC.

scholarly journals Long non-coding RNA FAM83H-AS1 acts as an oncogenic driver in human ovarian cancer

2020 ◽  
Author(s):  
Xiaolei Yuan ◽  
Ying Huang ◽  
Man Guo ◽  
Xiaowei Hu ◽  
Peiling Li
Keyword(s):  
Ovarian Cancer ◽  
Normal Control ◽  
Immune Cell ◽  
Multiple Cancer ◽  
Non Coding Rna ◽  
Incidence And Mortality ◽  
Cancer Types ◽  
Oncogenic Driver ◽  
Therapy Target ◽  
Long Non Coding Rna

Abstract Background Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) is demonstrated play an important roles in a many cancers, the detailed function and mechanism has not been reported in OC. Methods We integrated multiple kinds of bioinformatics approaches and experiments validated method to evaluate functions of FAM83H-AS1 in OC. Results Some differential expressed lncRNAs were identified between OC and normal control tissues. FAM83H-AS1 was one of most differentially expressed lncRNAs and up-regulated in multiple cancer types. Specially, expression of FAM83H-AS1 was higher in OC and showed difference in diverse stages. High FAM83H-AS1 expression is associated with worse pan-cancer and OC outcomes. FAM83H-AS1-centric network including lncRNA-miRNA, lncRNA-protein and lncRNA-mRNA ceRNA network were constructed to infer the function and mechanism of FAM83H-AS1. There were two methylation sites including cg01399317 and cg20519035 located at FAM83H-AS1. The methylation level of cg01399317 was correlated with gene expression of FAM83H-AS1. The expression level of FAM83H-AS1 was correlated with infiltration level of immune cell including macrophage, neutrphil and dendritic cell in OC patients. Lastly, qRT-PCR showed that the expression of FAM83H-AS1 was higher in OC tissues than normal control tissues. Conclusions Collectively, these results indicated that FAM83H-AS1 may act as an oncogenic driver and it may be a potential therapy target in OC.

scholarly journals Long non-coding RNA TINCR as potential biomarker and therapeutic target for cancer

Life Sciences ◽  
2020 ◽  
Vol 257 ◽  
pp. 118035 ◽  
Author(s):  
Uttam Sharma ◽  
Tushar Singh Barwal ◽  
Akshay Malhotra ◽  
Neha Pant ◽  
Vivek ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Non Coding Rna ◽  
Potential Biomarker ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA FAM83H-AS1 acts as an oncogenic driver in human ovarian cancer

2020 ◽  
Author(s):  
Xiaolei Yuan ◽  
Ying Huang ◽  
Man Guo ◽  
Xiaowei Hu ◽  
Peiling Li
Keyword(s):  
Ovarian Cancer ◽  
Normal Control ◽  
Immune Cell ◽  
Multiple Cancer ◽  
Non Coding Rna ◽  
Incidence And Mortality ◽  
Cancer Types ◽  
Oncogenic Driver ◽  
Therapy Target ◽  
Long Non Coding Rna

Abstract Background Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) is demonstrated play an important roles in a many cancers, the detailed function and mechanism has not been reported in OC. Methods We integrated multiple kinds of bioinformatics approaches and experiments validated method to evaluate functions of FAM83H-AS1 in OC. Results Some differential expressed lncRNAs were identified between OC and normal control tissues. FAM83H-AS1 was one of most differentially expressed lncRNAs and up-regulated in multiple cancer types. Specially, expression of FAM83H-AS1 was higher in OC and showed difference in diverse stages. High FAM83H-AS1 expression is associated with worse pan-cancer and OC outcomes. FAM83H-AS1-centric network including lncRNA-miRNA, lncRNA-protein and lncRNA-mRNA ceRNA network were constructed to infer the function and mechanism of FAM83H-AS1. There were two methylation sites including cg01399317 and cg20519035 located at FAM83H-AS1. The methylation level of cg01399317 was correlated with gene expression of FAM83H-AS1. The expression level of FAM83H-AS1 was correlated with infiltration level of immune cell including macrophage, neutrphil and dendritic cell in OC patients. Lastly, qRT-PCR showed that the expression of FAM83H-AS1 was higher in OC tissues than normal control tissues. Conclusions Collectively, these results indicated that FAM83H-AS1 may act as an oncogenic driver and it may be a potential therapy target in OC.

scholarly journals Long Non-Coding RNA FAM83H-AS1 Acts as a Potential Oncogenic Driver in Human Ovarian Cancer

2020 ◽  
Author(s):  
Xiaolei Yuan ◽  
Ying Huang ◽  
Man Guo ◽  
Xiaowei Hu ◽  
Peiling Li
Keyword(s):  
Ovarian Cancer ◽  
Normal Control ◽  
Immune Cell ◽  
Multiple Cancer ◽  
Non Coding Rna ◽  
Incidence And Mortality ◽  
Cancer Types ◽  
Oncogenic Driver ◽  
Therapy Target ◽  
Long Non Coding Rna

Abstract Objective Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) is demonstrated play an important roles in a many cancers, the detailed function and mechanism has not been reported in OC. Results We integrated multiple kinds of bioinformatics approaches and experiments validated method to evaluate functions of FAM83H-AS1 in OC. Some differential expressed lncRNAs were identified between OC and normal control tissues. FAM83H-AS1 was one of most differentially expressed lncRNAs and up-regulated in multiple cancer types. Specially, expression of FAM83H-AS1 was higher in OC and showed difference in diverse stages. High FAM83H-AS1 expression is associated with worse pan-cancer and OC outcomes. FAM83H-AS1-centric network including lncRNA-miRNA, lncRNA-protein and lncRNA-mRNA ceRNA network were constructed to infer the function and mechanism of FAM83H-AS1. There were two methylation sites including cg01399317 and cg20519035 located at FAM83H-AS1. The methylation level of cg01399317 was correlated with gene expression of FAM83H-AS1. The expression level of FAM83H-AS1 was correlated with infiltration level of immune cell including macrophage, neutrphil and dendritic cell in OC patients. Lastly, qRT-PCR showed that the expression of FAM83H-AS1 was higher in OC tissues than normal control tissues. Conclusion Collectively, these results indicated that FAM83H-AS1 may act as an oncogenic driver and it may be a potential therapy target in OC.

scholarly journals Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer

2021 ◽  
Author(s):  
Xiaolei Yuan ◽  
Ying Huang ◽  
Man Guo ◽  
Xiaowei Hu ◽  
Peiling Li
Keyword(s):  
Ovarian Cancer ◽  
Normal Control ◽  
Immune Cell ◽  
Multiple Cancer ◽  
Non Coding Rna ◽  
Incidence And Mortality ◽  
Cancer Types ◽  
Oncogenic Driver ◽  
Therapy Target ◽  
Long Non Coding Rna

Abstract Objective Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) is demonstrated play an important roles in a many cancers, the detailed function and mechanism has not been reported in OC. Results We integrated multiple kinds of bioinformatics approaches and experiments validated method to evaluate functions of FAM83H-AS1 in OC. Some differential expressed lncRNAs were identified between OC and normal control tissues. FAM83H-AS1 was one of most differentially expressed lncRNAs and up-regulated in multiple cancer types. Specially, expression of FAM83H-AS1 was higher in OC and showed difference in diverse stages. High FAM83H-AS1 expression is associated with worse pan-cancer and OC outcomes. FAM83H-AS1-centric network including lncRNA-miRNA, lncRNA-protein and lncRNA-mRNA ceRNA network were constructed to infer the function and mechanism of FAM83H-AS1. There were two methylation sites including cg01399317 and cg20519035 located at FAM83H-AS1. The methylation level of cg01399317 was correlated with gene expression of FAM83H-AS1. The expression level of FAM83H-AS1 was correlated with infiltration level of immune cell including macrophage, neutrphil and dendritic cell in OC patients. Lastly, qRT-PCR showed that the expression of FAM83H-AS1 was higher in OC tissues than normal control tissues. Conclusion Collectively, these results indicated that FAM83H-AS1 may act as an oncogenic driver and it may be a potential therapy target in OC.

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