scholarly journals Genomic and molecular alterations associated with early-onset and adolescent and young adult colorectal cancer

2020 ◽  
Vol 9 (3) ◽  
pp. CRC30
Author(s):  
James V Tricoli
Keyword(s):  
Colorectal Cancer ◽  
Young Adult ◽  
Early Onset ◽  
Adolescent And Young Adult ◽  
Molecular Characteristics ◽  
Contributing Factors ◽  
Molecular Alterations ◽  
The Us ◽  
Adolescent And Young Adults ◽  
Age Range

While the incidence of colorectal cancer (CRC) in the US has declined at a pace of 3% annually between 2003 and 2012, there has been an increase in the incidence of early-onset colorectal cancer (EOCRC). The reasons for this increase are unclear. Diet, the environment, the microbiome and alcohol consumption have all been proposed as contributing factors. There is the possibility that EOCRC has a unique biology. Overlapping with the EOCRC age range is CRC in adolescent and young adults (AYA) that share many molecular characteristics with EOCRC. The purpose of this review is to cover current progress in our understanding of the biology of CRC in the context of adolescent and young adult CRC and EOCRC and discuss future directions.

scholarly journals Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Dai Shida ◽  
Yuka Ahiko ◽  
Taro Tanabe ◽  
Takefumi Yoshida ◽  
Shunsuke Tsukamoto ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Young Adult ◽  
Stage Iv ◽  
Adult Patients ◽  
Adolescent And Young Adult ◽  
Stage Iv Colorectal Cancer

scholarly journals Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer

2019 ◽  
Vol 20 (4) ◽  
pp. 968 ◽  
Author(s):  
Edurne Álvaro ◽  
Juana M. Cano ◽  
Juan L. García ◽  
Lorena Brandáriz ◽  
Susana Olmedillas-López ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
Cpg Island ◽  
Low Frequency ◽  
Tumor Location ◽  
Molecular Characteristics ◽  
Braf Mutations ◽  
Rectal Cancers

Our aim was to characterize and validate that the location and age of onset of the tumor are both important criteria to classify colorectal cancer (CRC). We analyzed clinical and molecular characteristics of early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and we compared each tumor location between both ages-of-onset. In right-sided colon tumors, early-onset cases showed extensive Lynch syndrome (LS) features, with a relatively low frequency of chromosomal instability (CIN), but a high CpG island methylation phenotype. Nevertheless, late-onset cases showed predominantly sporadic features and microsatellite instability cases due to BRAF mutations. In left colon cancers, the most reliable clinical features were the tendency to develop polyps as well as multiple primary CRC associated with the late-onset subset. Apart from the higher degree of CIN in left-sided early-onset cancers, differential copy number alterations were also observed. Differences among rectal cancers showed that early-onset rectal cancers were diagnosed at later stages, had less association with polyps, and more than half of them were associated with a familial LS component. Stratifying CRC according to both location and age-of-onset criteria is meaningful, not only because it correlates the resulting categories with certain molecular bases, but with the confirmation across larger studies, new therapeutical algorithms could be defined according to this subclassification.

scholarly journals Colorectal Cancer in the Adolescent and Young Adult Population

2020 ◽  
Vol 16 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Y. Nancy You ◽  
Lucas D. Lee ◽  
Benjamin W. Deschner ◽  
David Shibata
Keyword(s):  
Colorectal Cancer ◽  
Young Adult ◽  
Clinical Management ◽  
Early Recognition ◽  
Adult Population ◽  
Multidisciplinary Care ◽  
Adolescent And Young Adult ◽  
Young Adult Population ◽  
Recent Trends ◽  
Key Aspects

Colorectal cancer in the young adult population is of increasing incidence and concern. Genetic predisposition and heritable syndromes contribute to this trend, but perhaps more concerning is the majority of new diagnoses that involve no traceable genetic risk factors. Prevention and early recognition, with a high suspicion in the symptomatic young adult, are critical in attenuating recent trends. Clinical management requires coordinated multidisciplinary care from diagnosis to surveillance in order to ensure appropriate management. This review provides a summary of key aspects related to colorectal cancer in adolescents and young adults, including epidemiology, biology, genetics, clinical management, and prevention.

scholarly journals Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma

Cancer ◽  
2016 ◽  
Vol 122 (7) ◽  
pp. 1017-1028 ◽  
Author(s):  
James V. Tricoli ◽  
Donald G. Blair ◽  
Carey K. Anders ◽  
W. Archie Bleyer ◽  
Lisa A. Boardman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Acute Lymphoblastic Leukemia ◽  
Young Adult ◽  
Clinical Characteristics ◽  
Lymphoblastic Leukemia ◽  
Adolescent And Young Adult ◽  
Cancer Breast

199 Clinical and Molecular Characteristics of Early-Onset Colorectal Cancer Across Various Ethnicities

2019 ◽  
Vol 114 (1) ◽  
pp. S121-S122
Author(s):  
Rawan Dayah ◽  
Mohammad Bilal ◽  
Nattpron Tun ◽  
Tewfeek Abu-Shami ◽  
Adam Booth ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Molecular Characteristics ◽  
Early Onset Colorectal Cancer

Hospital Costs, Length of Stay and Mortality Associated with Childhood, Adolescent and Young Adult Meningococcal Disease in the US

2011 ◽  
Vol 9 (3) ◽  
pp. 197-207 ◽  
Author(s):  
Keith L. Davis ◽  
Timothy J. Bell ◽  
Jacqueline M. Miller ◽  
Derek A. Misurski ◽  
Bela Bapat
Keyword(s):  
Young Adult ◽  
Length Of Stay ◽  
Meningococcal Disease ◽  
Hospital Costs ◽  
Adolescent And Young Adult ◽  
The Us

scholarly journals Adolescent and Young Adult Colorectal Cancer

2013 ◽  
Vol 11 (10) ◽  
pp. 1219-1225 ◽  
Author(s):  
Joleen M. Hubbard ◽  
Axel Grothey
Keyword(s):  
Colorectal Cancer ◽  
Young Adult ◽  
Adolescent And Young Adult
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