scholarly journals Management of Hypertension with Conventional and Herbals Drugs

2020 ◽  
Vol 10 (3) ◽  
pp. 280-287
Author(s):  
, Marjina ◽  
Amandeep Singh ◽  
Amit Sharma ◽  
Raj Kumar Narang ◽  
Gurmeet Singh
Keyword(s):  
Diabetes Mellitus ◽  
Pulmonary Hypertension ◽  
Adverse Drug Reactions ◽  
Ace Inhibitor ◽  
Channel Blocker ◽  
Antihypertensive Drugs ◽  
Herbal Drugs ◽  
Thiazide Diuretics ◽  
Drug Reactions ◽  
Ankle Oedema

In this article, we have discussed about Types (primary, secondary, isolated, white coat, malignant, resistant and pulmonary hypertension), classification, adverse drug reactions of antihypertensive drugs (beta-blocker induce psoriasis and calcium channel blocker cause peripheral oedema. ACE inhibitor produce ankle oedema and thiazide diuretics causes hypenatremia and also hyperglycaemia. These are some of the serious adverse drug reactions associated with patients who are being treated with these drugs), measurement, management, diagnosis and associated diseases (e.g. diabetes mellitus, heart disease, cerebrovascular disease) lastly concluded about the herbal approach for management of hypertension  . Keywords: Hypertension, conventional drugs, Herbal drugs

Safety of SGLT2 Inhibitors in Patients with Diabetes Mellitus

2019 ◽  
Vol 14 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Mahakpreet Singh ◽  
Ruchika Sharma ◽  
Anoop Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Diabetic Ketoacidosis ◽  
Adverse Drug Reactions ◽  
Sglt2 Inhibitor ◽  
Sglt2 Inhibitors ◽  
Drug Reactions ◽  
Authorization Holder

Background:Recently, Food and Drug Administration (FDA) has approved sodium/ glucose co-transporter 2 (SGLT2) inhibitors for the treatment of diabetes mellitus. However, regarding adverse drug reactions (ADRs) of SGLT2 inhibitors in large group of population, very less information is available. Thus, we have tried to find out the risk profile of SGLT2 inhibitors. Materials and Methods: A total of 1,042 studies have been published from Nov. 2012-Nov. 2017 regarding SGLT2 inhibitors. After inclusion and exclusion criteria, 27 studies have been selected for the analysis of risk. Results and Discussion:The emerging evidence indicates various adverse drug reactions such as foot and toe amputation, cancer, diabetic ketoacidosis, bone fracture risk and urinary as well as mycotic genital infection. The causality assessment has shown a correlation between SGLT2 inhibitors and diabetic ketoacidosis and urinary tract infection. Conclusion:In conclusion, Marketing Authorization Holder (MAH) and Regulatory Authorities (RA) should monitor various adverse drug reactions such as diabetic ketoacidosis and urinary tract infection with the use of SGLT2 inhibitor.

scholarly journals Concealed Renal Failure and Adverse Drug Reactions in Older Patients With Type 2 Diabetes Mellitus

2005 ◽  
Vol 60 (9) ◽  
pp. 1147-1151 ◽  
Author(s):  
A. Corsonello ◽  
C. Pedone ◽  
F. Corica ◽  
B. Mazzei ◽  
A. Di Iorio ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Renal Failure ◽  
Type 2 Diabetes Mellitus ◽  
Adverse Drug Reactions ◽  
Older Patients ◽  
Drug Reactions

scholarly journals Adverse drug reaction profile and prescription pattern of antihypertensive drug monotherapy at tertiary care hospital Nepalgunj, Nepal

2017 ◽  
Vol 7 (1) ◽  
pp. 75 ◽  
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai
Keyword(s):  
Adverse Drug Reactions ◽  
Antihypertensive Drug ◽  
Antihypertensive Drugs ◽  
Tertiary Care ◽  
Term Therapy ◽  
Care Hospital ◽  
Drug Reactions ◽  
Prescribing Pattern ◽  
Converting Enzyme Inhibitors ◽  
Prescription Pattern

Background: Hypertension is the leading cause of morbidity and mortality worldwide which requires long term therapy to prevent complication associated with it. As drugs are used for longer duration it is necessary to know potential undesirable effects for making the appropriate choice. Aim and objective of the study was to monitor the adverse drug reactions (ADRs) and to know prescribing pattern of antihypertensive monotherapy.Methods: The present work was an open, non-comparative, observational study conducted on seventy-three (73) hypertensive patients who were prescribed single antihypertensive drug at medical OPD of Nepalgunj Medical college by conducting patient interviews, recording the data on ADR monitoring form.Results: Calcium channel blockers were found to be the most frequently associated drugs with adverse drug reactions (n=12), followed by diuretics (n= 6), Angiotensin converting enzyme inhibitors (n=3), β-blockers (n= 2) and Angiotensin receptor blocker (n=1). Among individual drugs, amlodipine was found to be the commonest drug associated with adverse drug reactions (n = 10). On analysis of prescription pattern again amlodipine was most commonly prescribed antihypertensive monotherapy followed by hydrochlorothiazide.Conclusions:Amlodipine was most commonly associated with ADRs and it was also most commonly prescribed antihypertensive drugs as monotherapy. The above findings would be useful for physicians in rational prescribing. 

scholarly journals Drug utilization study and adverse drug reactions of oral anti diabetics among type 2 diabetes mellitus patients in tertiary care hospital

2019 ◽  
Vol 8 (4) ◽  
pp. 700
Author(s):  
Sahana M. Mogali ◽  
Aruna Bhushan ◽  
Jagadishchandra S. Ratnakar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Drug Utilization ◽  
Adverse Drug Reactions ◽  
Antidiabetic Drugs ◽  
Drug Reactions ◽  
Oral Antidiabetic Drugs ◽  
Oral Antidiabetic

Background: The aim was to evaluate the drug utilization pattern of oral antidiabetic drugs in type 2 diabetes mellitus outpatients and monitor adverse drug reactions (ADRs) associated with oral antidiabetic drugs.Methods: A retrospective observational study was carried out by collecting the data of type 2 diabetes mellitus patients visiting outpatient department of noncommunicable disease clinic of a tertiary care hospital for a period of one year. The data of demographic, drug utilization pattern and adverse drug reactions of patients on oral antidiabetic drugs was collected and entered in a proforma.Results: Total number of patients in this study were 39 out of which 21 (53.85%) patients were females and 18 (46.15%) patients were males. Majority of patients were in the age group 51-70 years (66.6%). Metformin was the most commonly prescribed drug 76.9% followed by Glibenclamide 17.9%. About 7.7% of patients who were taking oral antidiabetic drugs later switched over to insulin as their blood glucose levels were not controlled. Out of 18 (46.15%) patients, hypertension (38.5%) was the most common comorbid condition and a concomitant drug was prescribed was amlodipine 25.6%. Among all the adverse drug reactions observed, diarrhoea was the most common adverse drug reaction reported 76.9%.Conclusions: Metformin was the most commonly used oral antidiabetic drug. Diarrhoea was the common adverse drug reaction reported.

The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs

2019 ◽  
Vol 234 (11) ◽  
pp. 19339-19351 ◽  
Author(s):  
Habibeh Mashayekhi‐Sardoo ◽  
Amir Hooshang Mohammadpour ◽  
Homa Nomani ◽  
Amirhossein Sahebkar
Keyword(s):  
Diabetes Mellitus ◽  
Anticancer Drugs ◽  
Adverse Drug Reactions ◽  
Drug Reactions

Pulmonary Hypertension with Thalidomide Therapy; Hyperammonemia and Valproate; CNS Toxicity from Improper Use of Cyclopentolate Ophthalmic Drops; Glycemic Control Issues with Gatifloxacin; Infusion Phlebitis with Cyclosporine; Acute Hypersensitivity Reaction to HIV Fusion Inhibitor; Imatinib-Induced Hepatotoxicity

2005 ◽  
Vol 40 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Joel Shuster
Keyword(s):  
Pulmonary Hypertension ◽  
Glycemic Control ◽  
Hypersensitivity Reaction ◽  
Adverse Drug Reactions ◽  
Fusion Inhibitor ◽  
Drug Reactions ◽  
Improper Use ◽  
Infusion Phlebitis ◽  
Cns Toxicity

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), to discuss methods of prevention, and to promote reporting of ADRs to the FDA's medWatch program (800-FDA-1088). If you have reported an interesting preventable ADR to medWatch, please consider sharing the account with our readers.

scholarly journals A STUDY ON INFECTIOUS DISEASE BURDEN AND ASSESSMENT OF ADVERSE DRUG REACTIONS AMONG TYPE- II DIABETES MELLITUS SUBJECTS

2019 ◽  
Vol 8 (3) ◽  
Author(s):  
Adarsh Mathew ◽  
Bharathi DR ◽  
Abubaker Siddiq ◽  
Akza K Alex ◽  
Tejaswini S M
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Infectious Disease ◽  
Infectious Diseases ◽  
Adverse Drug Reactions ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Drug Reactions

Introduction: People with diabetes are more prone to development of infections. Elevated blood sugar levels enervate the patient’s immune system and make the patient vulnerable to infections.Assessing the prescription patterns assure quality medical care by providing feedback to the prescribers. Objectives: To assess the prevalence and the prescription pattern of antibiotics in infections associated with type II diabetes mellitus along with their quality of life. To assess the Adverse Drug Reactions associated with treatment of type-II diabetes mellitus. Materials and Methods: This prospective observational study was conducted in the General Medicine Department of Basaveshwara Medical College Hospital and Research Centre, Chitradurga for a period of 10 months. Results: In this study, a total of 300 diabetic subjects were included, out of which, 192 subjects were having infectious diseases. This study reveals association between infection and diabetes with a prevalence rate of 64%. The most commonly prescribed antibiotic was found to be ceftriaxone. The quality of life of the diabetic subjects associated with infections was found to be displeasing when assessed with a validated questionnaire. Conclusion: The study shows a higher rate of prevalence of infectious disease among diabetic subjects. It is suggested to conduct more studies on this topic. Keywords: Diabetes mellitus; Infectious diseases; Adverse drug reactions; Burden of disease.

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