scholarly journals ADVERSE DRUG REACTIONS OF ANTI-TUBERCULAR MEDICATIONS IN MDR AND XDR TB PATIENTS WITH DIABETES MELLITUS

CHEST Journal ◽  
2020 ◽  
Vol 157 (6) ◽  
pp. A59
Author(s):  
S. Patil
Keyword(s):  
Diabetes Mellitus ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Patients With Diabetes

Safety of SGLT2 Inhibitors in Patients with Diabetes Mellitus

2019 ◽  
Vol 14 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Mahakpreet Singh ◽  
Ruchika Sharma ◽  
Anoop Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Diabetic Ketoacidosis ◽  
Adverse Drug Reactions ◽  
Sglt2 Inhibitor ◽  
Sglt2 Inhibitors ◽  
Drug Reactions ◽  
Authorization Holder

Background:Recently, Food and Drug Administration (FDA) has approved sodium/ glucose co-transporter 2 (SGLT2) inhibitors for the treatment of diabetes mellitus. However, regarding adverse drug reactions (ADRs) of SGLT2 inhibitors in large group of population, very less information is available. Thus, we have tried to find out the risk profile of SGLT2 inhibitors. Materials and Methods: A total of 1,042 studies have been published from Nov. 2012-Nov. 2017 regarding SGLT2 inhibitors. After inclusion and exclusion criteria, 27 studies have been selected for the analysis of risk. Results and Discussion:The emerging evidence indicates various adverse drug reactions such as foot and toe amputation, cancer, diabetic ketoacidosis, bone fracture risk and urinary as well as mycotic genital infection. The causality assessment has shown a correlation between SGLT2 inhibitors and diabetic ketoacidosis and urinary tract infection. Conclusion:In conclusion, Marketing Authorization Holder (MAH) and Regulatory Authorities (RA) should monitor various adverse drug reactions such as diabetic ketoacidosis and urinary tract infection with the use of SGLT2 inhibitor.

scholarly journals Concealed Renal Failure and Adverse Drug Reactions in Older Patients With Type 2 Diabetes Mellitus

2005 ◽  
Vol 60 (9) ◽  
pp. 1147-1151 ◽  
Author(s):  
A. Corsonello ◽  
C. Pedone ◽  
F. Corica ◽  
B. Mazzei ◽  
A. Di Iorio ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Renal Failure ◽  
Type 2 Diabetes Mellitus ◽  
Adverse Drug Reactions ◽  
Older Patients ◽  
Drug Reactions

scholarly journals Drug utilization study and adverse drug reactions of oral anti diabetics among type 2 diabetes mellitus patients in tertiary care hospital

2019 ◽  
Vol 8 (4) ◽  
pp. 700
Author(s):  
Sahana M. Mogali ◽  
Aruna Bhushan ◽  
Jagadishchandra S. Ratnakar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Drug Utilization ◽  
Adverse Drug Reactions ◽  
Antidiabetic Drugs ◽  
Drug Reactions ◽  
Oral Antidiabetic Drugs ◽  
Oral Antidiabetic

Background: The aim was to evaluate the drug utilization pattern of oral antidiabetic drugs in type 2 diabetes mellitus outpatients and monitor adverse drug reactions (ADRs) associated with oral antidiabetic drugs.Methods: A retrospective observational study was carried out by collecting the data of type 2 diabetes mellitus patients visiting outpatient department of noncommunicable disease clinic of a tertiary care hospital for a period of one year. The data of demographic, drug utilization pattern and adverse drug reactions of patients on oral antidiabetic drugs was collected and entered in a proforma.Results: Total number of patients in this study were 39 out of which 21 (53.85%) patients were females and 18 (46.15%) patients were males. Majority of patients were in the age group 51-70 years (66.6%). Metformin was the most commonly prescribed drug 76.9% followed by Glibenclamide 17.9%. About 7.7% of patients who were taking oral antidiabetic drugs later switched over to insulin as their blood glucose levels were not controlled. Out of 18 (46.15%) patients, hypertension (38.5%) was the most common comorbid condition and a concomitant drug was prescribed was amlodipine 25.6%. Among all the adverse drug reactions observed, diarrhoea was the most common adverse drug reaction reported 76.9%.Conclusions: Metformin was the most commonly used oral antidiabetic drug. Diarrhoea was the common adverse drug reaction reported.

The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs

2019 ◽  
Vol 234 (11) ◽  
pp. 19339-19351 ◽  
Author(s):  
Habibeh Mashayekhi‐Sardoo ◽  
Amir Hooshang Mohammadpour ◽  
Homa Nomani ◽  
Amirhossein Sahebkar
Keyword(s):  
Diabetes Mellitus ◽  
Anticancer Drugs ◽  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals Perspective Review: Type 2 Diabetes and Readmission for Heart Failure

2018 ◽  
Vol 12 ◽  
pp. 117954681877958 ◽  
Author(s):  
Merlin C Thomas
Keyword(s):  
Heart Failure ◽  
Adverse Drug Reactions ◽  
Premature Mortality ◽  
Primary Diagnosis ◽  
Adverse Outcomes ◽  
Drug Reactions ◽  
Patients With Diabetes ◽  
Acute Decompensation ◽  
The Many ◽  
Mineralocorticoid Antagonists

Heart failure is a leading cause for hospitalisation and for readmission, especially in patients over the age of 65. Diabetes is an increasingly common companion to heart failure. The presence of diabetes and its associated comorbidity increases the risk of adverse outcomes and premature mortality in patients with heart failure. In particular, patients with diabetes are more likely to be readmitted to hospital soon after discharge. This may partly reflect the greater severity of heart disease in these patients. In addition, agents that reduce the chances of readmission such as β-blockers, renin-angiotensin-aldosterone system blockers, and mineralocorticoid receptor antagonists are underutilised because of the perceived increased risks of adverse drug reactions and other limitations. In some cases, readmission to hospital is precipitated by acute decompensation of heart failure (re-exacerbation) leading to pulmonary congestion and/or refractory oedema. However, it appears that for most of the patients admitted and then discharged with a primary diagnosis of heart failure, most readmissions are not due to heart failure, but rather due to comorbidity including arrhythmia, infection, adverse drug reactions, and renal impairment/reduced hydration. All of these are more common in patients who also have diabetes, and all may be partly preventable. The many different reasons for readmission underline the critical value of multidisciplinary comprehensive care in patients admitted with heart failure, especially those with diabetes. A number of new strategies are also being developed to address this area of need, including the use of SGLT2 inhibitors, novel nonsteroidal mineralocorticoid antagonists, and neprilysin inhibitors.

scholarly journals A STUDY ON INFECTIOUS DISEASE BURDEN AND ASSESSMENT OF ADVERSE DRUG REACTIONS AMONG TYPE- II DIABETES MELLITUS SUBJECTS

2019 ◽  
Vol 8 (3) ◽  
Author(s):  
Adarsh Mathew ◽  
Bharathi DR ◽  
Abubaker Siddiq ◽  
Akza K Alex ◽  
Tejaswini S M
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Infectious Disease ◽  
Infectious Diseases ◽  
Adverse Drug Reactions ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Drug Reactions

Introduction: People with diabetes are more prone to development of infections. Elevated blood sugar levels enervate the patient’s immune system and make the patient vulnerable to infections.Assessing the prescription patterns assure quality medical care by providing feedback to the prescribers. Objectives: To assess the prevalence and the prescription pattern of antibiotics in infections associated with type II diabetes mellitus along with their quality of life. To assess the Adverse Drug Reactions associated with treatment of type-II diabetes mellitus. Materials and Methods: This prospective observational study was conducted in the General Medicine Department of Basaveshwara Medical College Hospital and Research Centre, Chitradurga for a period of 10 months. Results: In this study, a total of 300 diabetic subjects were included, out of which, 192 subjects were having infectious diseases. This study reveals association between infection and diabetes with a prevalence rate of 64%. The most commonly prescribed antibiotic was found to be ceftriaxone. The quality of life of the diabetic subjects associated with infections was found to be displeasing when assessed with a validated questionnaire. Conclusion: The study shows a higher rate of prevalence of infectious disease among diabetic subjects. It is suggested to conduct more studies on this topic. Keywords: Diabetes mellitus; Infectious diseases; Adverse drug reactions; Burden of disease.

scholarly journals Studi Prospektif Adverse Drug Reactions (ADRS) Obat Hipoglikemik Oral Terhadap Pasien Diabetes Mellitus Tipe 2 di Suatu Rumah Sakit, Padang

2019 ◽  
Vol 5 (3) ◽  
pp. 169
Author(s):  
Rahmi Yosmar ◽  
Nadia Putri Inanta ◽  
Yelly Oktavia Sari
Keyword(s):  
Diabetes Mellitus ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Diabetes Melitus

Diabetes melitus tipe 2 merupakan penyakit gangguan metabolisme lemak, protein dan karbohidrat yang banyak dijumpai pada masyarakat. Terapi farmakologi diabetes melitus tipe 2 salah satunya dilakukan dengan pemberian obat hipoglikemik oral (OHO) yang dapat menyebabkan kemungkinan terjadinya Adverse Drug Reactions (ADRs). Jenis ADRs yang umum terjadi adalah reaksi tipe A (Augmented) yaitu reaksi yang diperkirakan sebelumnya dan bergantung pada dosis obat. Tujuan penelitian ini adalah untuk mengetahui karakteristik sosiodemografis pasien dan mengevaluasi angka kejadian serta jenis ADRs yang ditimbulkan oleh obat hipoglikemik oral pada pasien diabetes melitus tipe 2 di poliklinik penyakit dalam RSUP Dr. M. Djamil Padang periode Juli – September  2018. Metode yang digunakan adalah observasional dengan pengumpulan data secara prospektif. Setiap ADRs aktual yang terjadi dihitung probabilitasnya dengan menggunakan algoritma Naranjo scale.  Hasil penelitian ini menunjukkan sebanyak 37 sampel yang memenuhi kriteria inklusi, dimana 51,35% berjenis kelamin wanita dan berusia >56 tahun sebanyak 59,46%. Pola penggunaan obat hipoglikemik oral yang paling banyak digunakan adalah kombinasi metformin dengan glimepirid sekitar 32,43 %. Penelitian ini dapat disimpulkan bahwa 8,1 % pasien mengalami kasus ADRs. Obat hipoglikemik oral yang diduga menjadi penyebab timbulnya ADRs tersebut adalah metformin dan metformin-glimepirid dapat menyebabkan mual dengan kategori possible ADRs serta metformin-glimepirid-acarbose yang menyebabkan terjadinya flatulensi dengan kategori probable ADRs.  

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