scholarly journals In-vivo Evaluation of the Wound Healing Activity of the Sesamum Indicum L. Seed Extract in Novel Ethosomal Vesicular System

2018 ◽  
Vol 8 (5) ◽  
pp. 411-420 ◽  
Author(s):  
Sachin B Somwanshi ◽  
Shivanand N Hiremath
Keyword(s):  
Wound Healing ◽  
Breaking Strength ◽  
Wistar Rat ◽  
Treated Group ◽  
Sesamum Indicum ◽  
Seed Extract ◽  
Wound Contraction ◽  
In Vivo Evaluation ◽  
Wound Healing Activity

Aim: To establish the wound healing activity of Sesamum indicum L. of seed extract in novel ethosomal vesicles. Methods: The ethosomal vesicles were formulated with prepared seed extract of Sesamum indicum L. by solvent evaporation method and characterized it. The optimized ethosomal vesicles then incorporated into gel base for further in vivo study in wistar rat. The evaluation of the wound healing activity was performed by using two models i.e. incision and excision models. In excision model percentage wound contraction and period of epithelialization were established for both the extracts. In incision model the parameter which was carried out was breaking strength of wounded skin. Results: The results revealed that the percentage wound contraction, period of epithelialization in excision model was enhanced than that of other groups and tensile strength of skin in incision model was similar to that of standard treated group. Keywords: Sesamum indicum L., Wound Healing, Ethosomal gel.

IN VIVO EVALUATION OF WOUND HEALING AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF ROOTS OF CENTAUREA AFRICANA (L.) IN TOPICAL FORMULATION

2016 ◽  
Vol 10 (1) ◽  
pp. 341 ◽  
Author(s):  
Mohamed Zaouani ◽  
Arezki Bitam ◽  
Ahcen Baz ◽  
Yasmine Benali ◽  
Meriem Hind Ben-mahdi
Keyword(s):  
Wound Healing ◽  
Methanolic Extract ◽  
Wound Contraction ◽  
Inflammatory Activity ◽  
Hydroxyproline Content ◽  
Topical Formulation ◽  
In Vivo Evaluation ◽  
Anti Inflammatory ◽  
Wound Healing Activity

ABSTRACTObjective: The present study was to evaluate the anti-inflammatory and wound healing activities of methanolic extract of Centaurea africana rootsin albino Wistar rats.Methods: Following extraction of the C. africana roots with 80% methanol, the extract was formulated as an ointment (5% and 10% w/w). The ointmentwas then evaluated for wound healing activity using excision and incision wound models. Parameters, including wound contraction, epithelizationtime, histopathologically, and hydroxyproline content, were determined using the excision model, whereas tensile strength was measured from theincision model. In parallel, edema of the ear, locally induced by croton oil, was studied for the assessment of anti-inflammatory activity.Results: Wound treated with 5% and 10% methanolic extract ointment exhibited a significant wound healing activity in both models as evidencedby increased wound contraction, shorter epithelization time, higher tissue breaking strength, and increased hydroxyproline content. The methanolicextract also produced dose-related significant reduction (p<0.001) of inflammation.Conclusion: Results of the present study revealed that C. africana displays remarkable wound healing and anti-inflammatory activities.Keywords: Anti-inflammatory activity, Centaurea africana roots, Methanolic extract, Incision and excision wound model.

In vivo evaluation of cutaneous wound healing activity of Mirabilis jalapa L radix

2013 ◽  
Vol 14 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Jyotchna Gogoi ◽  
Khonamai Sewa Nakhuru ◽  
Pronobesh Chattophadhayay ◽  
Ashok Kumar Rai ◽  
Hemanta Kumar Gogoi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
In Vivo Evaluation ◽  
Cutaneous Wound ◽  
Mirabilis Jalapa ◽  
Wound Healing Activity

scholarly journals Experimental Evaluation of Ethanolic Extract ofCarapa guianensisL. Leaf for Its Wound Healing Activity Using Three Wound Models

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
B. Shivananda Nayak ◽  
Joel Kanhai ◽  
David Malcolm Milne ◽  
Lexley Pinto Pereira ◽  
William H. Swanston
Keyword(s):  
Wound Healing ◽  
Drinking Water ◽  
Granulation Tissue ◽  
Dead Space ◽  
Breaking Strength ◽  
Test Group ◽  
Ethanolic Extract ◽  
Wound Contraction ◽  
Hydroxyproline Content ◽  
Wound Healing Activity

The leaves ofCarapa guianensishave been used to treat ulcers, skin parasites, and skin problems. The ethanolic extract ofC. guianensisleaf was evaluated for its antibacterial and wound healing activity using excision, incision and dead space wound models in rats. The animals were randomly divided into two groups (n= 6) in all the models. In the excision wound model test group animals were treated topically with the leaf extract (250 mg kg−1body weight) whereas, control animals were treated with petroleum jelly. In the incision and dead space wound models, the test group animals were treated with extract (250 mg kg−1day−1) orally by mixing in drinking water and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, period of epithelialization, skin breaking strength, granulation tissue weight and hydoxyproline content. On Day 15 extract-treated animals exhibited 100% reduction in the wound area when compared to controls (95%) with significant decrease in the epithelialization period. The extract failed to demonstrate antibacterial activity. Skin breaking strength (P< .001), wet (P< .002) and dry (P< .02) granulation tissue and hydroxyproline content (P< .03) were significantly higher in extract treated animals. The increased rate of wound contraction, skin breaking strength and hydroxyproline content supports potential application ofC. guianensisin wound healing.

scholarly journals Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation

2017 ◽  
Vol 46 (5) ◽  
pp. 1009-1017 ◽  
Author(s):  
Mrinalini Sharma ◽  
Khageswar Sahu ◽  
Surya Prakash Singh ◽  
Beena Jain
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
In Vivo Evaluation ◽  
Wound Healing Activity

scholarly journals In Vivo Wound Healing and Anti-Inflammatory Activities of Leaf Latex of Aloe megalacantha Baker (Xanthorrhoeaceae)

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Leake Gebremeskel ◽  
Dayananda Bhoumik ◽  
Gereziher Geremedhin Sibhat ◽  
Kald Beshir Tuem
Keyword(s):  
Wound Healing ◽  
Breaking Strength ◽  
Negative Control ◽  
Wound Contraction ◽  
Traditional Use ◽  
Ointment Base ◽  
Healing Agent ◽  
Anti Inflammatory ◽  
Treatment Of Wounds

Background. Aloe megalacantha Baker (Xanthorrhoeaceae) is one of the Aloe species widely distributed in Ethiopia. The leaf latex of the plant is used for treatment of wounds, inflammation, and other multiple ailments in Ethiopian traditional medicine. Purpose. The aim of this study was to evaluate in vivo wound healing and anti-inflammatory activities of the leaf latex of Aloe megalacantha in mice. Methods. The wound healing activity of the leaf latex of the plant was studied topically by incorporating the latex in simple ointment base in a concentration of 5% (w/w) and 10% (w/w) using excision and incision models. In these models, wound contraction, period of epithelialization, and breaking strength of the wounded skin were determined. Carrageenan induced inflammation of paw model was also used to assess the anti-inflammatory activity of the leaf latex at doses of 200 mg/kg, 400mg/kg, and 600 mg/kg. The level of inflammation suppressions were measured at 1, 2, 3, and 4 hrs after carrageenan injection, and then the percentages of inflammation inhibition were computed as compared with the negative control. Result. In both wound models, mice treated with 5% (w/w) and 10% (w/w) latex ointment showed a significant (p<0.05) increment in the rate of wound contraction, reduction in epithelialization time, and higher skin breaking strength. Besides, the latex also exhibited a dose-dependent significant (p<0.05) reductions of inflammation as compared to negative control groups. Conclusion. The overall results of this study demonstrate that the leaf latex of A. megalacantha possesses wound healing and anti-inflammatory activities which can scientifically substantiate the traditional use of the plant as a wound healing agent.

scholarly journals Evaluation of Wound Healing Potential of Chrysophyllum albidum Hexane Seed Extract in Wistar Rat

2019 ◽  
Vol 2 (1) ◽  
pp. 82-90
Author(s):  
R D Oladeji ◽  
O Babatunde ◽  
I A Ajayi
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Test Group ◽  
Antimicrobial Activities ◽  
Negative Control ◽  
Seed Extract ◽  
Wound Contraction ◽  
Contraction Rate ◽  
Wound Healing Activity ◽  
Antioxidant And Antimicrobial Activities

Phytochemical, antioxidant and antimicrobial activities of the seeds of Chrysophyllum albidum have been established. However, scientific evaluation of its wound healing activity is lacking. Thus, this study was aimed at evaluating the wound healing potential of Chrysophyllum albidum hexane seed extract using wistar rats. The seed cotyledon was collected, air-dried, blended and extracted with n-hexane by continuous cold extraction. Phytochemicals, antioxidant and antimicrobial activities of the extracts were assayed by standard methods. Three groups of male wistar rats consisting of seven animals each were used for the animal studies. Wound excision was induced on all animals in the sterilized shaved dorsal fur region.Group1 served as the negative control (untreated), groups 2 and 3 were treated with n-hexane extract (test group) and Povidone-iodine ointment (positive control) respectively. Wound contraction rate and epithelialization time were used to assess the efficiency of the treatment. Group 3 rats had best wound contraction rate with epithelialization time of 16 post-wounding day followed by group 2 (20 days) and group 1 (28 days). The wound healing efficiency of the extract was less than that of the standard ointment but it healed the wound inflicted on the rats faster than the untreated ones. The low wound activity of the seed extract may be due to low phytochemical, antioxidant and antimicrobial activity of the extract. Chrysophyllum albidum hexane seed extract have some wound healing activity and therefore have potential for being used as wound healing ointment.

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