scholarly journals FRESH METHOD: 3D BIOPRINTING AS A NEW APPROACH FOR TISSUE AND ORGAN REGENERATION

2021 ◽  
Vol 7 (3) ◽  
pp. 79-82
Author(s):  
Alena Findrik Balogová ◽  
Marianna Trebuňová ◽  
Viktória Rajťúková ◽  
Radovan Hudák
Keyword(s):  
Additive Manufacturing ◽  
Three Dimensions ◽  
Live Cells ◽  
3D Bioprinting ◽  
New Approach ◽  
Cellular Spheroids ◽  
Organ Regeneration ◽  
Bearing Materials ◽  
Magnetic Resonance Imaging Mri ◽  
Viable Approach

Over the last decade, techniques of additive manufacturing of biomaterials have undergone a transformation, from a fast prototype tool used in research and development, to a viable approach in the production of customised medical devices. The key to this transformation is the ability of additive manufacturing to precisely define the structure and properties of a material in three dimensions, and to adjust those properties to unique anatomical and physiological criteria based on the medical data obtained by Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). The 3D bioprinting technique was developed as a solution to provide temporary and ubiquitous support of structures during the printing process. In general, integrated 3D printing may be understood as a building chamber that is filled with bearing materials, where biomaterials, cellular spheroids, cell-laden hydrogels and other materials (bioinks) are deposited using a syringe-based extruder. In particular, FRESH 3D bioprinting is a revolutionary technology, which may bring a fast and efficient advancement to medicine thanks to the ability to print new tissues from live cells.

scholarly journals 3D Bio-Printing: an Introduction to a New Approach for Cancer Patients at the Interface of Art and Medicine

Leonardo ◽  
2017 ◽  
Vol 50 (2) ◽  
pp. 195-196
Author(s):  
Eugen Bogdan Petcu
Keyword(s):  
Cancer Patients ◽  
Social Consequences ◽  
Clinical Settings ◽  
3D Bioprinting ◽  
Multidisciplinary Therapy ◽  
Significant Development ◽  
New Approach ◽  
Organ Regeneration ◽  
Art And Medicine ◽  
Actual Field

Cancer patients require a complex multidisciplinary therapy. In this context the 3D additive biological manufacturing could represent a significant development with potential significant medical and social consequences. This article reviews the 3D bioprinting methods and clinical settings in which this new revolutionary method could be applied. Apart from the actual field of post-cancer therapy prosthetics and medical education, this method could be applied in the actual molecular cancer research and organ regeneration/fabrication. Considering all of these, it is possible that in the future, 3D biological printing could be used on a regular basis in clinical oncology.

Improved Contrast in Ultra-Low-Field MRI with Time-Dependent Bipolar Prepolarizing Fields: Theory and NMR Demonstrations

2013 ◽  
Vol 20 (3) ◽  
pp. 327-336 ◽  
Author(s):  
Jaakko O. Nieminen ◽  
Jens Voigt ◽  
Stefan Hartwig ◽  
Hans Jürgen Scheer ◽  
Martin Burghoff ◽  
...  
Keyword(s):  
Field Strength ◽  
Time Course ◽  
Signal Strength ◽  
Relaxation Rates ◽  
Resonance Imaging ◽  
New Approach ◽  
Spin Lattice ◽  
Low Field ◽  
Low Field Mri ◽  
Magnetic Resonance Imaging Mri

Abstract The spin-lattice (T1) relaxation rates of materials depend on the strength of the external magnetic field in which the relaxation occurs. This T1 dispersion has been suggested to offer a means to discriminate between healthy and cancerous tissue by performing magnetic resonance imaging (MRI) at low magnetic fields. In prepolarized ultra-low-field (ULF) MRI, spin precession is detected in fields of the order of 10-100 μT. To increase the signal strength, the sample is first magnetized with a relatively strong polarizing field. Typically, the polarizing field is kept constant during the polarization period. However, in ULF MRI, the polarizing-field strength can be easily varied to produce a desired time course. This paper describes how a novel variation of the polarizing-field strength and duration can optimize the contrast between two types of tissue having different T1 relaxation dispersions. In addition, NMR experiments showing that the principle works in practice are presented. The described procedure may become a key component for a promising new approach of MRI at ultra-low fields

Three-dimensional Printing-Driving Liver Therapies

2021 ◽  
Vol 28 ◽  
Author(s):  
Xiaohong Li ◽  
Liang Wen ◽  
Jiao Liu ◽  
Xiaohong Wang
Keyword(s):  
Liver Diseases ◽  
Effective Means ◽  
Three Dimensional ◽  
3D Bioprinting ◽  
Three Dimensional Printing ◽  
Bottle Neck ◽  
Magnetic Resonance Imaging Mri ◽  
End Stage ◽  
Bioartificial Livers ◽  
Dimensional Printing

: End-stage liver diseases have long been a threat to human health, and so far, the treatment of these diseases lacks of effective means. Allogenic organ transplantation has become the last straw for most of the patients with end-stage liver diseases. However, this technique has been greatly limited by the serious shortage of donors and other factors, such as immune rejection, drug syndrome, and high cost. Recently, the emergence of three-dimensional (3D) bioprinting technologies, together with the magnetic resonance imaging (MRI) and computed tomography (CT) techniques, has driven the rapid growth of this field toward liver therapies. There are several basic requirements for liver 3D bioprinting. From information collection of diseased livers, to 3D printing of liver substitutes (containing the major structural, material and functional characters), and to clinical applications, suitable ‘bioinks’ and ‘bioprinters’ have played essential roles. In this review, we highlight the advanced ‘bioinks’ and ‘bioprinters’ that have been used for vascularized and innervated liver tissue 3D bioprinting. Further studies for the incorporation of biliary networks in the bioartificial livers have been emphasized. It is expected that when all the bottle-neck problems for liver 3D bioprinting are solved, batch (i.e. mass) and personalized production of bioartificial livers will make it very easy to treat end-stage liver diseases.

Measurement of cortical plate volume based on CBCT of frontal teeth in studies with retrusion and normality

2021 ◽  
pp. 17-21
Author(s):  
N. G. Meskhiya ◽  
I. S. Kopetskiy ◽  
I. A. Nikolskaya ◽  
D. A. Eremin ◽  
O. N. Kovaleva
Keyword(s):  
Orthodontic Treatment ◽  
Soft Tissues ◽  
Three Dimensions ◽  
Cone Beam ◽  
Cortical Plate ◽  
Imaging Method ◽  
New Approach ◽  
Accuracy Of Measurements ◽  
Bone Structures

Cone Beam Computed Tomography (CBCT) is the preferred imaging method for a comprehensive orthodontic examination. Thanks to the development of this technique, clinicians today can make most accurate measurements without fear of errors associated with projection distortion or localization of landmarks on radiographs. The quality of CBCT images gives to orthodontists the ability to analyze bone structures, teeth (even impacted teeth), and soft tissue in three dimensions. The accuracy of measurements of hard and soft tissues from CBCT images determines the accuracy of diagnosis and treatment planning. A fundamentally new approach has been proposed, which makes it possible to thoroughly study the bone tissue surrounding the tooth at the stages of planning orthodontic treatment. Аnalysis of radiation studies of patients with dentoalveolar anomalies was carried out to select the optimal treatment tactics and to control its effectiveness.

scholarly journals Bioinspired hierarchical composite design using machine learning: simulation, additive manufacturing, and experiment

2018 ◽  
Vol 5 (5) ◽  
pp. 939-945 ◽  
Author(s):  
Grace X. Gu ◽  
Chun-Teh Chen ◽  
Deon J. Richmond ◽  
Markus J. Buehler
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Additive Manufacturing ◽  
Convolutional Neural Networks ◽  
New Approach ◽  
Hierarchical Materials

A new approach to design hierarchical materials using convolutional neural networks is proposed and validated through additive manufacturing and testing.

scholarly journals Bone-inspired 3D printed structures for construction applications

2019 ◽  
Vol 14 (1) ◽  
pp. 111-124
Author(s):  
Roberto Naboni ◽  
Anja Kunic
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Computational Design ◽  
Bone Microstructure ◽  
Manufacturing Technology ◽  
Support Design ◽  
Efficient Construction ◽  
3D Printed ◽  
Viable Approach ◽  
Tectonic System

Overconsumption of resources is one of the greatest challenges of our century. The amount of material that is being extracted, harvested and consumed in the last decades is increasing tremendously. Building with new manufacturing technology, such as 3D Printing, is offering new perspectives in the way material is utilized sustainably within a construction. This paper describes a study on how to use Additive Manufacturing to support design logics inspired by the bone microstructure, in order to build materially efficient architecture. A process which entangles computational design methods, testing of 3D printed specimens, developments of prototypes is described. A cellular-based tectonic system with the capacity to vary and adapt to different loading conditions is presented as a viable approach to a material-efficient construction with Additive Manufacturing.

scholarly journals Synergic Sustainability Implications of Additive Manufacturing in Automotive Spare Parts: A Case Analysis

2020 ◽  
Vol 12 (20) ◽  
pp. 8461
Author(s):  
Luis Isasi-Sanchez ◽  
Jesus Morcillo-Bellido ◽  
Jose Ignacio Ortiz-Gonzalez ◽  
Alfonso Duran-Heras
Keyword(s):  
Additive Manufacturing ◽  
Case Analysis ◽  
Spare Parts ◽  
Three Dimensions ◽  
Sustainable Supply Chain ◽  
Bottom Line ◽  
Systematic Analysis ◽  
Chain Management ◽  
Trade Offs ◽  
Disruptive Innovations

Triple bottom line (3BL) approaches to sustainable supply chain management (SSCM) often involve trade-offs between their three dimensions (economic, environmental, and social), thus curtailing its application and leading to goal unalignment among stakeholders. Under some circumstances, however, synergic approaches (typically involving disruptive innovations) might allow simultaneous improvement in one or more dimensions without compromising the others. This paper analyzes one such case: the potential of properly designed additive manufacturing approaches in the automotive spare parts industry to simultaneously boost profits and reduce environmental impact. It is based on the systematic analysis of the real spare parts business of a mid-size automotive brand in Spain. Its results suggest that such synergic, self-reinforcing opportunities do indeed exist, and might even be further developed by strategically integrating sustainability constituents such as circularity.

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