scholarly journals 3D Bio-Printing: an Introduction to a New Approach for Cancer Patients at the Interface of Art and Medicine

Leonardo ◽  
2017 ◽  
Vol 50 (2) ◽  
pp. 195-196
Author(s):  
Eugen Bogdan Petcu
Keyword(s):  
Cancer Patients ◽  
Social Consequences ◽  
Clinical Settings ◽  
3D Bioprinting ◽  
Multidisciplinary Therapy ◽  
Significant Development ◽  
New Approach ◽  
Organ Regeneration ◽  
Art And Medicine ◽  
Actual Field

Cancer patients require a complex multidisciplinary therapy. In this context the 3D additive biological manufacturing could represent a significant development with potential significant medical and social consequences. This article reviews the 3D bioprinting methods and clinical settings in which this new revolutionary method could be applied. Apart from the actual field of post-cancer therapy prosthetics and medical education, this method could be applied in the actual molecular cancer research and organ regeneration/fabrication. Considering all of these, it is possible that in the future, 3D biological printing could be used on a regular basis in clinical oncology.

scholarly journals FRESH METHOD: 3D BIOPRINTING AS A NEW APPROACH FOR TISSUE AND ORGAN REGENERATION

2021 ◽  
Vol 7 (3) ◽  
pp. 79-82
Author(s):  
Alena Findrik Balogová ◽  
Marianna Trebuňová ◽  
Viktória Rajťúková ◽  
Radovan Hudák
Keyword(s):  
Additive Manufacturing ◽  
Three Dimensions ◽  
Live Cells ◽  
3D Bioprinting ◽  
New Approach ◽  
Cellular Spheroids ◽  
Organ Regeneration ◽  
Bearing Materials ◽  
Magnetic Resonance Imaging Mri ◽  
Viable Approach

Over the last decade, techniques of additive manufacturing of biomaterials have undergone a transformation, from a fast prototype tool used in research and development, to a viable approach in the production of customised medical devices. The key to this transformation is the ability of additive manufacturing to precisely define the structure and properties of a material in three dimensions, and to adjust those properties to unique anatomical and physiological criteria based on the medical data obtained by Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). The 3D bioprinting technique was developed as a solution to provide temporary and ubiquitous support of structures during the printing process. In general, integrated 3D printing may be understood as a building chamber that is filled with bearing materials, where biomaterials, cellular spheroids, cell-laden hydrogels and other materials (bioinks) are deposited using a syringe-based extruder. In particular, FRESH 3D bioprinting is a revolutionary technology, which may bring a fast and efficient advancement to medicine thanks to the ability to print new tissues from live cells.

scholarly journals Oxidative Stress and Cognitive Alterations Induced by Cancer Chemotherapy Drugs: A Scoping Review

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1116
Author(s):  
Omar Cauli
Keyword(s):  
Oxidative Stress ◽  
Cancer Patients ◽  
Repeated Administration ◽  
Caffeic Acid Phenethyl Ester ◽  
Scientific Basis ◽  
Clinical Settings ◽  
Chemotherapy Drugs ◽  
Scientific Attention ◽  
The Brain ◽  
Cognitive Alterations

Cognitive impairment is one of the most deleterious effects of chemotherapy treatment in cancer patients, and this problem sometimes remains even after chemotherapy ends. Common classes of chemotherapy-based regimens such as anthracyclines, taxanes, and platinum derivatives can induce both oxidative stress in the blood and in the brain, and these effects can be reproduced in neuronal and glia cell cultures. In rodent models, both the acute and repeated administration of doxorubicin or adriamycin (anthracyclines) or cisplatin impairs cognitive functions, as shown by their diminished performance in different learning and memory behavioural tasks. Administration of compounds with strong antioxidant effects such as N-acetylcysteine, gamma-glutamyl cysteine ethyl ester, polydatin, caffeic acid phenethyl ester, and 2-mercaptoethane sulfonate sodium (MESNA) counteract both oxidative stress and cognitive alterations induced by chemotherapeutic drugs. These antioxidant molecules provide the scientific basis to design clinical trials in patients with the aim of reducing the oxidative stress and cognitive alterations, among other probable central nervous system changes, elicited by chemotherapy in cancer patients. In particular, N-acetylcysteine and MESNA are currently used in clinical settings and are therefore attracting scientific attention.

Alzheimer's Electroencephalogram Event Scalp and Source Localization

2016 ◽  
pp. 33-49
Author(s):  
Pedro Miguel Rodrigues ◽  
João Paulo Teixeira ◽  
Diamantino R. S. Freitas
Keyword(s):  
Source Localization ◽  
The Elderly ◽  
Clinical Settings ◽  
New Approach ◽  
Brain Anomalies ◽  
Available Technology ◽  
Temporal Events ◽  
Near Future ◽  
Electroencephalogram Eeg ◽  
Irreversible Impairment

Alzheimer's disease is the most common cause of dementia which causes a progressive and irreversible impairment of several cognitive functions. The aging population has been increasing significantly in recent decades and this disease affects mainly the elderly. Its diagnostic accuracy is relatively low and there is not a biomarker able to detect AD without invasive tests. Despite the progress in better understanding the disease there remains no prospect of cure at least in the near future. The electroencephalogram (EEG) test is a widely available technology in clinical settings. It may help diagnosis of brain disorders, once it can be used in patients who have cognitive impairment involving a general decrease in overall brain function or in patients with a located deficit. This study is a new approach to improve the scalp localization and the detection of brain anomalies (EEG temporal events) sources associated with AD by using the EEG.

Detection of Alzheimer’s Disease Electroencephalogram Temporal Events

2013 ◽  
Vol 2 (3) ◽  
pp. 44-61 ◽  
Author(s):  
Pedro Miguel Rodrigues ◽  
Diamantino Rui Freitas ◽  
João Paulo Teixeira
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
The Elderly ◽  
Clinical Settings ◽  
Brain Disorder ◽  
New Approach ◽  
Self Organized ◽  
Available Technology ◽  
Temporal Events ◽  
Electroencephalogram Eeg

Alzheimer’s Disease (AD) is a chronic progressive and irreversible neurodegenerative brain disorder. The aging population has been increasing significantly in recent decades. Therefore, AD will continue to increase because the disease affects mainly the elderly. Its diagnostic accuracy is relatively low, and there is not a biomarker able to detect AD without invasive tests. The electroencephalogram (EEG) test is a widely available technology in clinical settings. It may help diagnosis of brain disorders, once it can be used in patients who have cognitive impairment involving a general decrease in overall brain function or in patients with a located deficit. This study is a new approach to detect EEG temporal events in order to improve the AD diagnosis. For that, K-means and Self-Organized Maps were used, and the results suggested that there are sequences of EEG energy variation that appear more frequently in AD patients than in healthy subjects.

scholarly journals 3D Bioprinting for Organ Regeneration

2016 ◽  
Vol 6 (1) ◽  
pp. 1601118 ◽  
Author(s):  
Haitao Cui ◽  
Margaret Nowicki ◽  
John P. Fisher ◽  
Lijie Grace Zhang
Keyword(s):  
3D Bioprinting ◽  
Organ Regeneration

Vitrification: an effective new approach to oocyte banking and preserving fertility in cancer patients

2008 ◽  
Vol 10 (5) ◽  
pp. 268-273 ◽  
Author(s):  
Ana Cobo ◽  
Javier Domingo ◽  
Sonia Pérez ◽  
Juana Crespo ◽  
José Remohí ◽  
...  
Keyword(s):  
Cancer Patients ◽  
New Approach

scholarly journals Sarcopenia in Cancer Patients

2019 ◽  
Vol 13 (3) ◽  
pp. 96 ◽  
Author(s):  
Andree Kurniawan
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cancer Patients ◽  
Muscle Mass ◽  
Current Evidence ◽  
Clinical Settings ◽  
Before And After ◽  
Impact Risk ◽  
Negative Impacts ◽  
And Function

Introduction: Sarcopenia in cancer patients, especially in advanced stage, recently known as an emerging problem. Firstly, sarcopenia is found in elderly patients. The diagnosis of sarcopenia needs evaluation of muscle composition and function and physical activity. Sarcopenia will give negative impacts such as increased mortality, chemo-toxicity, and decreased quality of life. Here, we review the current evidence describing the definition, impact, risk factors, mechanisms, diagnosis and treatment of sarcopenia in cancer patients.Method: We identified 48 studies and/or review articles evaluating sarcopenia in cancer patients by searching PubMed and EMBASE databases. Results: Sarcopenia is reported across all stages and types of cancers. There is a new definition of sarcopenia that is reported in 2019 paper. The risk factors or causes of sarcopenia in cancer are complex depending on the clinical settings of each patient. SARC-F questionnaire can be used to screen cancer patients in clinical settings. The diagnostic evaluation and cut-off measurement of sarcopenia especially in cancer varied across studies. The loss of muscle mass that happens during chemotherapy will make a poor prognosis. Sarcopenia can worsen chemotherapy toxicity. Combination exercise with adequate dietary supplementation, adequate energy, and protein are important in the management of sarcopenia in cancer patients.Conclusions: Patients with cancer belong to a population at risk of developing sarcopenia before and after chemotherapy. Sarcopenia diagnosis needs the evaluation of muscle mass and muscle strength or physical performance. Physical activity exercise is the best strategy to reduce sarcopenia in cancer patients.

scholarly journals New Approach for Collecting Cancer Patients’ Views and Preferences Through Medical Staff

2021 ◽  
Vol Volume 15 ◽  
pp. 375-385
Author(s):  
Tomoko Takayama ◽  
Yoji Inoue ◽  
Rie Yokota ◽  
Masayo Hayakawa ◽  
Chikako Yamaki ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Medical Staff ◽  
New Approach
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