Treatment of Chronic Plaque Psoriasis with Etanercept and Methotrexate

Objectives: The aim of study is to assess the efficacy of methotrexate and etanercept in the treatment of chronic plaque psoriasis. Methods: This therapeutic, interventional comparative single center study was carried out at the Center of Dermatology and Venereology, Baghdad Teaching Hospital, from January 2015 –July 2017. A total of 62 patients were enrolled; divided in to two groups. Group I: Thirty three patients (23 males and 10 females), their ages ranged between15 and 65 years mean ±SD 33.13±13.07, recieved etanercept 50mg twice weekly for 3 months then once weekly thereafter. Group II: Twenty nine patients (19 males and 10 females), their ages ranged between15 and 62 years mean ± SD 38.16±15.2 ,received methotrexate 15 mg per week for six monthes then tapered. Both groups were followed up monthly for 6 months and their PASI score, DLQI, side effect and pictures were recorded. Results: Seven patients defaulted from the study for unknown reason,30 patients completed in etanercept group, while 25 patients completed in methotrexate group. After 12 weeks the PASI score decrease from base line 19.13±10.67 to 6.38±4.96 and then to 3.34±5.38 after 24 weeks treatment with Etanercept compaired to reduction in PASI score from base line 18.97±10.54 to 5.72± 4.8 to 2.95±-6.01 after 12 weeks and 24 weeks respectively. There is significant statistical effect in the two groups. Conclusions: both are effective monotherapy for patients with moderate to severe plaque psoriasis with tolerable side effects.

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An open-label single-center study to assess the safety and efficacy of dose escalation of alefacept 15 mg IM for 6 weeks followed by 6 weeks of 30 mg IM in patients with moderate to severe chronic plaque psoriasis

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2004.10.720 ◽

2005 ◽

Vol 52 (3) ◽

pp. P177

Keyword(s):

Dose Escalation ◽

Plaque Psoriasis ◽

Single Center ◽

Chronic Plaque Psoriasis ◽

Open Label ◽

Safety And Efficacy ◽

Single Center Study ◽

Center Study

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Effect of Gall Bladder Retrieval via Epigestric Vs Umbilical Port in Laparoscopic Cholectystectomy

10.53350/pjmhs211571850 ◽

2021 ◽

Vol 15 (7) ◽

pp. 1850-1853

Author(s):

Mumtaz Ahmad Khan ◽

Ishfaq Ahmad Khan ◽

Farhan Ali ◽

Sadia Nazir ◽

Arshid Mahmood ◽

...

Keyword(s):

Gall Bladder ◽

Gallbladder Disease ◽

P Value ◽

Single Center ◽

Post Surgery ◽

Group I ◽

Single Center Study ◽

Group B ◽

Center Study ◽

Median Pain

Background and Aim: The retrieval of the gallbladder is a key event in laparoscopic cholecystectomy and significantly contributes to postoperative infections and pain. The GB is extracted through an umbilical or epigastric port. The goal of this single-center study was to compare GB retrieval via epigastric versus umbilical port in terms of postoperative site pain and infections. Materials and Methods:In this single-center study, 60 Cholelithiasis patients under went laparoscopic cholectystectomy (LC) for symptomatic gallbladder disease during the period from November 2020 to April 2021 at surgery department of Gambat Institute of Medical Sciences, Gambat Sindh Pakistan. The patients were selected out of the operating room for GB retrieval via umbilical port (Group-I with n = 30) versus epigastric port (Group-II with n = 30) randomly.All 60 patients had routine blood tests such as CBC, SGOT, SGPT, PT, and urine examinations. Until their bowels recovered, all of the patients were kept nil by mouth and on parenteral fluids. They were closely monitored in the post-operative period, with special attention paid to recording the pulse rate, temperature, and level of pain on a 24-hour basis. Results:Chronic Cholecystitis patients chosen randomly from the cholecystectomy list to have their gallbladder delivered through an umbilical or epigastric port.Group I had median pain (IQR) of 5 (1.5), 4 (1), and 2 (1) when compared to group II's median pain (IQR) of 4 (1), 2 (1), and 1 (0.5) one day after the procedure (p-value=0.001), at the time of hospital discharge (p-value0.001), and one month post-surgery (p-value0.001).In group B, there was a clear regression in postoperative pain from the day of surgery until a month later (p-value0.001). Conclusion:According to our findings, umbilical ports are preferable to epigastric ports in terms of post-operative pain, but there is an increased port site infection and hernia risk. Keywords:Cholecystectomy, Umbilical port, Epigastric port, Gall bladder retrieval, Laparoscopic.

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Comparison of MRI Visualization Following Minimally Invasive and Open TLIF: A Retrospective Single-Center Study

Diagnostics ◽

10.3390/diagnostics11050906 ◽

2021 ◽

Vol 11 (5) ◽

pp. 906

Author(s):

Vadim A. Byvaltsev ◽

Andrei A. Kalinin ◽

Morgan B. Giers ◽

Valerii V. Shepelev ◽

Yurii Ya. Pestryakov ◽

...

Keyword(s):

Minimally Invasive ◽

Single Center ◽

Muscle Area ◽

Multifidus Muscle ◽

Postoperative Mri ◽

Group I ◽

Single Center Study ◽

Mr Artifacts ◽

Transpedicular Screw Fixation ◽

Center Study

Analysis of magnetic resonance image (MRI) quality after open (Op)-transforaminal interbody fusion (TLIF) and minimally invasive (MI)-TLIF with the implantation of structurally different systems has not previously been performed. The objective of this study was to conduct a comparative analysis of the postoperative MRI following MI and Op one-segment TLIF. Material and Methods: The nonrandomized retrospective single-center study included 80 patients (46 men and 24 women) aged 48 + 14.2 years. In group I (n = 20) Op-TLIF with open transpedicular screw fixation (TSF) was performed, in II group (n = 60), the MI-TLIF technique was used: IIa (n = 20)—rigid interspinous stabilizer; IIb (n = 20)—unilateral TSF and contralateral facet fixation; IIc (n = 20)—bilateral TSF. Results: Comparison of the quality of postoperative imaging in IIa and IIb subgroups showed fewer MRI artifacts and a significantly greater MR deterioration after Op and MI TSF. Comparison of the multifidus muscle area showed less atrophy after MI-TLIF and significantly greater atrophy after Op-TLIF. Conclusion: MI-TLIF and Op-TLIF with TSF have comparable postoperative MR artifacts at the operative level, with a greater degree of muscle atrophy using the Op-TLIF. Rigid interspinous implant and unilateral TSF with contralateral facet fixation have less artifacts and changes in the multifidus muscle area.

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Calcipotriol/Betamethasone Dipropionate Aerosol Foam for Plaque Psoriasis: A Prospective, Observational, Non-Interventional, Single-Center Study of Patient Adherence and Satisfaction in Daily Use

Dermatology Practical & Conceptual ◽

10.5826/dpc.1103a56 ◽

2021 ◽

pp. 2021056

Author(s):

Francisco J Navarro-Triviño ◽

Mario Lozano-Lozano ◽

Ricardo Ruiz-Villaverde

Keyword(s):

Quality Of Life ◽

Plaque Psoriasis ◽

Treatment Satisfaction ◽

Betamethasone Dipropionate ◽

Single Center ◽

Adherence To Treatment ◽

Single Center Study ◽

Calcipotriol Betamethasone ◽

Center Study

Background: Psoriasis is a chronic inflammatory disease that has a negative impact on patients' quality of life. Patients with mild–moderate psoriasis can be treated with topical medications, such as the combination drug calcipotriol/betamethasone dipropionate (Cal/BD). Objectives: This study investigated the adherence of psoriasis patients to therapy with Cal/BD aerosol foam, as well as their satisfaction with the treatment’s efficacy, safety, and effect on their quality of life. Methods: Patients with mild–moderate plaque psoriasis were eligible to participate in this open-label, non-placebo controlled, prospective single-center study. Adherence to treatment was assessed using the Morisky-Green scale 4 and 12 weeks after the start of treatment. Satisfaction with the treatment was assessed using the abbreviated Treatment Satisfaction Questionnaire for Medication (TSQM-9). The severity of psoriasis was assessed on the mIGA and PGA scales, and the impact on quality of life was assessed using the PDI and DLQI scales. Results: A total of 65 patients entered the study. Adherence to treatment was good, with 73.8% of patients showing high adherence at 12 weeks. Satisfaction was also good, with 46 patients (70.8%) being completely satisfied. Conclusions: Over a 4-week period, patients treated with Cal/BD aerosol foam had significant improvement in disease severity that was directly related to treatment adherence.

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