scholarly journals Incidence of Prostatic Carcinoma in Transurethral Resection Specimen

2021 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Prostate Cancer ◽  
Cross Section ◽  
Prostatic Carcinoma ◽  
Screening Program ◽  
Prostate Adenocarcinoma ◽  
Prostatic Hyperplasia ◽  
Histopathological Analysis ◽  
High Grade ◽  
Prostatic Enlargement ◽  
Resection Specimen

Objective: This study done to identify the rates of incidentally detected prostate cancer in patients undergoing surgical management of Benign Prostatic Hyperplasia (BPH). Methods: This cross section study was done on all transurethral resections of the prostate (TURP) cases. One hundred and eighty one men, aged 45 to 94 year, underwent TURP and their specimens were sent for the histopathological analysis. Those with a known diagnosis of prostate cancer prior to TURP were excluded (𝑛 = 5) from the analysis. Results: Hundred eighty-one patients had prostatic enlargement; fifteen patients (8.29%) patients were found to have prostate adenocarcinoma. Grade of disease ranged from Gleason score 7 to 10. Majority of them (fourteen patients) aged 65 year or above. Conclusion: Prostate carcinoma is showing high grade at the diagnosis and widely frequent (8.29%) in TURP, especially in-patient above 65 years (11.0%) and therefore a screening program advised.

scholarly journals Misanian Men, are or aren't a Prostatic Adenocarcinoma?

2021 ◽  
Vol 14 ◽  
pp. 1-4
Author(s):  
Haider Qasim Alhelfi
Keyword(s):  
Prostate Cancer ◽  
Diabetes Mellitus ◽  
Risk Factor ◽  
Family History ◽  
Prostatic Carcinoma ◽  
Screening Program ◽  
High Grade ◽  
History Of ◽  
Male Patients ◽  
Oncology Center

It is an observational study in Al-Shafaa Oncology Center in Misan province about male patients with prostatic carcinoma to make an idea about the prevalence of this malignancy. This study was carried out during the period from July 2018 to March 2019 in Al-Shafaa Oncology Center in Al-Sadder teaching hospital in Misan province in which 53 male patients were involved. In our study we found that that the disease reaching a peak among patients between (70-80) years, (66.03%) of patients are a smoker (13.2%), had a family history of different type of cancer, (100%) of the patients had adenocarcinoma, (56.6%) that had high-grade cancer (Gleason score ˃8), (77.35%) of the patient had PSA level >100 ng/ml. The prostate cancer in Misan appears to be more likely to occur in the presence of particular risk factor like age, hypertension, family history, and less likely in the presence of diabetes mellitus. It is more likely to be presented with high grade and metastatic disease, and this may be primarily explained by the absence of the screening program.

scholarly journals The Combination of Human Glandular Kallikrein and Free Prostate-specific Antigen (PSA) Enhances Discrimination Between Prostate Cancer and Benign Prostatic Hyperplasia in Patients with Moderately Increased Total PSA

1999 ◽  
Vol 45 (11) ◽  
pp. 1960-1966 ◽  
Author(s):  
Angeliki Magklara ◽  
Andreas Scorilas ◽  
William J Catalona ◽  
Eleftherios P Diamandis
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Prostate Specific Antigen ◽  
Prostatic Carcinoma ◽  
Specific Antigen ◽  
Area Under The Curve ◽  
Prostatic Hyperplasia ◽  
Free Psa ◽  
Glandular Kallikrein ◽  
Total Psa

Abstract Background: Prostate-specific antigen (PSA) is the most reliable tumor marker available and is widely used for the diagnosis and management of prostate cancer. Unfortunately, PSA cannot distinguish efficiently between benign and malignant disease of the prostate, especially within the range of 4–10 μg/L. Among the refinements developed to enhance PSA specificity is the free/total PSA ratio, which is useful in discriminating between the two diseases within the diagnostic “gray zone”. Recent data indicate that human glandular kallikrein (hK2), a protein with high homology to PSA, may be an additional serum marker for the diagnosis and monitoring of prostate cancer. Methods: We analyzed 206 serum samples (all before treatment was initiated) from men with histologically confirmed benign prostatic hyperplasia (n = 100) or prostatic carcinoma (n = 106) with total PSA in the range of 2.5–10 μg/L. Total and free PSA and hK2 were measured with noncompetitive immunological procedures. Statistical analysis was performed to investigate the potential utility of the various markers or their combinations in discriminating between benign prostatic hyperplasia and prostatic carcinoma. Results: hK2 concentrations were not statistically different between the two groups of patients. There was a strong positive correlation between hK2 and free PSA in the whole patient population. hK2/free PSA ratio (area under the curve = 0.69) was stronger predictor of prostate cancer than the free/total PSA ratio (area under the curve = 0.64). At 95% specificity, the hK2/free PSA ratio identified 30% of patients with total PSA between 2.5–10 μg/L who had cancer. At 95% specificity, the hK2/free PSA ratio identified 25% of patients with total PSA between 2.5 and 4.5 μg/L who had cancer. Conclusions: Our data suggest that hK2 in combination with free and total PSA can enhance the biochemical detection of prostate cancer in patients with moderately increased total PSA concentrations. More specifically, the hK2/free PSA ratio appears to be valuable in identifying a subset of patients with total PSA between 2.5 and 4.5 μg/L who have high probability of cancer and who should be considered for biopsy.

scholarly journals Correlation of serum free prostate-specific antigen level with histological findings in patients with prostatic disease

1970 ◽  
Vol 8 (2) ◽  
pp. 158-163 ◽  
Author(s):  
M Lakhey ◽  
R Ghimire ◽  
R Shrestha ◽  
AD Bhatta
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Prostatic Hyperplasia ◽  
Free Form ◽  
High Grade ◽  
Prostatic Disease ◽  
Active Inflammation ◽  
The Relationship

Background: Prostate Specifi c Antigen (PSA) has been widely used in the diagnosis and management of patients with prostate cancer. It may be elevated in other prostatic diseases and surgical procedures. PSA exists in two forms, a major bound form (cPSA) and a free form (fPSA). Objectives: The objective of the study was to determine the relationship between serum fPSA levels and histologic findings in biopsy specimens of men with prostatic disease. Material and methods: This study includes 91 patients planned for transurethral resection of prostate (TURP). Blood samples were collected before TURP and tested for fPSA. Histology of the tissue samples collected after TURP were studied and the relationship with fPSA analysed using SPSS 11.5. Results: The median values for benign, premalignant and malignant lesions were 1.8ng/ml, 4.5ng/ml and 13.20ng/ml respectively (p<0.001). Most cases of benign prostatic hyperplasia(BPH) without inflammation had fPSA levels <2ng/ ml, while most with active inflammation had levels >5ng/ml. Low grade prostatic intraepithelial neoplasia (LGPIN) saw levels <5ng/ml while high grade intraepithelial neoplasia (HGPIN) and prostate cancer (PCa) had levels > 5ng/mL (p<0.05). For detection of high grade lesions (HGPIN and PCa), the sensitivity and specificity of fPSA level > 5ng/ml was found to be 88.8% and 90.2% respectively. Conclusions: Serum fPSA is elevated marginally in patients with BPH without inflammation. Active inflammation and high grade lesions are associated with fPSA level more than 5 ng/ml. Key words: Benign prostatic hyperplasia; fPSA; prostate cancer; prostatic intraepithelial neoplasia. DOI: 10.3126/kumj.v8i2.3550 Kathmandu University Medical Journal (2010), Vol. 8, No. 2, Issue 30, 158-163  

scholarly journals Metastatic prostate adenocarcinoma and high-grade appendiceal mucinous neoplasm mimicking acute appendicitis in a post-radiation therapy patient

2021 ◽  
Vol 9 ◽  
pp. 2050313X2098842
Author(s):  
Robert Propst ◽  
Yan Chen Wongworawat ◽  
Evelyn Choo ◽  
Camilla Cobb ◽  
Anwar Raza
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Acute Appendicitis ◽  
Prostate Adenocarcinoma ◽  
Rapid Weight Loss ◽  
High Grade ◽  
Older Patient ◽  
Early Presentation ◽  
Mucinous Neoplasm ◽  
Post Radiation

Prostate cancer is the most common visceral malignancy diagnosed in males. Surveillance for post-treatment neoplasms is very crucial. Here we report the first case of recurrent metastatic prostate cancer presenting as acute appendicitis in a background of a high-grade appendiceal mucinous neoplasm. In addition, this case also includes an unusually early presentation of a secondary primary malignancy after radiation therapy. A 70-year-old male with a history of prostate adenocarcinoma status post-proton radiation therapy presented with recurrent poorly differentiated prostate adenocarcinoma with disease progression and extra-prostatic extension. He underwent salvage proton therapy and testosterone replacement therapy. Two years later, the patient presented with right lower quadrant pain. A computed tomography scan showed perforated acute appendicitis with intra-abdominal abscess, which was treated with interval appendectomy. Upon histologic analysis, metastatic prostatic adenocarcinoma was noted in the appendiceal wall and mesoappendix. In addition, an incidental background of high-grade appendiceal mucinous neoplasm was found. Four months later, he presented with persistent abdominal pain, rapid weight loss, fatigue, and fever for 3 months. An abdominal CT scan revealed a 6.1 cm rectal mass. Pathologic analysis diagnosed an aggressive post-radiation spindle cell sarcoma, intermediate to high grade. The patient opted for palliative care. This case shows that a clinical presentation of acute appendicitis in an older patient may sometimes portend a neoplastic rather than infectious etiology. Clinical history and patient epidemiology should always be considered when evaluating an older patient with clinical signs and symptoms of acute appendicitis.

scholarly journals Incidence of Carcinoma Prostate in Transurethral Resection Specimen in a Teaching Hospital of Nepal

2016 ◽  
Vol 4 (2) ◽  
pp. 77
Author(s):  
Neeraj Thapa ◽  
Sachin Shris ◽  
Nabin Pokharel ◽  
Yashwant Gajanan Tambay ◽  
Yeshwant Ramakrishan Kher ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Clinical Symptoms ◽  
Tertiary Care ◽  
Histopathological Analysis ◽  
Carcinoma Prostate ◽  
High Prevalence ◽  
Resection Specimen ◽  
Tertiary Care Institution ◽  
Poorly Differentiated

Introduction: As suggested through several autopsy studies there is a high prevalence of latent prostate  cancer in the population. A much smaller proportion of prostate  cancer is detected because of clinical symptoms. This study was done to identify the rates of incidentally detected prostate cancer in patients undergoing surgical management of Benign Prostatic Hyperplasia (BPH) in our centre.   Methods: A retrospective review was done on all transurethral resections of the prostate (TURP)  cases from May 2014 to May 2015 at a single tertiary care institution. One hundred and three men, aged 40 to 88 year, underwent TURP and their specimens were sent for the  histopathological analysis.   Results: Five (4.85%) patients were diagnosed with the prostate  cancer. All the five patients had Gleason score of seven or more. Two patients had moderately differentiated adenocarcinoma  with Gleason score of seven. Three patients had poorly differentiated adenocarcinoma with Gleason score of eight or above. The Prostate cancer was seen only  in the age group above 65 years but it was not statistically significant.   Conclusion: Our series demonstrated that 4.85% of patients had latent prostate  cancer. It occurs mainly in men above 65 years of age though this was not statistically significant.

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