scholarly journals IMMUNE STATUS IN HIV-INFECTED PATIENTS COINFECTED WITH HEPАTITIS C VIRUS (HCV)

2019 ◽  
Vol 10 (4) ◽  
pp. 25-36
Author(s):  
K. V. Shmagel ◽  
V. A. Chereshnev
Keyword(s):  
Hepatitis C ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Immune Status ◽  
Direct Action ◽  
Hcv Infection ◽  
Viral Hepatitis C ◽  
Negative Effect ◽  
Negative Role

The most common co-infection associated with HIV infection is viral hepatitis C. More than half of HIV-infected patients is coinfected with HCV in Russia. Both infections can have a reciprocal negative effect, what is reflected in an increase in the morbidity and mortality of co-infected patients compared with mono-infected patients. The negative role of HIV infection in the development of hepatitis C is manifested by the acceleration of the process of fibrosis and the formation of cirrhosis of the liver, as well as the frequent occurrence of hepatocellular carcinoma. The effects of HCV infection on the course of HIV infection have been less studied. It is known that hepatitis can slow down the immune reconstitution while receiving antiretroviral therapy. In addition, a violation of the hepatic barrier for products supplying from the intestine, apparently, can lead to additional activation of the immune system, aggravatted immunodeficiency, increased systemic inflammation and the development of AIDS-non-associated diseases, primarily cardiovascular diseases. Most researchers see the solution of the problem in the early start of antiretroviral therapy, as well as in the transition from interferon therapy to the appointment of drugs of direct action in the treatment of HCV infection.

scholarly journals HIV Infection and Antiretroviral Therapy: Effect on Hepatitis C Virus Quasispecies Variability

2006 ◽  
Vol 193 (9) ◽  
pp. 1211-1218 ◽  
Author(s):  
Margaret C. Shuhart ◽  
Daniel G. Sullivan ◽  
Kirubeal Bekele ◽  
Robert D. Harrington ◽  
Mari M. Kitahata ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Therapy Effect

scholarly journals THE CASE OF DEATH FROM LIVER CIRRHOSIS IN THE FEMALE PATIENT WITH HIV INFECTION AND INFILTRATIVE PULMONARY TUBERCULOSIS

2013 ◽  
Vol 18 (1) ◽  
pp. 49-54
Author(s):  
I. Yu. Babaeva ◽  
M. G. Avdeeva ◽  
N. P. Shevchenko ◽  
V. V Kulagin ◽  
G. V Chumachenko ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Pulmonary Tuberculosis ◽  
Hiv Infection ◽  
Chronic Viral Hepatitis ◽  
Age Group ◽  
Viral Hepatitis C ◽  
Comparative Results ◽  
Age Range ◽  
Chronic Viral Hepatitis C

The paper presents comparative results of estimation of mortality from HIV infection, tuberculosis (TB), fibrosis and cirrhosis of the liver of nonalcoholic nature according to age group for the residents of the Krasnodar region for the period 2006 to 2011. The average age range of the probable development of death from HIV infection was 35-39, from tuberculosis - 45-49 and from liver cirrhosis 55-59 years. Given clinical case is demonstrating the importance of the underestimation of hepatitis "C" complicating diagnosis of cirrhosis in patients with HIV infection, suffering from secondary diseases: pulmonary tuberculosis, cytomegalovirus, toxoplasmosis, herpes infection, candidiasis. After a comprehensive review of the examples the authors provide recommendations for monitoring and management of patients with ТВ and HIV infection and chronic viral hepatitis "C".

scholarly journals Genetic Variants in JAK1 Gene and Susceptibility to Hepatitis C Viral Infection in Iraq

2016 ◽  
Vol 10 (1) ◽  
pp. 37-41
Author(s):  
Fatima Abood Chaloob
Keyword(s):  
Hepatitis C ◽  
Hcv Infection ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Global Challenge ◽  
Pcr Products ◽  
Chronic Hcv Infection ◽  
Chronic Hcv ◽  
Apparently Healthy

Infection with hepatitis C virus (HCV) imposes a global challenge with over 180 million cases worldwide. Only few patients spontaneously had their virus neutralized, while most patients develop chronic HCV infection. This implies a key role of genetic factors in viral clearance or persistence. The current study aimed at clarifying the effect of certain single nucleotide polymorphisms (SNPs) on individual's susceptibility to HCV infection.  A total of 60 patients with confirmed HCV infection and 35 apparently healthy individuals were enrolled in this study. Blood sample was obtained from each participant, from which DNA was extracted. The JAK1gene was amplified with conventional PCR technique using three sets of primers targeting three SNPs in this gene: rs2780895, rs4244165 and rs17127024. Restriction fragment length polymorphism (RFLP) was used for genotyping of PCR products. Each of rs2780895 and rs17127024 had two genotypes in both patients and controls, however, only the heterozygous genotype of the SNP rs2780895 (CT) significantly associated with the susceptibility to HCV. The SNP rs4244165 appeared in only with homozygous wild genotype (GG) in both patients and controls. It can be concluded that allele T of the SNP rs2780895 could be considered as a risk factor for infection with HCV

scholarly journals Increased levels of circulating IL-10 in persons recovered from hepatitis C virus (HCV) infection compared with persons with active HCV infection

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Dorcas Ohui Owusu ◽  
Richard Phillips ◽  
Michael Owusu ◽  
Fred Stephen Sarfo ◽  
Margaret Frempong
Keyword(s):  
Hepatitis C ◽  
Spontaneous Recovery ◽  
Predictive Marker ◽  
Serum Levels ◽  
Hcv Infection ◽  
Tnf Alpha ◽  
Hepatitis C Infection ◽  
Ifn Gamma ◽  
The Relationship

Abstract Objective Approximately 70% of all hepatitis C (HCV) infections develop chronic disease. Active or exacerbated chronic hepatitis C infection subsequently progress to liver disease. The role of T-cells secretions in achieving viral clearance is still not well understood. Thus, the current study was set to determine the relationship between the T cell cytokine profiles, biochemical parameters and persistent HCV infection or spontaneous recovery. Results Twenty-five percent (41/163) of the anti-HCV positive participants had recovered from HCV and had significantly higher concentration of IL-10 compared to those with active HCV infection (P < 0.012). Other circulating cytokines measured; IL-2, IFN gamma, TNF alpha, IL-5 and IL-17 were similar in both groups. Participants with active HCV infection had significantly higher aspartate transaminase (AST) (35 units) and alanine transaminase (46 units) compared to those in the recovered state (P < 0.001). Thus, serum levels of IL10 could be explored in larger prospective cohort study as a predictive marker of recovering from an active HCV infection.

scholarly journals Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands

2018 ◽  
Vol 19 (9) ◽  
pp. 2747 ◽  
Author(s):  
Imran Nizamuddin ◽  
Peter Koulen ◽  
Carole McArthur
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Exocrine Function ◽  
Lacrimal Glands ◽  
Immunodeficiency Virus ◽  
And Function ◽  
The Impact

The structure and function of exocrine glands are negatively affected by human immunodeficiency virus (HIV) infection and its co-morbidities, including innate and adaptive immune responses. At the same time, exocrine function may also be influenced by pharmacotherapies directed at the infectious agents. Here, we briefly review the role of the salivary glands and lacrimal glands in normal physiology and exocrine pathogenesis within the context of HIV infection and acquired immune deficiency syndrome (AIDS), including the contribution of antiretroviral therapies on both. Subsequently, we discuss the impact of HIV infection and the types of antiretroviral therapy on disease management and therapy development efforts.

Sign in / Sign up

Export Citation Format

Share Document