Antiatherogenic effect of lithium ascorbate in pregnant sows

Azoles are the main antifungal drug class. The main mechanism of the azoles action is the intercalation in the sterol biosynthesis regulation. At the same time, the effect of the azole derivates on mammals is antiatherogenic. But there were no publication about connection between azole derivates effect on hyperlipidemia and expression of genes with antiatherogenic effects. In our work we used triton model of hyperlipodemia on rats to analyze the effect of carmizole injection on the expression of the main antiatherogenic genes and their regulators Apo A-I, HDL, LDL. We had four groups of rats: intact control group, triton control group, phenophibrate group and carmizole group. During a seven days we gave a per oral injections of carmizole for the carmizole group, phenophibrate (as a comparison drug) for phenophibrate group and 1% starch solution for triton control group. Liver tissue samples were used for RNA extraction and following RT-PCR (Real Time PCR) with primers for Apo A-I mRNA sequence. We have found, that Apo A-I mRNA level decreased in the triton control group to 17%, but restored up to 89% in the carmizole group. Carmizole derivate drug works like stimulator of Apo A-I gene expression. That increasing of the expression of antiatherogenic protein gene could me the base of the antiatherogenic effect of the carmizole derivate.

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Prospects for the Use of Cannabinoid Receptor Ligands for the Treatment of Metabolic Syndrome and Atherosclerosis: Analysis of Experimental and Clinical Data

Annals of the Russian academy of medical sciences ◽

10.15690/vramn779 ◽

2017 ◽

Vol 72 (1) ◽

pp. 59-65 ◽

Cited By ~ 6

Author(s):

L. N. Maslov ◽

R. S. Karpov

Keyword(s):

Metabolic Syndrome ◽

Cannabinoid Receptor ◽

Glycosylated Hemoglobin ◽

Experimental Studies ◽

Blood Lipid ◽

Cb1 Receptors ◽

Cb2 Receptor ◽

Receptor Agonists ◽

Antiatherogenic Effect ◽

Patients With Diabetes

An antagonist of central cannabinoid CB1 receptors rimonabant causes weight loss in patients with obesity and metabolic syndrome, improves blood lipid parameters, increases the adiponectin level, decreases the rate of glucose and glycosylated hemoglobin in patients with diabetes mellitustype-2. However, rimonabant adverse effects include depression, anxiety, nausea, and dizziness which are apparently due to the blockade of central CB1 receptors. In mice with a high-calorie diet, we defined that the blockade of peripheral CB1 receptors prevents obesity, steatosis of the liver, improves lipid and carbohydrate metabolism. Experimental studies suggest that peripheral CB2 receptor agonists have antiatherogenic effect. To validate the expediency of clinical research of CB2 receptor agonists in patients with atherosclerosis the comparative analysis of antiatherogenic properties of cannabinoids should be performed. In addition, experiments are needed on the combination use of cannabinoids with well-known antiatherogenic agents, such as statins.

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Cardioprotective actions of thromboxane receptor antagonism in ischemic atherosclerotic rabbits

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1988.255.2.h318 ◽

1988 ◽

Vol 255 (2) ◽

pp. H318-H324 ◽

Cited By ~ 1

Author(s):

J. A. Osborne ◽

A. M. Lefer

Keyword(s):

Myocardial Ischemia ◽

Plasma Cholesterol ◽

Amino Nitrogen ◽

Oxygen Demand ◽

Myocardial Oxygen Demand ◽

Sham Operation ◽

Protective Effects ◽

Beneficial Effects ◽

Antiatherogenic Effect ◽

Nitrogen Containing Compounds

Atherosclerosis was induced in New Zealand White rabbits by feeding them a 0.5% cholesterol-enriched rabbit chow for 10–12 wk. Half of the cholesterol-fed rabbits were given BM 13505, a specific thromboxane A2/endoperoxide (TxA2/PGH2) receptor antagonist, and the other half were given its vehicle (i.e., 2% Na2CO3). At the end of 10–12 wk, the rabbits underwent experimental myocardial ischemia or an identical sham operation, except that the coronary artery was not occluded. BM 13505 was shown to protect the ischemic rabbit myocardium by three different methods: 1) maintenance of myocardial tissue creatine kinase (CK) activity in the ischemic myocardium; 2) reduced loss of free amino nitrogen-containing compounds from the myocardium; and 3) blunting the rise of plasma CK activity. Part of the mechanism for these effects may be due to inhibition of platelet aggregation and blockade of the vasoconstrictor effect of TxA2. However, these protective effects were not due to differences in myocardial oxygen demand among the groups. Finally, BM 13505 exhibited an antiatherogenic effect by reducing the deposition of cholesterol in the aortic wall and by retarding plaque formation in coronary arteries. However, it does not achieve this antiatherogenic effect by lowering plasma cholesterol concentrations or by scavenging superoxide free radicals. Thus blockade of TxA2 receptors exerts a variety of beneficial effects that reduce the severity of ischemic damage resulting from myocardial ischemia.

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Antiatherogenic Effect of Apolipoprotein A-I Containing Lipoproteins

Recent Developments in Lipid and Lipoprotein Research - Cholesterol Transport Systems and Their Relation to Atherosclerosis ◽

10.1007/978-3-642-83665-7_12 ◽

1989 ◽

pp. 89-91

Author(s):

N. Ghalim ◽

A. Barkia ◽

P. Puchois ◽

R. Barbaras ◽

G. Ailhaud ◽

...

Keyword(s):

Antiatherogenic Effect ◽

Apolipoprotein A

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Influence of complex medical rehabilitation methods with the inclusion of nicotinic acid electrophoresis on the dynamics of metabolic status indicators in patients with myocardial infarction after percutaneous coronary interventions

Fizioterapevt (Physiotherapist) ◽

10.33920/med-14-2108-02 ◽

2021 ◽

pp. 13-22

Author(s):

Irina Nikolaevna Smirnova ◽

Inna Ivanovna Antipova ◽

Elena Vasilievna Titskaya ◽

Anna Vladimirovna Tonkoshkurova ◽

Ekaterina Aleksandrovna Maritskaya

Keyword(s):

Nicotinic Acid ◽

Coronary Intervention ◽

Medical Rehabilitation ◽

Metabolic Status ◽

Antiatherogenic Effect ◽

Glucose Levels ◽

Percutaneous Coronary ◽

High Incidence ◽

Emergency Percutaneous Coronary Intervention ◽

Therapy Manual

A study of the metabolic status of 123myocardial infarction patients who underwent emergency percutaneous coronary intervention and were admitted to the inpatient stage of rehabilitation has been carried out. The examination of the patients revealed a high incidence of hyperglycemia, hyperuricemia, dyslipidemia and atherogenic cholesterol fraction. It has been found that the administration of a pathogenetically based therapeutic complex including physical therapy, manual massage, dry carbon dioxide baths, and 1% nicotinic acid electrophoresis has a significant antiatherogenic effect, and contributes to the correction of uric acid and glucose levels, and insulin resistance.

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