scholarly journals UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF AGOMELATINE IN COATED TABLETS

2017 ◽  
Vol 1 (2) ◽  
pp. 24-29
Author(s):  
Fábio De Souza Barbosa ◽  
Vanise Coty Rodrigues ◽  
Nadia Maria Volpato ◽  
Elfrides E. S. Schapoval ◽  
Martin Steppe ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Method ◽  
Low Cost ◽  
Drug Analysis ◽  
Uv Spectrophotometry ◽  
Recovery Test ◽  
Analytical Technique ◽  
Qualitative And Quantitative ◽  
Test Robustness

UV spectrophotometry is an analytical technique used routinely for qualitative and quantitative assay due the low cost and reliability during analysis. In this work, it was validated a quantitative UV method for determination of agomelatine in coated tablets. The parameters specificity, linearity, precision, accuracy and robustness were evaluated according to official guidelines. Methanol was selected as solvent and the maximum wavelength for drug analysis was 230 nm. The purposed assay showed to be specific and the linearity was proved in a range of 0.5 - 2.5 µg/mL. The RSD values obtained during precision assay (inter-day RSD = 1.75%) indicated the method reproducibility, and the accuracy testing showed good results from recovery test. Robustness assay was complementary and showed that the purposed method is adequate for drug quantitation in commercial samples, being a reliable alternative to chromatographic assay.

A low cost and rapid analytical technique for direct spectrophotometric determination of chromium in V–Cr–Ti alloys without a chromogenic agent

2017 ◽  
Vol 9 (30) ◽  
pp. 4471-4475 ◽  
Author(s):  
L. F. Tian ◽  
D. S. Zou ◽  
Y. C. Dai ◽  
L. L. Wang ◽  
W. Gao
Keyword(s):  
Ternary Alloy ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Low Cost ◽  
Analytical Technique ◽  
Ti Alloys ◽  
Chromogenic Agent

A simple, rapid and accurate spectrophotometric method was developed for the determination of chromium in V–Cr–Ti ternary alloy without any prior separation and chromogenic agent.

Quantitative Determination of Amlodipine Besylate in Tablets of Combined Antihypertensive Preparations by UV Spectrophotometry

2018 ◽  
Vol 12 (3) ◽  
pp. 14-18
Author(s):  
Sirazhudin Dzh. Mekhtikhanov ◽  
◽  
Dzhamilya P. Babaeva ◽  
Kusum M. Magomedova ◽  
Patimat A. Gamzatova ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Uv Spectrophotometry ◽  
Amlodipine Besylate

Qualitative and quantitative determination of trace aldehydes and ketones in food preservative propionic acid for quality improvement

2021 ◽  
Author(s):  
Yiwen Cao ◽  
Shenjie Zhu ◽  
Lin Zhang ◽  
Qun Cui ◽  
Haiyan Wang
Keyword(s):  
Quality Improvement ◽  
Quantitative Analysis ◽  
Quantitative Determination ◽  
Propionic Acid ◽  
Qualitative And Quantitative Analysis ◽  
Food Preservative ◽  
Qualitative And Quantitative ◽  
Aldehydes And Ketones ◽  
Aldehyde Content

Aiming at the difficulty in qualitative and quantitative analysis of trace compositions in food preservative propionic acid, the trace compositions and the key components influencing the total aldehyde content in...

Qualitative and quantitative determination of porphyrins in urine, blood and feces

1987 ◽  
Vol 20 (4) ◽  
pp. 290-291
Author(s):  
M. Moss ◽  
C.S.Y. Wong ◽  
T. McMahon ◽  
C. Cousins ◽  
C. Jacklyn
Keyword(s):  
Quantitative Determination ◽  
Qualitative And Quantitative

Qualitative and quantitative determination of ten iridoids and secoiridoids in Gentiana straminea Maxim. by LC-UV-ESI-MS

2011 ◽  
Vol 66 (1) ◽  
pp. 102-108 ◽  
Author(s):  
Shihu Wei ◽  
Peicheng Zhang ◽  
Xizhi Feng ◽  
Hiroyuki Kodama ◽  
Changyuan Yu ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Qualitative And Quantitative ◽  
Esi Ms

scholarly journals Determination of Free and Bound Maleic Hydrazide Residues in Tobacco by High Performance Liquid Chromatography

1994 ◽  
Vol 16 (2) ◽  
pp. 57-64 ◽  
Author(s):  
BS Dattilo ◽  
S Gallo ◽  
G Lionetti ◽  
SG Rossi
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Quantitative Determination ◽  
High Performance ◽  
Maleic Hydrazide ◽  
Dilute Solution ◽  
Tobacco Leaves ◽  
Qualitative And Quantitative ◽  
Curve Method

AbstractA new method is described for the qualitative and quantitative determination of both free and bound maleic hydrazide residues in tobacco leaves and cigarette filler by high performance liquid chromatography. Analyses were carried out by hydrolyzing samples of ground tobacco with 4 N hydrochloric acid for 40 minutes under reflux followed by sample chromatography, running isocratic elutions with a dilute solution of phosphoric acid. The quantitative determination of maleic hydrazide was performed by light absorption at 320 nm, by the calibration curve method. Recoveries of maleic hydrazide added to tobacco samples were greater than 90 %. The detection limit of the method, determined on ground tobacco leaves, was at least 5 ppm. The results obtained by this procedure and by the ISO standard method no. 4876 are in good accordance.

scholarly journals The Determination of Parkinson’s Drugs in Human Urine by Applying Chemometric Methods

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Guzide Pekcan Ertokus
Keyword(s):  
Urine Sample ◽  
Human Urine ◽  
Principal Component Regression ◽  
Principal Component ◽  
Healthy Person ◽  
Drug Analysis ◽  
Uv Spectrophotometry ◽  
Least Squares Regression ◽  
Chemometric Methods

The spectrophotometric-chemometric analysis of levodopa and carbidopa that are used for Parkinson’s disease was analyzed without any prior reservation. Parkinson’s drugs in the urine sample of a healthy person (never used drugs in his life) were analyzed at the same time spectrophotometrically. The chemometric methods used were partial least squares regression (PLS) and principal component regression (PCR). PLS and PCR were successfully applied as chemometric determination of levodopa and carbidopa in human urine samples. A concentration set including binary mixtures of levodopa and carbidopa in 15 different combinations was randomly prepared in acetate buffer (pH 3.5).). UV spectrophotometry is a relatively inexpensive, reliable, and less time-consuming method. Minitab program was used for absorbance and concentration values. The normalization values for each active substance were good (r2>0.9997). Additionally, experimental data were validated statistically. The results of the analyses of the results revealed high recoveries and low standard deviations. Hence, the results encouraged us to apply the method to drug analysis. The proposed methods are highly sensitive and precise, and therefore they were implemented for the determination of the active substances in the urine sample of a healthy person in triumph.

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