Quantitative Determination of Amlodipine Besylate in Tablets of Combined Antihypertensive Preparations by UV Spectrophotometry

2018 ◽  
Vol 12 (3) ◽  
pp. 14-18
Author(s):  
Sirazhudin Dzh. Mekhtikhanov ◽  
◽  
Dzhamilya P. Babaeva ◽  
Kusum M. Magomedova ◽  
Patimat A. Gamzatova ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Uv Spectrophotometry ◽  
Amlodipine Besylate

scholarly journals Development of UV-spectrophotometry Method of the Quantitative Determination of a New Substance Quinazoline-4(3h)-on Derivate

2020 ◽  
Vol 9 (1) ◽  
pp. 30-34
Author(s):  
E. S. Mishchenko ◽  
A. D. Lazaryan ◽  
T. T. Lihota
Keyword(s):  
Quantitative Determination ◽  
Active Substance ◽  
Research Work ◽  
Biologically Active ◽  
Uv Spectrophotometry ◽  
Pharmacological Effects ◽  
Specific Absorption ◽  
Biologically Active Substance ◽  
Effective Remedy

Introduction. The aim idea of this research article is a development of the quantitative determination of a biologically active substance quinazolin4(3H)-on derivate with laboratory cypher «VMA-10-182, by UV-spectrophotometry with followed validation. The substance is an effective remedy that combines several pharmacological effects, like an antidepressant, anxiolytic and nootropic. As a result of preclinical trials, the research compound has proven to be an effective remedy in the fight and prevention of acute cerebrovascular accident (stroke). The substance realized pharmacological effects by stimulating the production of nitric oxide by the endothelial cells of the brain. As aresult of stimulating is a vasodilation of the vessels and improvement of blood flow in the ischemic part of the vessels occur. Therefore, for introducing the biologically active substance into medical practice we need to develop ways to control the quality of substance.Aim. The objective of this research work is to develop a method of the quantitative determination of a biologically active substance, derivative quinazolin-4(3H)-on (laboratory sypher – VMA-10-18), by method of UV spectrophotometry. The results of the research work were validated.Materials and methods. In this research we used a substance VMA-10-18 wich was previously purified from the initial and intermediate products of the synthesis. This substance is a white crystalline powder, odorless, hygroscopic.Results and discussion. The quantitative content of the active substance derived quinazolin-4(3H)-on has been determined. The specific absorption rate was calculated, followed by statistical processing of the results. The validation was carried out according to the «Specificity», «Linearity», «Accuracy», «Repeatability». The results indicate the effectiveness of the developed methodology and experimental reproducibility.Conclusion. Researches of physicochemical properties show al us use 95 % ethanol as a solvent. As a result we developed a method for the quantitative determination of the substance which can be proposed for inclusion in the normative documents. The quantitative determination of the active substance in the test substance was established, and the specific absorption index was calculated. All information are statistically processed and meet the requirements of regulatory documentation.

Innovative NSAID dosage forms: lornoxicam suppositories and their standardization

2021 ◽  
pp. 71-76
Author(s):  
Viktoriya Viktorovna Skupchenko ◽  
Ekaterina Nikolaevna Mekhonoshina
Keyword(s):  
Standard Deviation ◽  
Quantitative Determination ◽  
Relative Standard Deviation ◽  
Absorption Spectra ◽  
Dosage Forms ◽  
Uv Spectrophotometry ◽  
Relative Standard ◽  
Standard Solutions

The article presents the studies on the development of a method for the quantitative determination of lornoxime in suppositories using UV spectrophotometry. The optical densities of the test solutions were recorded at a wavelength of 375 nm. The absorption spectra of standard solutions of lornoxicam, as well as of tested solutions of suppositories were obtained. The relative standard deviation was 2.31%.

Quantitative Determination of Isoniazid (INH) and p-Aminosalicylic Acid (PAS)

1967 ◽  
Vol 50 (3) ◽  
pp. 652-654
Author(s):  
John W Turczan
Keyword(s):  
Quantitative Determination ◽  
Uv Spectrophotometry ◽  
Aminosalicylic Acid

Abstract A procedure has been developed for the analysis of a combination of PAS with INH in tablets. This procedure is faster and more specific than the current AOAC assay. In the method, finely powdered tablets are dissolved in methanolic HCl. INH is determined by polarography, and PAS is determined by UV spectrophotometry.

UV SPECTROPHOTOMETRY IN THE ANALYSIS OF A COMBINED MEDICINAL PRODUCT BASED ON DRY LICORICE ROOT EXTRACT

2022 ◽  
pp. 35-38
Author(s):  
А.М. ОМАРИ ◽  
Т.А. АРЫСТАНОВА
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Determination ◽  
Viral Infections ◽  
Licorice Root ◽  
Root Extract ◽  
Uv Spectrophotometry ◽  
Prevention And Treatment ◽  
Licorice Extract ◽  
Licorice Root Extract

Работа посвящена разработке методики количественного определения глицирризина и аскорбиновой кислоты при их совместном присутствии в комбинированном лекарственном препарате в виде саше методом УФ-спектрофотометрии. This paper represents a developed technique for the quantitative determination of a new medicinal composition based on dry licorice extract and ascorbic acid for the prevention and treatment of immunode ciency in viral infections by UV spectrophotometry

scholarly journals The comparison of methods for the quantification of the pharmaceutical substance bismuth subsalicylate by UV-spectrophotometry and stripping voltammetry

2021 ◽  
pp. 73-80
Author(s):  
А.А. Vizer ◽  
◽  
Е.А. Ivanovskaya ◽  
A.V. Ligostaev ◽  
◽  
...  
Keyword(s):  
Detection Limit ◽  
Quantitative Determination ◽  
Stripping Voltammetry ◽  
Constant Term ◽  
Uv Spectrophotometry ◽  
Limit Of Quantification ◽  
Pharmaceutical Substance ◽  
Bismuth Subsalicylate ◽  
Quantification Accuracy

The results of a comparative study of methods for the quantitative determination of the active pharmaceutical substance (APS) bismuth subsalicylate by UV-spectrophotometry and stripping voltammetry (SV) are presented. Partial validation of the compared methods was carried out according to the following characteristics: linearity, detection limit, limit of quantification, accuracy. In the course of linearity assessment, the values of the correlation coefficient of the methods were established — 0.9987 for UV-spectrophotometry and 0.9982 for SV. The detection limit and the limit of quantification for UV-spectrophotometry were 2.35 and 7.12 μg/ml respectively, for SV — 1.16 and 3.52 μg respectively. The accuracy was determined by the constant term of the linearity equation, which was 3.34% of the interval’s middle value when analyzed by UV-spectrophotometry and 1.93% by SV. Thus, both methods can be used for the quantitative determination of the APS of bismuth subsalicylate; however, due to the fact that the content of bismuth is mainly determined in this case, the SV method is more preferable since it allows analyzing this particular part of the molecule.

scholarly journals Development of a Method of Analysis of Ofloxacin in the Complex Preparation "Ofloxazol"

2021 ◽  
Vol 10 (3) ◽  
pp. 70-75
Author(s):  
T. A. Kobeleva ◽  
A. I. Sichko ◽  
A. I. Zamaraeva ◽  
N. S. Bessonova
Keyword(s):  
Quantitative Determination ◽  
Dosage Form ◽  
Inflammatory Diseases ◽  
Statistical Processing ◽  
Chemotherapeutic Agents ◽  
Spectrophotometric Analysis ◽  
Uv Spectrophotometry ◽  
Treatment And Prevention ◽  
Complex Preparation

Introduction. The creation of new effective antibacterial drugs for the treatment and prevention of purulent-inflammatory diseases is an urgent task of modern pharmacy. Active use in the treatment of purulent infection is found by chemotherapeutic agents from the class of fluoroquinolones, which include ofloxacin.Aim. Development of a method for the quantitative determination of ofloxacin in the complex preparation "Ofloxazol".Materials and methods. For the analysis, the substance ofloxacin, titanium-containing gel "Tizol", solutions of ofloxacin on 95 % ethanol, hydrochloric acid 0.01 mol/l, ointment under the conditional name "Ofloxazol" containing 0.5 % of the drug in the gel "Tizol" were used. The study was carried out by near-UV spectrophotometry.Results and discussion. When studying the absorption spectra, it was found that for the quantitative spectrophotometric analysis of ofloxacin, it is rational to use the wavelength range of 275-320 nm (λmax = 294 nm). Statistical processing of the analysis results showed that the relative error of quantitative determination does not exceed ±1.66 %. The sensitivity of the determination of ofloxacin is 0.245 mcg/ml at A(min) = 0.02. The developed method is validated. Its specificity, linearity, correctness and precision are confirmed. According to the calibration schedule, the content of ofloxacin in the soft dosage form is determined, it is in the range of 0.0483-0.0562 g, which corresponds to the permissible deviations.Conclusion. The conducted studies allowed us to develop and propose a method for the quantitative determination of ofloxacin in the ointment "Ofloxazol", obtained on a titanium-containing basis. The method allows you to evaluate the quality of manufacturing the dosage form, including setting the content of the drug with an error that does not exceed the standard deviations.

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