Measurement of Fertility Benefits with Low Dose Thyroxine in Sub-fertile women

Introduction: High prevalence rate of thyroid dysfunction associated infertility is identified by a number of studies in Nepal. Thyroid dysfunction not only affects fertility but is also associated with miscarriage and fetal death. The objective of this study was to measure the fertility rate after low dose Thyroxine, 12.5 microgram, in women with subfertility. Methods: This was a descriptive and observational study done among women visiting infertility and in-vitro fertilization (IVF) center at Nepalgunj Medical College, Nepal. After undergoing baseline investigations for infertility, all women diagnosed with primary or secondary infertility were enrolled in the study. Male factor and tubal factor infertility was excluded. All 136 women who were enrolled in the study received 12.5 microgram of thyroxine supplementation for a period of three months and subsequently followed up until the same time period. Results: Out of 136 women, 83 (61.02%) women achieved pregnancy within three months of supplementation with low dose thyroxine. Among them, 34 (40.9%) women with primary infertility achieved pregnancy within three months. Similarly 14 (16.8%) women with previous miscarriage, 20 (24.09%) women with previous caesarean section within past five years back, and 15 (18.07%) with previous IUFD achieved pregnancy within three months. Conclusion: Low dose thyroxine supplementation would be beneficial and recommended to subfertile women of reproductive age group in the endemic regions of hypothyroidism. Dose adjustment would give extended benefits as soon as pregnancy is achieved.

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Results and experiences after 1000 IVF cycles at the Clinic for gynecology and obstetrics in Novi Sad

Medicinski pregled ◽

10.2298/mpns1112565k ◽

2011 ◽

Vol 64 (11-12) ◽

pp. 565-569

Author(s):

Vesna Kopitovic ◽

Stevan Milatovic ◽

Aleksandra Trninic-Pjevic ◽

Artur Bjelica ◽

Irena Bujas ◽

...

Keyword(s):

In Vitro Fertilization ◽

Intracytoplasmic Sperm Injection ◽

Clinical Pregnancy ◽

Reproductive Age ◽

Male Factor ◽

Fertilization Program ◽

Vitro Fertilization ◽

Gynecology And Obstetrics ◽

Novi Sad

Introduction. Infertility affects 15-17% of reproductive age couples in our country, and 10-15% of couples worldwide. The aim of this paper was to present results and experience gained after the first 1000 cycles of the national In Vitro Fertilization (IVF) program, to offer professional standard of work in our country and to compare it with results obtained in Europe and worldwide. Material and methods. The study prospectively included 1000 women who had undergone national In Vitro Fertilization program from October 2006 until November 2009 at the Department of Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi Sad. Results. The analysis included 1000 in vitro fertilization cycles. Male factor infertility was the leading cause (56.9%) followed by tubal factor (45.9%). The classic method of in vitro fertilization constituted 72.3% of all cycles, while intracytoplasmic sperm injection (ICSI) method was used in 27.7% of all cycles. The average number of embryos transferred was 2.67. The cycle cancellation rate was 14.10% and the aspiration rate was 94.40%. The clinical pregnancy and live birth rate were 33.41% and 26.78% per embryo transfer, respectively. Discussion and conclusion. The results in our study showed that in our setting there are far less intracytoplasmic sperm injection cycles compared with the European average of 66.5% of all fresh cycles, and that we transferred more embryos on average. Our success rates are comparable with those in other European countries where the clinical pregnancy rates per aspiration and per transfer for in vitro fertilization were 29 and 32.4%, respectively in the period of observation. For intracytoplasmic sperm injection, the corresponding rates were 29.9 and 33%.

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Overcoming male factor infertility with intracytoplasmic sperm injection

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.63.08.697 ◽

2017 ◽

Vol 63 (8) ◽

pp. 697-703 ◽

Cited By ~ 1

Author(s):

Edson Borges Jr. ◽

Bianca Ferrarini Zanetti ◽

Daniela Paes de Almeida Ferreira Braga ◽

Amanda Souza Setti ◽

Rita de Cássia Sávio Figueira ◽

...

Keyword(s):

Intracytoplasmic Sperm Injection ◽

Maternal Age ◽

Age Groups ◽

Control Group ◽

Male Factor Infertility ◽

Male Factor ◽

Vitro Fertilization ◽

Tubal Factor ◽

Icsi Outcomes

Summary Objective: To evaluate the effect of male factor infertility on intracytoplasmic sperm injection (ICSI) outcomes compared with a control group presenting isolated tubal factor. Method: This retrospective study included 743 couples undergoing ICSI as a result of isolated male factor and a control group consisting of 179 couples undergoing ICSI as a result of isolated tubal factor, performed in a private university- -affiliated in vitro fertilization center, between January/2010 and December/2016. Patients were divided into two groups according to maternal age: women ≤35 years old and >35 years old. The effects of infertility causes on laboratorial and clinical ICSI outcomes were evaluated using Student's t-test and (2 test. Results: No differences in controlled ovarian stimulation outcomes were observed between male factor cycles and tubal factor cycles in the two age groups. Implantation (male factor 35.5% vs. tubal factor 32.0%, p=0.340), pregnancy (male factor 46.9% vs. tubal factor 40.9%, p=0.184) and miscarriage (male factor 10.3% vs. tubal factor 10.6%, p=0.572) rates were similar between the infertility groups, irrespective of female age. Considering maternal age, the cancelation rate was higher in older women (>35 years old) undergoing ICSI as a result of male factor infertility (17.4% vs. 8.9%, p=0.013). Conclusion: Our results showed that there is no difference in the outcomes of pregnancy between couples with male or tubal factor infertility, which indicates that ICSI surpasses the worse specific outcomes associated with male factor.

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Menstrual disorders associated with thyroid dysfunction

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20175035 ◽

2017 ◽

Vol 6 (11) ◽

pp. 5113

Author(s):

Ramya M. R. ◽

. Parvathavarthini ◽

Darshan Savery ◽

R. Sankareswari

Keyword(s):

Thyroid Function ◽

Thyroid Dysfunction ◽

Cost Effective ◽

Thyroid Stimulating Hormone ◽

Reproductive Age ◽

Function Evaluation ◽

Medical College ◽

Normal Thyroid Function ◽

High Prevalence ◽

Menstrual Patterns

Background: Present study was done to evaluate the thyroid function in patients presenting with varying menstrual patterns of reproductive age group from 15 to 45 years of age.Methods: This prospective study was carried out in obstetrics and gynecology Department of Sri Venkateshwaraa Medical College, Pondicherry, India on 155 women, clinically given the provisional diagnosis of dysfunctional uterine bleeding (DUB). All these patients were investigated for T3, T4, TSH (Thyroid stimulating hormone) levels and grouped according to that.Results: Among the 155 women (58.7%) were normal thyroid function, (41.3%) had hypothyroid and (1.3%) had subclinical hypothyroidism.Conclusions: There is a high prevalence of thyroid disorders in cases which are clinically diagnosed as DUB. Evaluating for thyroid and treating it medically which was most accurate and cost effective and unnecessary surgery was avoided. Hence the thyroid function evaluation should be mandatory in cases of DUB to detect thyroid dysfunction and these cases should be referred to physician for further medical treatment.

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New in a diagnosis and treatment of chronic endometritis at infertility

GYNECOLOGY ◽

10.26442/20795696.2019.1.190222 ◽

2019 ◽

Vol 21 (1) ◽

pp. 14-18

Author(s):

Klara G Serebrennikova ◽

Igor I Babichenko ◽

Narina A Arutyunyan ◽

Sergey N Katsalap ◽

Albina S Akateva

Keyword(s):

Low Dose ◽

Uterine Cavity ◽

Reproductive Age ◽

High Tech ◽

Comprehensive Treatment ◽

Chronic Endometritis ◽

Vitro Fertilization ◽

Group 2 ◽

Group 1

Background. Chronic endometritis is one of the causes of infertility, miscarriage, failed in vitro fertilization and embryo transfer attempts. Treatment of chronic endometritis is quite complicated due to a multifactorial nature of endometrium morpho-functional disorders. There are lots of approaches to a comprehensive treatment of chronic endometritis which indicates a lack of a single algorithm for a management of such patients to date. One of the modern, perspective and high-tech methods for treatment of chronic endometritis is photodynamic therapy (PDT). Aim. To study chronic endometritis treatment efficacy in patients with infertility when using the method of PDT and low doses of 17b-estradiol. Materials and methods. 85 female patients of reproductive age with chronic endometritis were examined and treated. All patients were divided into 2 groups: group 1 (43 patients) got treated by a method of intravenous PDT with low-dose transdermal 17b-estradiol; group 2 (42 patients) received low-dose transdermal therapy with 17b-estradiol. Clinical examination and laboratory tests, pelvic ultrasound, endometrial aspiration biopsy followed by pathomorphlogical and immunohistochemical examination were carried out to all patient. Results. Ultrasound examination revealed an increase in endometrium thickness at 12th day following PDT session in group 1 and following transdermal therapy with 17b-estradiol in group 2 resulting in endometrium state improvement almost 2 times compared with baseline values before treatment. Conclusions. PDT is a minimally invasive, gentle and safe treatment method. Due to a diffuser design laser radiation is evenly distributed in the uterine cavity. PDT reliably restores receptor function to progesterone in the endometrial glands.

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ANALYSIS OF THE EFFICIENCY OF IFV TECHNIQUES (ICSI, PICSI) IN THE ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS

Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук ◽

10.12737/21586 ◽

2016 ◽

Vol 1 (3) ◽

pp. 15-19

Author(s):

Одареева ◽

Elena Odareeva ◽

Болдонова ◽

Natalya Boldonova ◽

Мыльникова ◽

...

Keyword(s):

Pregnancy Rate ◽

Negative Impact ◽

Reproductive Age ◽

Male Factor ◽

Vitro Fertilization ◽

Efficiency Assessment ◽

High Level

The male factor is the cause of infertility in 40 % of cases. This study is dedicated to the efficiency assessment of ICSI and PICSI techniques and the determination of indications of these methods. There are some relative indications for ICSI in clinical practice: advanced reproductive age of patients, a small number of obtained oocytes, prolonged infertility, repeated attempts of in vitro fertilization. However, normal sperm values are registered in 71.3 % of cases. PICSI method is more preferable at high level of DNA fragmentation and associated changes in sperm indicators. Nevertheless, the pregnancy rate after these methods was comparable – 19.3 % and 19.7 % respectively. The results indicate that the ICSI and PICSI methods do not have a negative impact on the quality of the embryos and do not increase the pregnancy rate.

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Analysis of Oocyte and Embryo Numbers, and Pregnancy Rate in Patients Undergone In Vitro Fertilization with Long and Short Protocols

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v36i2.294 ◽

2012 ◽

pp. 95-99

Author(s):

Nadia Shafira

Keyword(s):

In Vitro Fertilization ◽

Pregnancy Rate ◽

Cross Sectional Study ◽

Current Data ◽

Male Factor ◽

Cross Sectional ◽

Vitro Fertilization ◽

Tubal Factor ◽

Long Protocol

Objectives: To compare the oocyte count, embryo count, pregnancy rate, and the presence of OHSS in patients undergoing In Vitro Fertilization (IVF) with long and short protocols at Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta. Methods: A cross sectional study was done at Yasmin Reproductive Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Data was collected from the medical records of 200 infertile women undergoing IVF, 100 women with long protocols and the other 100 with short protocols. Variables compared in these 2 groups are the oocyte count, embryo count, the pregnancy rate, and presence OHSS using Mann-Whitney U Test with SPSS 11 Program. Result: From 200 women undergoing IVF procedure, 45.5% of them aged between 35-40 years old, with the youngest is 22 years old and the oldest is 48 years old (average age=35 years, SD=4.7), and almost half of them (45%) have BMI between 18.01-23.00 kg/m2. 185 women has primary infertility. These subjects came to the clinic mostly due to male factor (23.5%), idiopathic cause (19%), and ovulation disturbance (13%), whilst endometriosis, tubal factor, and other factors take just little percentage. When compared between long and short protocols, the number of oocyte retrieved is significantly different (p=0.007, CI=5.84-7.11), whereas embryo numbers (p=0.054, CI=1.80-2.39) and the pregnancy rate (p=0.525, CI=0.21-0.33) found to be not significantly different. There were 2 cases of moderate OHSS developed in the long protocol group. Conclusion: Although the number of embryo produced and the pregnancy rate are found to be not significantly different between the two groups, long protocol of IVF is found to produce more oocyte to be retrieved and develop more OHSS events compared to short protocol. Due to this result, GnRH antagonist can be considered when planning an IVF procedure. However, a longitudinal multicenter study with larger sample size is needed to validate the current data. [Indones J Obstet Gynecol 2012; 36-2: 95-9] Keywords: in vitro fertilization, long protocol, pregnancy rate, short protocol

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