scholarly journals ANALYSIS OF THE EFFICIENCY OF IFV TECHNIQUES (ICSI, PICSI) IN THE ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS

2016 ◽  
Vol 1 (3) ◽  
pp. 15-19
Author(s):  
Одареева ◽  
Elena Odareeva ◽  
Болдонова ◽  
Natalya Boldonova ◽  
Мыльникова ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Negative Impact ◽  
Reproductive Age ◽  
Male Factor ◽  
Vitro Fertilization ◽  
Efficiency Assessment ◽  
High Level

The male factor is the cause of infertility in 40 % of cases. This study is dedicated to the efficiency assessment of ICSI and PICSI techniques and the determination of indications of these methods. There are some relative indications for ICSI in clinical practice: advanced reproductive age of patients, a small number of obtained oocytes, prolonged infertility, repeated attempts of in vitro fertilization. However, normal sperm values are registered in 71.3 % of cases. PICSI method is more preferable at high level of DNA fragmentation and associated changes in sperm indicators. Nevertheless, the pregnancy rate after these methods was comparable – 19.3 % and 19.7 % respectively. The results indicate that the ICSI and PICSI methods do not have a negative impact on the quality of the embryos and do not increase the pregnancy rate.

scholarly journals Adenomyosis and its impact on fertility

2019 ◽  
Vol 8 (10) ◽  
pp. 4135
Author(s):  
Jaanam Altaf Khan ◽  
Xia Wang ◽  
Xiuli Wang
Keyword(s):  
Pregnancy Rate ◽  
Negative Impact ◽  
Abnormal Uterine Bleeding ◽  
Reproductive Age ◽  
Vitro Fertilization ◽  
Reproductive Ability ◽  
Child Bearing ◽  
Future Pregnancy ◽  
Benign Gynecological Disease

Adenomyosis is an estrogen dependent benign gynecological disease affecting women of reproductive age causing them to have an adverse effect. Symptoms in these patients include pelvic pain, menorrhagia, abnormal uterine bleeding and infertility. It has a negative impact on a woman’s reproductive ability. The gold standard treatment for adenomyosis is hysterectomy for whom fertility is not an issue and for whom future pregnancy has no concerns, however females who wish to retain uterus for child bearing purposes the treatment seems to be very challenging. In this literature we will focus on how adenomyosis affects the reproductive outcome in women and what is its impact on the pregnancy rate also we will enlighten the pregnancy outcomes and pregnancy rate in patient with adenomyosis after various treatment Including the medical, surgical and in-vitro fertilization.

scholarly journals Results and experiences after 1000 IVF cycles at the Clinic for gynecology and obstetrics in Novi Sad

2011 ◽  
Vol 64 (11-12) ◽  
pp. 565-569
Author(s):  
Vesna Kopitovic ◽  
Stevan Milatovic ◽  
Aleksandra Trninic-Pjevic ◽  
Artur Bjelica ◽  
Irena Bujas ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Intracytoplasmic Sperm Injection ◽  
Clinical Pregnancy ◽  
Reproductive Age ◽  
Male Factor ◽  
Fertilization Program ◽  
Vitro Fertilization ◽  
Gynecology And Obstetrics ◽  
Novi Sad

Introduction. Infertility affects 15-17% of reproductive age couples in our country, and 10-15% of couples worldwide. The aim of this paper was to present results and experience gained after the first 1000 cycles of the national In Vitro Fertilization (IVF) program, to offer professional standard of work in our country and to compare it with results obtained in Europe and worldwide. Material and methods. The study prospectively included 1000 women who had undergone national In Vitro Fertilization program from October 2006 until November 2009 at the Department of Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi Sad. Results. The analysis included 1000 in vitro fertilization cycles. Male factor infertility was the leading cause (56.9%) followed by tubal factor (45.9%). The classic method of in vitro fertilization constituted 72.3% of all cycles, while intracytoplasmic sperm injection (ICSI) method was used in 27.7% of all cycles. The average number of embryos transferred was 2.67. The cycle cancellation rate was 14.10% and the aspiration rate was 94.40%. The clinical pregnancy and live birth rate were 33.41% and 26.78% per embryo transfer, respectively. Discussion and conclusion. The results in our study showed that in our setting there are far less intracytoplasmic sperm injection cycles compared with the European average of 66.5% of all fresh cycles, and that we transferred more embryos on average. Our success rates are comparable with those in other European countries where the clinical pregnancy rates per aspiration and per transfer for in vitro fertilization were 29 and 32.4%, respectively in the period of observation. For intracytoplasmic sperm injection, the corresponding rates were 29.9 and 33%.

scholarly journals Measurement of Fertility Benefits with Low Dose Thyroxine in Sub-fertile women

2016 ◽  
Vol 4 (2) ◽  
pp. 80
Author(s):  
Upendra Pandit ◽  
Farhat Banu ◽  
Ayushma Adhikari
Keyword(s):  
Thyroid Dysfunction ◽  
Low Dose ◽  
Reproductive Age ◽  
Male Factor ◽  
Vitro Fertilization ◽  
Medical College ◽  
Time Period ◽  
High Prevalence ◽  
Tubal Factor

Introduction: High prevalence rate of thyroid dysfunction associated infertility is identified by a number of studies in Nepal. Thyroid dysfunction not only affects fertility but is also associated with miscarriage and fetal death. The objective of this study was to measure the fertility rate after low dose Thyroxine, 12.5 microgram, in women with subfertility.   Methods: This was a descriptive and observational study done among women visiting infertility and in-vitro fertilization (IVF) center at Nepalgunj Medical College, Nepal. After undergoing baseline investigations for infertility, all women diagnosed with primary or secondary infertility were enrolled in the study. Male factor and tubal factor infertility was excluded. All 136 women who were enrolled in the study received 12.5 microgram of thyroxine supplementation for a period of three months and subsequently followed up until the same time period.   Results: Out of 136 women, 83 (61.02%) women achieved pregnancy within three months of supplementation with low dose thyroxine. Among them, 34 (40.9%) women with primary infertility achieved pregnancy within three months. Similarly 14 (16.8%) women with previous miscarriage, 20 (24.09%) women with previous caesarean section within past five years back, and 15 (18.07%) with previous IUFD achieved pregnancy within three months.   Conclusion: Low dose thyroxine supplementation would be beneficial and recommended to subfertile women of reproductive age group in the endemic regions of hypothyroidism. Dose adjustment would give extended benefits as soon as pregnancy is achieved.

Stateof-the-art of realization of the fertility potential in the women of late reproductive age

2016 ◽  
Vol 94 (1) ◽  
pp. 10-15
Author(s):  
Kristina S. Ermolenko ◽  
V. E. Radzinsky ◽  
S. I. Rapoport
Keyword(s):  
In Vitro Fertilization ◽  
Reproductive Technologies ◽  
Reproductive Age ◽  
Vitro Fertilization ◽  
Biological Potential ◽  
Reproductive Material ◽  
Seasonal Biorhythms

Biological potential of childbearing in the women of late reproductive age is limited by natural impairment and loss of fertility. Despite a considerable progress in clinical application of new diagnostic and reproductive technologies, the problem of infertility remains a most serious challenge. Women’s age is one of the main factors responsible for the outcome of in vitro fertilization. The low effectiveness of in vitro fertilization programs is attributed to discoordination in the hypothalamic-pituitary system, depletion of ovarian resources, and deterioration of quality of reproductive material. Bearing in mind the role of melatonin in synchronizing circadian and seasonal biorhythms and regulating physiological and pathological processes, it is natural to suggest its role in the enhancement of efficiency of in vitro fertilization programs for women of late reproductive age.

Microinjection: choice of embryo transfer technique

1994 ◽  
Vol 6 (1) ◽  
pp. 57 ◽  
Author(s):  
RI McLachlan ◽  
G Fuscaldo ◽  
I Calderon ◽  
O Lacham-Kaplan ◽  
C Poulos ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Fallopian Tube ◽  
Controlled Trial ◽  
Initial Study ◽  
Gamete Intrafallopian Transfer ◽  
Male Factor Infertility ◽  
Motile Sperm ◽  
Male Factor ◽  
Vitro Fertilization

Subzonal sperm microinjection (SUZI) is indicated in severe oligoasthenozoospermia, in which the total count of motile sperm is inadequate for in vitro fertilization (IVF), and in cases with repeated failure of fertilization. Sperm for microinjection are selected following centrifugation on a Percoll gradient and stimulation with pentoxifylline and 2-deoxyadenosine. Motile sperm (2-10 per egg) are injected into the perivitelline space and fertilized oocytes are then cultured for two days prior to transfer into the Fallopian tube (tubal embryo stage transfer, TEST) or uterus. During 1992, SUZI results showed a total fertilization rate of 30% (19% were 2 pronuclear, 11% were polyspermic), a transfer rate of 55% and pregnancy rates of 15.2% per transfer and 8.3% per cycle. Recent pregnancy data in mild-moderate male factor infertility showed that gamete intrafallopian transfer (GIFT) results were consistently superior to TEST or IVF, suggesting a beneficial effect of the tubal environment on fertilization and early embryonic development. Accordingly, the combination of SUZI followed by the immediate transfer of injected oocytes into the Fallopian tube, the MIFT procedure, was explored. An initial study of 21 consecutive microinjection candidates showed a clinical pregnancy rate of 24% per cycle. Information regarding fertilization and polyspermy rates was available from supernumerary oocytes in 90% of patients. A randomized, controlled trial comparing MIFT with SUZI or TEST in severe male factor infertility is required to confirm the improved pregnancy rate in MIFT cycles.

Restoring of the reproductive function as an important constituent of the psychological condition of oncological female patients

2011 ◽  
Vol 26 (S2) ◽  
pp. 982-982
Author(s):  
N. Bakunina
Keyword(s):  
Reproductive Function ◽  
Reproductive Age ◽  
Psychological Status ◽  
List Type ◽  
Vitro Fertilization ◽  
Female Patients ◽  
Hormonal Function ◽  
Antineoplastic Treatment

Estimation of clinical-and-psychological status was conducted among female patients with diagnosis of cervical carcinoma and endometrial cancer. There were 2 sample groups.The first group consisted of 16 patients of early reproductive age from 20 to 35, not having patient parity. Tissue retrieval of ovary with following criopreservation was carried out among the patients of this group during the surgery stage. To restore the hormonal function of the ovary and rehabilitate the reproduction function after finishing of the complex treatment all patients underwent autotransplantation of the unfrozen ovary tissues into the abdominolvesical wall. Rehabilitation of the reproductive function consists of centesis of Graafian follicle, obtaining of the ovule, in vitro fertilization and transmitting of the embryo of the surrogate mother.The following methods were applied:- Informal clinical interviewing,- Abridged Multiphasic Personality Inventory (MMPI),- The State trait Anxiety Inventory,- Personality Questionnaire of the Bechterev Institution.Conclusions1.There has been found out the high intensity of anxious reaction in both groups of oncological female patients, which makes it necessary to provide psychological rehabilitations for patients.2.Euphoric, balanced and ergopatic Types of Attitude to the Disease have been frequently observed.3.The exceeding rates in the scales of neurotic triad observed through the MMPI need adequate correction.4.Restoring of the possibility for a woman to enjoy her reproductive function - improves the quality of life of such patients. Probably this will also increase the efficiency of the antineoplastic treatment and the life expectancy for this patients.

Micro-assisted fertilization

1995 ◽  
Vol 7 (4) ◽  
pp. 831 ◽  
Author(s):  
D Payne
Keyword(s):  
Poor Quality ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Vitro Fertilization ◽  
Fertilization Rates ◽  
Partial Zona Dissection ◽  
Oocyte Cytoplasm ◽  
Assisted Fertilization

In couples who undergo routine in vitro fertilization (IVF), 17% experience significant problems with fertilization and many others are unable to have routine IVF because the quality of their semen is too poor. Often, the only options previously available to these couples were to use sperm donated by fertile men or to remain childless. Micromanipulative assisted fertilization techniques have improved the treatment of severe male factor infertility significantly and this paper provides a brief overview of the recent methodologies. Initially, techniques such as zona drilling and partial zona dissection, in which a hole or slit is placed in the zona pellucida, demonstrated that fertilization and pregnancies could be achieved with semen of very poor quality, but successes were sporadic. Later, subzonal injection of spermatozoa provided more consistent results with many units reporting pregnancies; however, relatively low rates of fertilization (14-34%) and high rates of polyspermy remained unresolved problems. The latest technique, the injection of a single spermatozoon into the oocyte cytoplasm, although technically difficult in animal models, proved to be highly successful in the human, restoring fertilization rates to those seen in routine IVF (65%) and producing good pregnancy rates from transferred embryos. Intracytoplasmic sperm injection has become the method of choice in the treatment of severe male factor infertility and preliminary data suggest that there is no increase in congenital abnormality among babies born after the transfer of injected oocytes.

scholarly journals HYSTEROSCOPY BEFORE IN VITRO FERTILIZATION

2018 ◽  
pp. 76
Author(s):  
Dejan Mitić ◽  
Radomir Živadinović ◽  
Marin Bašić ◽  
Aleksandra Petrić ◽  
Milan Trenkić ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Negative Impact ◽  
Similar Rate ◽  
Control Group ◽  
Pathological State ◽  
Vitro Fertilization ◽  
Group I ◽  
Significant Difference

In the last decade, success after in vitro fertilization process (IVF) has remained at a similar rate despite all the improvements implemented in the stimulation protocols and laboratory techniques. Hysteroscopy is a method becoming more widely used with patients after a failed IVF cycle, considering a large incidence of uterus cavum pathological states which have a negative impact on the favorable outcome. Numerous studies have provided different results on the IVF outcome with hysteroscopy performed prior to this treatment in cases with no uterus cavum pathology. The aim of the research was to examine the effect of both diagnostic and surgical hysteroscopy on the outcome of IVF.  Hysteroscopy was performed with 74 patients 30 to 50 days prior to IVF and in 33 of them (group I) some pathological state was noticed, which was treated during the same procedure. The control group (group III) included 151 patients who had IVF performed with no prior hysteroscopy. There is no statistically significant difference in the rate of post hysteroscopy implantation between I and II group when compared to the control group (20.62% vs 23.28% vs 17.31%), nor in the rate of clinical pregnancies (45.45% vs 46.34% vs 34.44%). Following the correctional treatment of uterus cavum pathological states, implantation and pregnancy rates remain at a level comparable to hysteroscopically normal medical findings. Statistically significant higher pregnancy rate is present in group I after the first IVF cycle, compared to the next IVF in the same group and in comparison to the next IVF cycle in the control group (60.00% vs 27.91%, p<0.05). Hysteroscopy is a simple and safe method allowing nearly identical rate of clinical pregnancies after a surgical treatment of uterus cavum pathological states when compared to the control group, but statistically much higher pregnancy rate if the order of IVF procedure is being compared. In cases of normal ultrasound findings and negative hysteroscopical findings, performing hysteroscopy prior to IVF does not provide significantly better results. Therefore, its routine execution is not recommended.

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