scholarly journals Outcomes of Uncomplicated Type B Intramural Hematoma Patients with Type 2 Diabetes Mellitus

2020 ◽  
Author(s):  
Zhonggui Shan ◽  
Qu Chen ◽  
Dandan Jiang ◽  
Feng Kuang ◽  
Fan Yang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mortality Rate ◽  
Acute Phase ◽  
Intramural Hematoma ◽  
Elevated Risk ◽  
Type B ◽  
Related Mortality

Objectives We aimed to summarize the clinical presentations, therapeutic approaches, and outcomes of type B intramural hematoma (IMHB) patients with and without type 2 diabetes mellitus (DM). Methods Patients with uncomplicated IMHBs were included between January 2016 and January 2018 and divided into two groups according to whether or not they had DM. Cox proportional hazard analysis was utilized to investigate the risk factors for aortic-related mortality. Kaplan-Meier survival analysis was used to estimate cumulative mortality and aortic-related mortality. Results A total of 149 patients were included and were divided into the two groups (DM group [n=60] and non-DM group [n=89]). Patients in the non-DM group underwent thoracic endovascular aortic repair treatment more frequently (12% vs 2%, P=0.028) and had a higher reintervention rate during the follow-up (9 in 81 patients, 11% vs 2%, P=0.043). There were significant differences between the two groups regarding the aorta-related mortality rate during the acute phase (9% vs 0%, P=0.042) and the all-cause mortality rate (22% vs 7%, P=0.011). Ulcer-like projection (ULP) development (during the acute phase) (hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.01-1.31, P=0.008), C-reactive protein (CRP) levels (HR, 1.92; 95% CI, 1.51-2.49, P<0.001) and MMP-9 levels (HR, 16.82; 95% CI, 7.52-28.71, P<0.001) were associated with an elevated risk for aorta-related mortality. Conclusions IMHBs without DM are not benign and have a considerably high aortic-related mortality rate. ULP development (during the acute phase), CRP levels and maximum MMP-9 levels are associated with an elevated risk for aorta-related mortality.

Tu-P10:422 Disregulated T-cell function and acute phase response in type 1 and type 2 diabetes mellitus

2006 ◽  
Vol 7 (3) ◽  
pp. 277
Author(s):  
S. Giubilato ◽  
S. Brugaletta ◽  
D. Pitocco ◽  
V. Colafrancesco ◽  
M. Narducci ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
T Cell ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Cell Function ◽  
Phase Response

scholarly journals Risk of total and cardiovascular mortality, major cardiovascular events in patients with type 2 diabetes mellitus, depending on therapy choice upon making a diagnosis

2013 ◽  
Vol 17 (1 (65)) ◽  
pp. 80-84
Author(s):  
V. I. Pan’kiv ◽  
L. A. Khutorska
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mortality Rate ◽  
Cardiovascular Mortality ◽  
Risk Of Death ◽  
Major Cardiovascular Events ◽  
Type 2 Dm ◽  
Therapy Choice

The purpose of this research is studying the risk of the total and cardiovascular mortality rate as well as the risk of the development of myocardial infarction (MI) and acute disturbances of the cerebral circulation (ADCC) in patients with type 2 diabetes mellitus (DM), depending on the choice of a peroral sugar-reducting agent (PSRA) after making a diagnosis. A retrospective cohort study was undertaken on the basis of operative lists of type 2 DM patients, being on a dispensary registration at medical treatment – preventive facilities of the Transcarpathian region. The patients with type 2 DM were subdivided into cohorts, depending on the type of obtained therapy: with metformin, glyclazide, glibenclamide and glimepiride. Higher risks of the total and cardiovascular mortality rate, the risk of the development of ADCC and the risk of death from ADCC as well as the risk of the development of MI as compared to the starting metformin treatment were detected in patients with type 2 DM who received sulfonylurea drugs as staring therapy in 5 years after establishing the diagnosis. A relative risk (RR) of ADCC was higher with glyclazide, glibenclamide and glimepiride compared with metformin, however, a RR of fatal ADCC is considerably higher only with glibenclamide and with glimepiride. A reliable decrease of the risk of fatal ADCC was marked with glyclazide compared to glibenclamide.

scholarly journals MECHANISMS IN ENDOCRINOLOGY: Effect of long-term exposure to air pollution on type 2 diabetes mellitus risk: a systemic review and meta-analysis of cohort studies

2014 ◽  
Vol 171 (5) ◽  
pp. R173-R182 ◽  
Author(s):  
Bin Wang ◽  
Donghua Xu ◽  
Zhaohai Jing ◽  
Dawei Liu ◽  
Shengli Yan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Air Pollution ◽  
Type 2 Diabetes Mellitus ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Elevated Risk ◽  
Prospective Cohort Studies

ObjectiveTo assess the effect of long-term exposure to air pollution on type 2 diabetes risk, a meta-analysis of prospective cohort studies was performed.MethodsLiterature search was conducted with Pubmed, Embase, and Web of Science for prospective cohort studies investigating the association of type 2 diabetes risk with increments in particulate matter (PM, diameter <2.5 μm (PM2.5) or <10 μm (PM10)) or nitrogen dioxide (NO2). We used a random-effects model to calculate the overall relative risk (RR) with 95% CI.ResultsOf 808 identified articles, ten cohort studies were finally included, which involved a total of 2 371 907 participants and 21 095 incident cases of type 2 diabetes. Elevated risk of type 2 diabetes was significantly associated with long-term exposures to high levels of PM2.5 (RR=1.28, 95% CI 1.06–1.55,P=0.009,I2=83.5%), PM10 (RR=1.15, 95% CI 1.02–1.30,P=0.022,I2=0%), and NO2(RR=1.12, 95% CI 1.02–1.23,P=0.015,I2=63.5%). When using standardized risk estimates, the RRs of type 2 diabetes were significant for increments in concentrations of PM2.5 (1.39 per 10 μg/m3increment, 95% CI 1.14–1.68,P=0.001), PM10 (1.34 per 10 μg/m3increment, 95% CI 1.22–1.47,P<0.001), and NO2(1.11 per 10 μg/m3increment, 95% CI 1.07–1.16,P<0.001). No obvious evidence of publication bias was observed.ConclusionLong-term exposure to high levels of main air pollutants is significantly associated with elevated risk of type 2 diabetes mellitus.

Body mass index and the all-cause mortality rate in patients with type 2 diabetes mellitus

2018 ◽  
Vol 55 (6) ◽  
pp. 569-577 ◽  
Author(s):  
Rezvan Salehidoost ◽  
Asieh Mansouri ◽  
Massoud Amini ◽  
Sima Aminorroaya Yamini ◽  
Ashraf Aminorroaya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Mortality Rate ◽  
Body Mass ◽  
All Cause Mortality

Serum sialic acid and acute phase proteins in type 1 and type 2 diabetes mellitus

1993 ◽  
Vol 219 (1-2) ◽  
pp. 131-138 ◽  
Author(s):  
Martin A. Crook ◽  
Peter Tutt ◽  
Helen Simpson ◽  
John C. Pickup
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Sialic Acid ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Serum Sialic Acid
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