Computer-assisted versus oral-and-written family history taking for identifying people with elevated risk of type 2 diabetes mellitus

Author(s):  
Yannis Pappas ◽  
Igor Wei ◽  
Josip Car ◽  
Azeem Majeed ◽  
Aziz Sheikh
2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110166
Author(s):  
Yuan Wang ◽  
Hua Gao ◽  
Wen Di ◽  
Zhuowei Gu

Objective We aimed to investigate whether patients with polycystic ovary syndrome (PCOS) and a family history (FH) of type 2 diabetes mellitus (T2DM) are at increased risk of endocrinological and metabolic abnormalities, and whether this risk differs between first-degree and second-degree relatives, and between maternal and paternal transmission. Methods A total of 680 patients with PCOS were enrolled in this retrospective, single-center study. Endocrine and glycolipid metabolism parameters were compared. Results The free androgen index (FAI), and levels of fasting blood glucose (FBG), fasting insulin (FINS), homeostatic model assessment-insulin resistance (HOMA-IR), total cholesterol (TC), and low-density lipoprotein cholesterol were significantly higher, whereas sex hormone binding globulin (SHBG) levels were significantly lower in patients with PCOS and a FH of T2DM. In patients with PCOS with a FH of T2DM in first-degree relatives, age and levels of FBG, FINS, and HOMA-IR were significantly higher than those who had a FH of T2DM in second-degree relatives. A maternal history of T2DM was associated with a higher body mass index, FAI, and TG levels, and lower SHBG levels. Conclusions Patients with PCOS and a FH of T2DM have more severe hyperandrogenism and metabolic disorders, especially in those with maternal transmission.


2010 ◽  
Vol 12 (5) ◽  
pp. 504-513 ◽  
Author(s):  
Natalie L Rasgon ◽  
Heather A Kenna ◽  
Margaret F Reynolds-May ◽  
Pascale G Stemmle ◽  
Mytilee Vemuri ◽  
...  

2012 ◽  
Vol 77 (6) ◽  
pp. 382-387 ◽  
Author(s):  
Yeon Joung Oh ◽  
Hyo-Kyoung Nam ◽  
Young Jun Rhie ◽  
Sang Hee Park ◽  
Kee-Hyoung Lee

2012 ◽  
Vol 45 (1-2) ◽  
pp. 12-15 ◽  
Author(s):  
Elva Perez-Luque ◽  
Juan Manuel Malacara ◽  
Ma. Eugenia Garay-Sevilla ◽  
Martha Eugenia Fajardo

Medicina ◽  
2009 ◽  
Vol 45 (1) ◽  
pp. 61
Author(s):  
Lina Radzevičienė ◽  
Rytas Ostrauskas

The aim of the study was to determine the association between coffee consumption and the risk of type 2 diabetes mellitus. Material and methods. A case-control study included 234 cases with newly confirmed diagnosis of type 2 diabetes mellitus and 468 controls who were free of the disease in 2001. Cases and controls were matched by gender and age (±5 years). Data on age, education level, occupation status, marital status, family history of diabetes, lifestyle (dietary habits, smoking habits, coffee consumption, alcohol consumption, physical activity), and stress were collected via a questionnaire. Variables were retained in models as confounders when their inclusion changed the value of the OR by more than 10% in any exposure category. Conditional logistic regression to compute the odds ratio (OR), 95% confidence interval (CI), and P for trend was used. Results. After adjustment for possible confounders (family history of diabetes, body mass index, eating speed, morning exercise, cigarette smoking, years of education, and stress), a statistically significant relationship was observed between type 2 diabetes mellitus and coffee consumption. Individuals consuming four or more cups of coffee per day were at lower risk of 2 diabetes mellitus (OR=0.51; 95% CI, 0.27–0.97) compared to those who consumed one or less than one cup of coffee per day. Conclusion. Habitual coffee consumption of four or more cups per day might be related to the lower risk of type 2 diabetes mellitus.


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