scholarly journals Metal complexes of 3-chloro-4-hydrazino-carbonyl-methoxy-benzenesulfondibuthylamide

2008 ◽  
Vol 14 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Anca Mocanu ◽  
Corina Cernatescu
Keyword(s):  
Biological Activity ◽  
Organic Solvent ◽  
Metal Complexes ◽  
Organic Solvents ◽  
Elemental Analysis ◽  
Spectral Measurements ◽  
Melting Points ◽  
Solvent Medium ◽  
Transitional Metals ◽  
Metallic Salts

By taking the biological activity of 3-chloro-4-hydrazinocarbonyl-methoxy-benzenesulphondibuthylamide and of some transitional metals (Cu, Co, Cr, Fe, Mn, Ni, Sn) into account we considered it useful to capitalize the already obtained hydrazide by complexion reactions with various metallic salts. The reaction was carried out in the organic solvent medium, by heating under stirring. The obtained products were purified by recrystallization from organic solvents (especially ethanol) and characterized by means of melting points, elemental analysis and spectral measurements.

scholarly journals 1,3,4-Thiadiazole Derivatives. Part 91. Synthesis and Biological Activity of Metal Complexes of 5-(2-Aminoethyl)-2-Amino-1,3,4-Thiadiazole

1996 ◽  
Vol 3 (5) ◽  
pp. 227-232 ◽  
Author(s):  
Mihai Barboiu ◽  
Marilena Cimpoesu ◽  
Cornelia Guran ◽  
Claudiu T. Supuran
Keyword(s):  
Biological Activity ◽  
Antifungal Activity ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Electronic Spectroscopy ◽  
Candida Spp ◽  
Thiadiazole Derivatives ◽  
In Vitro Antifungal Activity

Metal complexes of the title ligand (L) containing Co(II), Ni(II) and Cu(II) were prepared and characterized by elemental analysis, IR, electronic spectroscopy and conductimetry. The new derivatives, possessing the following formulae, CuL2(OH)2, NiL2Cl2, and [Co2LCl4]n showed in vitro antifungal activity against Aspergillus and Candida spp.

Evaluation of biological activity of bone morphogenetic proteins on exposure to commonly used electrospinning solvents

2011 ◽  
Vol 26 (6) ◽  
pp. 578-589 ◽  
Author(s):  
Parthasarathy A Madurantakam ◽  
Isaac A Rodriguez ◽  
Matthew J Beckman ◽  
David G Simpson ◽  
Gary L Bowlin
Keyword(s):  
Tissue Engineering ◽  
Biological Activity ◽  
Organic Solvent ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Organic Solvents ◽  
Bone Morphogenetic Proteins ◽  
Biologically Active ◽  
Luciferase Reporter ◽  
Specific Response

Bone tissue engineering is one of the emerging strategies for developing functionally viable bone substitutes. The recent trend in bone tissue engineering is to combine the benefits of a three-dimensional nanofibrous scaffold with biologically active molecules and responsive stem cells. Electrospinning is the most versatile of the scaffold fabrication strategies and may involve the use of an organic solvent at one stage or another. In spite of all distinct advantages of electrospinning, valid concerns about potentially denaturing interactions between the organic solvent and the biomolecules exist. Efforts are ongoing to incorporate osteoinductive molecules, such as bone morphogenetic proteins (BMPs), during the electrospinning process. The challenge lies in ensuring that the biological activity of these incorporated molecules survives the process. This study was specifically designed to investigate the effects of exposure to commonly used organic solvents on heterodimeric BMP-2/7 using slot-blot assay quantified by infrared imaging and on embryonic myoblasts stably transfected with BMP-specific response element linked to a luciferase reporter – C2C12BRA. Overall, the biological activity of these molecules significantly decreased when exposed to organic solvents but can be restored to their original values by increasing the polarity of the solvent. It was found that an aqueous buffer can effectively overcome the deleterious effects of organic solvents on BMPs, thus generating osteoinductive bone scaffolds.

Synthesis and Characterization of New Ligand Derived from Benzimidazole and It's Complexes with Some Transition Metals

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Hayder Obaid Jamel ◽  
Najat jawad Al-Obaidi
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Octahedral Geometry ◽  
Molar Conductivity ◽  
Synthesis And Characterization ◽  
Melting Points ◽  
Tetrahedral Geometry ◽  
Metal Ligand

This work includes preparation of the new ligand 5- (1-benzoimidazol-2-ylamino)-1, 3, 4-thiadiazole-2-thiol (BIATT) by the reaction of 5-Amino-2-thio-1, 3, 4-thiadiazole with 2-mercaptobenzoimidazole by refluxin 1, 4-dioxane as solvent. The metal complexes of the ligand were prepared with metals chlorides of Co (II), Ni (II), Cu (II), Zn (II) and Cd (II) in ethanol as solvent. The ligand (L) and its metal complexes have been characterized by elemental analysis (C.H.N.),IR,1H-NMR and UV­- Vis. spectra, magnetic susceptibility measurements ,molar conductivity, melting points and atomic absorption. The metal-ligand ratio was determined by mole ratio method.The suggested structures for the Co (II), Ni (II) and Cu (II) complexes are octahedral geometry andfor the Zn (II) and Cd (II) complex are tetrahedral geometry.

scholarly journals Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones

2020 ◽  
pp. 83-83
Author(s):  
Bozidar Cobeljic ◽  
Marijana Zivkovic ◽  
Ivana Matic ◽  
Irena Novakovic ◽  
Dusan Sladic ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Thiosemicarbazone Complexes ◽  
E And Z Isomers

In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D NMR and 2D NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that new steroidal thiosemicarbazone complexes were significantly less cytotoxic than corresponding steroidal thiosemicarbazones. Also, complexes show lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.

scholarly journals Synthesis, Characterization, and Biological Activity of Some Transition Metal Complexes of N-Benzoyl-N′-2-thiophenethiocarbohydrazide

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Mahendra Yadav
Keyword(s):  
Magnetic Susceptibility ◽  
Biological Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Elemental Analysis ◽  
Spectral Studies ◽  
Antifungal Properties ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal

In the present study, Mn(II), Fe(II), Ni(II), and Cu(II) complexes of N-benzoyl -N′-2-thiophenethiocarbohydrazide (H2 BTTH) have been synthesized and characterized by elemental analysis, magnetic susceptibility measurements, infrared, NMR, electronic, and ESR spectral studies. The complexes were found to have compositions [Mn(H BTTH)2], [Ni(BTTH)(H2O)2], [Cu(BTTH)], and [Fe(H BTTH)2EtOH]. The antibacterial and antifungal properties of H2 BTTH and its metal complexes have been screened against several bacteria and fungi.

Synthesis and Biological Evaluation of Various New Substituted 1,3,4-oxadiazole-2-thiols

2008 ◽  
Vol 59 (4) ◽  
Author(s):  
Gabriela Laura Almajan ◽  
Stefania Felicia Barbuceanu ◽  
Ioana Saramet ◽  
Mihaela Dinu ◽  
Cristian Vasile Doicin ◽  
...  
Keyword(s):  
Biological Activity ◽  
Plant Growth ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Biological Evaluation ◽  
Ethyl Chloroacetate ◽  
Low Concentrations ◽  
Synthesis And Biological Evaluation

5-[4-(4X-phenylsulfonyl)phenyl]-1,3,4-oxadiazole-2-thiols, X=H, Cl, Br, reacted with ethyl chloroacetate to give S-alkylated compounds. Aminomethylation of the thione form of oxadiazoles yielded N(3)-derivatives. All the products have been characterized by elemental analysis, IR, 1H-NMR and 13C-NMR. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak stimulatory activities at low concentrations.

scholarly journals New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2288
Author(s):  
Ahmed Gaber ◽  
Moamen S. Refat ◽  
Arafa A.M. Belal ◽  
Ibrahim M. El-Deen ◽  
Nader Hassan ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Molecular Docking ◽  
Metal Complexes ◽  
Analytical Data ◽  
Docking Study ◽  
Spectroscopic Techniques ◽  
Molecular Docking Study ◽  
Tetrahedral Geometry ◽  
Thiosemicarbazone Complexes

Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn2+-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co2+, Ni2+, Cu2+, and Zn2+) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu2+ complexes showed significant antibacterial activity against Bacillus subtilis and Proteus vulgaris, better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein.

Structural characterization and biological activity of a new metal complexes based of Schiff base

2021 ◽  
Vol 330 ◽  
pp. 115522
Author(s):  
Ola A. El-Gammal ◽  
Farid Sh. Mohamed ◽  
Ghada N. Rezk ◽  
Ashraf A. El-Bindary
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Structural Characterization
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