scholarly journals Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones

2020 ◽  
pp. 83-83
Author(s):  
Bozidar Cobeljic ◽  
Marijana Zivkovic ◽  
Ivana Matic ◽  
Irena Novakovic ◽  
Dusan Sladic ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Thiosemicarbazone Complexes ◽  
E And Z Isomers

In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D NMR and 2D NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that new steroidal thiosemicarbazone complexes were significantly less cytotoxic than corresponding steroidal thiosemicarbazones. Also, complexes show lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.

scholarly journals New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2288
Author(s):  
Ahmed Gaber ◽  
Moamen S. Refat ◽  
Arafa A.M. Belal ◽  
Ibrahim M. El-Deen ◽  
Nader Hassan ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Molecular Docking ◽  
Metal Complexes ◽  
Analytical Data ◽  
Docking Study ◽  
Spectroscopic Techniques ◽  
Molecular Docking Study ◽  
Tetrahedral Geometry ◽  
Thiosemicarbazone Complexes

Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn2+-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co2+, Ni2+, Cu2+, and Zn2+) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu2+ complexes showed significant antibacterial activity against Bacillus subtilis and Proteus vulgaris, better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein.

scholarly journals Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems

2017 ◽  
Vol 13 (2) ◽  
pp. 6006-6020
Author(s):  
Amira A. El-Sayed ◽  
Maher El-HAshash ◽  
Sameh Rizk
Keyword(s):  
Antimicrobial Activity ◽  
Green Synthesis ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Antimicrobial Properties ◽  
One Pot ◽  
One Pot Synthesis ◽  
Electrophilic Reagents

One pot synthesis and reaction of triazinthione and triazinohydrazide derivatives with different electrophilic reagents in ordered to synthesis of some interesting non-mixed heterocyclic compounds. Structures of thiazolotriazine, triazolotriazine, pyrimidinyltriazine, and triazinotriazine derivatives were established via spectroscopic data and elemental analysis. The synthesized compounds were screened for their antimicrobial activity.

scholarly journals Functionalized 1,3-Thiazolidin-4-Ones from 2-Oxo-Acenaphthoquinylidene- and [2.2]Paracyclophanylidene-Thiosemicarbazones

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3069 ◽  
Author(s):  
Ashraf A. Aly ◽  
Nasr K. Mohamed ◽  
Alaa A. Hassan ◽  
Kamal M. El-Shaieb ◽  
Maysa M. Makhlouf ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Spectroscopic Data ◽  
Complex Structure ◽  
2D Nmr ◽  
Efficient Tool ◽  
X Ray ◽  
Dialkyl Acetylenedicarboxylates ◽  
Allyl Derivative

The reactions of dialkyl acetylenedicarboxylates with various 2-oxo-acenaphthoquinylidene- and 4-acetyl[2.2]paracyclophanylidene-thiosemicarbazones were investigated. Using simple experimental procedures, 1,3-Thiazolidin-4-ones derived from acenaphthequinone or [2.2]paracyclophane were obtained as major products in good yields. In the case of allyl derivative of acenaphthoquinylidene-thiosemicarbazones, a complex structure of tetramethyl 5-(2-(((Z,E)-N-allyl-N′-(2-oxoacenaphthylen-1(2H)-ylidene)carbamohydrazonoyl)thio)-1,2,3-tris-(methoxycarbonyl)-cyclopropyl)-4-methoxy-7-oxabicyclo[2.2.1]hepta-2,5-diene-1,2,3,6-tetracarboxylate was formed. Single crystal X-ray analysis was used as an efficient tool to confirm the structure of the synthesized compounds as well as different spectroscopic data (1H-NMR, 13C-NMR, 2D-NMR, mass spectrometry and elemental analysis). The mechanism of the obtained products was discussed.

scholarly journals Synthesis, Characterizations and Antimicrobial Activity of Metal Complexes of 2-(2-Furanylmethylaminocarbonyl)benzoic Acid

2011 ◽  
Vol 8 (1) ◽  
pp. 443-448 ◽  
Author(s):  
R. H. Patel ◽  
B. L. Hiran
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Transition Metal ◽  
Benzoic Acid ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Elemental Analysis ◽  
Magnetic Moments ◽  
Thermal Studies ◽  
Spectral Studies

The ligand, 2-(2-furanylmethylaminocarbonyl)benzoic acid (FMBA) and it’s transition metal complexes have been synthesized and characterized by elemental analysis, spectral studies, magnetic moments and thermal studies. The antifungal activity of all the samples was monitored against common fungi.

scholarly journals 1,3,4-Thiadiazole Derivatives. Part 91. Synthesis and Biological Activity of Metal Complexes of 5-(2-Aminoethyl)-2-Amino-1,3,4-Thiadiazole

1996 ◽  
Vol 3 (5) ◽  
pp. 227-232 ◽  
Author(s):  
Mihai Barboiu ◽  
Marilena Cimpoesu ◽  
Cornelia Guran ◽  
Claudiu T. Supuran
Keyword(s):  
Biological Activity ◽  
Antifungal Activity ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Electronic Spectroscopy ◽  
Candida Spp ◽  
Thiadiazole Derivatives ◽  
In Vitro Antifungal Activity

Metal complexes of the title ligand (L) containing Co(II), Ni(II) and Cu(II) were prepared and characterized by elemental analysis, IR, electronic spectroscopy and conductimetry. The new derivatives, possessing the following formulae, CuL2(OH)2, NiL2Cl2, and [Co2LCl4]n showed in vitro antifungal activity against Aspergillus and Candida spp.

scholarly journals Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide

Antibiotics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1158
Author(s):  
Abdelsamed I. Elshamy ◽  
Tarik A. Mohamed ◽  
Eman M. Elkady ◽  
Ibrahim A. Saleh ◽  
Ahmed A. El-Beih ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Spectroscopic Data ◽  
Soft Coral ◽  
2D Nmr ◽  
Organic Extracts

The organic extracts of the Red Sea soft coral Paralemnalia thyrsoides has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (1, 2). In addition to these newly characterized compounds, ten known metabolites (3–12) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (1–12) against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger. Compound 5 showed antimicrobial activity against all assayed microorganisms.

scholarly journals Metal complexes of 3-chloro-4-hydrazino-carbonyl-methoxy-benzenesulfondibuthylamide

2008 ◽  
Vol 14 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Anca Mocanu ◽  
Corina Cernatescu
Keyword(s):  
Biological Activity ◽  
Organic Solvent ◽  
Metal Complexes ◽  
Organic Solvents ◽  
Elemental Analysis ◽  
Spectral Measurements ◽  
Melting Points ◽  
Solvent Medium ◽  
Transitional Metals ◽  
Metallic Salts

By taking the biological activity of 3-chloro-4-hydrazinocarbonyl-methoxy-benzenesulphondibuthylamide and of some transitional metals (Cu, Co, Cr, Fe, Mn, Ni, Sn) into account we considered it useful to capitalize the already obtained hydrazide by complexion reactions with various metallic salts. The reaction was carried out in the organic solvent medium, by heating under stirring. The obtained products were purified by recrystallization from organic solvents (especially ethanol) and characterized by means of melting points, elemental analysis and spectral measurements.

scholarly journals Synthesis and studies of the biological activity of novel pyrimido fused acridine derivatives

2006 ◽  
Vol 71 (10) ◽  
pp. 1015-1023 ◽  
Author(s):  
Bhavesh Patel ◽  
Ranjan Patel ◽  
Manish Patel
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
Potassium Carbonate ◽  
Anthranilic Acid ◽  
Phosphorus Oxychloride ◽  
Type Ii ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

Anthranilic acid was reacted with various substituted 6-bromoquinazolinones in the presence of Cu-powder and anhydrous potassium carbonate in DMF to give acid intermediates (Ullmann Type-II condensation). All these acids were then cyclized in phosphorus oxychloride to give 11-chloropyrimido[4,5-b]acridin-4(3H)-ones. All the synthesized compounds were identified by conventional methods (1H-NMR, IR, elemental analysis) and were screened for their antimicrobial activity on some bacterial and fungal cultures. The results were compared with standard bactericides and fungicides. All the synthesized compounds exhibited moderate antibacterial and antifungal activity. .

Synthesis, characterization and biological activity of Pyrazoline derivatives

2021 ◽  
pp. 6223-6227
Author(s):  
Saras Kumar Jain ◽  
Rohit Singhal ◽  
Neetesh K. Jain
Keyword(s):  
Crystal Structure ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Acetic Acid ◽  
Biological Activity ◽  
Spectroscopic Data ◽  
Glacial Acetic Acid ◽  
Retardation Factor ◽  
Physical Parameters ◽  
Pyrazoline Derivative

Pyrazoline is dihydropyrazole having only one endocyclic double bond. Synthesis of pyrazoline derivatives from chalcones is an active arena of investigation due to established pharmacological result. In present study, chalcones were prepared by reacting of acetophenone with benzaldehyde. Then prepared chalcones react with isoniazid in the presence of glacial acetic acid results pyrazoline derivative. Physical parameters such as color, crystal structure, solubility, melting point, retardation factor (Rf) and % yield was evaluated. Confirmations of structures of all synthesized derivatives, were done by spectroscopic data of IR, 1HNMR and Mass spectroscopy. Also, all synthesized compounds were evaluated for antibacterial activity against B. subtilis, S. aureus, P.aeruginosa and E.coli, and antifungal activity was accomplished against C. albicans and A. niger at the different conc. and concluded that some compounds have excellent antimicrobial activity and most of the synthesized compounds exhibits moderate antimicrobial activity.

scholarly journals Synthesis Characterization and Antimicrobial Activity of Metal Chelates of 1, 7-Di (2-hydroxyphenyl) 1, 7 di (N-methyl) aza-1, 3, 5 heptarine-3-ol hydrochloride

2010 ◽  
Vol 7 (3) ◽  
pp. 775-778
Author(s):  
Nalin P. Patani ◽  
M. V. Hathi
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Complexes ◽  
Spectral Studies ◽  
Ir Reflectance ◽  
Amino Phenol ◽  
Metal Ligand

The Schiff base complexes derived from 2-furancarboxaldehyde and N-methyl-2-amino phenol have been prepared and characterized using several physical techniques, like elemental analysis, thermogravimetric analysis, magnetic moment measurements, infrared and resonance spectra.N-Methyl-2-amino phenol was condensed stoichiometrically with 2-furancarboxaldehyde in presence of methanol. The resulting 1,7-di(2-hydroxyphenyl) 1,7 di(N-methyl) aza-1,3,5 heptarine-3-ol hydrochloride was characterized by elemental analysis and spectral studies. The transition metal complexes of Cu2+, Zn2+, Ni2+, Co2+and Mn2+of the synthesized complexes were prepared. Metal ligand (M:L) ratio, IR, reflectance spectral studies, magnetic properties and antimicrobial activity of the synthesized complexes and its metal complexes were carried out.

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