scholarly journals Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid

2007 ◽  
Vol 61 (2) ◽  
pp. 83-89
Author(s):  
Maja Micic ◽  
Simonida Tomic ◽  
Jovanka Filipovic ◽  
Edin Suljovrujic
Keyword(s):  
Itaconic Acid ◽  
Biological Fluids ◽  
Radical Copolymerization ◽  
Hydroxyethyl Methacrylate ◽  
Ethanol Mixture ◽  
Good Biocompatibility ◽  
Poly Ethylene ◽  
Ph Range ◽  
Alkylene Glycol ◽  
Sensitive Behavior

New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25?C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37?C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hemolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs.

A novel high temperature retarder applied to a long cementing interval

RSC Advances ◽  
2016 ◽  
Vol 6 (17) ◽  
pp. 14421-14426 ◽  
Author(s):  
Ya Lu ◽  
Ming Li ◽  
Zihan Guo ◽  
Xiaoyang Guo
Keyword(s):  
High Temperature ◽  
Free Radical ◽  
Itaconic Acid ◽  
Radical Copolymerization ◽  
Hydroxyethyl Methacrylate ◽  
Free Radical Copolymerization ◽  
Styrene Sulfonate ◽  
Sodium Styrene Sulfonate

A retarder comprised of sodium styrene sulfonate, itaconic acid and hydroxyethyl methacrylate was synthesized by aqueous free radical copolymerization, which can be applied to a long cementing interval.

scholarly journals Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid

2012 ◽  
Vol 66 (6) ◽  
pp. 823-829 ◽  
Author(s):  
Marija Babic ◽  
Jovana Jovasevic ◽  
Jovanka Filipovic ◽  
Simonida Tomic
Keyword(s):  
Drug Release ◽  
Pore Size ◽  
Itaconic Acid ◽  
Hydroxyethyl Methacrylate ◽  
Release Process ◽  
In Vitro Drug Release ◽  
Ionic Groups ◽  
Variable Content ◽  
Alkylene Glycol

The aim of this paper is to propose equations for the diffusion of drugs for investigated drug/hydrogel systems using the parameters affecting the transport of drug through poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)), poly(2-hydroxyethyl acrylate/itaconic acid) (P(HEA/IA)), and poly(2-hydroxyethyl methacrylate/poly(alkylene glycol) (meth)acrylates) (P(HEMA/BIS)) copolymeric hydrogels. Different monomer types, as well as the variable content of some components in hydrogel composition (the amount of ionizable comonomer (IA) and different type of nonionic poly(alkylene glycol) (meth)acrylates), ultimately defined the pore size available for drug diffusion. The hydrogels synthesized ranged from nonporous to microporous, based on the classification in accordance to the pore size, and could be classified as hydrogels that contain ionic groups and hydrogels without ionic groups. The drugs selected for this study are bronchodilators-theophylline (TPH), fenethylline hydrochloride (FE), and antibiotic-cephalexin (CEX). Results of in vitro drug release tests defined the release systems based on the drug type, as well as the type of hydrogel used. The diffusion coefficient of drugs and the restriction coefficient, , defined as the ratio of solute to ?pore? radius (rs/r? ) that describes the ease of drug release from the gels, were used as factors that govern the release process.

scholarly journals Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid

2006 ◽  
Vol 57 (5) ◽  
pp. 691-702 ◽  
Author(s):  
Simonida Lj. Tomić ◽  
Edin H. Suljovrujić ◽  
Jovanka M. Filipović
Keyword(s):  
Itaconic Acid ◽  
Hydroxyethyl Methacrylate ◽  
Alkylene Glycol

scholarly journals Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels

2011 ◽  
Vol 65 (6) ◽  
pp. 675-685 ◽  
Author(s):  
Sava Dobic ◽  
Jovana Jovasevic ◽  
Marija Vojisavljevic ◽  
Simonida Tomic
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Cell Viability ◽  
Itaconic Acid ◽  
Hydroxyethyl Methacrylate ◽  
Poly Ethylene Glycol ◽  
Swelling Properties ◽  
Swelling Studies ◽  
Poly Ethylene

In this study novel series of hydrogels, based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and poly(ethylene glycol) dimethacrylates (PEGDMA) (of varying molecular weight and concentration) were prepared by free radical crosslinking copolymerization. Preliminary hemocompatibility characterization of hydrogels obtained by hemolytic activity assay indicated good compatibility with blood. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line revails that the cell viability of all samples was the range of 97?100%, with no significant decrease in cell viability with the change of PEGDMA molecular weight and concentration. Swelling studies were conducted for all P(HEMA/IA/PEGDMA) samples in a physiological pH and temperature range and network parameters were determined. Swelling studies showed pH sensitive behaviour, typical for anionic hydrogels, and temperature dependent swelling. The effects of concentration of PEGDMA component on hydrogel swelling properties depend on the PEGDMA molecular weight. The samples with 550PEGDMA show different swelling capacities when 550PEGDMA content is changed, whereas for P(HEMA/IA/875PEGDMA) samples there was practically no difference in equilibrium degree of swelling, qe ,with varying 875PEGDMA content, which trend is the same as in the case of qe versus pH dependences. It was concluded that P(HEMA/IA/PEGDMA) hydrogels show good potential to be used as biomedical materials.

Synthesis of poly(ethylene-co-butylene)-block-poly(ethylene oxide) surfactant and its use in the synthesis of polyhydroxyethyl methacrylate nanoparticles containing azo-dye

RSC Advances ◽  
2014 ◽  
Vol 4 (66) ◽  
pp. 35027-35034 ◽  
Author(s):  
Yee Song Ko ◽  
Monica V. Circu ◽  
Thomas Geiger ◽  
Simon Dünki ◽  
Frank A. Nüesch ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Azo Dye ◽  
Miniemulsion Polymerization ◽  
Hydroxyethyl Methacrylate ◽  
Polyhydroxyethyl Methacrylate ◽  
Inverse Miniemulsion ◽  
Poly Ethylene Oxide ◽  
Disperse Red 1 ◽  
Poly Ethylene

A new poly(ethylene-co-butylene)-block-poly(ethylene oxide) surfactant was synthesized and used in inverse miniemulsion polymerization of 2-hydroxyethyl methacrylate with encapsulated Disperse Red 1.

scholarly journals Surface-Enhanced Oxidation and Determination of Isothipendyl Hydrochloride at an Electrochemical Sensing Film Constructed by Multiwalled Carbon Nanotubes

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
S. N. Prashanth ◽  
Shankara S. Kalanur ◽  
Nagappa L. Teradal ◽  
J. Seetharamappa
Keyword(s):  
Limit Of Detection ◽  
Biological Fluids ◽  
Differential Pulse ◽  
Electrochemical Sensing ◽  
Good Precision ◽  
Multiwalled Carbon ◽  
Limit Of Quantification ◽  
Surface Enhanced ◽  
Ph Range

The electrochemical behavior of isothipendyl hydrochloride (IPH) was investigated at bare and multiwalled-carbon-nanotube modified glassy carbon electrode (MWCNT-GCE). IPH (55 μM) showed two oxidation peaks in Britton-Robinson (BR) buffer of pH 7.0. The oxidation process of IPH was observed to be irreversible over the pH range of 2.5–9.0. The influence of pH, scan rate, and concentration of the drug on anodic peak was studied. A differential pulse voltammetric method with good precision and accuracy was developed for the determination of IPH in pure and biological fluids. The peak current was found to be linearly dependent on the concentration of IPH in the range of 1.25–55 μM. The values of limit of detection and limit of quantification were noticed to be 0.284 and 0.949 μM, respectively.

The Influences of Monomer Structure and Solvent on the Radical Copolymerization of Tertiary Amine and PEGylated Methacrylates

2021 ◽  
Author(s):  
Priscila Quiñonez-Angulo ◽  
Robin Hutchinson ◽  
Angel Licea-Claverie ◽  
Enrique Saldivar ◽  
Ivan Zapata-Gonzalez
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Tertiary Amine ◽  
Radical Copolymerization ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Monomer Structure ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Tertiary Amine Methacrylates (TAMAs), such as 2-(N,N-diethylamino)ethyl methacrylate (DEAEMA) and 2-(N,N-dimethylamino)ethyl methacrylate (DMAEMA), and PEGylated (macro)monomers, such as 2-ethoxyethyl methacrylate (EEMA1) and poly(ethylene glycol) methyl ether methacrylates with 9 and...

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