scholarly journals Synthesis, physical characterization and antimicrobial activity of trivalent metal Shiff base complexes

2010 ◽  
Vol 75 (5) ◽  
pp. 629-637 ◽  
Author(s):  
Gajendra Kumar ◽  
Dharmendra Kumar ◽  
C.P. Singh ◽  
Amit Kumar ◽  
V.B. Rana
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Magnetic Measurements ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Trivalent Metal ◽  
E Coli ◽  
Pyramidal Geometry ◽  
Shiff Base ◽  
Square Pyramidal Geometry

M(III) complexes of Cr, Mn and Fe with a Schiff base derived from 2-amino-4-ethyl-5-hydroxy benzaldehyde and thiocarbohydrazide were synthesized and characterized by several techniques, including elemental analysis (C,H,N), molar conductance measurements, magnetic measurements, and electronic, mass and IR spectral studies. Based on these studies, a fivecoordinated square pyramidal geometry for all the complexes was proposed. The Schiff base ligand and the complexes were also tested for their antimicrobial activity (against the bacteria Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus megaterium, and the fungi Kluyveromyces fragilis, Rhodotorula rubra, Candida albicans and Trichoderma reesei) to assess their inhibiting potential. An attempt was also made to correlate the antimicrobial activity with the geometry of the complexes. All complexes were found to be less active against the pathogens E. coli, S. aureus and P. aeruginosa. The Cr(III) complex showed the best antimicrobial activity, but the ligand alone was found to be active against the fungus T. reesei.

scholarly journals Synthesis, Physical Characterization and Biological Evaluation of Schiff BaseCr(III), Mn(III) and Fe(III) Complexes

2010 ◽  
Vol 7 (3) ◽  
pp. 813-820 ◽  
Author(s):  
Gajendra Kumar ◽  
Dharmendra Kumar ◽  
Shoma Devi ◽  
Amit Kumar ◽  
Rajeev Johari
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Schiff Base ◽  
Magnetic Measurements ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Kluyveromyces Fragilis ◽  
Pyramidal Geometry ◽  
Square Pyramidal Geometry

M(III) complexes with Cr, Mn and Fe with Schiff base derived from 2-amino-4-ethyl-5-hydroxy benzaldehyde and oxocarbohydrazide were synthesized and characterized by several techniques using elemental analysis (C, H, N), molar conductance measurements, magnetic measurements, electronic, mass and IR spectral studies. On the bases of these studies, a five coordinated square pyramidal geometry for all these complexes has been proposed and found to be potential antimicrobial agent. The Schiff base ligand and complexes were also tested for their antimicrobial activity (against the bacteriaEscherichia coli, Staphylococcus aureus, Pseudomonas aeruginosaandBacillus megateriumand the fungiKluyveromyces fragilis, Rhodotorula rubra, Candida albicansandTrichoderma reesei) to assess their inhibiting potential. An attempt is also made to correlate the antimicrobial activity with geometry of the complexes. All complexes were found to be less active against the pathogensE.coli, S.aureusandP.aeruginosa. Cr(III) complex showed the best antimicrobial activity, but ligand alone was found to be active against the fungusT.reesei.

scholarly journals Trivalent metal ion directed synthesis and characterization of macrocyclic complexes

2007 ◽  
Vol 72 (11) ◽  
pp. 1069-1074 ◽  
Author(s):  
Pal Singh ◽  
Ramesh Kumar
Keyword(s):  
Metal Ion ◽  
Magnetic Measurements ◽  
Magnetic Moments ◽  
Macrocyclic Ligand ◽  
Far Infrared ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Molecular Weight Determination ◽  
Trivalent Metal ◽  
Pyramidal Geometry

A novel series of complexes of the type [M(TML)X]X2, where TML is a tetradentate macrocyclic ligand, M = Cr(III), Mn(III) or Fe(III), X = Cl-, CH3COO- or ? NO3, were synthesized by template condensation of dibenzoyl and thiocarbohydrazide in the presence of trivalent metal salts in a methanolic medium. The complexes were characterized with the help of elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. The electronic spectra together with the magnetic moments suggest five coordinate square pyramidal geometry for these complexes. The molar conductance indicates them to be 1:2 electrolytes.

scholarly journals Synthesis, Spectroscopic, Molecular Structure, and Antibacterial Studies of Dibutyltin(IV) Schiff Base Complexes Derived from Phenylalanine, Isoleucine, and Glycine

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Har Lal Singh ◽  
Jangbhadur Singh
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Schiff Bases ◽  
Molar Conductance ◽  
Schiff Base Complexes ◽  
Spectral Studies ◽  
E Coli ◽  
Elemental Analyses ◽  
In Vitro Antibacterial Activity

New series of organotin(IV) complexes and Schiff bases derived from amino acids have been designed and synthesized from condensation of1H-indole-2,3-dione, 5-chloro-1H-indole-2,3-dione, andα-amino acids (phenylalanine, isoleucine, and glycine). All compounds are characterized by elemental analyses, molar conductance measurements, and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance (1H,13C, and119Sn NMR) spectral studies. The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2]. Elemental analyses and NMR spectral data of the ligands with their dibutyltin(IV) complexes agree with their proposed distorted octahedral structures. Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus,Staphylococcusspp.) and Gram-negative (E. coli,Klebsiellaspp.) bacteria. The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

scholarly journals Macrocyclic complexes: Synthesis and characterization

2010 ◽  
Vol 75 (4) ◽  
pp. 475-482 ◽  
Author(s):  
Dharmpal Singh ◽  
Krishan Kumar
Keyword(s):  
Magnetic Measurements ◽  
Macrocyclic Ligand ◽  
Macrocyclic Complexes ◽  
Metal Salts ◽  
Trivalent Metal ◽  
Pyramidal Geometry ◽  
Elemental Analyses ◽  
Square Pyramidal Geometry ◽  
In Vitro Antifungal Activity

A novel series of complexes of the type [M(C28H24N4)X]X2, where M = Cr(III), Fe(III) or Mn(III), X = Cl?, NO3 ?, CH3COO? and (C28H24N4) corresponds to the tetradentate macrocyclic ligand, were synthesized in methanolic media by the template condensation of 1,8-diaminonaphthalene and 2,3- butanedione (diacetyl) in the presence of trivalent metal salts. The complexes were characterized by elemental analyses, conductance and magnetic measurements, and UV/Vis, NMR and IR spectroscopy. Based on these studies, a five-coordinate square pyramidal geometry for all the prepared complexes is proposed. All the synthesized macrocyclic complexes were tested for their in vitro antifungal activity against some fungal strains viz. Aspergillus niger and A. fumigatus. The results obtained were compared with the standard antifungal drug fluconazole.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Transition Metal Complexes of Schiff Base Ligand Derived from 3-Ethoxy Salicylaldehyde and 2-(2-Aminophenyl) 1-H-benzimidazole

2012 ◽  
Vol 9 (4) ◽  
pp. 2516-2523 ◽  
Author(s):  
Matangi Sunitha ◽  
Pragathi Jogi ◽  
Bathini Ushaiah ◽  
C. Gyana Kumari
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Mass Spectra ◽  
Free Ligand ◽  
Spectral Studies ◽  
Gram Negative Bacteria ◽  
Activity Data ◽  
E Coli ◽  
Gram Positive Bacteria

Metal complexes of Ni(II), Co(II), Cu(II), Mn(II) and Zn(II) VO(IV) with a Schiff base derived from 3-Ethoxy Salicylaldehyde and 2-(2-amino-phenyl)1-H-Benzimidazol(2-[(Z)-{(2-(1H-benzimidazole-2yl)phenyl] imino} methyl]-6-ethoxy phenol-BMEP) were synthesized successfully. The resulting complexes were characterized by elemental analysis, magnetic moment measurements, conductivity measurements, IR, UV-VIS, 1H NMR, mass spectra and ESR spectral studies. According to these data, we propose an octahedral geometry to all the metal complexes. Antimicrobial activity of the ligand and its metal complexes were studied against two gram negative bacteria:E. coli, Pseudomonas flourescenceand two gram positive bacteria:Bacillus subitilis, Staphylococcus aureus. The activity data show that the metal complexes are more potent than the free ligand.

scholarly journals Spectral, Theoretical and Biological Studies of 3-((4-Mercaptophenyl)imino)- 1-phenylindolin-2-one Schiff Base and Its Organotellurium(IV) Complexes

2021 ◽  
Vol 33 (8) ◽  
pp. 1749-1756
Author(s):  
Manish Kumar ◽  
Poonam Jangra Darolia ◽  
Nidhi Antil ◽  
Mahak Dalal ◽  
Jitender Narwal ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Receptor Proteins ◽  
E Coli ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Bacteria And Fungi

Schiff base ligand (3-((4-mercaptophenyl)imino)-1-phenylindolin-2-one) of 1-phenylindoline-2,3-dione and 4-aminothiophenol was synthesized by refluxing. Organotellurium(IV) complexes of type (RTeCl3.NPhIATP and R2TeCl2.NPhIATP, where R = 4-hydroxyphenyl, 4-methoxyphenyl and 3-methyl-4-hydroxyphenyl, NPhIATP = Schiff base ligand). The ligand and its organotellurium(IV) complexes (9a-f) were characterized by FT-IR, molar conductance, elemental analyses, UV-vis, mass, 1H & 13C NMR spectral studies. Geometry of all the compounds were optimized and octahedral geometry have been proposed for all the tellurium(IV) complexes. Molecular docking was studied to find the binding interactions between ligand (NPhIATP) and receptor proteins: E. coli (3t88) and S. aureus (3ty7). The antimicrobial activity of ligand and its tellurium(IV) complexes have been screened against bacteria and fungi. All the organotellurium(IV) complexes complexes showed good activity to ligand towards different studied microorganisms.

scholarly journals Structural and Biological Studies on Transition Metal Complexes of 4-Aminoantipyrine Derivative

2020 ◽  
Vol 32 (11) ◽  
pp. 2846-2854
Author(s):  
V. Soundaranayaki ◽  
A. Kulandaisamy
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Antimicrobial Activities ◽  
Esr Spectra ◽  
Molar Conductance ◽  
Schiff Base Complexes ◽  
Binding Potential ◽  
Planar Geometry ◽  
Pyramidal Geometry ◽  
Biological Studies

Novel tetra dentate Cu(II), Ni(II), Co(II), VO(II) and Zn(II) Schiff base complexes have been synthesized from salicylidene-4-iminoantipyrine and tyrosine. The synthesized Schiff base complexes was characterized by powder X-ray diffraction studies (XRD), scanning electron microscopy (SEM), FT-IR, ESR, 1H NMR, 13C NMR, UV-vis, molar conductance and magnetic susceptibility measurements. The general formula of complexes was confirmed as [ML] type [M = Cu(II), Co(II), Zn(II), Ni(II) and VO(II); L = C27H24N4O4]. Magnetic susceptibility, IR and UV-vis, spectral data showed that all the complexes have square planar geometry except vanadyl complex which suggests square pyramidal geometry. Lower molar conductance values proved that all the chelates were non-electrolytic nature. The X-band ESR spectra of [CuL] and [VOL] complexes in DMSO solution suggest that the complexes were predominant covalent character. Powder XRD and SEM image pattern evidenced that all the compounds were crystalline in nature and their size ranges from 100-40 nm. Calf thymus DNA binding potential of [CuL] and [VOL] complexes shows that the binding occurs through intercalation mode with low binding constant. The analgesic, CNS, antiulcer and antimicrobial activities of the investigated compounds report reveals that the chelates were significant effect than free Schiff base.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

scholarly journals Physico-chemical characterization and biological screening of metal complexes with Cyanex 301

1970 ◽  
Vol 34 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Tarun Kumar Pal ◽  
Md Ashraful Alam ◽  
Suchitra Rani Paul
Keyword(s):  
Metal Complexes ◽  
Magnetic Measurements ◽  
Chemical Characterization ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Physico Chemical ◽  
Dithiophosphinic Acid ◽  
Cyanex 301 ◽  
Antibacterial And Antifungal

New metal complexes of Mg(II), VO(II), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Pd(II) with cyanex 301(L) i.e., bis(2,4,4-trimethylpentyl) dithiophosphinic acid were synthesized. The complexes have been characterized by elemental analysis, molar conductivity, molecular mass determination, magnetic measurements, infrared and electronic spectral studies. The prepared metal complexes have the compositions: 2. [MgL2].H2O, 3. [VOL2], 4. K[MnL3].H2O, 5. [FeL3], 6. K[CoL3].H2O, 7. K[NiL3], 8. K[CuL3] and 9. [PdL2]. The complexes 2, 3 and 9 are assumed to have tetrahedral, square pyramidal and square planar geometries, respectively but the complexes 4 - 8 are octahedral based on experimental data. From magnetic measurements the complexes 2 and 9 are found to be diamagnetic and others are paramagnetic. Measured molar conductance showed that the complexes 2, 3, 5 and 9 are non-electrolytes and rest are electrolytes. Besides, some complexes have shown good antibacterial and antifungal activities. Key words: Cyanex 301; Antibacterial; Antifungal; DMSO; Bis (2, 4, 4-trimethylpentyl) dithiophosphinic acid DOI: 10.3329/jbas.v34i2.6859Journal of Bangladesh Academy of Sciences, Vol. 34, No. 2, 153-161, 2010

scholarly journals Characteristic Studies of Hexamethylene Diamine Complexes

2013 ◽  
Vol 2013 ◽  
pp. 1-12
Author(s):  
Hoda A. Bayoumi
Keyword(s):  
Electrical Conductivity ◽  
Schiff Base ◽  
Thermogravimetric Analysis ◽  
Chemical Analysis ◽  
Magnetic Measurements ◽  
Molar Conductance ◽  
Semiconductor Materials ◽  
Ortho Position ◽  
Hexamethylene Diamine ◽  
H Nmr

Preparation and chemical analysis of Mn(II), Fe(III), Co(II), Ni(II), and Zn(II) complexes with Schiff base L [o-HOC6H4CH:N(CH2)6N:CHC6H4OH-o] are the main tasks of this work. The octahedral (M2L2·nH2O·X) complexes in 1 : 1 M : L ratio (X = NO3− or Ac− group, L = ligand) were prepared by involving the hydroxylic group in ortho position. All complexes were characterized on the basis of elemental analysis, UV, IR, 1H NMR, Gc/Ms, thermogravimetric analysis, magnetic measurements, molar conductance, and electrical conductivity. The obtained data indicate that all the investigated compounds behave as semiconductor materials.

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