Complexes of some 3d-metals with a Schiff base derived from 5-acetamido-1,3,4-thiadiazole-2-sulphonamide and their biological activity

Using a bidentate ligand, a Schiff base of 5-acetamido-1,3,4- thiadiazole-2-sulphonamide, complexes of transition metals having the general formula ML2, where M = Mn(II), Fe(II), Ni(II) and Cu(II), were synthesized. The complexes were characterized by elemental analysis, molar conductivity, magnetic moment, electronic, ESR and IR spectroscopy, and particle size analysis. The conductivity data of the complexes suggests their non-electrolytic nature. The stability constants and free energy change for the complexes were calculated. Spectral studies and magnetic susceptibility measurements revealed an octahedral geometry for all the complexes. The ligand and its complexes were screened for their fungicidal activity against Aspergillus niger and A. flavus.

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Some Organotellurium(IV) Complexes of 1-Methyl-3-(p-tolylimino)indolin-2-one Schiff Base

Asian Journal of Chemistry ◽

10.14233/ajchem.2021.23159 ◽

2021 ◽

Vol 33 (6) ◽

pp. 1236-1244

Author(s):

Manish Kumar ◽

K.K. Verma ◽

Sapana Garg

Keyword(s):

Schiff Base ◽

Xanthomonas Campestris ◽

Computational Study ◽

Molar Conductance ◽

Bidentate Ligand ◽

Octahedral Geometry ◽

Azomethine Nitrogen ◽

Spectral Studies ◽

Distorted Octahedral Geometry ◽

No Donor

Six new hexa-coordinated organotellurium(IV) complexes of type RTeCl3·NMeIPT and R2TeCl2·NMeIPT (R = 4-hydroxyphenyl, 4-methoxyphenyl or 3-methy-4-hydroxyphenyl; NMeIPT(L) = Schiff base (1-methyl-3-(p-tolylimino)indolin-2-one) derived from condensation of 4-methylisatin and p-toluidine) have been synthesized and characterized by different spectral studies like elemental analyses, molar conductance, infrared, mass spectrometry, 1H NMR, 13C NMR and UV-visible spectroscopy. On the basis of spectroscopic data, it is evident that Schiff base behaves as NO donor bidentate ligand via azomethine nitrogen atom and oxygen atom from carbonyl group for all the tellurium(IV) complexes. The results showed that all the organotellurium(IV) complexes possess distorted octahedral geometry. Geometry of the all organotellurium(IV) complexes was optimized and their theoretical quantum mechanical parameters were calculated. This computational study also suggests octahedral geometry for complexes. The antimicrobial activity of NMeIPT and all the organotellurium(IV) complexes were screened against bacteria i.e. Xanthomonas campestris and Bacillus cereus and fungi i.e. Fusarium oxysporum, Candida albicans and Sclerotinia sclerotium.

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New Ternary Transition Metal Complexes of 2-{[(2-aminophenyl)imino] methyl}Phenol and Metformin: Synthesis, Characterization and Antimicrobial Activity

E-Journal of Chemistry ◽

10.1155/2011/723491 ◽

2011 ◽

Vol 8 (1) ◽

pp. 361-367 ◽

Cited By ~ 6

Author(s):

S. S. Sharma ◽

J. V. Ramani ◽

D. P. Dalwadi ◽

J. J. Bhalodia ◽

N. K. Patel ◽

...

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Thermal Studies ◽

Bidentate Ligand ◽

Octahedral Geometry ◽

Tridentate Ligand ◽

Spectral Studies ◽

Elemental Analyses

Complexes of Co(II), Ni(II) and Cu(II) were synthesized from Schiff base 2-{[(2-aminophenyl)imino]methyl}phenol and metformin. The authenticity of the transition metal complexes were characterized by elemental analyses, conductance and magnetic susceptibility measurements, as well as spectroscopic (IR, electronic) and thermal studies. IR spectral studies revealed the existence of the ligands in the amine form in the solid state. The magnetic and electronic spectral studies suggest an octahedral geometry for all the complexes. The metformin acts as a bidentate ligand and Schiff base ofo-phynelendiamine and salicylaldehyde acts as a tridentate ligand. Antimicrobial screening of the Schiff base, metformin and transition metal complexes were determined against the bacteriaEscherichia coliandBacillus megaterium.

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Molybdenum(VI) Complexes with Schiff Base Containing N-Hetero Atom

Letters in Applied NanoBioScience ◽

10.33263/lianbs101.18161824 ◽

2020 ◽

Vol 10 (1) ◽

pp. 1816-1824

Keyword(s):

Schiff Base ◽

Octahedral Geometry ◽

Molar Conductivity ◽

Spectral Studies ◽

Distorted Octahedral Geometry ◽

Tetradentate Ligand ◽

Molybdenum Complex ◽

Molybdenum Complexes ◽

Distorted Octahedral ◽

Elemental Analyses

Parent dioxomolybdenum(VI) complex formation by the reaction of MoO2(acac)2 with Schiff base tetradentate ligand, described in this paper. Schiff base tetradentate ligand [H2NCH2CH2 N=CC4H3S-CC4H3S=NCH2CH2NH2] obtained from the condensation of di-2-thienylethanedione with 1,2-diaminoethane. Macrocyclic molybdenum complexes were obtained from the cyclization of a synthesized complex with different 1,3 – diketones. The general formula of parent molybdenum complex is given as [MoO2( H2NCH2CH2 N=CC4H3S – CC4H3S=N CH2CH2NH2)](acac)2 and for macrocyclic molybdenum complex is [MoO2{(CH2CH2 N=CC4H3S – CC4H3S=N CH2CH2) N=C(R)CH2C(R’)=N}](acac)2. Ligand and all molybdenum complexes were characterized by elemental analyses(EA), molar conductivity(ΛM), ultraviolet(UV-Vis), and infrared (IR) spectral studies. The distorted octahedral geometry of element Mo in the parent as well as in macrocyclic molybdenum complexes is completed by two oxo O-atoms, four N-atoms from derived Schiff ligand.

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Five-Coordinate Zinc(II) Complex: Synthesis, Characterization, Molecular Structure, and Antibacterial Activities of Bis-[(E)-2-hydroxy-N′-{1-(4-methoxyphenyl)ethylidene}benzohydrazido]dimethylsulfoxidezinc(II) Complex

International Journal of Inorganic Chemistry ◽

10.1155/2017/7520640 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Zhi-Qiang Liu ◽

Yoke Mooi Ng ◽

Pei Jen Tiong ◽

Ruwaida Asyikin Abu Talip ◽

Nornadia Jasin ◽

...

Keyword(s):

Schiff Base ◽

Dmso Molecule ◽

Antibacterial Activities ◽

Bidentate Ligand ◽

Ethanol Solution ◽

Metal Center ◽

Diffusion Method ◽

Spectral Studies ◽

X Ray Diffraction ◽

Vis Spectroscopy

The titled Zn(II) complex was synthesized by reacting the compound (E)-2-hydroxy-N′-{1-(4-methoxyphenyl)ethylidene}benzohydrazide with zinc(II) acetate dihydrate in alkaline DMSO and ethanol solution under reflux condition for 28 hours. The resulting solid was filtered and recrystallized from the mixture of ethanol and DMSO. The hydrazone Schiff base and its Zn(II) complex were characterized using 1H, 13C NMR, FTIR, UV-Vis spectroscopy, and single crystal X-ray diffraction analysis. Meanwhile, their antibacterial activities were examined using disc diffusion method. The spectral studies showed that the hydrazone Schiff base underwent keto-enol tautomerization, forming a bidentate ligand (N,O) towards Zn(II) ion. Surprisingly, on top of the two hydrazone Schiff base molecules which coordinated to the Zn metal center, an additional DMSO molecule was found attached to the Zn metal center in the crystal data, resulting in a 5-coordinate distorted trigonal bipyramidal Zn(II) complex. Both hydrazone Schiff base and its Zn(II) complexes were found to exhibit low antibacterial activity even when the concentrations were increased to 800 ppm.

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SYNTHESIS AND STABILITY TEST OF RESVERATROL-CONJUGATED GOLD NANOPARTICLE WITH POLYVINYL ALCOHOL STABILIZATION

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2020.v12s1.ff049 ◽

2020 ◽

pp. 221-229

Author(s):

SUTRIYO SUTRIYO ◽

RADITYA ISWANDANA ◽

MARINA DWI HAFSHARI

Keyword(s):

Particle Size ◽

Zeta Potential ◽

Physical Stability ◽

Drug Efficacy ◽

Particle Size Analysis ◽

Size Analysis ◽

Chloroauric Acid ◽

Stability Tests ◽

The Stability ◽

Effective Site

Objective: Gold nanoparticles (AuNPs) have been developed as a promising effective site-specific drug to increase drug efficacy and reduce potentialside effects. However, AuNPs are unstable because they easily aggregate. This study aims to produce stable resveratrol (RSV)-conjugated AuNPs usingpolyvinyl alcohol (PVA).Methods: AuNPs were synthesized using the Turkevich method, which involves the reduction of chloroauric acid with sodium citrate as a reductor.AuNPs were then modified with PVA as a stabilizing agent and conjugated with RSV as a drug model in the carrier system. The formed conjugates werecharacterized using ultraviolet–visible spectrophotometry, Fourier transform infrared spectroscopy, particle size analysis, and high-performanceliquid chromatography. Furthermore, stability tests were performed in various media (2% bovine serum albumin [BSA], 1% cysteine, phosphatebufferedsaline [PBS] pH 4, PBS pH 7.4, and 0.9% NaCl) for 28 days.Results: RSV–AuNPs–PVA had a particle size of 78.75 nm, with polydispersity index (PDI) of 0.356, zeta potential of −36.1 mV, and highest entrapmentefficiency of 78.1%±0.7. RSV–AuNPs without PVA stabilization had a particle size of 51.97 nm, with PDI of 0.694 and zeta potential of −24.6 mV. Theresults of the stability tests demonstrated that RSV–AuNPs–PVA was stable in 2% BSA, PBS pH 7.4, PBS pH 4, and NaCl 0.9% and were unstable in 1%cysteine. RSV–AuNPs without PVA were stable in 2% BSA and PBS pH 7.4 and unstable in 1% cysteine, PBS pH 4, and 0.9% NaCl.Conclusion: PVA can improve the physical stability of RSV-AuNPs conjugates.

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Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug

International Journal of Inorganic Chemistry ◽

10.1155/2013/549805 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Suman Malik ◽

Suparna Ghosh ◽

Bharti Jain ◽

Archana Singh ◽

Mamta Bhattacharya

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Elemental Analysis ◽

Biological Evaluation ◽

Molar Conductance ◽

Bidentate Ligand ◽

Azomethine Nitrogen ◽

Spectral Studies ◽

Elemental Analysis Data ◽

Central Metal

The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from xipamide, a diuretic drug. The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio. Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis. The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L]. All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms. Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex. The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus. The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.

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Synthesis and Characterization of a New Bidentate Ligand 5-Substituted-(2-methyl-5-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione and its Metal Complexes of Ag(I), Cu(II) and Zn(II)

E-Journal of Chemistry ◽

10.1155/2011/280682 ◽

2011 ◽

Vol 8 (s1) ◽

pp. S127-S136

Author(s):

Shabbir A. A. Kazi

Keyword(s):

Metal Complexes ◽

Transition Metal Complexes ◽

Thermal Studies ◽

Bidentate Ligand ◽

Octahedral Geometry ◽

Spectral Studies ◽

Ligand Molecule ◽

H Nmr ◽

Elemental Analyses

A new ligand (2-methyl-5-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione (L) and its Ag(I),Cu(II) and Zn(II) complexes were synthesized. The authenticity of the ligand and its transition metal complexes were established by elemental analyses, conductance and magnetic susceptibility measurements, as well as spectroscopic (IR,1H NMR, electronic, mass and ESR) and thermal studies. The IR spectral studies revealed the existence thiol-thione tautamerism in the ligand molecule. The magnetic and electronic spectral studies suggest an octahedral geometry for Cu(II) and Zn(II) complexes. The ligand acts as a bidentate coordinating through the N-3 nitrogen and the exocyclic sulfur atoms of oxadiazole rings. Antimicrobial screening of the ligand and its metal complexes were determined against the bacteriaEscherichia coliandSalmonella paratyphiA.

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Synthesis, Characterization and Antimicrobial Activity of Cu(II), Co(II) and Ni(II) Complexes with O, N, and S Donor Ligands

E-Journal of Chemistry ◽

10.1155/2008/170631 ◽

2008 ◽

Vol 5 (3) ◽

pp. 577-583 ◽

Cited By ~ 15

Author(s):

Vidyavati Reddy ◽

Nirdosh Patil ◽

S. D. Angadi

Keyword(s):

Schiff Base ◽

Magnetic Measurements ◽

Antimicrobial Activities ◽

Octahedral Geometry ◽

Donor Ligands ◽

Azomethine Nitrogen ◽

Spectral Studies ◽

Conductivity Measurements ◽

Schiff Base Ligands ◽

Plate Method

The complexes of the type ML2[where M = Cu(II), Co(II), and Ni(II)] L = 1-phenyl-1-ene-3-(2-hydroxyphenyl)-prop-2-ene with 3- substituted-5-mercapto-4-amino-1,2,4-triazoles. Schiff base ligands have been prepared by reacting 3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one and 3-phenyl/pyridyl-4-amino-5-mercapto-1,2,4-triazoles in an alcoholic medium. The complexes are non-electrolytes in DMF. The resulting complexes were characterized by elemental analysis, magnetic measurements, conductivity measurements and spectral studies. The Schiff base acts as a tridentate dibasic and coordinating through the deprotonated oxygen, thioenolic sulphur and azomethine nitrogen atoms. It is found that Cu(II), Co(II), and Ni(II) complexes exhibited octahedral geometry. The antimicrobial activities of ligands and its complexes were screened by cup plate method.

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CNTs Mixed into W and B by Ball-Milling Method and their Application in Delay Composition

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.924.343 ◽

2014 ◽

Vol 924 ◽

pp. 343-348 ◽

Cited By ~ 1

Author(s):

Si Yi Wang ◽

Hui Ren ◽

Qing Jie Jiao ◽

Bao Liang Han

Keyword(s):

Burning Rate ◽

Ball Milling ◽

Size Structure ◽

High Heat ◽

Particle Size Analysis ◽

Size Analysis ◽

Transmission Electron ◽

Milling Method ◽

Delay Composition ◽

The Stability

With the progress in science and technology, the dynamic security, the reliability, the accuracy and the stability of delay composition in complicated condition attracts more and more attentions. Traditional delay composition can not meet our requirements of the reliability and security. Its the first time carbon nanotubes (CNTs) with high heat conductivity and high intensity are added into the system of Tungsten type delay composition and boron type delay composition. CNTs were mixed into W and B by ball-milling method. Particle size analysis and transmission electron microscopy (TEM) are utilized to analyse the size structure and dispersity of W/ CNTs and B/ CNTs. Optimum conditions of preparing W/CNTs and B/CNTs were found to apply to fuel agent of delay composition. In addition, burning rate and delay precision of the four delay charges (BaCrO4/W, BaCrO4/W/CNTs,BaCrO4/B and BaCrO4/B/CNTs delay compositions) were reseached. Results show that delay compositions added to CNTs had higher burning rate and better delay precision than original delay charges (burning rate of BaCrO4/W/CNTs was as much as 3-4 times higher than that of BaCrO4/W under the same constraints. Meanwhile, burning rate of BaCrO4/B/CNTs is 2 times higher than that of BaCrO4/B). Especially, the ignition reliability of charges added to CNTs were improved while charge density exceeds about 6000 Kg/m3. So the addition of certain amount of CNTs in the delay compositions can obviously increase the burning rate and the ignition reliability of delay compositions.

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