The sensitivity of electromyoneurography in the diagnosis of diabetic polyneuropathy

Diabetic polyneuropathy is a complex set of clinical syndromes, which deplete various regions of the nervous system. The process leading to diabetic neuropathy is multi-factorial. Its symptoms are paresthesia, dysesthesia and pain. The signs of damage to the peripheral neurons are hypoesthesia, hypoalgesia, hyperesthesia and hyperalgesia, decreased tendon reflexes, and, possibly, weakness and muscle atrophy. There is no universal classification. Electromyoneurography is indispensable in the diagnosis of diabetic polyneuropathy. However, there is no agreement on the most sensitive parameter for an early diagnosis. One hundred patients with diabetes mellitus were examined in order to investigate the sensitivity of different electromyographic parameters. Electromyographic techniques proved to be entirely sensitive for the early diagnosis of diabetic polyneuropathy. Some of the parameters are more suitable for an early detection of peripheral nerve damage, and others, which are not so sensitive but easy to use and stable, are suitable to follow up the course of diabetic polyneuropathy.

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Diffculties and ways to overcome them in selection of therapy for pain syndromes in patients with diabetes mellitus

Medical alphabet ◽

10.33667/2078-5631-2021-22-25-30 ◽

2021 ◽

pp. 25-30

Author(s):

K. A. Makhinov ◽

P. R. Kamchatnov

Keyword(s):

Diabetes Mellitus ◽

Nervous System ◽

Pain Syndrome ◽

Neurological Complications ◽

Neuropathic Pain Syndrome ◽

Peripheral Nerve Damage ◽

Pain Syndromes ◽

Patients With Diabetes ◽

Therapeutic Possibilities ◽

Selection Of

Diabetes mellitus (DM) causes damage to various body systems, including the peripheral nervous system. The main variants of peripheral nerve damage in diabetes mellitus are considered. Information on the development of this kind of lesion, in particular, on the formation of neuropathic pain syndrome, is given. The therapeutic possibilities of drugs from various pharmacological groups for the treatment of patients with neurological complications of diabetes are analyzed.

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Diagnosis and treatment of the early stages of diabetic polyneuropathy

Medical Council ◽

10.21518/2079-701x-2020-7-56-65 ◽

2020 ◽

pp. 56-65 ◽

Cited By ~ 1

Author(s):

V. N. Khramilin ◽

A. N. Zavyalov ◽

I. Yu. Demidova

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Nervous System ◽

Early Diagnosis ◽

Diabetic Polyneuropathy ◽

Nerve Fibers ◽

Skin Reactions ◽

Small Nerve

Diabetic polyneuropathy (DPN) is the most common and earliest complication of diabetes mellitus and it may occur much earlier in patients with type-2 diabetes than in patients with type-1. Distal polyneuropathy can develop not only in diabetes mellitus, but also at the stage of prediabetes and even in patients with metabolic syndrome without impaired glycemic state. Hyperglycemia viewed as a major, but not the sole factor, responsible for development and progression DPN. The control of blood glucose as an obligatory step of therapy to delay or reverse DPN is no longer an arguable issue. Damage of peripheral nervous system in prediabetes and in the initial stages of diabetes mainly affects small nerve fibers, which also leads to disorders of the autonomic nervous system. Cardiac autonomic neuropathy diagnosed in 5-7.7% of patients at the time of diagnosis of type 1 and type 2 diabetes mellitus. For the early diagnosis of DPN, both routine assessment of peripheral sensation can be used, as well as specialized methods (sympathetic skin reactions, skin biopsy, confocal corneal microscopy, quantitative sensory tests) and validated questionnaires (Utah Early Neuropathy Scale) focused on assessing the function of small nerve fibers. Non-electrophysiological studies also were tested for early diagnosis of DPN: peripheral nerve sonoelastography, optical coherence tomography, MRI neurography, spiral positron emission CT (SPECT) with 123I-MIBG. DPN diagnosis in the pre-clinical stage very important, because treatment with diet and lifestyle intervention may be successful. The correlation between the severity of oxidative stress and the activity of antioxidant defense is considered as a potential mechanism for early nerves damage with hyperglycemia and as a possible target for therapeutic intervention. In this work, we will review prevalence, diagnostic approaches and potential treatment options for early diabetic polyneuropathy.

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Knowledge and Awareness of Diabetic Retinopathy among Diabetic Sudanese Patients, Khartoum State, Sudan, 2018

Sudan Journal of Medical Sciences ◽

10.18502/sjms.v16i4.9945 ◽

2021 ◽

Author(s):

Mohammed I. M. Ahmed

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Early Diagnosis ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Cross Sectional ◽

Convenience Sample ◽

Diagnosis And Management ◽

Patients With Diabetes

Background: The level of awareness of diabetic retinopathy is considered an important factor for early diagnosis and management of diabetic retinopathy. This study aimed to assess the level of awareness of diabetic retinopathy among patients with diabetes mellitus in Khartoum, Sudan. Methods: This cross-sectional study was conducted among diabetic patients attending Zeenam and Abdullah Khalil Diabetic Centers between June and September 2018. A convenience sample of diabetic patients was used. Information on the sociodemographic characteristics of the patients, patients’ knowledge, compliance with available treatments, and routine eye examinations was collected using a semi-structured questionnaire. Patients were also asked about the barriers that may interfere with a regular eye examination. Results: A total of 200 patients were enrolled and 94 (47%) of them were female; 13% of the respondents were diagnosed with diabetic retinopathy, 31.5% were hypertensive, and 13.5% had hyperlipidemia. Additionally, 88.5% of the patients were aware that DM can affect their eyes and 87% had never been diagnosed with diabetic retinopathy. Although around 83% thought that diabetic retinopathy could lead to blindness, only 35.5% of them had undergone fundus examination by ophthalmologists. Moreover, 39% of the participants had irregular diabetes follow-up and 43% monthly follow-up. Only 31% went for regular eye check-up; however, their compliance with routine retinal assessment was poor, with a total of 72.5% of participants assuming that they have good vision and need not get their eyes checked up regularly. The chief factor that was related to increased awareness of diabetic retinopathy in the study was the level of education. Conclusion: Although a large proportion of diabetic patients in Khartoum are aware that diabetes mellitus can affect their eyes, regular retinal assessment of patients was poor, thus hindering early diagnosis and management.

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Vitamin D supplementation and dynamics of LDF skin microcirculation in patients with diabetes mellitus and diabetic polyneuropathy

Endocrine Abstracts ◽

10.1530/endoabs.63.gp122 ◽

2019 ◽

Author(s):

Anna Stepanova ◽

Tatiana Karonova ◽

Mikhail Galagoudza ◽

Edvard Jude

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Diabetic Polyneuropathy ◽

Vitamin D Supplementation ◽

Skin Microcirculation ◽

Patients With Diabetes

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Modification of the Functional State of Patients with Diabetes Mellitus II by Means of Neurofeedback with a Neural Network Assessment of the Activity of the Autonomic Nervous System

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.02.205 ◽

2020 ◽

Vol 12 (02) ◽

Keyword(s):

Neural Network ◽

Diabetes Mellitus ◽

Nervous System ◽

Autonomic Nervous System ◽

Functional State ◽

Autonomic Nervous ◽

Patients With Diabetes

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Short-term and long-term follow-up of patients with diabetes mellitus with minor amputations

Clinical Biomechanics ◽

10.1016/j.clinbiomech.2008.03.041 ◽

2008 ◽

Vol 23 (5) ◽

pp. 697-698

Author(s):

Vadim B. Bregovsky ◽

Tatiana L. Tsvetkova

Keyword(s):

Diabetes Mellitus ◽

Short Term ◽

Patients With Diabetes ◽

Long Term Follow Up

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Diabetic polyneuropathy: diagnosis, prevention, and treatment

Neurology neuropsychiatry Psychosomatics ◽

10.14412/2074-2711-2020-4-113-118 ◽

2020 ◽

Vol 12 (4) ◽

pp. 113-118

Author(s):

V. A. Golovacheva ◽

I. A. Strokov

Keyword(s):

Diabetes Mellitus ◽

Clinical Trials ◽

Nervous System ◽

Lipoic Acid ◽

Diabetic Polyneuropathy ◽

Patient Treatment ◽

Alpha Lipoic Acid ◽

Sensorimotor Polyneuropathy ◽

Chronic Hyperglycemia ◽

Prevention And Treatment

The most common form of peripheral nervous system damage in diabetes mellitus is distal symmetric sensorimotor polyneuropathy (DSSMPN). Chronic hyperglycemia, dyslipidemia, and impaired microcirculation are considered to be the key mechanisms for the development of DSSMPN, but its pathogenesis is still unclear and continues to be studied. The paper analyzes the issues of diagnosis of DSSMPN and the effective principles of patient treatment. It also discusses the use of alpha-lipoic acid (ALA) as a drug for the pathogenetic treatment of DSSMPN and describes the results of clinical trials of its treatment with ALA preparations.

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