scholarly journals Cholestatic hepatitis associated with nimesulide: A case report

2009 ◽  
Vol 137 (9-10) ◽  
pp. 550-553 ◽  
Author(s):  
Snezana Lukic ◽  
Miodrag Krstic ◽  
Nemanja Damjanov ◽  
Ivan Boricic ◽  
Dragan Popovic ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Hepatitis ◽  
Clinical Laboratory ◽  
Fatal Outcome ◽  
European Medicines Agency ◽  
Clinical Centre ◽  
Inflammatory Drugs ◽  
The Right

Introduction A toxic effect of drugs, including non-steroidal anti-inflammatory drugs, may be one of aetiological factors for the occurrence of acute hepatitis. Nimesulide is a selective cyclooxygenase-2 inhibitor, whose adverse effects on the liver range from acute hepatitis to more serious conditions, involving the development of acute liver failure and fatal outcome. Case Outline A female patient, aged 73, was admitted to the Gastroenterology and Hepatology Clinic of the Clinical Centre of Serbia in Belgrade because of liver failure. Due to the pain in the right knee, she received a therapy of 100 mg nimesulide in tablets, two times a day, for two months before admission to the Clinic. The analysis of the results of clinical, laboratory and radiographic examinations, and of histopathological findings of the liver biopsy showed that acute hepatitis was associated with the administration of nimesulide. Once the patient discontinued the intake of this drug, she fully convalesced. Conclusion The patient who received nimesulide over a period of two months developed acute hepatitis. In view of the similar cases described in literature and the fact that the use of nimesulide has been discontinued in a number of European countries and restricted by the European Medicines Agency, restriction or ban on the use of nimesulide on the Serbian market should be considered.

Novel protocol including liver biopsy to identify and treat CD8+ T-cell predominant acute hepatitis and liver failure

2014 ◽  
Vol 18 (5) ◽  
pp. 503-509 ◽  
Author(s):  
Rebecca B. McKenzie ◽  
William E. Berquist ◽  
Kari C. Nadeau ◽  
Christine Y. Louie ◽  
Sharon F. Chen ◽  
...  
Keyword(s):  
T Cell ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Hepatitis ◽  
Cd8 T Cell

scholarly journals Adnexal Torsion after Isolated Salpingeal Torsion: An Undesired Complication of Conservative Management: A Case Report

2020 ◽  
Author(s):  
Eniola R. Ibirogba ◽  
Faheema Abduljalil Alshehabi ◽  
Afeefa Ashfaq Konchwalla ◽  
Mohammed Sobhy Badr Sobei ◽  
Amal Hassan Hassan Ismail
Keyword(s):  
Case Report ◽  
Fallopian Tube ◽  
Conservative Management ◽  
Clinical Laboratory ◽  
Reproductive Age ◽  
Adnexal Torsion ◽  
Lower Quadrant ◽  
Radiographic Findings ◽  
Clinically Significant ◽  
The Right

Objective: Isolated salpingeal torsion (IST) is a rare cause of acute abdomen in women of the reproductive age group. The lack of pathognomonic clinical, laboratory or radiographic findings makes early diagnosis a challenge. We describe a case of IST in a 13-year-old who suffered from a repeat torsion following initial conservative management. Case Report: A 13-year-old girl presented with acute right lower quadrant abdominal pain of insidious onset. Her past medical history was non-contributory and her initial workup was unremarkable. Exploratory laparoscopy subsequently revealed isolated torsion of the right fallopian tube which was detorted. She presented 10 months later with similar complaints and further workup demonstrated right adnexal torsion which was confirmed by laparoscopy; salpingo-oophorectomy was necessary due to gangrenous necrosis. Conclusion: Conservative management of fallopian tube torsion confers the advantage of fertility preservation but the risk of repeat torsion remains clinically significant.

scholarly journals WES Reveals Novel Heterozygous NBAS Gene Mutations Associated with Fanconi Syndrome in a Patient with SOPH Syndrome: Case Report

2021 ◽  
Vol 3 (1) ◽  
pp. 1-10
Author(s):  
Thong JY ◽  
Li Z ◽  
Halim A ◽  
Wang X ◽  
Halim M ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Early Detection ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Optic Atrophy ◽  
Fanconi Syndrome ◽  
Clinical Laboratory ◽  
Gene Mutations ◽  
Whole Exome

Variations in the NBAS gene is known to cause a spectrum of phenotypes ranging from isolated recurrent acute liver failure (RALF) to a multisystemic presentation known as SOPH syndrome. Patients with SOPH present with optic atrophy, acute liver failure, short stature, and Pelger-Huet anomaly. We report the presence of a novel pair of biallelic heterozygous mutations c.5139-5T>G and c.2203-2A>G in the NBAS gene of a patient with SOPH syndrome. A 9-year-old patient was clinically diagnosed with SOPH following clinical laboratory analyses. Current interventions for managing the disease encompass IVIG, methylprednisolone, calcium, and vitamin D administration. Whole-exome sequencing (WES) results showed two mutations: c.2203-2A>G and c.5139-5T>G, in the NBAS gene, which had not been previously reported. Notably, we hypothesize that NBAS mutations could potentially contribute to the development of Fanconi syndrome, a clinical diagnosis reported in our patient. Our study also supports the renaming of SOPH to SOPHIA to allow early detection and effective treatment.

scholarly journals Acute liver failure due to visceral leishmaniasis in Barcelona: a case report

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Iratxe Martinez de Narvajas ◽  
Alba Díaz ◽  
Octavio Bassegoda ◽  
Adriá Carpio ◽  
Carla Fuster ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Acute Hepatitis ◽  
Unknown Origin ◽  
Human Migration ◽  
Negative Results ◽  
Biopsy Specimens ◽  
Inflammatory Pattern

Abstract Background Leishmaniasis is an emerging infectious disease. Due to human migration and tourism, visceral leishmaniasis may become more common in non-endemic areas. In the Mediterranean basin, visceral leishmaniasis typically occurs in rural regions. Case presentation We present an unusual urban case of acute liver failure due to visceral leishmaniasis, following a prolonged fever of unknown origin. After obtaining negative results from the bone marrow aspirate, we performed a liver biopsy that elucidated the diagnosis. The liver involvement in visceral leishmaniasis may appear as chronic granulomatous hepatitis. However diffuse hepatitis process, a necro-inflammatory pattern, without forming granulomas were observed in the liver biopsy specimens in this case. Intracytoplasmic Leishmania amastigotes were observed in the liver biopsy specimens and a polymerase chain reaction confirmed the diagnosis. Only five pathological confirmed cases of acute hepatitis due to visceral leishmaniasis have been described so far, just two in adults and both from Barcelona. A revision of the literature is performed. Conclusions Acute hepatitis is an uncommon debut of visceral leishmaniasis in immunocompetent patients. Furthermore there are only few cases in the literature that describe the histopathological changes that we found in this patient. In conclusion, in case of acute hepatitis leading to liver failure, leishmaniasis should be considered a differential diagnosis (even in non-endemic countries and without clear epidemiological exposure) and liver biopsy can elucidate the diagnosis.

Fulminant Liver Failure Due to Acute Hepatitis E Infection in an Immunocompetent Male: A Case Report

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S1322
Author(s):  
Sachit Sharma ◽  
Ashu Acharya ◽  
Alok Uprety ◽  
Abhushan Poudyal ◽  
Sadikshya Sharma
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Acute Hepatitis ◽  
Hepatitis E ◽  
Fulminant Liver Failure ◽  
Acute Hepatitis E

scholarly journals Pulmonary mucormycosis presenting as central bronchopleural fistula—a case report with review of literature

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Elamparidhi Padmanaban ◽  
Preethi Kannan ◽  
Umamageswari Amirthalingam ◽  
Sudhakar Pitchumani ◽  
Padma Rekha
Keyword(s):  
Case Report ◽  
High Mortality ◽  
Bronchopleural Fistula ◽  
Fatal Outcome ◽  
Lower Lobe ◽  
High Index ◽  
Central Type ◽  
Pulmonary Mucormycosis ◽  
The Right ◽  
High Index Of Suspicion

Abstract Background Bronchopleural fistula (BFF) is a fistulous communication between the trachea or bronchus and the pleural space. Central type of bronchopleural fistula is usually post-surgical. Infective cause for central bronchopleural fistula is rare. This case report encompasses an infective cause of central bronchopleural fistula, mucormycosis. Pulmonary mucormycosis is a rapidly progressive condition with high mortality. A high index of suspicion and timely intervention is required to alleviate fatal outcome. The present case is discussed in detail about the clinical presentation and diagnostic imaging of pulmonary mucormycosis presenting with central bronchopleural fistula. Case presentation Thirty-five years old diabetic male, presented with fever, productive cough, mild haemoptysis and chest pain for 10 days duration. The patient was pale on general examination and had decreased breath sound in the right suprascapular and interscapular areas with coarse crackles in the right infrascapular and infra-axillary areas. The laboratory investigations were unremarkable except for anaemia and raised blood glucose level. Sputum examination on potassium hydroxide (KOH) mount showed broad aseptate hyphae. There was a loculated right hydropneumothorax with collapsed lung in chest radiograph. Multi-detector computed tomography of the thorax revealed central type of bronchopleural fistula with the right main bronchus, consolidation of the middle lobe and superior segment of the right lower lobe with multiple internal thick-walled cavities. Right pneumonectomy was performed as the patient did not improve on medical management and showed worsening of symptoms. Histopathological examination was suggestive of mucormycosis. Conclusion Central bronchopleural fistula due to an infective aetiology is uncommon. However, mucormycosis should be considered as a differential diagnosis in cases of central bronchopleural fistula with the destroyed lung, especially in diabetic individuals. Hence, a high index of suspicion is necessary for early diagnosis and management as mucormycosis is a rapidly progressive disease with delay in treatment leading to high mortality.

scholarly journals Relentless placoid chorioretinitis: A case report

2016 ◽  
Vol 144 (9-10) ◽  
pp. 527-530
Author(s):  
Ljiljana Obradovic ◽  
Svetlana Jovanovic ◽  
Nenad Petrovic ◽  
Suncica Sreckovic ◽  
Zorica Jovanovic
Keyword(s):  
Case Report ◽  
Clinical Laboratory ◽  
Clinical Course ◽  
Laboratory Diagnostics ◽  
Intermediate Form ◽  
Serpiginous Choroiditis ◽  
Clinical Center ◽  
Retinal Distribution ◽  
The Right ◽  
Relentless Placoid Chorioretinitis

Introduction. Relentless placoid chorioretinitis is an entity which belongs to the group of an atypical intermediate form of primary inflammatory choriocapillaropathies, resembling both acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis, but the retinal distribution and clinical course are not the same. Because of this similarity this entity was termed ?AMPPiginous?. This entity was first described by Jones et al. in 2000. The aim of our case report is to present a very specific case where the clinical course was progressive, with loss of vision in the affected eye. Case Outline. A 31-year-old man, with no previous ophthalmic diseases, was hospitalized at the Clinic of Ophthalmology, Clinical Center Kragujevac, because of a reduction of vision in the right eye, and scotoma and metamorphopsia in the left eye. The clinical course of retinal lesions in the left eye resembled the changes observed in acute posterior multifocal placoid pigment epitheliopathy, and the right eye changes were between acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis. The diagnosis of relentless placoid chorioretinitis was confirmed after clinical, laboratory, immunological, virological, and angiography examinations. Conclusion. The progressive clinical course of the disease, complemented by multimodal imaging and extensive laboratory diagnostics, has led us to the diagnosis of relentless placoid chorioretinitis. The combined anti-inflammatory and immunomodulatory therapy led to the stabilization of visual acuity of the left eye as opposed to the right, where there has been no recovery.

scholarly journals A Case Report of Hypogenesis of the Right Lobe of the Associated with Acute Hepatitis B

1996 ◽  
Vol 49 (0) ◽  
pp. 224-225
Author(s):  
Haruki Hoshinaga ◽  
Katsuhisa Nakatsuka ◽  
Motoko Nachi ◽  
Yasutaka Mamiya ◽  
Yuji Osada ◽  
...  
Keyword(s):  
Case Report ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Acute Hepatitis B ◽  
Right Lobe ◽  
The Right

PREDOMINANCE of cd8+ T-Cells On Liver Biopsy in Pediatric Patients With Indeterminate Acute Hepatitis and Liver Failure.

2014 ◽  
Vol 98 ◽  
pp. 716
Author(s):  
R. McKenzie ◽  
C. Louie ◽  
W. Berquist ◽  
K. Nadeau ◽  
R. Sibley ◽  
...  
Keyword(s):  
T Cells ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Hepatitis ◽  
Cd8 T Cells ◽  
Pediatric Patients

scholarly journals Spontaneous rupture of giant liver hemangioma: Case report

2013 ◽  
Vol 141 (1-2) ◽  
pp. 95-99 ◽  
Author(s):  
Krstina Doklestic ◽  
Branislav Stefanovic ◽  
Aleksandar Karamarkovic ◽  
Vesna Bumbasirevic ◽  
Branislava Stefanovic ◽  
...  
Keyword(s):  
Case Report ◽  
Hemorrhagic Shock ◽  
Solid Tumor ◽  
Spontaneous Rupture ◽  
Fatal Outcome ◽  
Vascular Occlusion ◽  
Exploratory Laparotomy ◽  
Left Lobe ◽  
Liver Hemangioma ◽  
The Right

Introduction. Hemangioma is the most frequent benign solid tumor of the liver. It is well known that a giant liver hemangioma carries the risk of spontaneous rupture, followed by hemoperitoneum and hemorrhagic shock with possible fatal outcome. Case Outline. This is a case report of the spontaneous rupture of a giant cavernous hemangioma of the liver in an 85-year old patient. The patient was presented with abdominal pain and hemorrhagic shock. Emergency ultrasonography and computed tomography of the abdomen showed a heterogeneous ruptured solid tumor of the right liver lobe, multiple cysts in the left lobe and massive hemoperitoneum. The patient was successfully managed by immediate exploratory laparotomy, surgical enucleation of the hemangioma under intermittent inflow vascular occlusion, temporary perihepatic packing and planned second look relaparotomy. Conclusion. Immediate surgical procedure is indicated mandatory in unstable patients with a ruptured giant hemangioma of the liver. Surgical enucleation under intermittent inflow vascular occlusion and temporary perihepatic packing could be a life-saving procedure in those patients.

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