scholarly journals Effect of pretreatment with omega-3 polyunsaturated fatty acids (PUFAs) on hematological parameters and platelets aggregation in patients during elective coronary artery bypass grafting

2013 ◽  
Vol 70 (4) ◽  
pp. 396-402 ◽  
Author(s):  
Milic Veljovic ◽  
Ivana Mihajlovic ◽  
Vesna Subota ◽  
Mirjana Antunovic ◽  
Jasna Jevdjic ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Coronary Artery ◽  
Platelet Aggregation ◽  
Polyunsaturated Fatty Acids ◽  
Coronary Artery Bypass ◽  
Hematological Parameters ◽  
Artery Bypass ◽  
Control Group ◽  
Omega 3

Bacground/Aim. Using omega-3 polyunsaturated fatty acids (PUFAs) in coronary artery bypass graft surgery (CABG) could provide protection against ischemicreperfusion damage, prevention of postoperative arrhythmia and attenuation of inflammatory response. However, omega-3 PUFAs inhibit cyclooxygenase (and thus decrease the synthesis of thromboxane A2 from arachidonic acid in platelets), which leads to decreased platelet aggregation. In cardiac surgery it is necessary to achieve a balance between inhibition and full platelets function. It is as well as important to closely follow hematological parameters, impaired by CABG itself. Therefore, the aim of the study was to establish the effects of pretreatment with omega- PUFAs on hematological parameters and plateletes aggregation in patients with elective CABG. Methods. This prospective, randomized, placebo-controlled, single-center trial was performed on parallel groups. The patients (n = 40) undergoing elective CABG were randomized receiving preoperative intravenous omega-3 PUFAs (Omegaven? 10%) infusion (the PUFAs group) or the same volume of 0.9% saline solution infusion (the control group). Infusion was given a day before surgery and repeated four hours before starting extracorporeal circulation (CPB) via the peripheral vein at single doses of 100 mL (25 mL/h). Platelet function analysis was performed using multiple electrode aggregometry (MEA, multiplate-analyzer) before starting CPB and 2 h postoperatively for the patients of both groups. Results. There were no clinically relevant differences in baseline characteristics between the groups. Hematological parameters were not significantly different between the groups pre-, intra- and postoperatively. During the first 24 h after surgery, the loss of blood was similar in the PUFAs and the control group (680 ? 274 mL and 608 ? 210 mL, respectively; p = 0.356). Postoperatively, platelet aggregation was not significantly different between the PUFAs and the control group in adenosine diphosphate (ADP) test (39 ? 11 and 42 ? 15, respectively; p = 0.701), arachidonic acid (ASPI) test (64 ? 24 and 70 ? 27, respectively; p = 0.525) and trombin receptor-activating peptide (TRAP) test (68 ? 25 and 75 ? 26, respectively; p = 0.396), while their aggregation in collagen (COL) test was statistically significantly lower in the PUFAs related to the control group (32 ? 15 and 47 ? 20, respectively; p = 0.009). Conclusion. Acute pretreatment with omega-3 PUFAs insignificantly affected the activity of platelets and did not influence postoperative blood loss.

COMPARATIVE ANALYSIS OF UNSATURATED INDICATORS FATTY ACIDS IN ELDERLY PATIENTS IN INITIAL STAGES OF ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA

2020 ◽  
pp. 265-272
Author(s):  
Е. Е. Дубинина ◽  
Л. В. Щедрина ◽  
К. В. Ющин ◽  
Е. В. Светкина ◽  
Н. М. Залуцкая ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Comparative Analysis ◽  
Polyunsaturated Fatty Acids ◽  
Vascular Dementia ◽  
Cognitive Functions ◽  
Control Group ◽  
Omega 3

Снижение когнитивных функций вплоть до развития деменции у пожилых людей связывают с уменьшением в крови уровня полиненасыщенных жирных кислот, особенно Омега-3, которое происходит на фоне окислительного стресса. В работе представлен сравнительный анализ спектра полиненасыщенных жирных кислот и активности отдельных компонентов ферментативной антиоксидантной системы в крови у лиц пожилого возраста с нарушением показателей когнитивного функционирования до уровня «мягкое когнитивное снижение» первично-атрофической (MCI БА, продромальная болезнь Альцгеймера) или васкулярной этиологии (MCI СД, продромальная сосудистая деменция) по сравнению с пожилыми людьми без признаков нарушений когнитивных функций. Выявлено снижение концентрации Омега-3 полиненасыщенных жирных кислот в крови обеих групп обследованных больных по сравнению с контрольной группой. У пациентов с MCI БА обнаружено резкое снижение концентрации арахидоновой кислоты (Омега-6) по сравнению с больными MCI СД и контрольной группой. Выявленное нами снижение активности антиоксидантной ферментативной системы и снижение полиненасыщенных жирных кислот за счет их пероксидации свидетельствует об интенсификации процессов окислительного стресса у пациентов с нарушением когнитивных функций. Обсуждается вопрос о патогенетической роли арахидоновой кислоты у больных, предрасположенных в будущем к развитию болезни Альцгеймера. A decrease in cognitive functions up to the development of dementia in the elderly is associated with a decrease in the blood level of polyunsaturated fatty acids, especially Omega-3, which occurs against the background of oxidative stress. The paper presents a comparative analysis of the spectrum of polyunsaturated fatty acids and the activity of individual components of the enzymatic antioxidant system in the blood of elderly people with impaired cognitive performance to the level of «mild cognitive decline» (MCI AD, prodromal Alzheimer’s disease) or vascular etiology (MCI VaD, prodromal vascular dementia) compared with older people without signs of cognitive impairment. A decrease in the concentration of Omega-3 polyunsaturated fatty acids in the blood of both groups of the examined patients was revealed compared with the control group. In patients with AD MCI, a sharp decrease in the concentration of arachidonic acid (Omega-6) was detected compared with patients with MCI VaD and the control group. The decrease in the activity of the antioxidant enzymatic system and the decrease in polyunsaturated fatty acids due to their peroxidation revealed in this study indicate an intensification of the OS processes in patients with impaired cognitive functions. The question of the pathogenetic role of arachidonic acid in patients predisposed in the future to the development of AD is discussed.

n-3 Polyunsaturated Fatty Acids After Coronary Artery Bypass Grafting

2011 ◽  
Vol 91 (4) ◽  
pp. 1169-1175 ◽  
Author(s):  
Umberto Benedetto ◽  
Giovanni Melina ◽  
Roberta di Bartolomeo ◽  
Emiliano Angeloni ◽  
Davide Sansone ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Polyunsaturated Fatty Acids ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Artery Bypass Grafting

scholarly journals Omega-3 fatty acids do not alter P-wave parameters in electrocardiogram or expression of atrial connexins in patients undergoing coronary artery bypass surgery

EP Europace ◽  
2016 ◽  
Vol 18 (10) ◽  
pp. 1521-1527 ◽  
Author(s):  
Palaniappan Saravanan ◽  
Annette L. West ◽  
Ben Bridgewater ◽  
Neil C. Davidson ◽  
Philip C. Calder ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
P Wave ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wave Parameters

scholarly journals N-3 polyunsaturated fatty acids reduces post-operative atrial fibrillation incidence in patients undergoing “on-pump” coronary artery bypass graft surgery

2015 ◽  
Vol 76 (2) ◽  
Author(s):  
Mario Sorice ◽  
Francesco Paolo Tritto ◽  
Chiara Sordelli ◽  
Rosario Gregorio ◽  
Luigi Piazza
Keyword(s):  
Atrial Fibrillation ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Polyunsaturated Fatty Acids ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Pump Coronary Artery Bypass

Background: The aim of this study was to evaluate the efficacy of preoperative and postoperative therapy with n-3 polyunsaturated fatty acids in reducing the incidence of atrial fibrillation after coronary artery bypass graft surgery. Methods: 201 patients undergoing coronary artery bypass graft surgery were randomized to 1) a control group (105 patients), or 2) n-3 polyunsaturated fatty acids 2 g/day group (96 patients) for at least 5 days before surgery and until hospital discharge. Groups were further subdivided in four subgroups according to the operative technique: “off-pump” or “on-pump”. The primary end point was to evaluate the reduced incidence of postoperative in-hospital atrial fibrillation in the (N-3 PUFA) group. Secondary end points were the impact of the surgical technique on the incidence of postoperative arrhythmia and the impact of n-3 polyunsaturated fatty acids therapy on post-operative hospital length of stay. Results: The overall incidence of post-operative atrial fibrillation was 17.4% (35/201). The arrhythmia occurred in 11.4% (11/96) of the patients in therapy with n-3 polyunsaturated fatty acids and in 22.8% (24/105) in the control groups. In particular, the statistical analysis of subgroups showed a significant reduction of postoperative atrial fibrillation only in the group including patients treated with n-3 polyunsaturated fatty acids undergoing “on-pump” coronary artery bypass graft surgery. The length of hospital stay did not differ among all groups. Conclusions: N-3 polyunsaturated fatty acids administration significantly reduces the incidence of post-operative atrial fibrillation in patients undergoing “on-pump” coronary artery bypass graft surgery. N-3 polyunsaturated fatty acids therapy is not associated with a shorter hospital stay.

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