Toward a Functional Definition of the A Priori

1944 ◽  
Vol 41 (6) ◽  
pp. 155
Author(s):  
Arthur Child
Keyword(s):  
A Priori ◽  
Author(s):  
Chiara Treghini ◽  
Alfonso Dell’Accio ◽  
Franco Fusi ◽  
Giovanni Romano

AbstractChronic lung infections are among the most diffused human infections, being often associated with multidrug-resistant bacteria. In this framework, the European project “Light4Lungs” aims at synthesizing and testing an inhalable light source to control lung infections by antimicrobial photoinactivation (aPDI), addressing endogenous photosensitizers only (porphyrins) in the representative case of S. aureus and P. aeruginosa. In the search for the best emission characteristics for the aerosolized light source, this work defines and calculates the photo-killing action spectrum for lung aPDI in the exemplary case of cystic fibrosis. This was obtained by applying a semi-theoretical modelling with Monte Carlo simulations, according to previously published methodology related to stomach infections and applied to the infected trachea, bronchi, bronchioles and alveoli. In each of these regions, the two low and high oxygen concentration cases were considered to account for the variability of in vivo conditions, together with the presence of endogenous porphyrins and other relevant absorbers/diffusers inside the illuminated biofilm/mucous layer. Furthermore, an a priori method to obtain the “best illumination wavelengths” was defined, starting from maximizing porphyrin and light absorption at any depth. The obtained action spectrum is peaked at 394 nm and mostly follows porphyrin extinction coefficient behavior. This is confirmed by the results from the best illumination wavelengths, which reinforces the robustness of our approach. These results can offer important indications for the synthesis of the aerosolized light source and definition of its most effective emission spectrum, suggesting a flexible platform to be considered in further applications.


Author(s):  
D. Egorov

Adam Smith defined economics as “the science of the nature and causes of the wealth of nations” (implicitly appealing – in reference to the “wealth” – to the “value”). Neo-classical theory views it as a science “which studies human behavior in terms of the relationship between the objectives and the limited funds that may have a different use of”. The main reason that turns the neo-classical theory (that serves as the now prevailing economic mainstream) into a tool for manipulation of the public consciousness is the lack of measure (elimination of the “value”). Even though the neo-classical definition of the subject of economics does not contain an explicit rejection of objective measures the reference to “human behavior” inevitably implies methodological subjectivism. This makes it necessary to adopt a principle of equilibrium: if you can not objectively (using a solid measurement) compare different states of the system, we can only postulate the existence of an equilibrium point to which the system tends. Neo-classical postulate of equilibrium can not explain the situation non-equilibrium. As a result, the neo-classical theory fails in matching microeconomics to macroeconomics. Moreover, a denial of the category “value” serves as a theoretical basis and an ideological prerequisite of now flourishing manipulative financial technologies. The author believes in the following two principal definitions: (1) economics is a science that studies the economic system, i.e. a system that creates and recombines value; (2) value is a measure of cost of the object. In our opinion, the value is the information cost measure. It should be added that a disclosure of the nature of this category is not an obligatory prerequisite of its introduction: methodologically, it is quite correct to postulate it a priori. The author concludes that the proposed definitions open the way not only to solve the problem of the measurement in economics, but also to address the issue of harmonizing macro- and microeconomics.


In the previous chapter we argued that the conception of creatio ex nihilo is the determinant of hierarchy and stratification in Judaism and Christianity; Islam teaches that God created divisions as a way for human beings to recognize each other. The metaphysical origin of sociality and the reality of tribal and clan structure are reflected in the Islamic conception of community, gamaat; on a larger scale it is called ummah. Members in Islamic ummah are set apart from non-Muslims. This is dissimilar to the ancient Judaic racial and ethnic symbiosis which came to be known as the “chosen people,” an early manifestation of stratification in monotheistic religions. Among the Muslim scholars of the Middle Ages, Ibn Khaldun approached the objective foundations of sociality, attending to an implicit conception of stratification by appropriating detached observational methods to explain the rise and fall of dynasties. Principally, his work demonstrates the possibility of synthetically a posteriori, based on his personal experience and analytical a priori by which he asserted that the rise and fall are part of the definition of all dynasties. However, since Ibn Khaldun's day, our notion of the objects of structure and function of societies requires that we distinguish many variables in order to understand Islamic societies – particularly the way that their stratification systems are affected by globalization, or their transition toward, or their opposition to modernity. Using geometry metaphorically, it is true that we have departed from Euclidian theorems with the advent of various geometries. Yet Euclidian geometry still has many functions, a point that amplifies the intersections of both Euclidian and non-Euclidian geometries. Notwithstanding the various intersections among political, economic, religious, cultural and social matrices that provide multiple logics to understand the operations of societies, the Khaldunic notion of rise and fall has survived to this day.


The Condor ◽  
2002 ◽  
Vol 104 (1) ◽  
pp. 208-215 ◽  
Author(s):  
Steven R. Beissinger ◽  
Noel F. R. Snyder

Abstract Dreitz et al. (2001) analyzed the factors affecting nest success of the Snail Kite (Rostrhamus sociabilis) in Florida. They concluded that success was unrelated to water levels because Akaike's Information Criterion rated models with water-level terms as poor compared to other models. Their suite of candidate models, however, did not include models with area-specific differences in the way that water levels affect nest success. We believe that such differences should have been included among the a priori models examined, and that their best model is neither ecologically informative nor useful for management. Using the same statistical methods, we reanalyze Dreitz et al.'s data on nesting success from the five areas with sufficient years and nests for analysis (comprising 89% of their 1542 nests) and show that, when spatial effects of water levels are included, water levels have an important influence on nest success over the entire range of water levels, not just during low water conditions. Furthermore, Dreitz et al.'s definition of nesting attempts excluded nests found during the 10–21 day pre-laying period, when many nests fail. Thus, they overestimated nest success and underestimated the amount of nesting activity under low water conditions. Low water conditions occur relatively frequently throughout much of the kite's range, and under these conditions few kites nest and even fewer fledge young. The effects of low water extend well beyond nest success, causing many kites to forgo nesting altogether, shortening the breeding season, and decreasing the opportunity for multiple brooding. Los Niveles de Agua Afectan el Éxito de Nidos de Rostrhamus sociabilis en Florida: Criterio de Información de Akaike y la Omisión de Modelos Potenciales Relevantes Resumen. Dreitz et al. (2001) analizaron los factores que afectan el éxito de anidación de Rostrhamus sociabilis en Florida. Ellos concluyeron que el éxito no está relacionado con los niveles de agua porque según el Criterio de Información de Akaike, los modelos que incluían términos relacionados con el nivel de agua eran de poco valor en comparación con otros modelos. Sin embargo, entre los modelos evaluados no incluyeron aquellos con diferencias específicas de área en la manera en que los niveles de agua afectan el éxito de los nidos. Nosotros creemos que dichas diferencias han debido ser incluidas en los modelos evaluados a priori y que su mejor modelo no es ecológicamente informativo ni útil en términos de manejo. Utilizando los mismos métodos estadísticos, reanalizamos los datos de éxito de anidación de Dreitz et al. de las cinco áreas que tenían suficientes años y nidos para analizar (comprendiendo el 89% de sus 1542 nidos). Demostramos que cuando se incluyen los efectos espaciales de los niveles de agua, éstos tienen una influencia importante en el éxito de los nidos en todo el rango de niveles de agua (no sólo en condiciones de aguas bajas). Más aún, la definición de intentos de anidación empleada por Dreitz et al. excluyó a aquellos nidos encontrados durante el período de 10 a 21 días pre-postura, cuando muchos nidos fracasan. Por lo tanto, ellos sobreestimaron el éxito de los nidos y subestimaron la cantidad de actividad de anidación en condiciones de aguas bajas. Las condiciones de aguas bajas se presentan con relativa frecuencia en gran parte del rango de distribución de R. sociabilis. Bajo esas condiciones, pocos individuos anidan y aún menos crían polluelos exitosamente. Los efectos de aguas bajas se extienden más allá del éxito de los nidos, causando que muchos individuos totalmente renuncien a anidar, acortando la época reproductiva y reduciendo las oportunidades de tener múltiples nidadas.


Kant-Studien ◽  
2019 ◽  
Vol 110 (3) ◽  
pp. 477-497
Author(s):  
David Hyder

Abstract The theory of space-time developed in Kant’s Critique of Pure Reason and his (1786) Metaphysical Foundations of Natural Science is connected to Leonhard Euler’s proof of invariance under Galilean transformations in the “On Motion in General” of the latter’s 1736 Analytical Mechanics. It is argued that Kant, by using the Principle of Relativity that is the output of Euler’s proof as an input to his own proof of the kinematic parallelogram law, makes essential use of absolute simultaneity. This is why, in the Transcendental Aesthetic, he observes that “our theory of time explains as much a priori knowledge as the general theory of motion displays.” (KrV, B 67) In conclusion, it is shown that the same proof-method, under a different definition of simultaneity, leads to the parallelogram law of the “Kinematic Part” of Einstein’s 1905 “On the Electrodynamics of Moving Bodies”.


Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 774 ◽  
Author(s):  
Ángela Hernández-Ruiz ◽  
Belén García-Villanova ◽  
Eduardo Guerra-Hernández ◽  
Pilar Amiano ◽  
Miguel Ruiz-Canela ◽  
...  

Oxidative Balance Scores (OBSs) are tools that have emerged to evaluate the global balance of individuals’ oxidation—reduction status. The aim was to compare OBSs available in the literature regarding their characteristics and associations with chronic diseases in epidemiological studies. Studies that developed OBSs were searched in PubMed until August 2018. A total of 21 OBSs were identified. These OBSs presented different scoring schemes and different types of anti- and pro-oxidant components, including dietary factors (dietary intake and/or nutrient biomarkers), lifestyle factors, and medications. Most OBSs were based on over 10 components, and some included only dietary factors. Few considered weighted components in the score. Only three OBSs were validated as potential surrogates of oxidative balance through inflammation and OS-related biomarkers. Notably, all the OBSs were associated—to a varying degree—with a reduced risk of cardiovascular diseases, chronic kidney disease, colorectal adenomas, and different cancer types (colorectal and breast cancer), as well as with all-cause and cancer-related mortality. For other outcomes, e.g., prostate cancer, contradictory results were reported. In summary, there is a great heterogeneity in the definition of OBSs. Most studies are concordant in supporting that excessive OS reflected by a lower OBS has deleterious effects on health. Unified criteria for defining the proper OBSs, valuable to gauge OS-related aspects of the diet and lifestyle that may lead to adverse health outcomes, are needed.


Cephalalgia ◽  
2019 ◽  
Vol 39 (8) ◽  
pp. 1058-1066 ◽  
Author(s):  
Marie Deen ◽  
Daniele Martinelli ◽  
Judith Pijpers ◽  
Hans-Christoph Diener ◽  
Stephen Silberstein ◽  
...  

Introduction Since the definition of chronic migraine as a new disease entity in 2004, numerous clinical trials have examined the efficacy of preventive treatments in chronic migraine. Our aim was to assess the adherence of these trials to the Guidelines of the International Headache Society published in 2008. Methods We searched PubMed for controlled clinical trials investigating preventive treatment for chronic migraine in adults designed after the release of the Guidelines and published until December 2017. Trial quality was evaluated with a 13-item scoring system enlisting essential recommendations adapted from the Guidelines. Results Out of 3352 retrieved records, we included 16 papers in the analysis dealing with pharmacological treatment of chronic migraine. The median score was 6.5 (range 2–13). All trials were randomized, the large majority (81.25%) were placebo-controlled and double-blinded (87.5%). Adherence was lowest on i) a priori definition of outcomes (31.25%), ii) primary endpoint definition (37.5%%) and iii) trial registration (37.5%). Discussion Most clinical trials adhered to the recommendations of the IHS, whereas adherence to migraine-specific recommendations was lower. Greater awareness and adherence to the guidelines are essential to improve the quality of clinical trials, validity of publications and the generalizability of the results.


Geophysics ◽  
2012 ◽  
Vol 77 (4) ◽  
pp. WB19-WB35 ◽  
Author(s):  
Cyril Schamper ◽  
Fayçal Rejiba ◽  
Roger Guérin

Electromagnetic induction (EMI) methods are widely used to determine the distribution of the electrical conductivity and are well adapted to the delimitation of aquifers and clayey layers because the electromagnetic field is strongly perturbed by conductive media. The multicomponent EMI device that was used allowed the three components of the secondary magnetic field (the radial [Formula: see text], the tangential [Formula: see text], and the vertical [Formula: see text]) to be measured at 10 frequencies ranging from 110 to 56 kHz in one single sounding with offsets ranging from 20 to 400 m. In a continuing endeavor to improve the reliability with which the thickness and conductivity are inverted, we focused our research on the use of components other than the vertical magnetic field Hz. Because a separate sensitivity analysis of [Formula: see text] and [Formula: see text] suggests that [Formula: see text] is more sensitive to variations in the thickness of a near-surface conductive layer, we developed an inversion tool able to make single-sounding and laterally constrained 1D interpretation of both components jointly, associated with an adapted random search algorithm for single-sounding processing for which almost no a priori information is available. Considering the complementarity of [Formula: see text] and [Formula: see text] components, inversion tests of clean and noisy synthetic data showed an improvement in the definition of the thickness of a near-surface conductive layer. This inversion code was applied to the karst site of the basin of Fontaine-Sous-Préaux, near Rouen (northwest of France). Comparison with an electrical resistivity tomography tends to confirm the reliability of the interpretation from the EMI data with the developed inversion tool.


2007 ◽  
Vol 28 (6) ◽  
pp. 931-946 ◽  
Author(s):  
Rick Iedema

This essay considers the ways that organizational discourse studies have deployed the concept `discourse'. A review of the literature reveals conceptual ambiguities in the definition of `discourse', as well as pre-analytical distinctions that are imposed between discourse, action and text, and between discourse, beliefs and material practices. The paper suggests that such a priori analytical categories risk tying the researcher to an inflexible research agenda, ruling out engaging with organizational specifics and emergent aspects of practice. The essay argues for an alternative view of discourse that centres on the following three arguments: discourse is not limited to language but also includes image, design, technology and other modes of meaning making; discourse and materiality co-emerge; and discourse manifests a specific, historically situated form of life.


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