Lamluda as sample area for intensive investigation

2020 ◽  
pp. 167-182
Keyword(s):  
Sample Area ◽  
Intensive Investigation

Transmodulation of Dopaminergic Signaling to Mitigate Hypodopminergia and Pharmaceutical Opioid-induced Hyperalgesia

2020 ◽  
Vol 9 (3) ◽  
pp. 164-184
Author(s):  
Raymond Brewer ◽  
Kenneth Blum ◽  
Abdalla Bowirrat ◽  
Edward J. Modestino ◽  
David Baron ◽  
...  
Keyword(s):  
Opioid Analgesic ◽  
Opioid Analgesics ◽  
Well Being ◽  
Deficiency Syndrome ◽  
Pain Tolerance ◽  
Opioid Agonist ◽  
Opioid Agonist Therapy ◽  
Analgesic Agents ◽  
Opioid Induced Hyperalgesia ◽  
Intensive Investigation

Neuroscientists and psychiatrists working in the areas of “pain and addiction” are asked in this perspective article to reconsider the current use of dopaminergic blockade (like chronic opioid agonist therapy), and instead to consider induction of dopamine homeostasis by putative pro-dopamine regulation. Pro-dopamine regulation could help pharmaceutical opioid analgesic agents to mitigate hypodopaminergia-induced hyperalgesia by inducing transmodulation of dopaminergic signaling. An optimistic view is that early predisposition to diagnosis based on genetic testing, (pharmacogenetic/pharmacogenomic monitoring), combined with appropriate urine drug screening, and treatment with pro-dopamine regulators, could conceivably reduce stress, craving, relapse, enhance well-being and attenuate unwanted hyperalgesia. These concepts require intensive investigation. However, based on the rationale provided herein, there is a good chance that combining opioid analgesics with genetically directed pro-dopamine-regulation using KB220 (supported by 43 clinical studies). This prodopamine regulator may become a front-line technology with the potential to overcome, in part, the current heightened rates of chronic opioid-induced hyperalgesia and concomitant Reward Deficiency Syndrome (RDS) behaviors. Current research does support the hypothesis that low or hypodopaminergic function in the brain may predispose individuals to low pain tolerance or hyperalgesia.

scholarly journals Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels

2021 ◽  
Vol 22 (14) ◽  
pp. 7588
Author(s):  
Zoltan Gombos ◽  
Erika Koltai ◽  
Ferenc Torma ◽  
Peter Bakonyi ◽  
Attila Kolonics ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Hypertrophy ◽  
Male Rats ◽  
Cellular Interactions ◽  
Molecular Signaling ◽  
Protein Breakdown ◽  
Rat Skeletal Muscle ◽  
Plantaris Muscle ◽  
Skeletal Muscle Hypertrophy ◽  
Intensive Investigation

Despite the intensive investigation of the molecular mechanism of skeletal muscle hypertrophy, the underlying signaling processes are not completely understood. Therefore, we used an overload model, in which the main synergist muscles (gastrocnemius, soleus) of the plantaris muscle were surgically removed, to cause a significant overload in the remaining plantaris muscle of 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic molecular signaling pathways, NAD and H2S levels of this overload-induced hypertrophy were studied. Fourteen days of overload resulted in a significant 43% (p < 0.01) increase in the mass of plantaris muscle compared to sham operated animals. Cystathionine-β-synthase (CBS) activities and bioavailable H2S levels were not modified by overload. On the other hand, overload-induced hypertrophy of skeletal muscle was associated with increased SIRT1 (p < 0.01), Akt (p < 0.01), mTOR, S6 (p < 0.01) and suppressed sestrin 2 levels (p < 0.01), which are mostly responsible for anabolic signaling. Decreased FOXO1 and SIRT3 signaling (p < 0.01) suggest downregulation of protein breakdown and mitophagy. Decreased levels of NAD+, sestrin2, OGG1 (p < 0.01) indicate that the redox milieu of skeletal muscle after 14 days of overloading is reduced. The present investigation revealed novel cellular interactions that regulate anabolic and catabolic processes in the hypertrophy of skeletal muscle.

PIXE ANALYSIS OF CARTILAGE SAMPLES

1992 ◽  
Vol 02 (04) ◽  
pp. 481-487 ◽  
Author(s):  
J. VOGT ◽  
G. OTTO ◽  
K.H. Dannhauer
Keyword(s):  
Trace Element ◽  
Proton Beam ◽  
Pixe Analysis ◽  
Domestic Pigs ◽  
Element Concentrations ◽  
Elemental Contents ◽  
Intensive Investigation ◽  
Pixe Method

Despite intensive investigation, normal and abnormal calcification mechanisms are still poorly understood. In our study we measured the change of main and trace element concentrations across the calcification area of the mandibular cartilage of domestic pigs of different age. The PIXE method was employed for the analysis of the cartilage samples, using a proton beam with an energy of 1700 keV. Concentration values of the elements P, S, Cl, K, Fe, Ni, Cu, Zn, Br, Rb, and Sr were evaluated from the measured spectra. Significant changes of elemental contents across the calcification area could be observed.

Munich, Milan, and a Marian Motet: Dating Josquin's Ave Maria …… virgo serena

2003 ◽  
Vol 56 (2) ◽  
pp. 239-350 ◽  
Author(s):  
Joshua Rifkin
Keyword(s):  
Potential Conflict ◽  
Josquin Des Prez ◽  
Recent Developments ◽  
Intensive Investigation ◽  
The Relationship

Abstract Recent developments in the biography of Josquin des Prez have focused new attention on the motet Ave Maria …… virgo serena. In 1974, Thomas Noblitt showed that watermark evidence assigned a copy of the piece in Munich, Bayerische Staatsbibliothek, Mus. ms. 3154 to 1476; the dating appeared unassailable philologically, and the style of the music tied it to a repertory created at the court of Milan in a period when Josquin supposedly worked there. But with the discovery by Lora Matthews and Paul Merkley that Josquin had no connection with Milan until 1484, a potential conflict between style, date, and perhaps authorship has emerged. Reexamination of the motet and its transmission affirms both the Milanese character of the music and Josquin's authorship; a more intensive investigation of the relationship between script and paper in Munich 3154, however, shows that the Ave Maria represents a previously unrecognized phase in the work of its copyist, datable to 1485 or an adjacent year. Even against this revised background, Munich 3154 remains the earliest securely datable source for any music of Josquin, and the Ave Maria seems in all likelihood the earliest composition of his that we can identify.

Das Corpus Doctrinae Philippicum und seine Nachwirkung

2021 ◽  
Vol 8 (1) ◽  
pp. 119-134
Author(s):  
Irene Dingel
Keyword(s):  
Seventeenth Century ◽  
16Th Century ◽  
The Reformation ◽  
History Of ◽  
The Common ◽  
Intensive Investigation

Abstract Hardly any corpus doctrinae had as intensive a reception and as wide a dissemination as the Corpus Doctrinae Philippicum (1560). Situating it in the history of the concept of a corpus doctrinae and briefly sketching its origin and goal elucidate the function and significance of this collection of Melanchthon’s writings. An intensive investigation reveals however any connection of this work with the development of the Reformation in Siebenbürgen (ung. Erdély, rum. Transilvania) in the later 16th century. The records of the Siebenbürgen synods mention the Corpus Doctrinae Philippicum occasionally, revealing the extent to which it served as a norm for public teaching. Unique and characteristic for Siebenbürgen is that the Formula of Concord (1577) did not replace this Corpus Doctrinae; it remained influential long into the seventeenth century. It was however interpreted within the horizon of a Wittenberg theology that was marked by the pre-confessional harmony and doctrinal agreement between Luther and Melanchthon while seeking to ignore Philippist interpretations and focusing on the common teachings of both reformers.

HYBRID SILICON-MOLECULAR ELECTRONICS

2008 ◽  
Vol 22 (12) ◽  
pp. 1183-1202 ◽  
Author(s):  
QILIANG LI
Keyword(s):  
Molecular Electronics ◽  
New Technologies ◽  
Electronic System ◽  
Cmos Technology ◽  
Smooth Transition ◽  
Molecular Memory ◽  
Molecular Systems ◽  
Redox Active ◽  
Hybrid Silicon ◽  
Intensive Investigation

As CMOS technology extends beyond the current technology node, many challenges to conventional MOSFET were raised. Non-classical CMOS to extend and fundamentally new technologies to replace current CMOS technology are under intensive investigation to meet these challenges. The approach of hybrid silicon/molecular electronics is to provide a smooth transition technology by integrating molecular intrinsic scalability and diverse properties with the vast infrastructure of traditional MOS technology. Here we discuss: (1) the integration of redox-active molecules into Si -based structures, (2) characterization and modeling of the properties of these Si /molecular systems, (3) single and multiple states of Si /molecular memory, and (4) applications based on hybrid Si /molecular electronic system.

Steel Corrosion Rate Studies Using Sample Area as a Variable

1988 ◽  
Vol 135 (6) ◽  
pp. 1333-1337 ◽  
Author(s):  
John N. Murray ◽  
Patrick J. Moran
Keyword(s):  
Corrosion Rate ◽  
Steel Corrosion ◽  
Sample Area

scholarly journals A Case Study of Socially-Accepted Potentials for the Use of End User Flexibility by Home Energy Management Systems

2020 ◽  
Vol 13 (1) ◽  
pp. 132
Author(s):  
Christian Pfeiffer ◽  
Markus Puchegger ◽  
Claudia Maier ◽  
Ina V. Tomaschitz ◽  
Thomas P. Kremsner ◽  
...  
Keyword(s):  
Energy Management ◽  
Management System ◽  
Management Systems ◽  
System Support ◽  
Energy Management System ◽  
Energy Management Systems ◽  
Sample Area ◽  
Home Energy Management ◽  
Support Optimization ◽  
Home Energy Management System

Due to the increase of volatile renewable energy resources, additional flexibility will be necessary in the electricity system in the future to ensure a technically and economically efficient network operation. Although home energy management systems hold potential for a supply of flexibility to the grid, private end users often neglect or even ignore recommendations regarding beneficial behavior. In this work, the social acceptance and requirements of a participatively developed home energy management system with focus on (i) system support optimization, (ii) self-consumption and self-sufficiency optimization, and (iii) additional comfort functions are determined. Subsequently, the socially-accepted flexibility potential of the home energy management system is estimated. Using methods of online household survey, cluster analysis, and energy-economic optimization, the socially-accepted techno-economic potential of households in a three-community cluster sample area is computed. Results show about a third of the participants accept the developed system. This yields a shiftable load of nearly 1.8 MW within the small sample area. Furthermore, the system yields the considerably larger monetary surplus on the supplier-side due to its focus on system support optimization. New electricity market opportunities are necessary to adequately reward a systemically useful load behavior of households.

scholarly journals Renal medullary 11β-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension

2008 ◽  
Vol 36 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Yong Liu ◽  
Ravinder J. Singh ◽  
Kristie Usa ◽  
Brian C. Netzel ◽  
Mingyu Liang
Keyword(s):  
Blood Pressure ◽  
Urinary Excretion ◽  
Molecular Mechanisms ◽  
Renal Medulla ◽  
Hydroxysteroid Dehydrogenase ◽  
Induced Hypertension ◽  
Intensive Investigation ◽  
Salt Sensitive Hypertension ◽  
Interfering Rna

The Dahl salt-sensitive rat is a widely used model of human salt-sensitive forms of hypertension. The kidney plays an important role in the pathogenesis of Dahl salt-sensitive hypertension, but the molecular mechanisms involved remain a subject of intensive investigation. Gene expression profiling studies suggested that 11β-hydroxysteroid dehydrogenase type 1 might be dysregulated in the renal medulla of Dahl salt-sensitive rats. Additional analysis confirmed that renal medullary expression of 11β-hydroxysteroid dehydrogenase type 1 was downregulated by a high-salt diet in SS-13BN rats, a consomic rat strain with reduced blood pressure salt sensitivity, but not in Dahl salt-sensitive rats. 11β-Hydroxysteroid dehydrogenase type 1 is known to convert inactive 11-dehydrocorticosterone to active corticosterone. The urinary corticosterone/11-dehydrocorticosterone ratio as well as urinary excretion of corticosterone was higher in Dahl salt-sensitive rats than in SS-13BN rats. Knockdown of renal medullary 11β-hydroxysteroid dehydrogenase type 1 with small-interfering RNA attenuated the early phase of salt-induced hypertension in Dahl salt-sensitive rats and reduced urinary excretion of corticosterone. Knockdown of 11β-hydroxysteroid dehydrogenase type 1 did not affect blood pressure in SS-13BN rats. Long-term attenuation of salt-induced hypertension was achieved with small hairpin RNA targeting renal medullary 11β-hydroxysteroid dehydrogenase type 1. In summary, we have demonstrated that suppression of 11β-hydroxysteroid dehydrogenase type 1 expression in the renal medulla attenuates salt-induced hypertension in Dahl salt-sensitive rats.

Sign in / Sign up

Export Citation Format

Share Document