Malignant Cutaneous Tumors

2018 ◽  
Author(s):  
Allan C Halpern ◽  
Patricia L. Myskowski
Keyword(s):  
Cell Carcinoma ◽  
Malignant Tumors ◽  
Tnm Classification ◽  
Kaposi Sarcoma ◽  
Dermatofibrosarcoma Protuberans ◽  
Staging System ◽  
Primary Cutaneous Melanoma ◽  
Primary Tumors ◽  
Paget Disease ◽  
Cutaneous Lymphomas

This chapter reviews the most common malignant cutaneous tumors. The section on malignant tumors of the epidermis discusses nonmelanoma skin cancer (i.e., basal cell carcinoma and squamous cell carcinoma) and malignant melanoma. The section on malignant tumors of the dermis covers metastatic tumors, primary tumors (Merkel cell carcinoma, Paget disease, extramammary Paget disease, angiosarcoma, and dermatofibrosarcoma protuberans), and Kaposi sarcoma (i.e., classic Kaposi sarcoma, African Kaposi sarcoma, organ-transplant Kaposi sarcoma, and HIV-associated Kaposi sarcoma). The final section covers cutaneous lymphomas. The coverage of each disease includes a discussion of epidemiology, etiology, diagnosis, differential diagnosis, treatment, and prognosis. Tables provide the adjusted estimated relative risks of melanoma by nevus type and number, the American Joint Committee on Cancer (AJCC) TNM classification and staging system, the estimated probability of 10-year survival in patients with primary cutaneous melanoma, and an overview of overview of therapy for cutaneous T cell lymphoma. Figures illustrate the presentation of many malignant cutaneous tumors. This review contains 10 highly rendered figures, 5 tables, and 105 references.

Malignant Cutaneous Tumors

2018 ◽  
Author(s):  
Allan C Halpern ◽  
Patricia L. Myskowski
Keyword(s):  
Cell Carcinoma ◽  
Malignant Tumors ◽  
Tnm Classification ◽  
Kaposi Sarcoma ◽  
Dermatofibrosarcoma Protuberans ◽  
Staging System ◽  
Primary Cutaneous Melanoma ◽  
Primary Tumors ◽  
Paget Disease ◽  
Cutaneous Lymphomas

This chapter reviews the most common malignant cutaneous tumors. The section on malignant tumors of the epidermis discusses nonmelanoma skin cancer (i.e., basal cell carcinoma and squamous cell carcinoma) and malignant melanoma. The section on malignant tumors of the dermis covers metastatic tumors, primary tumors (Merkel cell carcinoma, Paget disease, extramammary Paget disease, angiosarcoma, and dermatofibrosarcoma protuberans), and Kaposi sarcoma (i.e., classic Kaposi sarcoma, African Kaposi sarcoma, organ-transplant Kaposi sarcoma, and HIV-associated Kaposi sarcoma). The final section covers cutaneous lymphomas. The coverage of each disease includes a discussion of epidemiology, etiology, diagnosis, differential diagnosis, treatment, and prognosis. Tables provide the adjusted estimated relative risks of melanoma by nevus type and number, the American Joint Committee on Cancer (AJCC) TNM classification and staging system, the estimated probability of 10-year survival in patients with primary cutaneous melanoma, and an overview of overview of therapy for cutaneous T cell lymphoma. Figures illustrate the presentation of many malignant cutaneous tumors. This review contains 10 highly rendered figures, 5 tables, and 105 references.

Malignant Cutaneous Tumors

2013 ◽  
Author(s):  
Allan C Halpern ◽  
Patricia L. Myskowski
Keyword(s):  
Cell Carcinoma ◽  
Malignant Tumors ◽  
Tnm Classification ◽  
Kaposi Sarcoma ◽  
Dermatofibrosarcoma Protuberans ◽  
Staging System ◽  
Primary Cutaneous Melanoma ◽  
Primary Tumors ◽  
Paget Disease ◽  
Cutaneous Lymphomas

This chapter reviews the most common malignant cutaneous tumors. The section on malignant tumors of the epidermis discusses nonmelanoma skin cancer (i.e., basal cell carcinoma and squamous cell carcinoma) and malignant melanoma. The section on malignant tumors of the dermis covers metastatic tumors, primary tumors (Merkel cell carcinoma, Paget disease, extramammary Paget disease, angiosarcoma, and dermatofibrosarcoma protuberans), and Kaposi sarcoma (i.e., classic Kaposi sarcoma, African Kaposi sarcoma, organ-transplant Kaposi sarcoma, and HIV-associated Kaposi sarcoma). The final section covers cutaneous lymphomas. The coverage of each disease includes a discussion of epidemiology, etiology, diagnosis, differential diagnosis, treatment, and prognosis. Tables provide the adjusted estimated relative risks of melanoma by nevus type and number, the American Joint Committee on Cancer (AJCC) TNM classification and staging system, the estimated probability of 10-year survival in patients with primary cutaneous melanoma, and an overview of overview of therapy for cutaneous T cell lymphoma. Figures illustrate the presentation of many malignant cutaneous tumors. This review contains 10 highly rendered figures, 5 tables, and 105 references.

scholarly journals PLASTIC SURGERY & ADVANCED SCALP TUMORS: EPIDEMIOLOGICAL PROFILE AND SURGICAL MANAGEMENT ABOUT 65 CASES

2021 ◽  
Vol 9 (5) ◽  
pp. 1171-1177
Author(s):  
Sahibi Mohamed Elmehdi ◽  
Mahrouch El Mehdi ◽  
Yafi Imane ◽  
Elgueouatri Mehdi ◽  
Zineddine Ismail ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Plastic Surgery ◽  
Surgical Management ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Dermatofibrosarcoma Protuberans ◽  
Surgical Excision ◽  
Frequent Site ◽  
Epidemiological Profile

The scalp is the most frequent site of occurrence of malignant tumors. As an area that is generally neglected by the patient and not closely monitored during physical examinations. Plastic surgery has a double interest in the management of malignant tumors of the scalp: it allows oncologic tumor excision and coverage of defects induced. The present study reports 65 cases of giant malignant tumors of the scalp and who underwent surgical management, from January 2011 to June 2019. It included oncologic resection and repair of the defect. The average age in our series was 69.3 years, with a sex ratio of 5.1. Disease duration before consultation was on average 21 months. The location of the tumor was mostly parietal in 75%. The histological types were found in our series: 36 cases of squamous cell carcinoma, 16 cases of basal cell carcinoma, 6 cases of melanoma, 3 cases of trichilemmal carcinoma, 2 cases of dermatofibrosarcoma protuberans and one case of sarcoma and one case of adenoid cystic carcinoma . To cover the defect we used: skin graft in 44 cases and by local flaps in 21 cases. 42 patients benefited from radiotherapy and the evolution was marked by a reactivation in 3 cases of squamous cell carcinoma. The management of malignant tumors of the scalp is surgical and consists of two components: surgical excision and coverage. This repair is achieved through multiple techniques, facilitated by the vascular richness of this anatomical region.

scholarly journals The second modification of a dedicated staging system for lung metastases

2021 ◽  
Author(s):  
Michel Gonzalez ◽  
Marcello Migliore
Keyword(s):  
Classification System ◽  
Curative Resection ◽  
Pulmonary Metastases ◽  
Lung Metastases ◽  
Tnm Classification ◽  
Staging System ◽  
Primary Tumors ◽  
Future Studies ◽  
Results Of Treatment ◽  
Lung Metastasectomy

The topic of pulmonary metastases has long been of high interest and ongoing controversy. There is a group of patients with pulmonary metastases who may benefit from curative resection. It remains unclear which among them will benefit from surgery in terms of survival. This work updates a previously proposed classification system for pulmonary metastases, similar in its essence to the tumor, nodes, metastasis (TNM) classification used for primary tumors and named pmTNM classification, where ‘pm' stands for ‘pulmonary metastasis’. The objective is to allow future studies to explore predictive and survival prognostic factors for pulmonary metastases and separate patients who will benefit from lung metastasectomy from those who will not. The secondary aim is to provide a classification system that will allow physicians, oncologists and surgeons to speak the same language in comparing their data and assessing the results of treatment of lung metastases.

scholarly journals Pathological Level VI Lymph Node Metastasis in Clinical N3b Pyriform Sinus Squamous Cell Carcinoma

2021 ◽  
pp. 000348942110457
Author(s):  
Hidetoshi Matsui ◽  
Shigemichi Iwae ◽  
Yuta Yamamura ◽  
Yuto Horichi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Tnm Classification ◽  
Pyriform Sinus ◽  
Curative Intent ◽  
Node Metastasis

Objective: The frequency of metastasis to level VI lymph nodes in advanced pyriform sinus squamous cell carcinoma (PSSCC) is unknown. We intended to analyze the clinical features and pathological presence or absence of level VI lymph node metastasis in patients with PSSCC. Methods: The data of 270 patients with previously untreated hypopharyngeal squamous cell carcinoma from 2006 to 2016 were obtained. Patients who underwent pharyngolaryngectomy for the pyriform sinus subsite with a curative intent with level VI dissection were included. We retrospectively analyzed the clinical Tumor-Node (TN) status (TNM classification of malignant tumors, eighth edition) and the presence or absence of pathological level VI lymph node metastasis. Results: A total of 34 patients were included. Eight patients (24%) had pathological level VI lymph node metastasis. The rate of pathological level VI lymph node metastasis was directly proportional to the clinical N status ( P = .0002, Chi-square test for trend). In all, 5 patients with cN2b- 3 were classified as cN3b. Ipsilateral pathological level VI lymph node metastasis was observed in 1 patient, and bilateral metastasis was observed in 3 patients. There was no association between clinical T status or pyriform sinus apex invasion and pathological level VI metastasis (both P > .99, Fisher’s exact test). Conclusions: PSSCC with cN3b is prone to bilateral level VI metastasis. We recommend that patients with PSSCC with cN3b should undergo bilateral level VI lymph node dissection.

Long-term outcome of almost 3,000 patients with carcinoma of the esophagus: Evaluation of the new UICC/AJCC staging system.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 64-64 ◽  
Author(s):  
R. Gertler ◽  
T. Schuster ◽  
M. Feith
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tnm Classification ◽  
Staging System ◽  
Tumor Type ◽  
Uicc Stage ◽  
Tumor Site ◽  
Carcinoma Of The Esophagus ◽  
7Th Edition

64 Background: In the new 7th edition of the TNM classification for cancers of the esophagus, the UICC stage groups are still based on the anatomic extent of the tumor alone. In contrast, the AJCC prognostic groupings is the first staging system for esophageal cancer to add histologic tumor type, tumor site and grade. Methods: Data of a single center cohort of 2,920 patients operated for cancers of the esophagus were analyzed. Statistical methods to evaluate survival of the patients and the prognostic performance of the new staging systems included Kaplan-Meier analyzes and time dependent ROC-analysis. Results: UICC stage, R-status, histologic tumor type and age were identified as independent prognostic factors for cancers of the esophagus. Grade and tumor site, additional parameters in the new AJCC prognostic groupings, were not significantly correlated with survival. Patients with esophageal adenocarcinoma had a significantly better long-term prognosis after resection than patients with squamous cell carcinoma (p < 0.0001). The new number-dependent N- classification proved superior to the former site-dependent classification with significantly decreasing prognosis with increasing number of lymph node metastases (p < 0.001). The new subclassification of T1 tumors also revealed significant differences in prognosis between pT1a and pT1b patients (p < 0.001). However, the multiple new UICC and AJCC subgroupings did not prove distinctive for survival between stages IIA and IIB, IIIA and IIIB, and between IIIC and IV. Conclusions: The new 7th edition of the TNM classification improved the predictive ability for cancers of the esophagus, however, stage groups could be condensed to a clinically relevant number. Differences in patient characteristics, pathogenesis and especially survival clearly identify adenocarcinomas and squamous cell carcinoma of the esophagus as two separate tumor entities requiring differentiated therapeutic concepts. No significant financial relationships to disclose.

scholarly journals Skin Cancer: 13-Year Experience at the Department of Dermatology, Hospital Kuala Lumpur, Malaysia

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 79s-79s
Author(s):  
A. Mohd Affandi
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Kaposi Sarcoma ◽  
Kuala Lumpur ◽  
Skin Cancers ◽  
Cutaneous Lymphomas ◽  
Number Of Patients ◽  
Study Results

Background: Unlike other types of cancers, skin cancer has received little attention in Malaysia, and there's little awareness of it among the public. According to the third report of the National Cancer Registry, Malaysia (2003-2005), skin cancer ranked the tenth most common cancer in Malaysia. Aim: The objective of this study was to determine the demography and the types of skin cancers seen in the Department of Dermatology, Hospital Kuala Lumpur. Methods: This was a 13-year retrospective review of all patients with skin cancers seen at the Department of Dermatology, Kuala Lumpur Hospital between 2005-2017. All patients confirmed to have skin cancer histologically were included in this study. Results: The total number of patients diagnosed to have skin cancer between the 13-year period was 426. The mean age of the patients was 59.5 ± 17.8. 56.1% of the patients were male and 43.9% were female. Majority of the patients were Chinese (46.2%), followed by Malay (34.3%), Indian (11.5%) and other ethnic groups (8.0%). The commonest type of skin cancer was basal cell carcinoma (31.9%), followed by cutaneous lymphoma (25.4%) and squamous cell carcinoma (24.2%). Malignant melanoma was not common and accounted for 5.6% of the patients. Other types of skin cancers such as cutaneous metastasis were seen in 4.5% of patients, extramammary Paget's disease in 4.2%, Kaposi sarcoma in 1.9% and other types of tumors accounted for 2.3% of the patients. Majority of the patients with primary cutaneous lymphomas were cutaneous T-cell lymphoma (CTCL), which accounted for 97.2% of all cases of primary cutaneous lymphomas. Conclusion: Basal cell carcinoma was the commonest skin cancer seen at the Department of Dermatology between 2005-2017. This is consistent with the reports from other parts of the world, which reported basal cell carcinoma as the commonest type of skin cancer.

A proposal for a TNM staging system for extramammary Paget disease: Retrospective analysis of 301 patients with invasive primary tumors

2016 ◽  
Vol 83 (3) ◽  
pp. 234-239 ◽  
Author(s):  
Kuniaki Ohara ◽  
Yasuhiro Fujisawa ◽  
Koji Yoshino ◽  
Yoshio Kiyohara ◽  
Takafumi Kadono ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Staging System ◽  
Tnm Staging ◽  
Primary Tumors ◽  
Paget Disease ◽  
Tnm Staging System
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