scholarly journals Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves  -Cell Function Under Stress

Diabetes ◽  
2010 ◽  
Vol 59 (9) ◽  
pp. 2188-2197 ◽  
Author(s):  
D. Gurevitch ◽  
S. Boura-Halfon ◽  
R. Isaac ◽  
G. Shahaf ◽  
M. Alberstein ◽  
...  
Keyword(s):  
Feedback Control ◽  
Signaling Pathway ◽  
Negative Feedback ◽  
Insulin Signaling ◽  
Cell Function ◽  
Insulin Signaling Pathway ◽  
Control Mechanisms ◽  
Negative Feedback Control

scholarly journals Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo

Diabetes ◽  
2017 ◽  
Vol 66 (7) ◽  
pp. 1879-1889 ◽  
Author(s):  
Roi Isaac ◽  
Yaron Vinik ◽  
Sigalit Boura-Halfon ◽  
Lydia Farack ◽  
Sarina Streim ◽  
...  
Keyword(s):  
Feedback Control ◽  
Signaling Pathway ◽  
Negative Feedback ◽  
Insulin Signaling ◽  
Cell Function ◽  
Control Mechanisms ◽  
Β Cell ◽  
Β Cell Function ◽  
Negative Feedback Control

scholarly journals Absence of negative feedback control of bile acid biosynthesis in cultured rat hepatocytes.

1985 ◽  
Vol 260 (25) ◽  
pp. 13459-13463 ◽  
Author(s):  
W M Kubaska ◽  
E C Gurley ◽  
P B Hylemon ◽  
P S Guzelian ◽  
Z R Vlahcevic
Keyword(s):  
Bile Acid ◽  
Feedback Control ◽  
Negative Feedback ◽  
Rat Hepatocytes ◽  
Acid Biosynthesis ◽  
Bile Acid Biosynthesis ◽  
Cultured Rat Hepatocytes ◽  
Negative Feedback Control

scholarly journals Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2268
Author(s):  
Dina Medina-Vera ◽  
Juan Antonio Navarro ◽  
Rubén Tovar ◽  
Cristina Rosell-Valle ◽  
Alfonso Gutiérrez-Adan ◽  
...  
Keyword(s):  
Oral Administration ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Insulin Response ◽  
Pharmacological Action ◽  
Akt Signaling ◽  
Insulin Signaling Pathway ◽  
Acute Administration ◽  
Insulin Sensitizer ◽  
Peripheral Tissues

D-Pinitol (DPIN) is a natural occurring inositol capable of activating the insulin pathway in peripheral tissues, whereas this has not been thoroughly studied in the central nervous system. The present study assessed the potential regulatory effects of DPIN on the hypothalamic insulin signaling pathway. To this end we investigated the Phosphatidylinositol-3-kinase (PI3K)/Protein Kinase B (Akt) signaling cascade in a rat model following oral administration of DPIN. The PI3K/Akt-associated proteins were quantified by Western blot in terms of phosphorylation and total expression. Results indicate that the acute administration of DPIN induced time-dependent phosphorylation of PI3K/Akt and its related substrates within the hypothalamus, indicating an activation of the insulin signaling pathway. This profile is consistent with DPIN as an insulin sensitizer since we also found a decrease in the circulating concentration of this hormone. Overall, the present study shows the pharmacological action of DPIN in the hypothalamus through the PI3K/Akt pathway when giving in fasted animals. These findings suggest that DPIN might be a candidate to treat brain insulin-resistance associated disorders by activating insulin response beyond the insulin receptor.

scholarly journals Effects of resveratrol on the insulin signaling pathway of obese mice

2014 ◽  
Vol 15 (2) ◽  
pp. 179 ◽  
Author(s):  
Hyun Ju Hong ◽  
Wonyoung Kang ◽  
Dong Geon Kim ◽  
Dae Ho Lee ◽  
Youngjae Lee ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Insulin Signaling ◽  
Insulin Signaling Pathway ◽  
Obese Mice
Sign in / Sign up

Export Citation Format

Share Document