scholarly journals Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population

Diabetes ◽  
2015 ◽  
Vol 64 (7) ◽  
pp. 2646-2657 ◽  
Author(s):  
Robert L. Hanson ◽  
Rong Rong ◽  
Sayuko Kobes ◽  
Yunhua Li Muller ◽  
E. Jennifer Weil ◽  
...  
Diabetes Care ◽  
2010 ◽  
Vol 33 (11) ◽  
pp. 2383-2389 ◽  
Author(s):  
H. C. Looker ◽  
J. Krakoff ◽  
V. Andre ◽  
K. Kobus ◽  
R. G. Nelson ◽  
...  

2017 ◽  
Vol 19 (4) ◽  
pp. 622-629 ◽  
Author(s):  
Stephanie K Tanamas ◽  
Sanil P Reddy ◽  
Melissa A Chambers ◽  
Elena J Clark ◽  
Diana L Dunnigan ◽  
...  

Author(s):  
Vasiuddin Khan ◽  
Deepti Bhatt ◽  
Shahbaz Khan ◽  
AMIT KUMAR VERMA ◽  
Rameez Hasan ◽  
...  

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disease described by hyperglycemia, which is caused by insulin resistance or reduced insulin secretion. Interaction between various genetic variants and environmental factors triggers T2DM. The main aim of this study was to find the risk associated with genetic variant (rs5210) of KCNJ11gene in the development of T2D in Indian Population. A total number of 300 cases of T2D and 100 control samples were studied to find the polymorphism in KCNJ11 through PCR-RFLP. The genotype and allele frequencies in T2DM cases were significantly different from the control population. We found a significant association of KCNJ11 (rs5210) gene polymorphism with T2DM in North Indian patients indicating the role of this variant in developing risk for T2DM.


Genomics ◽  
2019 ◽  
Vol 111 (4) ◽  
pp. 980-985 ◽  
Author(s):  
Nirali Rathwa ◽  
Roma Patel ◽  
Sayantani Pramanik Palit ◽  
A.V. Ramachandran ◽  
Rasheedunnisa Begum

1999 ◽  
Vol 1 (2) ◽  
pp. 44-57 ◽  
Author(s):  
Frank Varon ◽  
Lynn Mack-Shipman

Abstract Diabetes mellitus, specifically type 2 diabetes, is one of the major public health issues facing the world in the 21st Century. This article summarizes the rapid changes in the management of diabetes and its impact on dental practice. The reader will find many “hyperlinks” to other diabetes information on the Internet throughout this article as these links provide greater detail. The incidence of type 1 diabetes has increased slowly, while that of type 2 diabetes has increased explosively. The worldwide incidence of type 2 is likely to double by the year 2010 due in large part to changing lifestyles, longer life expectancy, and rapid growth of ethnic and racial populations that have high prevalence rates. There are 15.7 million people or 5.9% of the population in the United States who have diabetes. While an estimated 10.3 million have been diagnosed, it is unfortunate that 5.4 million people are not aware they have the disease. Diabetic dental patient management strategies are presented. Dental professionals are urged to remain current in their knowledge of this disease in order to provide proper care for their patients.


2019 ◽  
Vol 26 (19) ◽  
pp. 3613-3619 ◽  
Author(s):  
Paloma Almeda-Valdes ◽  
Roberto J. Herrera-Mercadillo ◽  
Carlos A. Aguilar-Salinas ◽  
Misael Uribe ◽  
Nahum Méndez-Sánchez

Metabolic syndrome is a frequent metabolic disorder characterized by obesity and insulin resistance seems to be the main pathophysiological alteration. The goal of treating metabolic syndrome is to reduce the risk of coronary heart disease and the development of type 2 diabetes. The lifestyle modification therapy combines specific recommendations on diet alone or combined with other strategies. In this review, we address the following topics: 1) the importance of the high prevalence of metabolic syndrome and obesity, and 2) the role of lifestyle modification focusing on dietary fat intake in the management of MS.


2017 ◽  
Vol 119 (1) ◽  
pp. 31-36.e1 ◽  
Author(s):  
Lyle G. Best ◽  
Crystal Azure ◽  
Alexandre Segarra ◽  
Kendra J. Enright ◽  
Shawn Hamley ◽  
...  

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