Secular Trends in Treatment and Control of Type 2 Diabetes in an American Indian Population: A 30-Year Longitudinal Study

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disease described by hyperglycemia, which is caused by insulin resistance or reduced insulin secretion. The interaction between various genetic variants and environmental factors triggers T2DM. The aim of this study was to find risk associated with genetic variants rs5210 and rs2237895 of KCNJ11 and KCNQ1 genes, respectively, in the development of T2DM in the Indian population. A total number of 300 cases of T2DM and 100 control samples were studied to find the polymorphism in KCNJ11 and KCNQ1 through PCR-RFLP. The genotype and allele frequencies in T2DM cases were significantly different compared to the control population. KCNJ11 rs5210 and KCNQ1 rs2237895 variants were found to be significantly associated with risk of T2DM in dominant (KCNJ11: OR, 2.07; 95% CI, 1.30–3.27; p−0.001; KCNQ1: OR, 2.33; 95% CI, 1.46–3.70; p−0.0003) and codominant models (KCNJ11: OR, 1.76; 95% CI, 1.09–2.84; p−0.020; KCNQ1: OR, 1.85; 95% CI, 1.16–2.95; p−0.009). We also compared clinicopathological characteristics between cases and control and observed a significant difference in all the parameters except HDL, gender, and family history. In this study, clinicopathological data with a carrier of a variant allele of both KCNJ11 and KCNQ1 genes were also analysed, and a significant association was found between the carrier of a variant allele with gender and PPG in KCNJ11 and with triglyceride in KCNQ1. We confirm the significant association of KCNJ11 (rs5210) and KCNQ1 (rs2237895) gene polymorphism with T2DM, indicating the role of these variants in developing risk for T2DM in Indian population.

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Serum lipids and mortality in an American Indian population: A longitudinal study

Journal of Diabetes and its Complications ◽

10.1016/j.jdiacomp.2017.09.015 ◽

2018 ◽

Vol 32 (1) ◽

pp. 18-26 ◽

Cited By ~ 1

Author(s):

Stephanie K. Tanamas ◽

Pierre-Jean Saulnier ◽

Robert L. Hanson ◽

Robert G. Nelson ◽

Wen-Chi Hsueh ◽

...

Keyword(s):

Longitudinal Study ◽

American Indian ◽

Serum Lipids ◽

Indian Population ◽

American Indian Population

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Abstract #251: Prevalence of Vitamin D Deficiency in Type 2 Diabetes Patients in North Indian Population and its Correlation with Diabetic Complications and Comorbidities

Endocrine Practice ◽

10.1016/s1530-891x(20)44959-6 ◽

2016 ◽

Vol 22 ◽

pp. 56-57

Author(s):

Brij Makkar ◽

Namrata Harichandan ◽

Jugal Sharma ◽

Rajeev Chawla ◽

Shalini Jaggi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Diabetic Complications ◽

Indian Population ◽

North Indian Population ◽

Diabetes Patients

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Quantitative ultrasonometry of the phalanges in post-menopausal women with type 2 diabetes mellitus: the first results of a 3-year longitudinal study

Bone Abstracts ◽

10.1530/boneabs.3.pp277 ◽

2014 ◽

Author(s):

Cosimo Neglia ◽

Nadia Agnello ◽

Alberto Argentiero ◽

Giovanna Chitano ◽

Elena Gianicolo ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Longitudinal Study ◽

Menopausal Women ◽

First Results ◽

Quantitative Ultrasonometry ◽

Post Menopausal

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1701-P: Genome-Wide Association Study Identifies Novel Potential Associations with Birth Weight in a Southwestern American Indian Population

Diabetes ◽

10.2337/db19-1701-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 1701-P

Author(s):

LAUREN E. WEDEKIND ◽

WEN-CHI HSUEH ◽

SAYUKO KOBES ◽

MUIDEEN T. OLAIYA ◽

WILLIAM C. KNOWLER ◽

...

Keyword(s):

Birth Weight ◽

American Indian ◽

Association Study ◽

Indian Population ◽

Genome Wide Association Study ◽

Genome Wide Association ◽

American Indian Population ◽

Genome Wide

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Relative risk of cardiovascular disease is higher in women with type 2 diabetes, but not in those with prediabetes, as compared with men

10.2337/figshare.12915272 ◽

2020 ◽

Author(s):

Elena Succurro ◽

Teresa Vanessa Fiorentino ◽

Sofia Miceli ◽

Maria Perticone ◽

Angela Sciacqua ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Longitudinal Study ◽

Relative Risk ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Adverse Outcomes ◽

Cross Sectional ◽

Normal Glucose

Objective: Most, but not all studies suggested that women with type 2 diabetes have higher relative risk (RR) for cardiovascular disease (CVD) than men. More uncertainty exists on whether the RR for CVD is higher in prediabetic women compared to men. Research Design and Methods: In a cross-sectional study, in 3540 normal glucose tolerant (NGT), prediabetic, and diabetic adults, we compared the RR for prevalent non-fatal CVD between men and women. In a longitudinal study including 1658 NGT, prediabetic, and diabetic adults, we compared the RR for incident major adverse outcomes, including all-cause death, coronary heart disease, and cerebrovascular disease events after 5.6 years follow-up. Results: Women with prediabetes and diabetes exhibited greater relative differences in BMI, waist circumference, blood pressure, total, LDL and HDL cholesterol, triglycerides, fasting glucose, hsCRP, and white blood cell count than men with prediabetes and diabetes when compared with their NGT counterparts. We found a higher RR for prevalent CVD in diabetic women (RR 9.29; 95% CI 4.73-18.25; P<0.0001) than in men (RR 4.56; 95% CI 3.07-6.77; P<0.0001), but no difference in RR for CVD was observed comparing prediabetic women and men. In the longitudinal study, we found that diabetic, but not prediabetic women have higher RR (RR 5.25; 95% CI 3.22-8.56; P<0.0001) of incident major adverse outcomes than their male counterparts (RR 2.72; 95% CI 1.81-4.08; P<0.0001). Conclusions: This study suggests that diabetic, but not prediabetic, women have higher RR for prevalent and incident major adverse outcomes than men.

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Prevalence, awareness, treatment and control of type 2 diabetes mellitus in a semi-urban area of Nepal

10.26226/morressier.59d5184ad462b80296ca3228 ◽

2017 ◽

Author(s):

Bishal Gyawali

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Urban Area ◽

And Control

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Epidemiology of Hypertension and Diabetes Mellitus in Latin America

Current Hypertension Reviews ◽

10.2174/1573402116999200917152952 ◽

2020 ◽

Vol 16 ◽

Author(s):

Patricio Lopez-Jaramillo ◽

Jose Lopez-Lopez ◽

Daniel Cohen ◽

Natalia Alarcon-Ariza ◽

Margarita Mogollon-Zehr

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Latin America ◽

Cardiovascular Diseases ◽

Latin American ◽

Premature Mortality ◽

Increased Risk ◽

And Control

: Hypertension and type 2 diabetes mellitus are two important risk factors that contribute to cardiovascular diseases worldwide. In Latin America hypertension prevalence varies from 30 to 50%. Moreover, the proportion of awareness, treatment and control of hypertension is very low. The prevalence of type 2 diabetes mellitus varies from 8 to 13% and near to 40% are unaware of their condition. In addition, the prevalence of prediabetes varies from 6 to 14% and this condition has been also associated with increased risk of cardiovascular diseases. The principal factors linked to a higher risk of hypertension in Latin America are increased adiposity, low muscle strength, unhealthy diet, low physical activity and low education. Besides being chronic conditions, leading causes of cardiovascular mortality, both hypertension and type 2 diabetes mellitus represent a substantial cost for the weak health systems of Latin American countries. Therefore, is necessary to implement and reinforce public health programs to improve awareness, treatment and control of hypertension and type 2 diabetes mellitus, in order to reach the mandate of the Unit Nations of decrease the premature mortality for CVD.

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