scholarly journals Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling

Diabetes ◽  
2019 ◽  
Vol 68 (5) ◽  
pp. 1062-1072 ◽  
Author(s):  
Geoffrey P. Roberts ◽  
Pierre Larraufie ◽  
Paul Richards ◽  
Richard G. Kay ◽  
Sam G. Galvin ◽  
...  
Keyword(s):  
Enteroendocrine Cells ◽  
Peptidomic Profiling

scholarly journals Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling

2018 ◽  
Author(s):  
Geoffrey P Roberts ◽  
Pierre Larraufie ◽  
Paul Richards ◽  
Richard G Kay ◽  
Sam G Galvin ◽  
...  
Keyword(s):  
Peptide Hormone ◽  
G Protein Coupled Receptors ◽  
Enteroendocrine Cells ◽  
Sequencing Analysis ◽  
Liquid Chromatography Mass Spectrometry ◽  
Food Absorption ◽  
G Protein Coupled ◽  
Diabetes And Obesity ◽  
Human And Mouse ◽  
Peptidomic Profiling

AbstractEnteroendocrine cells (EECs) produce hormones that regulate food absorption, insulin secretion and appetite. Both EECs and their peptide products are foci of drug discovery programmes for diabetes and obesity. We compared the human and mouse EEC transcriptome and peptidome to validate mouse as a model of the human enteroendocrine axis. We present the first RNA sequencing analysis of human EECs, and demonstrate strong correlation with mouse, although with outliers including some low abundance G-protein coupled receptors. Liquid chromatography mass spectrometry (LC-MS) identified peptide hormone gradients along the human and mouse gut that should enhance progress in gut physiology and therapeutics.

The Preprohormone Expression Profile of Enteroendocrine Cells following Roux-en-Y Gastric Bypass in Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1981-P
Author(s):  
LISE BIEHL RUDKJAER ◽  
CHEN ZHANG ◽  
KRISTOFFER RIGBOLT ◽  
SØREN L. PEDERSEN ◽  
MECHTHILDE FALKENHAHN ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Expression Profile ◽  
Enteroendocrine Cells

scholarly journals The Specification and Function of Enteroendocrine Cells in Drosophila and Mammals: A Comparative Review

FEBS Journal ◽  
2021 ◽  
Author(s):  
Xingting Guo ◽  
Jiaying Lv ◽  
Rongwen Xi
Keyword(s):  
Enteroendocrine Cells ◽  
Comparative Review ◽  
And Function

scholarly journals The Function of Gastrointestinal Hormones in Obesity—Implications for the Regulation of Energy Intake

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1839
Author(s):  
Mona Farhadipour ◽  
Inge Depoortere
Keyword(s):  
Energy Homeostasis ◽  
Gastric Bypass Surgery ◽  
Gastrointestinal Hormones ◽  
Enteroendocrine Cells ◽  
Hormone Balance ◽  
Gut Hormone ◽  
Control Food ◽  
Induce Weight Loss ◽  
Novel Strategy ◽  
Control Food Intake

The global burden of obesity and the challenges of prevention prompted researchers to investigate the mechanisms that control food intake. Food ingestion triggers several physiological responses in the digestive system, including the release of gastrointestinal hormones from enteroendocrine cells that are involved in appetite signalling. Disturbed regulation of gut hormone release may affect energy homeostasis and contribute to obesity. In this review, we summarize the changes that occur in the gut hormone balance during the pre- and postprandial state in obesity and the alterations in the diurnal dynamics of their plasma levels. We further discuss how obesity may affect nutrient sensors on enteroendocrine cells that sense the luminal content and provoke alterations in their secretory profile. Gastric bypass surgery elicits one of the most favorable metabolic outcomes in obese patients. We summarize the effect of different strategies to induce weight loss on gut enteroendocrine function. Although the mechanisms underlying obesity are not fully understood, restoring the gut hormone balance in obesity by targeting nutrient sensors or by combination therapy with gut peptide mimetics represents a novel strategy to ameliorate obesity.

The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi-infected individuals with chagasic megacolon

2021 ◽  
Author(s):  
Patrícia Rocha Martins ◽  
Josiane Fakhry ◽  
Adriana Jacaúna de Oliveira ◽  
Thayse Batista Moreira ◽  
Linda J. Fothergill ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Enteroendocrine Cells ◽  
Chagasic Megacolon ◽  
Chemical Coding

Immunohistochemical relationships of huntingtin-associated protein 1 with enteroendocrine cells in the pyloric mucosa of the rat stomach

2020 ◽  
Vol 122 (8) ◽  
pp. 151650
Author(s):  
Akie Yanai ◽  
Md Nabiul Islam ◽  
Maki Hayashi-Okada ◽  
Mir Rubayet Jahan ◽  
Abu Md Mamun Tarif ◽  
...  
Keyword(s):  
Enteroendocrine Cells ◽  
Rat Stomach ◽  
Pyloric Mucosa
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