1702-P: Fine-Scale Haplotype Mapping of PPM1K Gene Reveals New Genetic Markers for the Study of Insulin Resistance at Clinical Scale

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1702-P
Author(s):  
SARA HAYDAR ◽  
CORINNE LAUTIER ◽  
FLORIN GRIGORESCU
Keyword(s):  
Insulin Resistance ◽  
Genetic Markers ◽  
Fine Scale ◽  
Clinical Scale ◽  
Haplotype Mapping

scholarly journals Tissue inhibitor of metalloproteinases (TIMP-1), genetic markers of insulin resistance and cardiomyopathy in patients with kidney failure

2011 ◽  
Vol 27 (6) ◽  
pp. 2440-2445 ◽  
Author(s):  
B. Spoto ◽  
A. Testa ◽  
R. M. Parlongo ◽  
G. Tripepi ◽  
G. D'Arrigo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Genetic Markers ◽  
Kidney Failure ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor

scholarly journals GESTATIONAL DIABETES MELLITUS: GENETIC MARKERS OF INSULIN RESISTANCE, DIAGNOSTIC CRITERIA AND MANAGEMENT TACTICS

2020 ◽  
Vol 18 (6) ◽  
pp. 732-738
Author(s):  
L. V. Nikonova ◽  
◽  
S. V. Tishkovskiy ◽  
O. S. Butrim ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Diagnostic Criteria ◽  
Genetic Markers ◽  
Metabolic Disorder ◽  
Depth Study

Gestational diabetes mellitus is the most common metabolic disorder in pregnant women. An in-depth study of the pathogenetic mechanisms of the development of gestational diabetes mellitus will allow more accurate prediction of the course, adverse perinatal and long-term metabolic consequences, and will also contribute to the development of effective technologies for the prevention and management of this pathology.

scholarly journals Genetic markers of insulin resistance in gestational diabetes

2009 ◽  
Vol 12 (4) ◽  
pp. 38-41
Author(s):  
Tatiana Vasil'evna Sebko ◽  
Yulia Eduardovna Dobrokhotova ◽  
Tatiana Alekseevna Ivanova ◽  
Valery Vyacheslavovich Nosikov ◽  
Tatiana Alekseevna Osipova ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Genetic Markers ◽  
Molecular Genetic ◽  
Published Data ◽  
Impaired Insulin Secretion ◽  
Kcnj11 Gene ◽  
Impaired Insulin

Aim. To search for genetic markers of insulin resistance and impaired insulin secretion in pregnant women with gestational diabetes mellitus (GDM). Materials and methods. A total of 100 healthy pregnant women and 185 patients with GDM were available for examination. 80 patients developedGDM during current pregnancy, in 105 it was diagnosed 4-19 years ago. 25 of the 105 GDM patients had a history of type 2 DM. The following parameterswere measured: beta-cell secretory activity (proinsulin, ITI, C-peptide), total cholesterol (CH), HDL and LDL CH, triglycerides, HbA1c,fasting glycemia. Molecular-genetic DNA testing using PCR included studies of KCNJ 11, TCF7L2, PPARG2, ADIPOQ, ADIPOR1, ADIPOR2gene polymorphism. These genes were chosen based on the published data associating them with disturbed insulin secretion and sensitivity in DM2patient. Results. Pregnant women with GDM and obesity showed elevated IRI and leptin levels compared with controls. This rise was accompanied bymarked insulin resistance in 75% of these patients. In 50% of the healthy women proinsulin and insulin secretion decreased. Obesity in pregnantpatients was associated with significant elevation of proinsulin, IRI, and C-peptyide levels and GDM with Lys/Lys genotype of polymorphous markerGlu23k of KCNJ11 gene, pro and ala allele of polymorphous marker A219T of ADIPOR2 gene. These associations suggest specific genetic featuresof GDM related to impaired insulin secretion and sensitivity. Conclusion. Studies of common genetic nature of GDM and DM2 permit to identify risk groups at the preclinical stage, plan prevention and treatmentof these disorders.

Classifying disease chromosomes arising from multiple founders, with application to fine-scale haplotype mapping

2004 ◽  
Vol 27 (3) ◽  
pp. 173-181 ◽  
Author(s):  
K. Yu ◽  
R.B. Martin ◽  
A.S. Whittemore
Keyword(s):  
Fine Scale ◽  
Haplotype Mapping

High Resolution Stereography of Complementary Freeze-Fracture Replicas Reveals the Presence of Depressions Opposite Membrane Associated Particles of Split Membranes

1971 ◽  
Vol 29 ◽  
pp. 442-443
Author(s):  
Russell L. Steere
Keyword(s):  
High Resolution ◽  
Cardiac Muscle ◽  
Electron Micrographs ◽  
Chromic Acid ◽  
Freeze Fracture ◽  
Distilled Water ◽  
Fine Scale ◽  
Acid Cleaning ◽  
Cleaning Solution

Complementary replicas have revealed the fact that the two common faces observed in electron micrographs of freeze-fracture and freeze-etch specimens are complementary to each other and are thus the new faces of a split membrane rather than the original inner and outer surfaces (1, 2 and personal observations). The big question raised by published electron micrographs is why do we not see depressions in the complementary face opposite membrane-associated particles? Reports have appeared indicating that some depressions do appear but complementarity on such a fine scale has yet to be shown.Dog cardiac muscle was perfused with glutaraldehyde, washed in distilled water, then transferred to 30% glycerol (material furnished by Dr. Joaquim Sommer, Duke Univ., and VA Hospital, Durham, N.C.). Small strips were freeze-fractured in a Denton Vacuum DFE-2 Freeze-Etch Unit with complementary replica tooling. Replicas were cleaned in chromic acid cleaning solution, then washed in 4 changes of distilled water and mounted on opposite sides of the center wire of a Formvar-coated grid.

HFE genotype and the insulin resistance syndrome among subjects with iron overload

2001 ◽  
Vol 120 (5) ◽  
pp. A565-A565
Author(s):  
J TALWALKAR ◽  
H TORGERSON ◽  
D BRANDHAGEN
Keyword(s):  
Insulin Resistance ◽  
Iron Overload ◽  
Insulin Resistance Syndrome
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