363-OR: ChREBP-Beta Controls Both Proliferation and Cell Death of Pancreatic Beta Cells

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 363-OR
Author(s):  
LIORA S. KATZ ◽  
GABRIEL BRILL ◽  
MARK A. HERMAN ◽  
DONALD SCOTT
Keyword(s):  
Cell Death ◽  
Beta Cells ◽  
Pancreatic Beta Cells

Osteoprotegerin (OPG) protects pancreatic beta cells from Interleukin-1 induced cell death

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
J Schrader ◽  
U Niebergall ◽  
M Schoppet ◽  
D Hörsch ◽  
LC Hofbauer
Keyword(s):  
Cell Death ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Interleukin 1

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

Diabetes ◽  
1995 ◽  
Vol 44 (7) ◽  
pp. 733-738 ◽  
Author(s):  
H. Kaneto ◽  
J. Fujii ◽  
H. G. Seo ◽  
K. Suzuki ◽  
T. Matsuoka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

scholarly journals Phenylpropenoic Acid Glucoside from Rooibos Protects Pancreatic Beta Cells against Cell Death Induced by Acute Injury

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157604 ◽  
Author(s):  
Eddy Himpe ◽  
Daniel A. Cunha ◽  
Imane Song ◽  
Marco Bugliani ◽  
Piero Marchetti ◽  
...  
Keyword(s):  
Cell Death ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Acute Injury

scholarly journals MANF protects human pancreatic beta cells against stress-induced cell death

Diabetologia ◽  
2018 ◽  
Vol 61 (10) ◽  
pp. 2202-2214 ◽  
Author(s):  
Elina Hakonen ◽  
Vikash Chandra ◽  
Christopher L. Fogarty ◽  
Nancy Yiu-Lin Yu ◽  
Jarkko Ustinov ◽  
...  
Keyword(s):  
Cell Death ◽  
Beta Cells ◽  
Pancreatic Beta Cells

scholarly journals Mesencephalic astrocyte-derived neurotrophic factor is secreted from interferon-γ–activated tumor cells through ER calcium depletion

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250178
Author(s):  
Michael Peled ◽  
Tali H. Bar-Lev ◽  
Efrosiniia Talalai ◽  
Haggar Zoë Aspitz ◽  
Inbal Daniel-Meshulam ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Tumor Cells ◽  
Beta Cells ◽  
Neurotrophic Factor ◽  
Pancreatic Beta Cells ◽  
Interferon Γ ◽  
Calcium Depletion ◽  
Ifn Γ ◽  
Er Calcium

The most successful immunotherapeutic agents are blocking antibodies to either programmed cell death-1 (PD-1), an inhibitory receptor expressed on T lymphocytes, or to its ligand, programmed cell death-ligand 1 (PD-L1). Nevertheless, many patients do not respond, and additional approaches, specifically blocking other inhibitory receptors on T cells, are being explored. Importantly, the source of the ligands for these receptors are often the tumor cells. Indeed, cancer cells express high levels of PD-L1 upon stimulation with interferon-γ (IFN-γ), a major cytokine in the tumor microenvironment. The increase in PD-L1 expression serves as a negative feedback towards the immune system, and allows the tumor to evade the attack of immune cells. A potential novel immunoregulator is mesencephalic astrocyte-derived neurotrophic factor (MANF), an endoplasmic reticulum (ER)-resident protein that is secreted from pancreatic beta cells upon cytokines activation, and can induce an alternatively activated macrophage phenotype (M2), and thus may support tumor growth. While MANF was shown to be secreted from pancreatic beta cells, its IFN-γ-induced secretion from tumor cells has never been assessed. Here we found that IFN-γ induced MANF secretion from diverse tumor cell-lines—melanoma cells, colon carcinoma cells and hepatoma cells. Mechanistically, there was no increase in MANF RNA or intracellular protein levels upon IFN-γ stimulation. However, IFN-γ induced ER calcium depletion, which was necessary for MANF secretion, as Dantrolene, an inhibitor of ER calcium release, prevented its secretion. Thus, MANF is secreted from IFN-γ-stimulated tumor cells, and further studies are required to assess its potential as a drug target for cancer immunotherapy.

Protective effect of 15-deoxy-delta12,14-prostaglandin J2 on cell death induced by nitric oxide in pancreatic beta cells

2002 ◽  
Vol 1245 ◽  
pp. 415-416
Author(s):  
Yuki Ueno ◽  
Toshihiko Osawa ◽  
Jun-ichi Miyazaki ◽  
Koji Uchida
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Protective Effect ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Prostaglandin J2

scholarly journals S-Equol Enantioselectively Activates cAMP-Protein Kinase A Signaling and Reduces Alloxan-Induced Cell Death in INS-1 Pancreatic ^|^beta;-Cells

2014 ◽  
Vol 60 (4) ◽  
pp. 291-296 ◽  
Author(s):  
Hiroko HORIUCHI ◽  
Naoki HARADA ◽  
Tetsuya ADACHI ◽  
Yoshihisa NAKANO ◽  
Hiroshi INUI ◽  
...  
Keyword(s):  
Cell Death ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Kinase A
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