244-OR: Toward Improved Identification of Adult-Onset Type 1 Diabetes (T1D): Clinical Characteristics Associated with T1D Polygenic Risk Scores in the Million Veteran Program (MVP)

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 244-OR
Author(s):  
PETER K. YANG ◽  
SANDRA JACKSON ◽  
BRIAN R. CHAREST ◽  
MICHAEL N. WEEDON ◽  
YILING J. CHENG ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Clinical Characteristics ◽  
Risk Scores ◽  
Adult Onset ◽  
Polygenic Risk ◽  
Onset Type

scholarly journals Genetic risk scores in adult-onset type 1 diabetes – Authors' reply

2018 ◽  
Vol 6 (3) ◽  
pp. 169
Author(s):  
Nicholas J Thomas ◽  
Samuel E Jones ◽  
Michael N Weedon ◽  
Beverley M Shields ◽  
Andrew T Hattersley ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Risk ◽  
Risk Scores ◽  
Adult Onset ◽  
Onset Type ◽  
Genetic Risk Scores

scholarly journals Genetic risk scores in adult-onset type 1 diabetes

2018 ◽  
Vol 6 (3) ◽  
pp. 168-169 ◽  
Author(s):  
Richard David Leslie ◽  
Åke Lernmark
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Risk ◽  
Risk Scores ◽  
Adult Onset ◽  
Onset Type ◽  
Genetic Risk Scores

scholarly journals Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes

Diabetes Care ◽  
2000 ◽  
Vol 23 (9) ◽  
pp. 1326-1332 ◽  
Author(s):  
E. Sabbah ◽  
K. Savola ◽  
T. Ebeling ◽  
P. Kulmala ◽  
P. Vahasalo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Clinical Characteristics ◽  
Adult Onset ◽  
Onset Type

scholarly journals DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life

Diabetologia ◽  
2021 ◽  
Author(s):  
Nicholas J. Thomas ◽  
John M. Dennis ◽  
Seth A. Sharp ◽  
Akaal Kaur ◽  
Shivani Misra ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Major Type ◽  
Diabetes Incidence ◽  
Diabetes Diagnosis ◽  
Risk Haplotype ◽  
Adult Onset ◽  
Uk Biobank ◽  
Onset Type ◽  
Increased Risk

Abstract Aims/hypothesis Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought to quantify DR15-DQ6 protection against type 1 diabetes as age of onset increased. Methods In two independent cohorts we assessed the proportion of type 1 diabetes cases presenting through the first 50 years of life with DR15-DQ6, compared with population controls. In the After Diabetes Diagnosis Research Support System-2 (ADDRESS-2) cohort (n = 1458) clinician-diagnosed type 1 diabetes was confirmed by positivity for one or more islet-specific autoantibodies. In UK Biobank (n = 2502), we estimated type 1 diabetes incidence rates relative to baseline HLA risk for each HLA group using Poisson regression. Analyses were restricted to white Europeans and were performed in three groups according to age at type 1 diabetes onset: 0–18 years, 19–30 years and 31–50 years. Results DR15-DQ6 was protective against type 1 diabetes through to age 50 years (OR < 1 for each age group, all p < 0.001). The following ORs for type 1 diabetes, relative to a neutral HLA genotype, were observed in ADDRESS-2: age 5–18 years OR 0.16 (95% CI 0.08, 0.31); age 19–30 years OR 0.10 (0.04, 0.23); and age 31–50 years OR 0.37 (0.21, 0.68). DR15-DQ6 also remained highly protective at all ages in UK Biobank. Without DR15-DQ6, the presence of major type 1 diabetes high-risk haplotype (either DR3-DQ2 or DR4-DQ8) was associated with increased risk of type 1 diabetes. Conclusions/interpretation HLA DR15-DQ6 confers dominant protection from type 1 diabetes across the first five decades of life. Graphical abstract

scholarly journals Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes

Diabetologia ◽  
2007 ◽  
Vol 50 (11) ◽  
pp. 2276-2279 ◽  
Author(s):  
Y. M. Cho ◽  
J. T. Kim ◽  
K. S. Ko ◽  
B. K. Koo ◽  
S. W. Yang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Adult Onset ◽  
Fulminant Type 1 Diabetes ◽  
Onset Type ◽  
High Prevalence ◽  
Fulminant Type

scholarly journals Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes

Endocrine ◽  
2015 ◽  
Vol 49 (3) ◽  
pp. 693-702 ◽  
Author(s):  
Ananta Poudel ◽  
Omid Savari ◽  
Deborah A. Striegel ◽  
Vipul Periwal ◽  
Jerome Taxy ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Adult Onset ◽  
Onset Type ◽  
Beta Cell Destruction ◽  
Cell Destruction

Adult-Onset Type 1 Diabetes: A Qualitative Study of Decision-Making Needs

2016 ◽  
Vol 40 (2) ◽  
pp. 164-169 ◽  
Author(s):  
Janet Jull ◽  
Holly O. Witteman ◽  
Judi Ferne ◽  
Manosila Yoganathan ◽  
Dawn Stacey
Keyword(s):  
Decision Making ◽  
Type 1 Diabetes ◽  
Qualitative Study ◽  
Adult Onset ◽  
Onset Type

scholarly journals Adult-Onset Type 1 Diabetes: Current Understanding and Challenges

Diabetes Care ◽  
2021 ◽  
Vol 44 (11) ◽  
pp. 2449-2456
Author(s):  
R. David Leslie ◽  
Carmella Evans-Molina ◽  
Jacquelyn Freund-Brown ◽  
Raffaella Buzzetti ◽  
Dana Dabelea ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Current Understanding ◽  
Adult Onset ◽  
Onset Type

BONE MINERAL DENSITY AT TIME OF CLINICAL DIAGNOSIS OF ADULT-ONSET TYPE 1 DIABETES MELLITUS

2001 ◽  
Vol 7 (5) ◽  
pp. 346-351 ◽  
Author(s):  
Pablo-José López-Ibarra ◽  
Ma Mar Campos Pastor ◽  
Fernando Escobar-Jiménez ◽  
Ma Dolores Serrano Pardo ◽  
Antonio García González ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Diagnosis ◽  
Bone Mineral ◽  
Adult Onset ◽  
Mineral Density ◽  
Onset Type
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