scholarly journals Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S.

Diabetes Care ◽  
2020 ◽  
Vol 44 (1) ◽  
pp. 231-239
Author(s):  
John Epoh Dibato ◽  
Olga Montvida ◽  
Francesco Zaccardi ◽  
Jack Alistair Sargeant ◽  
Melanie J. Davies ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Cardiovascular Events ◽  
Adult Type ◽  
The U.S

scholarly journals Association of cardiometabolic multimorbidity and depression with cardiovascular events in early-onset adult type 2 diabetes: a multi-ethnic study in the USA

2020 ◽  
Author(s):  
John Epoh Dibato ◽  
Olga Montvida ◽  
Francesco Zaccardi ◽  
Jack Alistair Sargeant ◽  
Melanie J Davies ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Ethnic Groups ◽  
Early Onset ◽  
Age Groups ◽  
Atherosclerotic Cardiovascular Disease ◽  
Diabetes Diagnosis ◽  
Adult Type ◽  
The Usa

<b>Objective: </b>To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasian (WC) and African American (AA) with early-onset type 2 diabetes, and their impact on long-term Atherosclerotic Cardiovascular Disease (ASCVD). <p><b>Research Design and Methods: </b>From US electronic medical record, 101,104 AA and 505,336 WC subjects with type 2 diabetes diagnosis between 2000-2017 were identified (mean follow-up: 5.3 years). Among those without ASCVD at diagnosis, risk of ASCVD and MACE-3 (HF, myocardial infarction, or stroke) was evaluated between ethnicities by age groups. </p> <p><b>Results: </b>Proportion of patients diagnosed at <50 years increased during 2012-2017 (AA: 34-38%; WC: 26-29%). Depression prevalence increased during 2000-2017 (AA: 15-23%; WC: 20-34%) with an increasing trend for CM at diagnosis in both groups. </p> <p>Compared to WC, the adjusted MACE-3 risk was significantly higher in AA across all age groups, more pronounced in 18-39 years group (HR CI: 1.42-1.88) and in people with and without depression. AA had 17% (HR CI: 1.05-1.31) significantly higher adjusted ASCVD risk in the 18-39 years group only. Depression was independently associated with ASCVD and MACE-3 risk in both ethnic groups across all age groups. Other comorbidities were independently associated with ASCVD and MACE-3 risk only among WC. </p> <p><b>Conclusions: </b>AA have higher cardiovascular risk compared to WC, particularly in early-onset T2DM. CM and depression at diabetes diagnosis has been increasing over last two decades in both ethnic groups.<b> </b>Strategies for screening and optimal management of CM and depression particularly in early-onset T2DM may result in a lower cardiovascular risk. </p>

scholarly journals Association of cardiometabolic multimorbidity and depression with cardiovascular events in early-onset adult type 2 diabetes: a multi-ethnic study in the USA

2020 ◽  
Author(s):  
John Epoh Dibato ◽  
Olga Montvida ◽  
Francesco Zaccardi ◽  
Jack Alistair Sargeant ◽  
Melanie J Davies ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Ethnic Groups ◽  
Early Onset ◽  
Age Groups ◽  
Atherosclerotic Cardiovascular Disease ◽  
Diabetes Diagnosis ◽  
Adult Type ◽  
The Usa

<b>Objective: </b>To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasian (WC) and African American (AA) with early-onset type 2 diabetes, and their impact on long-term Atherosclerotic Cardiovascular Disease (ASCVD). <p><b>Research Design and Methods: </b>From US electronic medical record, 101,104 AA and 505,336 WC subjects with type 2 diabetes diagnosis between 2000-2017 were identified (mean follow-up: 5.3 years). Among those without ASCVD at diagnosis, risk of ASCVD and MACE-3 (HF, myocardial infarction, or stroke) was evaluated between ethnicities by age groups. </p> <p><b>Results: </b>Proportion of patients diagnosed at <50 years increased during 2012-2017 (AA: 34-38%; WC: 26-29%). Depression prevalence increased during 2000-2017 (AA: 15-23%; WC: 20-34%) with an increasing trend for CM at diagnosis in both groups. </p> <p>Compared to WC, the adjusted MACE-3 risk was significantly higher in AA across all age groups, more pronounced in 18-39 years group (HR CI: 1.42-1.88) and in people with and without depression. AA had 17% (HR CI: 1.05-1.31) significantly higher adjusted ASCVD risk in the 18-39 years group only. Depression was independently associated with ASCVD and MACE-3 risk in both ethnic groups across all age groups. Other comorbidities were independently associated with ASCVD and MACE-3 risk only among WC. </p> <p><b>Conclusions: </b>AA have higher cardiovascular risk compared to WC, particularly in early-onset T2DM. CM and depression at diabetes diagnosis has been increasing over last two decades in both ethnic groups.<b> </b>Strategies for screening and optimal management of CM and depression particularly in early-onset T2DM may result in a lower cardiovascular risk. </p>

Semaglutide Consistently Reduces Cardiovascular Events in Both Male and Female Subjects with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1085-P ◽  
Author(s):  
IRENE HRAMIAK ◽  
CYRUS DESOUZA ◽  
JOCHEN SEUFERT ◽  
THOMAS HANSEN ◽  
DESIREE THIELKE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Events ◽  
Male And Female ◽  
Female Subjects

98-OR: Placental DNA Methylation Changes Associated with Birthweight and Overlaps with Adult Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 98-OR
Author(s):  
FASIL TEKOLA-AYELE ◽  
TSEGASELASSIE WORKALEMAHU ◽  
XUEHUO ZENG
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Adult Type

427-P: Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Are Mutually Independent Predictors of Cardiovascular Events in Patients with Established Cardiovascular Disease

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 427-P
Author(s):  
CHRISTOPH H. SAELY ◽  
ALEXANDER VONBANK ◽  
MAXIMILIAN MAECHLER ◽  
BARBARA LARCHER ◽  
LUKAS SPRENGER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Cardiovascular Events ◽  
Nonalcoholic Fatty Liver ◽  
Mutually Independent

415-P: Remnant Cholesterol in Patients with Established Coronary Artery Disease Predicts Cardiovascular Events Both among Patients with Type 2 Diabetes and among Nondiabetic Subjects

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 415-P
Author(s):  
CHRISTOPH H. SAELY ◽  
MAXIMILIAN MAECHLER ◽  
ARTHUR MADER ◽  
BARBARA LARCHER ◽  
LUKAS SPRENGER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Events ◽  
Established Coronary Artery Disease ◽  
Remnant Cholesterol ◽  
Artery Disease
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