98-OR: Placental DNA Methylation Changes Associated with Birthweight and Overlaps with Adult Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 98-OR
Author(s):  
FASIL TEKOLA-AYELE ◽  
TSEGASELASSIE WORKALEMAHU ◽  
XUEHUO ZENG
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Adult Type

scholarly journals Associations of maternal early-pregnancy blood glucose and insulin concentrations with DNA methylation in newborns

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Madelon L. Geurtsen ◽  
Vincent W. V. Jaddoe ◽  
Romy Gaillard ◽  
Janine F. Felix
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Glucose Metabolism ◽  
Early Pregnancy ◽  
Fasting Glucose ◽  
Normal Weight ◽  
Obese Women ◽  
Differentially Methylated Regions ◽  
Adult Type

Abstract Background Intrauterine exposure to a disturbed maternal glucose metabolism is associated with adverse offspring outcomes. DNA methylation is a potential mechanism underlying these associations. We examined whether maternal early-pregnancy glucose and insulin concentrations are associated with newborn DNA methylation. In a population-based prospective cohort study among 935 pregnant women, maternal plasma concentrations of non-fasting glucose and insulin were measured at a median of 13.1 weeks of gestation (95% range 9.4–17.4). DNA methylation was measured using the Infinium HumanMethylation450 BeadChip (Ilumina). We analyzed associations of maternal early-pregnancy glucose and insulin concentrations with single-CpG DNA methylation using robust linear regression models. Differentially methylated regions were analyzed using the dmrff package in R. We stratified the analyses on normal weight versus overweight or obese women. We also performed a look-up of CpGs and differently methylated regions from previous studies to be associated with maternal gestational diabetes, hyperglycemia or hyperinsulinemia, or with type 2 diabetes in adults. Results Maternal early-pregnancy glucose and insulin concentrations were not associated with DNA methylation at single CpGs nor with differentially methylated regions in the total group. In analyses stratified on maternal BMI, maternal early-pregnancy glucose concentrations were associated with DNA methylation at one CpG (cg03617420, XKR6) among normal weight women and at another (cg12081946, IL17D) among overweight or obese women. No stratum-specific associations were found for maternal early-pregnancy insulin concentrations. The two CpGs were not associated with birth weight or childhood glycemic measures (p values > 0.1). Maternal early-pregnancy insulin concentrations were associated with one CpG known to be related to adult type 2 diabetes. Enrichment among nominally significant findings in our maternal early-pregnancy glucose concentrations was found for CpGs identified in a previous study on adult type 2 diabetes. Conclusions Maternal early-pregnancy glucose concentrations, but not insulin concentrations, were associated with DNA methylation at one CpG each in the subgroups of normal weight and of overweight or obese women. No associations were present in the full group. The role of these CpGs in mechanisms underlying offspring health outcomes needs further study. Future studies should replicate our results in larger samples with early-pregnancy information on maternal fasting glucose metabolism.

scholarly journals Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S.

Diabetes Care ◽  
2020 ◽  
Vol 44 (1) ◽  
pp. 231-239
Author(s):  
John Epoh Dibato ◽  
Olga Montvida ◽  
Francesco Zaccardi ◽  
Jack Alistair Sargeant ◽  
Melanie J. Davies ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Cardiovascular Events ◽  
Adult Type ◽  
The U.S

1135-P: Type 2 Diabetes Modulates DNA Methylation in Human Sperm

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 1135-P
Author(s):  
LEI SU ◽  
DANIELLE WOLFS ◽  
MARIE-FRANCE HIVERT ◽  
JAY PATEL ◽  
LAUREN RICHARDSON ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Human Sperm ◽  
P Type

scholarly journals Effectiveness of telephone interventions as a strategy for glycemic control: an integrative literature review

2013 ◽  
Vol 22 (1) ◽  
pp. 239-246 ◽  
Author(s):  
Hérica Cristina Alves de Vasconcelos ◽  
Roberto Wagner Júnior Freire de Freitas ◽  
Niciane Bandeira Pessoa Marinho ◽  
Marta Maria Coelho Damasceno ◽  
Thelma Leite de Araújo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Literature Review ◽  
Self Management ◽  
Inclusion Criteria ◽  
Adult Type ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Time Period

The objective of this study was to analyze the effectiveness of telephone interventions as a strategy for glycemic control in adult Type 2 Diabetes Mellitus patients. An integrative literature review was undertaken in April and May 2011 through surveys in the Cochrane, PubMed/Medline, Lilacs and Cinahl databases. Nine studies complied with the inclusion criteria, mainly randomized controlled clinical trials. Concerning the time period analyzed in each study, it varied from eight weeks to twelve months. 1294 patients participated in the study, being 671 randomized to telephone follow-ups and 479 to usual care. In eight studies analyzed, glycemic control was based on the levels of glycated hemoglobin (HbA1c). The information found showed that the interventions are effective for glycemic control in patients who have type 2 Diabetes. Self-management was improved and possible complications of the disease were reduced.

Patient education as a management intervention for adult type 2 diabetes

2000 ◽  
Vol 50 ◽  
pp. 30 ◽  
Author(s):  
Paula Corabian ◽  
Christa Harstall ◽  
Ellen Toth
Keyword(s):  
Type 2 Diabetes ◽  
Patient Education ◽  
Adult Type ◽  
Management Intervention

scholarly journals Trends in First-Line Glucose-Lowering Drug Use in Adults With Type 2 Diabetes in Light of Emerging Evidence for SGLT-2i and GLP-1RA

2021 ◽  
Author(s):  
HoJin Shin ◽  
Sebastian Schneeweiss ◽  
Robert J. Glynn ◽  
Elisabetta Patorno
Keyword(s):  
Type 2 Diabetes ◽  
Line Treatment ◽  
Medicare Beneficiaries ◽  
First Line ◽  
Adult Type ◽  
Antidiabetic Treatment ◽  
Glucagon Like Peptide 1 ◽  
Lowering Drug ◽  
First Line Treatment

<p>Objective: We evaluated recent utilization trends and predictors of first-line antidiabetic treatment in patients with type 2 diabetes.</p> <p>Research Design and Methods: Using two large U.S. health insurance databases (Clinformatics and Medicare), we identified adult type 2 diabetes patients who initiated antidiabetic treatment from 2013 through 2019. Quarterly trends in use of first-line antidiabetic treatment were plotted overall and stratified by cardiovascular disease (CVD). Multinomial logistic regressions were fit to estimate predictors of first-line antidiabetic treatment, using metformin, the recommended first-line treatment for type 2 diabetes, as the common referent.</p> <p>Results: Metformin was the most frequently initiated medication used by 80.6% of Medicare beneficiaries and 83.1% of commercially insured patients. Sulfonylureas were used by 8.7% (Medicare) and 4.7% (commercial). Both populations had low use of sodium-glucose cotransporter 2 inhibitors (SGLT-2i, 0.8% [Medicare] and 1.7% [commercial]) and glucagon-like peptide 1 receptor agonists (GLP-1RA, 1.0% [Medicare] and 3.5% [commercial]), with increasing trends over time (P < 0.01). Initiators of antidiabetic drugs with established cardiovascular benefits (SGLT-2i and GLP-1RA) were more likely to be younger, and had prevalent CVD or higher socioeconomic status compared with initiators of metformin. </p> <p>Conclusions: Among adult patients with type 2 diabetes, metformin was by far the most frequent first-line treatment. While the use of SGLT-2i and GLP-1RA was low from 2013 through 2019, it increased among patients with CVD.</p>

scholarly journals Positive Psychosocial Factors in Childhood Predicting Lower Risk for Adult Type 2 Diabetes: The Cardiovascular Risk in Young Finns Study, 1980–2012

2017 ◽  
Vol 52 (6) ◽  
pp. e157-e164 ◽  
Author(s):  
Laura Pulkki-Råback ◽  
Marko Elovainio ◽  
Christian Hakulinen ◽  
Jari Lipsanen ◽  
Laura D. Kubzansky ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Psychosocial Factors ◽  
Lower Risk ◽  
Adult Type ◽  
Young Finns Study
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