Femininity and gynecologic oncologic surgery: the key role of a tailored approach

2020 ◽  
Vol 71 (6) ◽  
Author(s):  
Lavinia Domenici ◽  
Maria G. Salerno ◽  
Pierluigi Benedetti Panici
2019 ◽  
Vol 20 (7) ◽  
pp. 1748 ◽  
Author(s):  
Valentina Zuccaro ◽  
Andrea Lombardi ◽  
Erika Asperges ◽  
Paolo Sacchi ◽  
Piero Marone ◽  
...  

The crosstalk between gut microbiota (GM) and the immune system is intense and complex. When dysbiosis occurs, the resulting pro-inflammatory environment can lead to bacterial translocation, systemic immune activation, tissue damage, and cancerogenesis. GM composition seems to impact both the therapeutic activity and the side effects of anticancer treatment; in particular, robust evidence has shown that the GM modulates the response to immunotherapy in patients affected by metastatic melanoma. Despite accumulating knowledge supporting the role of GM composition in lymphomagenesis, unexplored areas still remain. No studies have been designed to investigate GM alteration in patients diagnosed with lymphoproliferative disorders and treated with chemo-free therapies, and the potential association between GM, therapy outcome, and immune-related adverse events has never been analyzed. Additional studies should be considered to create opportunities for a more tailored approach in this set of patients. In this review, we describe the possible role of the GM during chemo-free treatment of lymphoid malignancies.


2020 ◽  
Vol 17 (1) ◽  
pp. 147-172
Author(s):  
Stefano M. Lanza ◽  
Vitalija Lanza

SummaryThe paper presents a new tool for approaching foreign languages. The “A1 for everyone” (A1FE1) project aims to promote multilingualism (meaning the ability of an individual to use different languages) in tune with the focuses of EU language policy, i.e. “to make a wider range of languages available to learners to allow individual choice”. A1FE1 aims to create a series of compact manuals, language introduction guides, different from self-study courses or tourist phrasebooks, which should allow everyone to reach level A1 (“Breakthrough”) in a foreign language (L2), using the technologies available today and a new reader-tailored approach. In fact it is not a guide for a single language being translated into several others, but each L2 guide is written specifically for a type of L1 users, since combinations of typologically distant languages (Danish for Spanish, Czech for Finnish) must tackle the same A1 material in a different way compared to especially genetically similar languages (Danish for Swedish, Czech for Slovaks). The paper introduces the Italian language guide for Lithuanians (Italų kalba šnekantiems lietuviškai). There are two main principles in this project: the comparative and contrastive approach, which proceeds from what is familiar (L1) to illustrate what is new (L2) and the central role of the lexicon as vehicle of communication and unifying element of the three components of grammar (phonetics, morphology and syntax). This is the reason why the bulk of each guide consists of four sections presenting the sounds, the basic forms, logical connections and words of the L2, followed by a two-way minimal dictionary full with communicative examples. The level descriptors of the Common European Framework are not language-specific, hence A1 structures and lexicon should be selected according to teaching practice resources available in the countries where the L2 is spoken, such as syllabuses, word frequency lists, etc. Audio recordings of all L2 material presented in the guides and additional videos following the books’ structure can be accessed online. Italų kalba šnekantiems lietuviškai will serve in fact as a prototype, outlining practical and problematic aspects to take into consideration when drafting other guides. After its release, feedback from users and field experts will help evaluate the real development possibilities of the project, including the involvement of institutions at European level.


2020 ◽  
Vol 2 (4) ◽  
pp. FDD49
Author(s):  
Edgar Ross ◽  
Roshni Ramachandran ◽  
Jason D Ross ◽  
Ashish Bhandari ◽  
Patrick W Mantyh ◽  
...  

Opioids have long been the mainstay of cancer pain treatment and have been used without any consideration for their effect on cancer growth and long-term prognosis. There is now growing evidence that the continued use of opioids for this indication should be reviewed and even reconsidered. Although current evidence and literature covering this subject is mixed and does not yet allow for a clear determination to be made about safety, there is enough data to support the search for new treatment paradigms, beginning with anesthesia for oncologic surgery and management of cancer pain over the disease course.


2019 ◽  
Vol 9 (2) ◽  
pp. 20 ◽  
Author(s):  
Belinda Lee ◽  
Peter Gibbs

It is estimated that pancreatic cancer will be the second leading cause of cancer-related deaths globally by 2030, highlighting the ongoing lack of effective treatment options for this devastating condition. There is a lack of reliable prognostic or predictive markers in pancreatic cancer to guide management decisions, whether for systemic chemotherapy, molecularly targeted therapies, or immunotherapies. To date, the results for targeted agents and immunotherapies in unselected populations of chemo-refractory pancreatic cancer have not met expectations. The reasons for this lack of efficacy of immunotherapy in pancreatic cancer are not completely understood. The challenges in pancreatic cancer include the physical barrier created by the dense desmoplastic stroma surrounding the tumor, chemokine-mediated exclusion of T cells, relatively poorer antigenicity compared to other solid tumors, paucity of infiltrating T cells within the tumor, ultimately leading to an immunosuppressive microenvironment. A better understanding of the role of inflammation in pancreatic cancer, its tumor microenvironment and individualized patient-related features, be they molecular, clinical or histopathological, would enable a more effective tailored approach to the management of pancreatic cancer. In this review, the role of inflammation, the immune tumor microenvironment and potential immune biomarkers in pancreatic cancer are explored.


2021 ◽  
Vol 11 (10) ◽  
pp. 1041
Author(s):  
Alessandro Granito ◽  
Antonio Facciorusso ◽  
Rodolfo Sacco ◽  
Laura Bartalena ◽  
Cristina Mosconi ◽  
...  

The aim of the present study was to correlate laboratory data and postprocedural parameters after conventional transarterial chemoembolization (cTACE) for hepatocellular carcinoma (HCC) with the radiological response. The study consisted of a retrospective analysis of prospectively collected data from 70 consecutive patients who underwent cTACE. Laboratory parameters were assessed daily after cTACE and compared to pretreatment values. Post-treatment radiological response was assessed using mRECIST at one month from cTACE, and factors associated with treatment response (complete and objective response) were assessed by logistic regression analysis. The optimal cutoff points in predicting the complete response of target lesions were a 52% ALT and a 46% AST increase after cTACE compared to the pre-treatment values. Using multivariate analyses, >46% AST and >52% ALT increases with respect to the pre-treatment value were significantly correlated with the objective response (p = 0.03 and p = 0.04, respectively) and the complete response (p = 0.02 and p = 0.02, respectively). No patients experienced liver function deterioration after cTACE, and no specific treatment was required. This study showed that post-treatment transient transaminase elevation was predictive of objective response to superselective cTACE in clinical practice, representing a simple tool to guide treatment strategy of HCC patients in a tailored approach.


2018 ◽  
Vol 35 (04) ◽  
pp. 229-237
Author(s):  
Bruno Odisio ◽  
Rahul Sheth ◽  
Lambros Tselikas ◽  
Thierry de Baère ◽  
Frederic Deschamps ◽  
...  

AbstractIntegrated CT–fluoroscopy equipment augments the comprehensive approach to the treatment of musculoskeletal (MSK) malignancy by interventional radiology techniques. As the role of minimally invasive treatment expands to meet the highly variable presentation of MSK malignancy, creative solutions to treatment challenges are required to improve locoregional tumor control and durability of pain palliation. Challenges to effective treatment can often be attributed to a combination of aggressive tumor biology, large size, forbidding location, and adverse vascularity. In these cases, a tailored treatment approach may necessitate the application of multiple interventional radiology (IR) techniques that require different image guidance capabilities. Integrated CT–fluoroscopy equipment provides the means to leverage both imaging modalities within the same procedural setting to facilitate the simultaneous application of multiple synergistic treatments and protective measures. This article examines the potential role of hybrid units in the IR treatment of challenging MSK malignancies as a means to empower a paradigm transition for a more comprehensive and patient-tailored approach.


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