scholarly journals MERKEL CELL CARCINOMA

10.23856/3614 ◽  
2019 ◽  
Vol 36 (5) ◽  
pp. 118-123
Author(s):  
Krzysztof Nocoń ◽  
Jakub Majewski ◽  
Józef Kurek ◽  
Goran Stojiljković ◽  
Antoni Stadnicki
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Lymphatic System ◽  
Histopathological Examination ◽  
Diagnostic Procedures ◽  
Merkel Cell ◽  
The Face ◽  
Diagnostic Difficulties ◽  
The Right ◽  
Classification And Treatment

In XXI century Merkel cell carcinoma (MCC) is a still very rare form of the skin cancer with an aggressive behavior. We present a case of 77-year-old female patient with a tumor with bluish skin, approx. 2 cm diameter, hard texture palpation of the right zygomatic area of the face. There were no enlarged lymph nodes in the head or neck. Tumor was surgically excised. The result of the histopathological examination including immunohistochemical tests allowed to diagnose Merkel cell carcinoma. After 6 months tumor recurrence was found. The right cheek tumor and the right lymphatic system of the neck was removed and radiotherapy was carried out. In  imaging examination no pathological changes were found. The patient have complained about dry eye syndrome as side effect o treatment. A literature review concerning risk factors, diagnostic difficulties, classification and treatment of Merkel cell carcinoma is presented and discussed. Randomized studies are required to clarify  diagnostic procedures, prognostic factors and  treatment in clinical stages of the disease

Merkel cell carcinoma of the face: an analysis of 16 cases in the Japanese

2009 ◽  
Vol 62 (10) ◽  
pp. 1272-1276 ◽  
Author(s):  
Akira Saito ◽  
Arata Tsutsumida ◽  
Hiroshi Furukawa ◽  
Noriko Saito ◽  
William Mol ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
The Face

scholarly journals Epileptic Seizure Provoked by Bone Metastasis of Chronic Lymphoid Leukemia and Merkel Cell Carcinoma – Case Report

2019 ◽  
Author(s):  
András Folyovich ◽  
Angéla Majoros ◽  
Tamás Jarecsny ◽  
Gitta Pánczél ◽  
Zsuzsanna Pápai ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Cerebral Metastasis ◽  
Merkel Cell ◽  
Lymphoid Leukemia ◽  
Chronic Lymphoid Leukemia ◽  
History Of ◽  
The Right ◽  
The Brain

Abstract Background Merkel cell carcinoma (MCC) is a rare primary neuroendocrine cutaneous tumor, rarely metastatizing to the brain. Chronic lymphoid leukemia (CLL) is a disease predisposing to MCC. According to previous reports, headache and focal neurological deficits suggest disease progression to the brain. We present a patient with MCC whose seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. Case presentation The 62-year-old female patient had a history of CLL. A lesion with the appearance of an atheroma was removed from the right upper arm. Histology confirmed the diagnosis of MCC. She was admitted to the neurology department with her first GM seizure. The cranial MRI/MRA showed bone metastases in the right parietal and left frontal areas, compressing the brain. Flow cytometry of CSF did not reveal metastasis of MCC or CLL. No surgery was performed, chemotherapy was continued. Conclusions The case history of the patient was unique even among the rare cases of MCC with neurological involvement. The seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. In addition to patient history, clinical presentation and radiological findings enabled a suspected diagnosis preceding confirmation by laboratory methods.

scholarly journals Metastatic Merkel cell carcinoma of the face

2016 ◽  
Vol 82 (5) ◽  
pp. 562
Author(s):  
Mario Vaccaro ◽  
Emanuele Magaudda ◽  
Pina Brianti ◽  
Luana Licata ◽  
Roberta Cardia ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
The Face

scholarly journals Epileptic Seizure Provoked by Bone Metastasis of Chronic Lymphoid Leukemia and Merkel Cell Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
András Folyovich ◽  
Angéla Majoros ◽  
Tamás Jarecsny ◽  
Gitta Pánczél ◽  
Zsuzsanna Pápai ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Cerebral Metastasis ◽  
Merkel Cell ◽  
Lymphoid Leukemia ◽  
Chronic Lymphoid Leukemia ◽  
History Of ◽  
The Right ◽  
The Brain

Background. Merkel cell carcinoma (MCC) is a rare primary neuroendocrine cutaneous tumor, rarely metastasizing to the brain. Chronic lymphoid leukemia (CLL) is a disease predisposing to MCC. According to previous reports, headache and focal neurological deficits suggest disease progression to the brain. We present a patient with MCC whose seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. Case Presentation. A 62-year-old female patient had a history of CLL. A lesion with the appearance of an atheroma was removed from the right upper arm. Histology confirmed the diagnosis of MCC. She was admitted to the neurology department with her first GM seizure. The cranial MRI/MRA showed bone metastases in the right parietal and both frontal areas, compressing the brain. Flow cytometry of CSF did not reveal metastasis of MCC. Conclusions. The case history of the patient was unique even among the rare cases of MCC with neurological involvement. The seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. In addition to patient history, clinical presentation and radiological findings enabled a suspected diagnosis of skull metastasis of MCC compressing the brain, causing symptomatic epileptic seizures.

A case of Merkel cell carcinoma of the right big toe with Merkel cell polyomavirus infection

Skin Cancer ◽  
2016 ◽  
Vol 31 (1) ◽  
pp. 30-34
Author(s):  
Shintaro MAEDA ◽  
Miyu KANO ◽  
Tadahiro KOBAYASHI ◽  
Kyosuke OISHI ◽  
Takashi MATSUSHITA ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell ◽  
The Right

scholarly journals Case Report: Favorable Response to the Tyrosine Kinase Inhibitor Apatinib in Recurrent Merkel Cell Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Yiyi Feng ◽  
Xin Song ◽  
Renbing Jia
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Kinase Inhibitor ◽  
Progression Free Survival ◽  
Complete Response ◽  
Lower Eyelid ◽  
Merkel Cell ◽  
The Right

BackgroundAs angiogenesis is an essential step in tumor growth and metastasis, the tyrosine kinase inhibitor (TKI) apatinib has become a revolutionary anticancer therapy across various malignancies. However, its efficiency and safety in Merkel cell carcinoma (MCC) are uncertain.Case presentationThe current study described the case of a 91-year-old man who presented with a 3.2 × 3.0 × 2.2 cm rapidly growing, solitary tumor of the right lower eyelid. It was diagnosed as MCC pathologically. Twenty-seven days after the surgery, the patient returned to the hospital with recurrent MCC. Apatinib was then administered to this patient. The patient had a complete response (CR) to apatinib after 4.4 months of targeted therapy. Twenty-seven months of progression-free survival (PFS) was achieved with controllable treatment-related adverse events (AEs).ConclusionTreatment with apatinib demonstrated clinical benefit in our patient with recurrent MCC, highlighting its potential utility in other MCC patients. Further clinical trials are needed to determine the efficacy and safety of apatinib in MCC patients.

Merkel cell carcinoma of the gluteal region: a rare case report and literature review

2021 ◽  
pp. 1-8
Author(s):  
Mahmut Corapli ◽  
Burcin Pehlivanoglu ◽  
Haci Taner Bulut ◽  
Huseyin Alakus ◽  
Nadiye Akdeniz
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Survival Rates ◽  
Gluteal Region ◽  
Adjuvant Chemoradiotherapy ◽  
Merkel Cell ◽  
Neuroendocrine Cancer ◽  
Rare Case Report ◽  
The Right

Abstract Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine cancer that shows aggressive biologic behavior. Although it usually occurs in sun-exposed areas, it can rarely be seen in non-sun-exposed sites. Here, we present a 66-year-old woman with MCC arising from the right gluteal region that was treated wide excision and adjuvant chemoradiotherapy. In the 24th month follow-up, the case was disease and recurrence free, representing the longest survival among patients with gluteal MCC. Early diagnosis and treatment are important to improve survival rates in patients with non-sun-exposed MCC. Keywords: Merkel cell carcinoma, non-sun-exposed, Continuous...

Complete Spontaneous Regression of Merkel Cell Carcinoma

2005 ◽  
Vol 114 (5) ◽  
pp. 376-380 ◽  
Author(s):  
Luis Junquera ◽  
Aintza Torre ◽  
Luis García-Consuegra ◽  
Juan C. Vicente ◽  
Manuel F. Fresno
Keyword(s):  
Computed Tomography ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Spontaneous Regression ◽  
Case Reports ◽  
The Elderly ◽  
Merkel Cell ◽  
Review Of The Literature ◽  
The Right

Merkel cell carcinoma (MCC) is a very aggressive primary cutaneous neoplasm most often occurring on the head and neck of the elderly. Spontaneous regression of MCC was first described in 1986. A 79-year-old woman with MCC on the right cheek underwent spontaneous regression of the malignancy, documented by photographic follow-up, computed tomography, and histologic studies. A review of the literature is presented. Complete clinical and histologic regression of MCC was observed in the present case. Although the literature documents 11 similar cases, only 6 can be regarded as complete spontaneous regressions following exclusive performance of a biopsy (primary complete spontaneous regression). Primary complete spontaneous regression of MCC is infrequent, and most case reports describe this phenomenon in women with MCC on the cheek. The reasons underlying regression are unknown.

scholarly journals Cerebral metastasis of Merkel cell carcinoma following resection with negative margins and adjuvant external beam radiation: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Alex F. Grubb ◽  
Elizabeth Hankollari
Keyword(s):  
Cell Carcinoma ◽  
Stereotactic Radiosurgery ◽  
Merkel Cell Carcinoma ◽  
Cerebral Metastasis ◽  
External Beam Radiation ◽  
External Beam ◽  
Merkel Cell ◽  
Beam Radiation ◽  
History Of ◽  
The Right

Abstract Background Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin. It is associated with advanced age, ultraviolet (UV) radiation, and Merkel cell polyomavirus. It has a predilection for the lymphatic system, but rarely spreads to the central nervous system. Case presentation A 71-year-old Caucasian man with a history of rheumatoid arthritis and MCC of the right lower eyelid and cheek presented with left-sided hemineglect and word-finding difficulty. Twenty months earlier he had undergone local excision of a 3 cm lesion with negative margins, negative sentinel lymph node biopsy, and external beam radiation. On presentation he was found to have a 6.3 cm mass in the right frontotemporal region. He underwent prompt resection, with pathological analysis consistent with metastatic MCC. He subsequently underwent stereotactic radiosurgery (SRS) and adjunctive immunotherapy with pembrolizumab. He has since tolerated the therapy well and is currently without neurological symptoms or evidence of recurrence. Conclusions Cerebral metastasis of MCC is a rare event and should be considered when a patient with a history of MCC presents with neurological symptoms. Optimal treatment regimens of these rare cases are unclear; however, prompt resection, stereotactic radiosurgery, and adjunctive immunotherapy have shown an initial positive response in this patient.

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