scholarly journals The Northern Ireland Baby Hearts Study: A Case-Control study using a hybrid data linkage method

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Nichola McCullough ◽  
Helen Dolk ◽  
Maria Loane ◽  
Briege M Lagan ◽  
Frank Casey ◽  
...  
Keyword(s):  
Northern Ireland ◽  
Data Collection ◽  
Case Control Study ◽  
Heart Defects ◽  
Health Behaviours ◽  
First Trimester ◽  
Case Control ◽  
Self Report ◽  
Hybrid Data ◽  
Control Study

BackgroundThe Northern Ireland (NI) Baby Hearts study aimed to investigate risk factors for congenital heart defects (CHD), and to investigate the health behaviours of a representative sample of NI pregnant women. MethodsWe performed a case-control study with hybrid data collection methods, including self-administered iPad questionnaire or postal questionnaire, information held in maternity records and linkage to prescription records. Cases (n=286) were recruited following diagnosis prenatally or postnatally, controls (n=966) were recruited during recruitment months in each maternity unit at 18-20 weeks gestation. FindingsRefusal rates for questionnaire completion were low (7-8%). Among those recruited, consent for access and linkage to medical records was high (98%). Recruitment of both cases and controls was closely representative of the NI population in terms of age, area of residence and deprivation. There was considerable discordance between self-report questionnaires, maternity records and prescription records regarding medications taken in the first trimester, and between self-report questionnaires and maternity records regarding behaviours such as preconceptional folic acid, pregnancy planning, and smoking. However, there were no differences between cases and controls that would indicate recall bias. ConclusionsOur results suggest that hybrid data collection approaches are a useful way forward for aetiological studies.

First-trimester use of paroxetine and congenital heart defects: A population-based case-control study

2009 ◽  
pp. NA-NA ◽  
Author(s):  
Marian K. Bakker ◽  
Wilhelmina S. Kerstjens-Frederikse ◽  
Charles H. C. M. Buys ◽  
Hermien E. K. de Walle ◽  
Lolkje T. W. de Jong-van den Berg
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Case Control Study ◽  
Heart Defects ◽  
First Trimester ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals The Baby Hearts Study – a case-control methodology with data linkage to evaluate risk and protective factors for congenital heart disease

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Nichola McCullough ◽  
Helen Dolk ◽  
Maria Loane ◽  
Briege M Lagan ◽  
Frank Casey ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Northern Ireland ◽  
Data Collection ◽  
Congenital Heart ◽  
Data Linkage ◽  
Case Control ◽  
Self Report ◽  
Recall Bias ◽  
Hybrid Data

IntroductionThe Baby Hearts study aimed to investigate risk and protective factors for congenital heart disease (CHD), and to investigate the health behaviours of a representative sample of pregnant women in Northern Ireland. ObjectivesWe describe and evaluate the population-based case-control design enhanced with data linkage to administrative health data. MethodsCases (mothers of babies with CHD, n=286) were recruited following diagnosis prenatally or postnatally. Controls (mothers of babies without CHD, n=966) were recruited at 18-22 weeks gestation, from all women attending each maternity unit during a designated month. Hybrid data collection methods were used, including a self-administered iPad/postal questionnaire, and linkage to maternity and prescription records. ResultsRefusal rates were low (8%). iPad questionnaire completion at clinic or home visit had high acceptability whereas postal questionnaires were poorly returned leading to a further 9-10% loss of eligible cases/controls. In total, 61% of eligible cases and 68% of eligible controls were recruited, closely representative of the Northern Ireland population, with no evidence of selection bias. Of those recruited, 97% gave consent for linkage to medical records. Thirty-three percent of women had an unplanned pregnancy and 76% suspected they were pregnant by 5 weeks gestation, with no significant differences between cases and controls. There was considerable discordance between self-report, maternity and prescription records regarding medications obtained/taken in the first trimester, but no evidence of differences between cases and controls that would indicate substantial recall bias. Although there was high concordance between self-report and maternity records regarding folic acid supplementation, cases had significantly lower concordance than controls. ConclusionsOur results suggest hybrid data collection approaches are a useful way forward for aetiological studies to reduce responder burden and address and estimate recall bias, and that the Baby Hearts study protocol is suitable for replication in other populations, modified to the local context.

Italian multicenter case-control study of clinically diagnosed Alzheimer disease: Strategies and instruments for data collection

1987 ◽  
Vol 8 (2) ◽  
pp. 97-108 ◽  
Author(s):  
W. A. Rocca ◽  
L. Fratiglioni ◽  
L. Bracco ◽  
F. Grigoletto ◽  
L. Amaducci ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Data Collection ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

First-trimester fetal growth discordance and development of preeclampsia in dichorionic twin pregnancies

2015 ◽  
Vol 43 (6) ◽  
Author(s):  
Tanya Maric ◽  
Natasha Singh ◽  
Keith Duncan ◽  
Guy J. Thorpe-Beeston ◽  
Makrina D. Savvidou
Keyword(s):  
Fetal Growth ◽  
Case Control Study ◽  
Subsequent Development ◽  
First Trimester ◽  
Case Control ◽  
Retrospective Case ◽  
Crown Rump Length ◽  
Significant Difference ◽  
Twin Pregnancies ◽  
Control Study

AbstractTo investigate the relation between first-trimester fetal growth discrepancy, as assessed by crown-rump length (CRL) at 11+0 to 13+6 weeks of gestation, and subsequent development of preeclampsia (PE) in dichorionic diamniotic (DCDA) twin pregnancies. The association between inter-twin CRL and birth weight (BW) discrepancy was also investigated.This was a retrospective, case-control study of DCDA twin pregnancies. Inter-twin CRL discrepancy was calculated as 100×(larger CRL–smaller CRL)/larger CRL. BW discordance was calculated as 100×(larger BW–smaller BW)/larger BW.The study included 299 DCDA pregnancies that remained normotensive and 35 that subsequently developed PE. There was no significant difference in the inter-twin CRL discrepancy between pregnancies complicated by PE and those that were not [3.2%, interquartile range (IQR): 0.5–4.5% vs. 3.3%, IQR: 1.4–5.5%; P=0.17]. There was a positive correlation between inter-twin CRL and BW discrepancy but only in pregnancies that remained normotensive (P<0.001). In women that subsequently developed PE, there was no association between inter-twin CRL and BW discordance (P=0.54).In unselected DCDA twins, first-trimester CRL discrepancy is not different between pregnancies that subsequently develop PE and those that remain normotensive. Furthermore, in pregnancies that are complicated by PE, the association between inter-twin CRL and BW discrepancy appears to be lost.

First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study

2019 ◽  
Vol 47 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Paula J. Correa ◽  
Pia Venegas ◽  
Yasna Palmeiro ◽  
Daniela Albers ◽  
Gregory Rice ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Case Control Study ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
First Trimester ◽  
Case Control ◽  
Low Density ◽  
Control Study

AbstractObjectivesTo evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM).MethodsThe study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24–28 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF).ResultsThe GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria.ConclusionWomen who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.

scholarly journals Maternal residential greenness and congenital heart defects in infants: A large case-control study in Southern China

2020 ◽  
Vol 142 ◽  
pp. 105859
Author(s):  
Zhiqiang Nie ◽  
Boyi Yang ◽  
Yanqiu Ou ◽  
Michael S. Bloom ◽  
Fengzhen Han ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Case Control Study ◽  
Southern China ◽  
Heart Defects ◽  
Case Control ◽  
Control Study ◽  
Large Case
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