Development of a portable setup suitable for in vivo measurement of the dielectric properties of biological tissues

2017 ◽  
Author(s):  
L. Farina ◽  
G. Ruvio ◽  
R. Pinto ◽  
L. Vannucci ◽  
M. Cavagnaro ◽  
...  
Keyword(s):  
Dielectric Properties ◽  
Biological Tissues ◽  
In Vivo Measurement

scholarly journals Machine learning estimation of tissue optical properties

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Brett H. Hokr ◽  
Joel N. Bixler
Keyword(s):  
Neural Network ◽  
Optical Properties ◽  
Biological Tissues ◽  
Homogeneous Layer ◽  
In Vivo Measurement ◽  
Tissue Optical Properties ◽  
The Neural Network ◽  
Spatio Temporal ◽  
Fully Connected

AbstractDynamic, in vivo measurement of the optical properties of biological tissues is still an elusive and critically important problem. Here we develop a technique for inverting a Monte Carlo simulation to extract tissue optical properties from the statistical moments of the spatio-temporal response of the tissue by training a 5-layer fully connected neural network. We demonstrate the accuracy of the method across a very wide parameter space on a single homogeneous layer tissue model and demonstrate that the method is insensitive to parameter selection of the neural network model itself. Finally, we propose an experimental setup capable of measuring the required information in real time in an in vivo environment and demonstrate proof-of-concept level experimental results.

scholarly journals A THREE-PHASE INDUCTIVE SENSOR FOR IN VIVO MEASUREMENT OF ELECTRICAL ANISOTROPY OF BIOLOGICAL TISSUES

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Yukio Kosugi ◽  
Tadashi Takemae ◽  
Hiroki Takeshima ◽  
Atsushi Kudo ◽  
Kazuyuki Kojima ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Electrical Conductivity ◽  
High Frequency ◽  
Reference Signal ◽  
Biological Tissues ◽  
Electrical Anisotropy ◽  
Conductivity Anisotropy ◽  
In Vivo Measurement ◽  
Surgical Operations

Biological tissue will have anisotropy in electrical conductivity, due to the orientation of muscular fibers or neural axons as well as the distribution of large size blood vessels. Thus, the in vivo measurement of electrical conductivity anisotropy can be used to detect deep-seated vessels in large organs such as the liver during surgeries. For diagnostic applications, decrease of anisotropy may indicate the existence of cancer in anisotropic tissues such as the white matter of the brain or the mammary gland in the breast. In this paper, we will introduce a new tri-phase induction method to drive rotating high-frequency electrical current in the tissue for the measurement of electrical conductivity anisotropy. In the measurement, three electromagnets are symmetrically placed on the tissue surface and driven by high-frequency alternative currents of 0 kHz, modulated with 1 kHz 3-phase signals. In the center area of three magnets, magnetic fields are superimposed to produce a rotating induction current. This current produces electrical potentials among circularly arranged electrodes to be used to find the conductivity in each direction determined by the electrode pairs. To find the horizontal and vertical signal components, the measured potentials are amplified by a 2ch lock-in amplifier phase-locked with the 1 kHz reference signal. The superimposed current in the tissue was typically 45 micro Amperes when we applied 150 micro Tesla of magnetic field. We showed the validity of our method by conducting in vitro measurements with respect to artificially formed anisotropic materials and preliminary in vivo measurements on the pig’s liver. Compared to diffusion tensor MRI method, our anisotropy sensor is compact and advantageous for use during surgical operations because our method does not require strong magnetic field that may disturb ongoing surgical operations.

Measurement of the Optical Properties of Muscle Tissue In Vivo

2000 ◽  
Author(s):  
P. L. Kopsombut ◽  
D. Willis ◽  
A. E. Schen ◽  
L. X. Xu ◽  
X. Xu
Keyword(s):  
Optical Properties ◽  
Transport Theory ◽  
Rapid Development ◽  
Ccd Camera ◽  
High Sensitivity ◽  
Biological Tissues ◽  
In Vivo Measurement ◽  
Living Tissues

Abstract Along with rapid development of diagnostic and therapeutic applications of lasers in medicine, optical properties of various biological tissues have been extensively studied [1]. Most of the studies were performed in vitro owing to the complexity involved in in vivo measurement. To date, it is well understood that living tissue is an absorbing and scattering heterogeneous medium because of its complex structures including blood network. The transport theory cannot be readily used due to the heterogeneity and the absence of the optical properties of living tissues [2]. In this research, we have developed a procedure for measuring the total attenuation coefficient (μ1) of the exteriorized rat 2-D spinotrapezius muscle in the wavelength ranged from 480–560 nm using the collimated light from a Nitrogen-pumped dye laser and a high-sensitivity CCD camera.

Comparison of in-vivo and ex-vivo dielectric properties of biological tissues

2017 ◽  
Author(s):  
Saqib Salahuddin ◽  
Alessandra La Gioia ◽  
Muhammad Adnan Elahi ◽  
Emily Porter ◽  
Martin O'Halloran ◽  
...  
Keyword(s):  
Dielectric Properties ◽  
Ex Vivo ◽  
Biological Tissues

scholarly journals Comparative analysis of indentation and magnetic resonance elastography for measuring viscoelastic properties

2021 ◽  
Author(s):  
Yu Chen ◽  
Suhao Qiu ◽  
Zhao He ◽  
Fuhua Yan ◽  
Ruokun Li ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Viscoelastic Properties ◽  
Soft Tissues ◽  
Biological Tissues ◽  
Magnetic Resonance Elastography ◽  
Small Samples ◽  
Model Parameters ◽  
In Vivo Measurement ◽  
Pathological Behavior

Abstract Measurement the viscoelastic properties is important for studying the developmental and pathological behavior of soft biological tissues. Magnetic resonance elastography (MRE) is a non-invasive method for in vivo measurement of tissue viscoelasticity. As a flexible method capable of testing small samples, indentation has been widely used for characterizing soft tissues. Using 2nd-order Prony series and dimensional analysis, we analyzed and compared the model parameters estimated from both indentation and MRE. Conversions of the model parameters estimated from the two methods were established. We found that the indention test is better at capturing the dynamic response of tissues at a frequency less than 10 Hz, while MRE is better for describing the frequency responses at a relatively higher range. The results provided helpful information for testing soft tissues using indentation and MRE. The models analyzed are also helpful for quantifying the frequency response of viscoelastic tissues. Graphic Abstract

scholarly journals In Vivo Measurement of Neurochemical Abnormalities in the Hippocampus in a Rat Model of Cuprizone-Induced Demyelination

Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 45
Author(s):  
Do-Wan Lee ◽  
Jae-Im Kwon ◽  
Chul-Woong Woo ◽  
Hwon Heo ◽  
Kyung Won Kim ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Rat Model ◽  
Resonance Spectroscopy ◽  
Chow Diet ◽  
Gamma Aminobutyric Acid ◽  
Sprague Dawley ◽  
In Vivo Measurement ◽  
Hippocampal Lesions ◽  
Total Creatine

This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton magnetic resonance spectroscopy. Nineteen Sprague Dawley rats were randomly divided into two groups and fed a normal chow diet or cuprizone (0.2%, w/w) for 7 weeks. Demyelinated hippocampal lesions were quantitatively measured using a 7 T magnetic resonance imaging scanner. All proton spectra were quantified for metabolite concentrations and relative ratios. Compared to those in the controls, the cuprizone-induced rats had significantly higher concentrations of glutamate (p = 0.001), gamma-aminobutyric acid (p = 0.019), and glutamate + glutamine (p = 0.001); however, creatine + phosphocreatine (p = 0.006) and myo-inositol (p = 0.001) concentrations were lower. In addition, we found that the glutamine and glutamate complex/total creatine (p < 0.001), glutamate/total creatine (p < 0.001), and GABA/total creatine (p = 0.002) ratios were significantly higher in cuprizone-treated rats than in control rats. Our results showed that cuprizone-induced neuronal demyelination may influence the severe abnormal metabolism in hippocampal lesions, and these responses could be caused by microglial activation, mitochondrial dysfunction, and astrocytic necrosis.

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