False Negative Tuberculin Skin Test (TST) Response in Asymptomatic HIV-1 Infected Blood Donors with Subclinical Iron Overload Developing High Incidence of Pulmonary Tuberculosis on Follow Up

Abstract Early detection of individuals with hereditary hemochromatosis (HH) is important to manage iron levels and prevent future organ damage. Although theHFE mutations that cause most cases of HH have been identified, their geographic distribution is highly variable, and their contribution to iron overload is not fully understood. All new registered blood donors at the Sahlgrenska University hospital between 1998 and 2015 were included in the study. Donors with signs of iron overload at baseline and subsequent follow-up testing were recommended genotyping of the HFE gene. Of the 50,493 donors that were included in the study, 950 (1.9%) had signs of iron overload on both test occasions. Of the 840 donors with iron overload that performed HFE genotyping, 117 were homozygous for C282Y, and 97 were compound heterozygotes. The prevalence of C282Y homozygosity was 0.23%. Iron overload screening effectively detects individuals at risk of carrying the C282Y mutation of the HFE gene and enables early treatment to prevent HH complications.

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Frequency of coreceptor tropism in PBMC samples from HIV-1 recently infected blood donors by massively parallel sequencing: the REDS II study

Virology Journal ◽

10.1186/s12985-015-0307-3 ◽

2015 ◽

Vol 12 (1) ◽

Cited By ~ 3

Author(s):

Rodrigo Pessôa ◽

Ester C Sabino ◽

Sabri S Sanabani

Keyword(s):

Blood Donors ◽

Massively Parallel Sequencing ◽

Massively Parallel ◽

Infected Blood ◽

Parallel Sequencing ◽

Coreceptor Tropism ◽

Hiv 1

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Subclinical Iron Overload Hampers the Beneficial Effect of Human Pegivirus (Hpgv) On Disease Progression in Human Immunodeficiency Virus Type-1 Infected Blood Donors

International Journal of Virology and AIDS ◽

10.23937/2469-567x/1510074 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Chattopadhya Debasish ◽

Verghese Alice ◽

Sharma Uma ◽

Rai Arvind

Keyword(s):

Human Immunodeficiency Virus ◽

Iron Overload ◽

Beneficial Effect ◽

Disease Progression ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Blood Donors ◽

Infected Blood ◽

Immunodeficiency Virus

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Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors

The Journal of Infectious Diseases ◽

10.1086/591466 ◽

2008 ◽

Vol 198 (7) ◽

pp. 979-983 ◽

Cited By ~ 30

Author(s):

Leslie H. Tobler ◽

Mark J. Cameron ◽

Marion C. Lanteri ◽

Harry E. Prince ◽

Ali Danesh ◽

...

Keyword(s):

Viral Load ◽

West Nile Virus ◽

Blood Donors ◽

Nucleic Acid Amplification ◽

Host Responses ◽

West Nile ◽

Infected Blood ◽

Initial Control ◽

Serial Samples

Abstract To understand early host responses controlling West Nile virus (WNV) infection, acutely viremic blood donors, identified by nucleic acid amplification testing, were enrolled and monitored for RNA-clearance and WNV-specific IgM and IgG antibodies. Viral load and chemokine and cytokine assays were performed on serial samples from donors whose index and first follow-up samples tested negative for IgM. A total of 84% of the specimens obtained from viremic donors before IgM/IgG seroconversion demonstrated a decreasing viral load. Levels of interferon (IFN)-α ere significantly increased before IgM seroconversion, relative to those in control specimens. CXCL10 and CCL2 were significantly elevated in donor specimens obtained before IgM seroconversion, compared with those obtained after IgM seroconversion. These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication.

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HIV-1/2 indeterminate Western blot results: follow-up of asymptomatic blood donors in Belo Horizonte, Minas Gerais, Brazil

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651999000300004 ◽

1999 ◽

Vol 41 (3) ◽

pp. 155-158 ◽

Cited By ~ 9

Author(s):

A.B.F. CARNEIRO-PROIETTI ◽

I.W. CUNHA ◽

M.M. SOUZA ◽

D.R. OLIVEIRA ◽

N.M. MESQUITA ◽

...

Keyword(s):

Western Blot ◽

Blood Donors ◽

Past History ◽

Public Health Importance ◽

Sexually Transmitted ◽

Negative Results ◽

History Of ◽

Belo Horizonte ◽

Hiv 1

The clinical and public health importance of indeterminate results in HIV-1/2 testing is still difficult to evaluate in volunteer blood donors. At Fundação Hemominas, HIV-1/2 ELISA is used as the screening test and, if reactive, is followed by Western blot (WB). We have evaluated 84 blood donors who had repeatedly reactive ELISA tests for HIV-1/2, but indeterminate WB results. Sixteen of the 84 donors (19.0%) had history of sexually transmitted diseases; 18/84 (21.4%) informed receiving or paying for sex; 3/84 (3.6%) had homosexual contact; 2/26 women (7.6%) had past history of multiple illegal abortions and 3/84 (3.6%) had been previously transfused. Four out of 62 donors (6.5%) had positive anti-nuclear factor (Hep2), with titles up to 1:640. Parasitological examination of the stool revealed eggs of S. mansoni in 4/62 (6.4%) donors and other parasites in 8/62 (12.9%). Five (5.9%) of the subjects presented overt seroconversion for HIV-1/2, 43/84 (51.2%) had negative results on the last visit, while 36/84 (42.9%) remained WB indeterminate. Although some conditions could be found associated with the HIV-1/2 indeterminate WB results and many donors had past of risky behavior, the significance of the majority of the results remains to be determined.

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