Barrier Contraceptive Methods Practice and its Predictors among Human Immunodeficiency Virus (HIV) Positive Women Attending Anti Retro Viral Therapy (ART) in Hadiya Zone Public Hospitals, South Ethiopia

There are limited data on human papillomavirus (HPV) type-specific cervical cancer risk among human immunodeficiency virus (HIV)-positive women. Previous studies have suggested that HPV 16 would be relatively less important as a causative agent among HIV-positive compared with HIV-negative women. This study investigates HPV type-specific cervical cancer risk in a population in which HIV is endemic. At the Central Hospital, Maputo, Mozambique, 221 cervical cancer cases and 203 hospital-based controls were consecutively enrolled. HPV typing from cervical samples, HIV testing and recording of socio-demographic factors were performed. Logistic regression modelling was used to assess HPV type-specific risk and effect modification between HIV and HPV infection. Infection with HPV 16, 18 and ‘high-risk non-HPV 16/18 types’ (HPV 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59) was associated with cervical cancer in both crude and adjusted analyses. HPV 16 and 18 were the most common types detected in cancer biopsies among both HIV-negative and HIV-positive women. There was no significant evidence of effect modification between any HPV type and HIV infection, and there were no significant differences in the HPV type-specific prevalence when cervical cancers among HIV-positive and HIV-negative women were compared. Within the limitations of the study, the relative importance of different HPV types in cervical carcinogenesis appears not to be modified greatly by HIV infection, suggesting that HPV vaccines might not need to be type-specifically modified to be suitable for populations where HIV is endemic.

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501: The use of protease inhibitors (PI) during pregnancy and the risk for intrauterine growth restriction in human immunodeficiency virus (HIV) positive women

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2008.09.530 ◽

2008 ◽

Vol 199 (6) ◽

pp. S148

Author(s):

Teresa Martino ◽

Abimbola Aina-Mumuney ◽

Maria Palmquist ◽

Anadir Silva

Keyword(s):

Human Immunodeficiency Virus ◽

Protease Inhibitors ◽

Intrauterine Growth Restriction ◽

Growth Restriction ◽

Hiv Positive ◽

Intrauterine Growth ◽

Hiv Positive Women ◽

Immunodeficiency Virus

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Human papillomavirus (HPV) genotypes and HPV16 variants in human immunodeficiency virus-positive Italian women

Journal of General Virology ◽

10.1099/vir.0.83553-0 ◽

2008 ◽

Vol 89 (6) ◽

pp. 1380-1389 ◽

Cited By ~ 26

Author(s):

Maria Lina Tornesello ◽

Maria Luisa Duraturo ◽

Paolo Giorgi-Rossi ◽

Matilde Sansone ◽

Roberto Piccoli ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Sequencing Analysis ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

Hpv Genotypes ◽

Italian Women ◽

Hiv Negative

Human immunodeficiency virus (HIV)-positive women have high rates of cervical squamous intraepithelial lesions (SIL) and concurrent human papillomavirus (HPV) infections with a variety of genotypes whose oncogenic risk is poorly documented. The prevalence and persistence of HPV genotypes and HPV16 variants were analysed in 112 HIV-positive and 115 HIV-negative Italian women. HIV-positive women were more likely than HIV-negative women to be infected by HPV at the initial examination (39.3 vs 13.9 %, P<0.001) and to have a higher period prevalence of HPV infection over a 3-year follow-up (43.8 % vs 17.4 %, P<0.001), regardless of CD4+ cell counts and anti-retroviral therapy. ‘High-risk’ and ‘probable high-risk’ HPVs (types 16, 18, 31, 33, 35, 45, 52, 58 and 66), among the 20 different viral genotypes identified, were predominant in HIV-positive (33.9 %) compared with HIV-negative (13.9 %) women. Among HIV-infected women, with normal cytology as well as with SIL of any grade, the most common genotypes were HPV16 followed by HPV81, -58, -72, -33 and -62. HPV16 isolates from 18 HIV-positive and eight HIV-negative women were classified into variant lineages based on sequencing analysis of E6 and E7 genes and the long control region. Whilst the HPV16 G350 European variant was prevalent in both HIV-positive (10.7 %) and -negative women (3.5 %), HPV16 African 2 variant was only detected in HIV-positive women (3.6 %), suggesting different sexual mixing behaviours. The increased prevalence of uncommon viral genotypes and HPV16 variants in HIV-positive Italian women underscores the need to target a wide range of HPV types in cervical screening of high-risk women.

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Abnormal cervical cytology amongst women infected with human immunodeficiency virus in Limpopo province, South Africa

African Journal of Primary Health Care & Family Medicine ◽

10.4102/phcfm.v12i1.2215 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Samuel T. Ntuli ◽

Eric Maimela ◽

Linda Skaal ◽

Mabina Mogale ◽

Provia Lekota

Keyword(s):

South Africa ◽

Cervical Cancer ◽

Human Immunodeficiency Virus ◽

Limpopo Province ◽

Cervical Cytology ◽

Hiv Positive ◽

Abnormal Cytology ◽

Abnormal Cervical Cytology ◽

Hiv Positive Women ◽

Immunodeficiency Virus

Background: Cervical cancer remains the major public problem worldwide and the most common gynaecological malignancy in the developing world, particularly in sub-Saharan Africa.Aim: To determine the prevalence of abnormal cervical cytology amongst women with and without human immunodeficiency virus (HIV) and examine the association between HIV and histological grading.Setting: The study was conducted in Limpopo province, which is the northernmost province of South Africa. The province has five district municipalities with one tertiary, five regional and thirty four district hospitals.Methods: We retrospectively reviewed cervical cancer cases in Limpopo province (LP) of South Africa, using data collected routinely by the National Health Laboratory Services (NHLS). The data on smears submitted for cytology between 2013 and 2015 were extracted from the Central Data Warehouse (CDW) database.Results: A total of 84 466 women were screened for cervical cytology smears. Their mean age was 39.8 ± 13.6 years, with range from 15 to 113 years; 77.2% were in the age group 30 years and older and 19.6% had an abnormal cervical cytology result. Overall, 46.4% of the women screened for cervical cancer were HIV infected. A significantly higher proportion of HIV-positive women had abnormal cytology than HIV-negative women (31.8% vs. 9.2%).Conclusion: The prevalence of abnormal cytology amongst HIV-positive women is relatively high, and the risk appears to be significantly greater in all age groups. This finding highlights the need to ascertain HIV status of all women presenting with cervical cancer.

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Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

Viruses ◽

10.3390/v14010024 ◽

2021 ◽

Vol 14 (1) ◽

pp. 24

Author(s):

Cremildo Maueia ◽

Alltalents Murahwa ◽

Alice Manjate ◽

Soren Andersson ◽

Jahit Sacarlal ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Study Cohort ◽

Hpv Prevalence ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

Hpv Types ◽

Hiv Negative

Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate HPV prevalence, genotypes and its characteristics, according to the HIV status in women from Maputo in Mozambique. Methods: A total of 233 participants with ages ranging from fourteen to forty-five were included. Cervical samples were collected, DNA extracted, and HPV genotyping was performed using the HPV Direct Flow CHIP Kit. Results: In total, 177 HIV-negative and 56 HIV-positive women were included in the analysis. The overall HPV prevalence was 63% and was significantly higher among HIV-positive women (79% versus 58% among HIV-negative women; p = 0.005). The prevalence of multiple HPV type infections was 32%. High-risk HPV types 52, 68, 35, 18 and 16 were the most frequent. A higher proportion of HIV-positive women had multiple HPV types compared with HIV-negative women. Conclusions: This study demonstrated a high prevalence of HPV in the study cohort. HIV-positive women were identified as having the highest HPV prevalence and infection with multiple HPV types across all ages. High-risk genotypes were the most commonly found.

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The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

The Journal of Infection in Developing Countries ◽

10.3855/jidc.9711 ◽

2018 ◽

Vol 12 (06) ◽

pp. 477-484 ◽

Cited By ~ 2

Author(s):

Ahd Ouladlahsen ◽

Naouar Fayssel ◽

Rajaa Bensghir ◽

Hanâ Baba ◽

Hassan Lamdini ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

High Risk ◽

Hpv Infection ◽

Hiv Positive ◽

Cell Counts ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

High Prevalence ◽

Hpv Types

Introduction: Women infected with human immunodeficiency virus (HIV) have a higher risk of contracting human papillomavirus (HPV) infections and are more prone to develop cervical cancer. The objective of this study was to determine the prevalence of HPV and its association with risk factors among Moroccan women living with HIV/AIDS. Methodology: We enrolled 251 HIV-infected non-pregnant women in Morocco from February 2013 to September 2016. Sociodemographic, lifestyles, behavioral and clinical data were collected. Polymerase chain reaction followed by sequencing were performed for molecular detection and HPV genotyping in cervical samples, respectively. Results: Abnormal cervical smears were found in 34/246 patients (13.82%). The overall prevalence of HPV was 74.50%. HPV 58 was the most prevalent (39.29%) followed by HPV 18 (10.71%), HPV 70 (8.93%), HPV 33 (7.14%), HPV 6 (6.25%) and other genotypes (< 3%). Overall, high-risk HPV (HR-HPV) types were present in 75% (84/112) of patients and the prevalence of HR-HPV types in samples with abnormal Pap was higher than in normal Pap (55/83, 66.27% vs. 28/83, 33.33%, p < 0.0001). Univariate analyses showed that none of the socio-demographic and behaviors factors was associated with HPV infection. Moreover, Pap results were not affected by HPV status (p = 0.532). Whereas, CD4 T-cell counts above 200/mm3 at enrolment were apparently not protective to HPV infection. We found a high prevalence of HPV infection and HR-HPV types among HIV-positive women that significantly associated with abnormal Pap. Conclusion: Our findings suggest a high prevalence of HPV infection with high-risk types was observed among HIV-positive women warrant to implement a regular screening by Pap smear.

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